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PMC:2674207 JSONTXT 20 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T754 22-36 http://purl.obolibrary.org/obo/GO_0051170 denotes Nuclear Import
T756 41-56 http://purl.obolibrary.org/obo/GO_0016310 denotes Phosphorylation
T757 720-732 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T758 857-867 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T759 1288-1323 http://purl.obolibrary.org/obo/GO_0002147 denotes glucocorticoid receptor for nuclear
T760 1316-1333 http://purl.obolibrary.org/obo/GO_0051169 denotes nuclear transport
T761 1324-1333 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T755 1346-1362 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear importer
T762 1434-1458 http://purl.obolibrary.org/obo/GO_0034199 denotes activated protein kinase
T763 1434-1458 http://purl.obolibrary.org/obo/GO_0032147 denotes activated protein kinase
T764 1434-1458 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinase
T765 1434-1458 http://purl.obolibrary.org/obo/GO_0032111 denotes activated protein kinase
T766 1460-1464 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T768 1466-1477 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T767 1517-1520 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T3225 7246-7258 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammation
T3226 7549-7561 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T3229 7614-7627 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3232 7720-7740 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T3233 7814-7835 http://purl.obolibrary.org/obo/GO_0006338 denotes chromatin remodelling
T3227 7887-7899 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T3234 8482-8497 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T3235 8836-8850 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T3238 8851-8857 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T3240 8870-8881 http://purl.obolibrary.org/obo/GO_0006810 denotes transported
T3242 8870-8898 http://purl.obolibrary.org/obo/GO_0051169 denotes transported into the nucleus
T3244 8891-8928 http://purl.obolibrary.org/obo/GO_0006606 denotes nucleus by the nuclear import protein
T3236 8906-8920 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T3245 8914-8928 http://purl.obolibrary.org/obo/GO_0017038 denotes import protein
T3246 9029-9041 http://purl.obolibrary.org/obo/GO_0051179 denotes localisation
T3247 9111-9123 http://purl.obolibrary.org/obo/GO_0051179 denotes localisation
T3251 9198-9213 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T3253 9243-9246 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T3255 9255-9279 http://purl.obolibrary.org/obo/GO_0034199 denotes activated protein kinase
T3256 9255-9279 http://purl.obolibrary.org/obo/GO_0032147 denotes activated protein kinase
T3257 9255-9279 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinase
T3258 9255-9279 http://purl.obolibrary.org/obo/GO_0032111 denotes activated protein kinase
T3254 9281-9285 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T3241 9393-9402 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T3243 9393-9419 http://purl.obolibrary.org/obo/GO_0051169 denotes transport into the nucleus
T3228 9492-9504 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T3259 9758-9781 http://purl.obolibrary.org/obo/GO_0051384 denotes glucocorticoid response
T3230 10008-10021 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3248 10163-10175 http://purl.obolibrary.org/obo/GO_0051179 denotes localisation
T3260 10180-10189 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T3249 10228-10240 http://purl.obolibrary.org/obo/GO_0051179 denotes localisation
T3261 10280-10289 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T3239 10290-10297 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T3262 10322-10336 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T3263 11016-11026 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T3237 11048-11062 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T3265 11108-11121 http://purl.obolibrary.org/obo/GO_0003755 denotes immunophilins
T3266 11181-11187 http://purl.obolibrary.org/obo/GO_0003777 denotes dynein
T3267 11525-11528 http://purl.obolibrary.org/obo/GO_0004096 denotes CAT
T3264 11818-11828 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T3231 11883-11896 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3252 11981-11996 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T3268 12096-12111 http://purl.obolibrary.org/obo/GO_0001775 denotes cells activated
T3250 12240-12252 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T4298 13496-13499 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T4299 13826-13838 http://purl.obolibrary.org/obo/GO_0009293 denotes Transduction
T4599 14488-14500 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T4829 14566-14587 http://purl.obolibrary.org/obo/GO_0001171 denotes Reverse Transcription
T4830 14574-14587 http://purl.obolibrary.org/obo/GO_0006351 denotes Transcription
T4831 14622-14627 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T4832 14854-14856 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T4833 14914-14916 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T5179 15314-15319 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T5180 15541-15549 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T6713 19324-19330 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T7113 19992-20001 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion
T7114 20641-20650 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion
