| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-21 |
protein_family_or_group |
denotes |
Transcription factors |
| T2 |
22-25 |
protein_molecule |
denotes |
Sp1 |
| T3 |
30-34 |
protein_molecule |
denotes |
AP-2 |
| T4 |
56-77 |
protein_family_or_group |
denotes |
acid sphingomyelinase |
| T5 |
85-110 |
other_name |
denotes |
monocytic differentiation |
| T6 |
127-161 |
cell_line |
denotes |
human monocytic leukemia cell line |
| T7 |
162-167 |
cell_line |
denotes |
THP-1 |
| T8 |
239-272 |
other_organic_compound |
denotes |
phorbol 12-myristate -13- acetate |
| T9 |
274-277 |
other_organic_compound |
denotes |
PMA |
| T10 |
280-305 |
lipid |
denotes |
1,25-dihydroxy-vitamin D3 |
| T11 |
380-396 |
protein_family_or_group |
denotes |
lysosomal enzyme |
| T12 |
397-418 |
protein_family_or_group |
denotes |
acid sphingomyelinase |
| T13 |
514-525 |
cell_line |
denotes |
THP-1 cells |
| T14 |
556-584 |
cell_type |
denotes |
human mononuclear phagocytes |
| T15 |
592-609 |
other_name |
denotes |
Northern blotting |
| T16 |
611-616 |
protein_molecule |
denotes |
RNase |
| T17 |
639-662 |
other_name |
denotes |
nuclear run-on analyses |
| T18 |
698-712 |
other_name |
denotes |
ASM expression |
| T19 |
776-793 |
other_name |
denotes |
protein synthesis |
| T20 |
819-831 |
other_name |
denotes |
ASM activity |
| T21 |
870-873 |
other_organic_compound |
denotes |
PMA |
| T22 |
925-948 |
other_name |
denotes |
transcriptional control |
| T23 |
962-985 |
DNA_family_or_group |
denotes |
5' deletion derivatives |
| T24 |
993-1019 |
DNA_domain_or_region |
denotes |
upstream regulatory region |
| T25 |
1033-1062 |
other_name |
denotes |
transient transfection assays |
| T26 |
1075-1092 |
DNA_family_or_group |
denotes |
promoter elements |
| T27 |
1126-1141 |
other_name |
denotes |
gene expression |
| T28 |
1145-1148 |
other_organic_compound |
denotes |
PMA |
| T29 |
1202-1227 |
DNA_domain_or_region |
denotes |
-319 and -219 bp upstream |
| T30 |
1278-1318 |
DNA_family_or_group |
denotes |
transcription factor expression plasmids |
| T31 |
1323-1327 |
protein_molecule |
denotes |
AP-2 |
| T32 |
1332-1335 |
protein_molecule |
denotes |
Sp1 |
| T33 |
1358-1379 |
other_name |
denotes |
ASM promoter activity |
| T34 |
1410-1423 |
DNA_domain_or_region |
denotes |
binding sites |
| T35 |
1466-1503 |
other_name |
denotes |
electrophoretic mobility shift assays |
| T36 |
1508-1525 |
other_name |
denotes |
supershift assays |
| T37 |
1583-1586 |
protein_molecule |
denotes |
Sp1 |
| T38 |
1591-1595 |
protein_molecule |
denotes |
AP-2 |
| T39 |
1626-1642 |
cell_component |
denotes |
nuclear extracts |
| T40 |
1684-1695 |
cell_line |
denotes |
THP-1 cells |
| T41 |
1768-1784 |
cell_component |
denotes |
nuclear extracts |
| T42 |
1790-1793 |
other_organic_compound |
denotes |
PMA |
| T43 |
1882-1903 |
protein_family_or_group |
denotes |
transcription factors |
| T44 |
1904-1908 |
protein_molecule |
denotes |
AP-2 |
| T45 |
1913-1916 |
protein_molecule |
denotes |
Sp1 |
| T46 |
1938-1952 |
other_name |
denotes |
up -regulation |
| T47 |
1956-1970 |
other_name |
denotes |
ASM expression |
| T48 |
1993-2019 |
other_name |
denotes |
macrophage differentiation |