| T130 |
0-644 |
Epistemic_statement |
denotes |
Accumulating evidence from our laboratory and others support the notion that a critical component of any future CD8 T cell vaccine against highly virulent respiratory viruses must be the capacity to (1) promote robust expansion of naïve precursor T cells reactive with viral antigenic peptides; (2) allow a high frequency of these virus-specific effector T cells to survive over time as memory T cells; (3) allow high numbers of these memory cells to persist in the lung parenchyma and airways in the absence of persisting antigen; and (4) to retain high effector function in order to provide optimal surveillance against subsequent infections. |