T7596 21257-21263 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T8657 23314-23329 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T8658 23439-23453 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T8659 23851-23860 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T16601 24370-24385 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T16602 24406-24420 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T16603 24766-24778 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T16604 24985-24989 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T16605 25212-25214 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T19152 25526-33640 http://purl.obolibrary.org/obo/GO_0031296 denotes stimulated. (E) FP (10 nM) reduces the ability of anti-CD3/CD28-stimulated GATA-3 to associate with the native IL-5 promoter 60 min after stimulation. Data are also shown graphically as mean±SEM of three independent experiments. All data were analysed by ANOVA followed by Newman-Keuls post-test. Ligand-Activated GR Competes with GATA-3 for Importin-α We confirmed and extended previous data [20] to show that ligand-activated GR as well as GATA-3 uses importin-α for its nuclear import (Figure 2A and 2B). This interaction between GR and importin-α was significant at concentrations as low as 10−12 M and was maximal with 10−8 M FP. Subsequent GR nuclear translocation was rapid and sustained at significant levels for at least 14 h (Figure 2B). Using IP-Western blotting we showed that FP at 10−12–10−8 M decreased the association between GATA-3 and importin-α induced by anti-CD3/CD28 stimulation in a concentration-dependent manner (Figure 2C). In addition, using GFP-labelled GATA-3 and confocal microscopy we demonstrated that GATA-3 nuclear import following anti-CD3/CD28 stimulation for 30 min was attenuated by pretreatment with FP (10−8 M) (Figure 2D). 10.1371/journal.pmed.1000076.g002 Figure 2 Fluticasone propionate reduces GATA-3 association with importin-α and GATA-3 nuclear import. (A) Western blot analysis demonstrates a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent induction of FP-activated GR interaction with importin-α (Imp-α). A positive control for GR association with importin is shown. Quantification of the densitometry data is shown below. Each bar represents mean±SEM of at least three independent experiments. *** p<0.001 compared to control, ### p<0.001. (B) Western blot analysis demonstrated a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent induction of FP-activated GR nuclear translocation measured by IP. Quantification of the densitometry data is shown below. Each bar represents mean±SEM of at least three independent experiments. ***p<0.001 compared to control. (C) Western blot analysis of HuT-78 cells treated with FP and anti-CD3/CD28 co-stimulation demonstrated a concentration-dependent decrease in GATA-3–importin-α association at 20 min. Quantification of the densitometry data is shown below. Each bar represents mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to αCD3/CD28-stimulated cells. (D) GFP-tagged GATA-3 was overexpressed and cells stimulated (b, c) or not (a) for 30 min with anti-CD3/CD28. The effect of 30 min pretreatment of cells with FP (10−8 M, c) is also shown. All data were analysed by ANOVA followed by Newman-Keuls post-test. Effect on MKP-1 Dexamethasone inhibits p38 MAPK function in a cell type–specific manner through the rapid induction of the dual kinase phosphatase MKP-1 (MAPK phosphatase-1), and this effect lasts for up to 24 h [28]. FP (10−8 M) treatment of HuT-78 cells activated by anti-CD3/CD28 in vitro significantly decreased p38 MAPK phosphorylation (Figure 3A) and activity measured by phosphorylation of the downstream target ATF-2 (Figure 3B). This effect was detected at 30 min and lasted for at least 14 h (Figure 3B). FP (10−8 M) also significantly reduced GATA-3 serine phosphorylation induced by anti-CD3/CD28 stimulation in both a time- and concentration-dependent manner (Figure 3C). This reduction in GATA-3 phosphorylation was also seen with lower concentrations of FP. We found that FP significantly induced MKP-1 mRNA in both a time- and concentration-dependent manner, reaching a plateau at 10−8 M after 10 min (Figure 3D and 3E). However, the effects of FP on GATA-3 nuclear import, importin-α association and IL-4 mRNA expression are seen at 10,000-fold lower concentrations (10−12 M, see Figure 2). 10.1371/journal.pmed.1000076.g003 Figure 3 Fluticasone propionate–mediated inhibition of p38 MAP kinase phosphorylation and activation is associated with a marked down-regulation of GATA-3 serine phosphorylation. (A) Western blot analysis shows that FP (10−8 M, 30 min) treatment reduced dual phosphorylation (threonine-180 and tyrosine-182) of p38 MAPK in anti-CD3/CD28–co-stimulated HuT-78 cells. (B) Time course of the effect of FP (10−8 M) on phosphorylation of activated transcription factor 2 (ATF-2), a measure of p38 MAPK activity. (C) FP-induced inhibition of p38 MAPK activity is associated with the decrease of anti-CD3/CD28 co-stimulation–induced serine phosphorylation (P-Ser) of GATA-3. For (A–C), quantification of the densitometry data is also shown. Each bar represents mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to αCD3/CD28-stimulated cells. (D) FP induced MKP-1 mRNA in a concentration-dependent manner. All results are representative of at least three independent experiments and where appropriate expressed as means±SEM, *p<0.05. (E) FP induces MKP-1 mRNA in a time-dependent manner. Results are representative of two independent experiments. All data except (E) were analysed by ANOVA followed by Newman-Keuls post-test. Using an in vitro competition assay (Figure 4A) utilizing purified activated GATA-3, importin-α, and activated GR, we demonstrated that activated GR significantly increased GR-importin-α association in the presence and absence of activated GATA-3 (Figure 4B). This effect is not mutual, since activated GATA-3 did not block GR–importin-α association (Figure 4C). These data also suggest that both activated GR and phospho-GATA-3 can directly associate with importin-α (Figure 4D) and that activated GR attenuates the phospho-GATA-3/importin-α interaction in a concentration-dependent manner (Figure 4E). Together, this suggests that ligand-activated GR may compete with phospho-GATA-3 for importin-α and thereby limit GATA-3 nuclear import. 