Epistemic_Statements  

CORD-19:61803c63a48fdddedfd407f8d440fe6b19b4a238 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 418-535 Epistemic_statement denotes Probiotics therapy could be an alternative method of antiviral prevention and modulation against rotavirus infection.
T2 1295-1442 Epistemic_statement denotes Overall, these results indicate that L. ruminis SPM0211, B. longum SPM1205 and 1206 efficiently inhibit rotavirus replication in vitro and in vivo.
T3 1594-1776 Epistemic_statement denotes Anti-rotaviral effects of the 3 probiotics are likely due to their modulation of the immune response through promoting type I IFNs, which are key regulators in IFN signaling pathway.
T4 1985-2096 Epistemic_statement denotes The symptoms normally disappear within 3-7 days, but may last for up to 2-3 weeks (Desselberger et al., 2009) .
T5 2422-2495 Epistemic_statement denotes The incidence rate of rotavirus disease seems similar all over the world.
T6 2496-2663 Epistemic_statement denotes However, the mortality rate is due to vaccination, fatalities are rare in young children in developed countries (Parashar et al., 2009; Chen et al., 2012; WHO, 2013) .
T7 2664-2774 Epistemic_statement denotes Rotavirus vaccines are safe and efficient for preventing rotavirus gastroenteritis, although they have limits.
T8 2941-3128 Epistemic_statement denotes Alternative method of antiviral agents is suggested application of probiotic bacteria (Chai et al., 2013; Kwak et al., 2013; Lee et al., 2013; Kim et al., 2014; Lehtoranta et al., 2014) .
T9 3301-3522 Epistemic_statement denotes and Bifidobacterium spp., are reported multiple potential health benefits including blocking gastroenteric pathogens, enhancing immune responses, and neutralizing viruses (Rolfe, 2000; Minocha, 2009; Zhang et al., 2013) .
T10 3785-3991 Epistemic_statement denotes Recently, some researchers reported that probiotics are effective in the treatment of rotavirus gastroenteritis (Dubey et al., 2008; Maragkoudakis et al., 2010; Ventola et al., 2012; Vlasova et al., 2013) .
T11 4242-4381 Epistemic_statement denotes Continuously, we investigated how probiotics suppress rotavirus infection using quantitative real time polymerase chain reaction (RT-qPCR).
T12 14013-14203 Epistemic_statement denotes To determine whether the 3 probiotics had antiviral activity through inhibition of rotavirus replication, we evaluated rotavirus RNA expression in rotavirus-infected Caco-2 cells by RT-qPCR.
T13 15328-15478 Epistemic_statement denotes To assess the potential antiviral activity of the 3 probiotics, we evaluated rotavirus gene expression in the rotavirus-infected neonatal mouse model.
T14 16016-16172 Epistemic_statement denotes We examined whether the 3 probiotics inhibited rotavirus infection through a type I IFN signaling pathway in Wa rotavirus-infected neonatal mice by RT-qPCR.
T15 17554-17651 Epistemic_statement denotes (2012) L. rhamnosus GG may increase rotavirus clear-ance from the body and reduce colon swelling.
T16 18921-19042 Epistemic_statement denotes (2007) probiotics could block viral attachment at the surface of intestinal cells by competitive inhibition during entry.
T17 19043-19175 Epistemic_statement denotes However, these results did not confirm whether the probiotics inhibited rotavirus replication through modulation of the viral cycle.
T18 20646-20758 Epistemic_statement denotes These results indicated that all 3 probiotics might inhibit rotavirus infection and reduce symptom and duration.
T19 22971-23126 Epistemic_statement denotes These results indicated that novel probiotics modulate the immune response by promoting type I IFNs, which are key regulators in the IFN signaling pathway.
T20 23127-23264 Epistemic_statement denotes Interestingly, the antiviral activity of the 3 probiotics was not congruous with the gene expression of IFNinducible antiviral effectors.
T21 23766-23902 Epistemic_statement denotes L. ruminis exists in various species, but there is lack of research on the biological activity of them relatively to other Lactobacilli.
T22 24167-24346 Epistemic_statement denotes Recently, some researchers isolated L. ruminis strains from various species and reported the character of them (Forde et al., 2011; Gärtner et al., 2015; O'Donnell et al., 2015) .
T23 24347-24419 Epistemic_statement denotes However, there was no report about the antiviral activity of L. ruminis.
T24 24494-24700 Epistemic_statement denotes Overall, our results indicated that L. ruminis SPM0211 and B. longum SPM1205 and 1206 efficiently inhibit rotavirus replication in Wa rotavirus-infected Caco-2 cells and in an infected neonatal mouse model.
T25 24701-24886 Epistemic_statement denotes The antiviral effects of the three probiotics are likely due to a modulation of the immune response through promoting type I IFNs, which are key regulators in the IFN signaling pathway.
T26 25027-25186 Epistemic_statement denotes Our data suggest B. longum SPM1205, 1206, and L. ruminis SPM0211 have the potential to be a new prevention and reliever tool against rotavirus gastroenteritis.