Epistemic_Statements  

CORD-19:53be4000821ac430bae87a7faf22ee1e493e5832 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 739-872 Epistemic_statement denotes Histologically, acute and chronic inflammatory infiltration of the vascular walls was associated with necrosis of the muscular layer.
T2 1458-1592 Epistemic_statement denotes PAN can affect every organ, but generally the lungs are spared; venules and capillaries are not involved (Forbess and Bannykh, 2015) .
T3 1716-2184 Epistemic_statement denotes It has been described in blue foxes (Alopex lagopus) (Nordstoga and Westbye, 1976) , cynomolgus macaques (Macaca fascicularis) (Albassam et al., 1993; Porter et al., 2003) , sheep (Landsverk and Bratberg, 1979; Ferreras et al., 2013; Wessel et al., 2017; Pesavento et al., 2018) , cattle (Filippich and Mudie, 1972) , pigs (Hamir, 1980; Liu et al., 2005) , dogs (Carpenter et al., 1988; Snyder et al., 1995) and cats (Altera and Bonasch, 1966; Campbell et al., 1972) .
T4 2612-2657 Epistemic_statement denotes The pathogenesis of PAN is poorly understood.
T5 3233-3494 Epistemic_statement denotes In veterinary medicine, PAN has been described in blue foxes associated with encephalitozoonosis (Nordstoga and Westbye, 1976) , in lambs with sarcocystosis (Landsverk and Bratberg, 1979) and in sheep infected with ovine herpesvirus 2 (Pesavento et al., 2018) .
T6 3495-3586 Epistemic_statement denotes A relationship with streptococcal infection has been suspected in pigs (Liu et al., 2005) .
T7 3587-3757 Epistemic_statement denotes However, no infectious agents have been detected in most cases of PAN in animals (Carpenter et al., 1988; Snyder et al., 1995; Porter et al., 2003; Wessel et al., 2017) .
T8 8257-8887 Epistemic_statement denotes Selected sections were labelled immunohistochemically with antibodies specific for CD3 (clone F7.2.38; 1 in 100 dilution; Dako, Glostrup, Denmark), CD20 (RB9013; 1 in 400 dilution; Thermo Scientific, Fremont, California, USA), Iba-1 (1 in 300 dilution; Wako, Osaka, Japan), major histocompatibility complex class II (MHC class II; clone 1AL.1B5; 1 in 10 dilution; Dako), feline IgG, IgM and complement factor C3 (each 1 in 10 dilution; Binding Site, Birmingham, UK), feline coronavirus (FIPV3-70; 1 in 200 dilution; OriGene Technologies Inc., Rockville, Maryland, USA) and smooth muscle actin (clone 1A4; 1 in 500 dilution; Dako).
T9 9646-9836 Epistemic_statement denotes 3 ) and fewer CD20-positive lymphocytes, plasma cells and rare neutrophils, infiltrated the adventitia and perivascular tissues, spreading within the artery wall to the subendothelial layer.
T10 9914-10128 Epistemic_statement denotes Inflammatory cell infiltration was associated with necrosis and loss of smooth muscle fibres of the tunica media and delamination and disintegration of the internal and external elastic laminae (Supplementary Figs.
T11 10403-10527 Epistemic_statement denotes 6 ), were associated with chronic stages characterized by severe thickening of the arterial wall and narrowing of the lumen.
T12 10770-10881 Epistemic_statement denotes Rarely, intraluminal thrombi and haemosiderin-laden macrophages, suggesting previous haemorrhage, were evident.
T13 10943-11092 Epistemic_statement denotes Coronary arteries and all of their branches in the myocardium showed severe inflammatory changes associated with marked thickening of arterial walls.
T14 11214-11360 Epistemic_statement denotes In both kidneys, severe vascular lesions were associated with multifocal interstitial nephritis and fibrosis without involvement of the glomeruli.
T15 11818-12018 Epistemic_statement denotes This latter lesion was associated with affected vessels of the meninges and was characterized by malacia and white matter degeneration, gliosis and infiltration of macrophages laden with haemosiderin.
T16 12326-12459 Epistemic_statement denotes Vascular lesions were associated with axonal degeneration and a slight loss of large and medium myelinated fibres of nerve fascicles.
T17 12460-12666 Epistemic_statement denotes In muscle samples, there was moderate variation in muscle fibre size and shape, mainly in the cranial tibial muscle, in which there were many angular or rounded atrophic fibres and rare hypertrophic fibres.
T18 13473-13678 Epistemic_statement denotes Although some authors proposed the term 'systemic necrotizing arteritis' instead of PAN (Robinson and Robinson, 2016) , the present cat showed lesions strongly resembling those described in human patients.
T19 14424-14530 Epistemic_statement denotes Although no complement deposition was detected, an immune complex-mediated disorder could not be excluded.
T20 14531-14655 Epistemic_statement denotes Indeed, the observed lesions could result from a progression of immune mechanisms from type III to type IV hypersensitivity.
T21 15725-16066 Epistemic_statement denotes Although PAN involving the coronary arteries, with subsequent myocardial infarction, has been described in man and dogs (Carpenter et al., 1988; Odhav et al., 1994; Yuce et al., 2011) , no clinical signs of acute coronary syndrome were identified, and no haemorrhages or infarcts were detected on post-mortem examination in the present case.
T22 16067-16305 Epistemic_statement denotes Central neurological signs, such as circling and seizures, were likely due to involvement of the meningeal vessels and the presence of cerebral infarction as described in sows and dogs with PAN (Carpenter et al., 1988; Liu et al., 2005) .
T23 16836-16994 Epistemic_statement denotes Necrotizing vascular neuropathies secondary to PAN are common in man (Imboden, 2017; James et al., 2018) , but have not been described in veterinary medicine.
T24 16995-17172 Epistemic_statement denotes Peripheral nerve involvement was associated with neurogenic muscle atrophy and primary myopathic findings, such as perifascicular atrophy, were suggestive of ischaemic myopathy.
T25 17173-17294 Epistemic_statement denotes In conclusion, PAN should be included in the differential diagnoses of cardiovascular and neurological syndromes in cats.
T26 17295-17395 Epistemic_statement denotes Combined muscle and nerve biopsy could provide useful clues for ante-mortem diagnosis of feline PAN.