10.1371/journal.pmed.1000076.g004 Figure 4 Fluticasone propionate competes with phospho-GATA-3 for importin-α. (A) schematic representation of the in vitro binding competition assay. (B) GR isolated from FP (10−8 M) stimulated cells enhances GR–importin-α binding in the presence (•) and absence (▪) of activated GATA-3. * p<0.05 compared to no activated GR. (C) GATA-3 isolated from anti-CD3/CD28–stimulated cells does not attenuate GR–importin-α association. *p<0.05 compared to control. (D) Activated GR blocks the ability of purified phospho-GATA-3 isolated from anti-CD3/CD28–stimulated cells interacting with immobilised importin-α in an in vitro binding assay. *p<0.05 compared to GATA-3 isolated from unstimulated cells. # p<0.05 compared to stimulated GATA-3-importin binding. (E) The effect of activated (•) versus unstimulated (○) GR on attenuation of GATA-3–importin-α association was concentration-dependent. *p<0.05, **p<0.01 between groups. All results are expressed as mean±SEM of three independent experiments and analysed by ANOVA followed by Newman-Keuls post-test. Other possible interpretations of our results could include an effect of FP on GATA-3 nuclear export and/or degradation. Leptomycin B, which inhibits nuclear export, did not affect the ability of FP to block GATA-3 nuclear localization (Figure 5A). Additionally, FP had no effect on whole cell GATA-3 expression during the time course of these experiments (Figure 5B). Nor did addition of FP subsequent to anti-CD3/CD28 nuclear translocation affect GATA-3 nuclear residency (Figure 5C), suggesting that activated GR does not enhance GATA-3 nuclear export. Finally, the effect of FP on GATA-3 nuclear import was not nonspecific, since FP (10−8 M) had no effect on p65 nuclear translocation measured at 60 min (Figure 5D). 10.1371/journal.pmed.1000076.g005 Figure 5 Fluticasone propionate does not affect GATA-3 nuclear export. (A) Western blot analysis showing that the nuclear export inhibitor leptomycin B (2 nM) does not affect the ability of FP (10−8 M) to prevent anti-CD3/CD28–stimulated GATA-3 nuclear localization measured at 60 min. ***p<0.001 compared to unstimulated cells, ### p<0.001 compared to anti-CD3/CD28–stimulated cells. (B
T9278 26000-26014 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T9279 26568-26582 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T17414 26812-26826 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T17415 28038-28057 http://purl.obolibrary.org/obo/GO_0002672 denotes cells stimulated (b
T17416 28038-28057 http://purl.obolibrary.org/obo/GO_0045579 denotes cells stimulated (b
T17417 28038-28057 http://purl.obolibrary.org/obo/GO_0002869 denotes cells stimulated (b
T17418 28038-28057 http://purl.obolibrary.org/obo/GO_0002904 denotes cells stimulated (b
T17419 28038-28057 http://purl.obolibrary.org/obo/GO_0050871 denotes cells stimulated (b
T17420 28038-28057 http://purl.obolibrary.org/obo/GO_0031296 denotes cells stimulated (b
T17421 28038-28057 http://purl.obolibrary.org/obo/GO_0030890 denotes cells stimulated (b
T10687 28290-28293 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T10688 28294-28298 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10691 28386-28397 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T10689 28405-28409 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10692 28410-28421 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T10693 28501-28516 http://purl.obolibrary.org/obo/GO_0001775 denotes cells activated
T10690 28571-28575 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10694 28576-28591 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10695 28629-28644 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10696 28819-28834 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10697 28961-28976 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10698 29225-29239 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T18100 29449-29452 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18106 29464-29479 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18111 29464-29494 http://purl.obolibrary.org/obo/GO_0042327 denotes phosphorylation and activation
T18113 29528-29538 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T18107 29556-29571 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18108 29653-29668 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18101 29705-29708 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18103 29709-29713 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18109 29807-29822 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18112 29807-29835 http://purl.obolibrary.org/obo/GO_0042327 denotes phosphorylation of activated
T18114 29826-29856 http://purl.obolibrary.org/obo/GO_0051091 denotes activated transcription factor
T18115 29826-29856 http://purl.obolibrary.org/obo/GO_0032793 denotes activated transcription factor
T18116 29826-29856 http://purl.obolibrary.org/obo/GO_1901485 denotes activated transcription factor
T18117 29836-29849 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T18102 29881-29884 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18104 29885-29889 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18118 29915-29937 http://purl.obolibrary.org/obo/GO_1903753 denotes inhibition of p38 MAPK
T18105 29933-29937 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18110 30026-30041 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10701 30947-30953 http://purl.obolibrary.org/obo/GO_0085030 denotes mutual
T10699 31393-31407 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T18536 31655-31673 http://purl.obolibrary.org/obo/GO_0005049 denotes importin-α binding
T10702 32583-32597 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T10705 32605-32616 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T10703 32647-32661 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T10706 32720-32732 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T10704 33037-33051 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T10700 33089-33103 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T19149 33308-33322 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T19150 33367-33381 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T19151 33506-33518 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T19154 33723-33734 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T19153 33789-33808 http://purl.obolibrary.org/obo/GO_0031296 denotes cells stimulated (b
T19155 33789-33808 http://purl.obolibrary.org/obo/GO_0002672 denotes cells stimulated (b
T19156 33789-33808 http://purl.obolibrary.org/obo/GO_0045579 denotes cells stimulated (b
T19157 33789-33808 http://purl.obolibrary.org/obo/GO_0002869 denotes cells stimulated (b
T19158 33789-33808 http://purl.obolibrary.org/obo/GO_0002904 denotes cells stimulated (b
T19159 33789-33808 http://purl.obolibrary.org/obo/GO_0050871 denotes cells stimulated (b
T19160 33789-33808 http://purl.obolibrary.org/obo/GO_0030890 denotes cells stimulated (b
T19579 34874-34886 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T12574 35776-35791 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T12576 36854-36862 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T12577 36863-36875 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T12579 37831-37834 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T12580 37835-37839 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T12582 37840-37855 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T20243 38030-38042 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T20244 38162-38174 http://purl.obolibrary.org/obo/GO_0051179 denotes localisation
T20245 39244-39259 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T20246 39296-39299 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T20247 39300-39304 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T12578 39483-39495 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T12581 39693-39697 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T12583 39714-39729 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T12584 39854-39868 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T12575 39891-39906 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T15238 40051-40064 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T15242 40215-40229 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15250 40272-40289 http://purl.obolibrary.org/obo/GO_0051169 denotes nuclear transport
T15251 40280-40289 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T15252 40420-40423 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15258 40424-40428 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15266 40486-40508 http://purl.obolibrary.org/obo/GO_1900745 denotes activation of p38 MAPK
T15253 40500-40503 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15259 40504-40508 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15267 40524-40539 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T15243 40615-40629 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15239 41018-41031 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T15244 41114-41128 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15245 41253-41267 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15270 41323-41344 http://purl.obolibrary.org/obo/GO_0005049 denotes binding of importin-α
T15240 41484-41497 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T15271 41843-41857 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T15272 41885-41896 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T15273 42306-42323 http://purl.obolibrary.org/obo/GO_0006412 denotes protein synthesis
T15274 42314-42323 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T15246 42406-42420 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15254 42567-42570 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15260 42571-42575 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15261 42650-42654 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15247 42864-42878 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15255 42894-42897 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15262 42898-42902 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15268 42934-42949 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T15256 43065-43068 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15263 43069-43073 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15257 43221-43224 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15264 43225-43229 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15248 43317-43331 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15276 43426-43438 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T15241 43698-43711 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T15277 44554-44566 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T15249 44671-44685 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15279 44679-44693 http://purl.obolibrary.org/obo/GO_0017038 denotes import protein
T15275 44751-44760 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T15265 44790-44794 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15269 44816-44831 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T15278 45022-45034 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T15280 45328-45339 http://purl.obolibrary.org/obo/GO_0032502 denotes development