Epistemic_Statements  

CORD-19:066d9708265a90886808c378340547b6460afde9 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 960-1137 Epistemic_statement denotes Expression of CD56, synonymous with neural cell adhesion molecule, is rare in B-cell lymphomas and has not been reported in feline B-cell lymphomas or feline neurolymphomatosis.
T2 1599-1925 Epistemic_statement denotes Lymphoma of the nervous system can manifest as intraparenchymal brain lymphoma; lymphomatosis cerebri; intravascular lymphoma; lymphomatous choroiditis and meningitis; extradural, intraduraleextramedullary or intramedullary lymphoma in the spinal cord; or neurolymphomatosis in the peripheral nerves (Guil-Luna et al., 2013) .
T3 2344-2508 Epistemic_statement denotes In man, CD56 positivity is a rare event in B-cell lymphoma and is usually recognized in neoplastic B cells derived from extranodal sites (Weisberger et al., 2006) .
T4 2509-2714 Epistemic_statement denotes Aberrant expression of CD56 by the neoplastic lymphoid cells is considered as a possible factor in infiltration of neoplastic cells into peripheral nerves (Misdraji et al., 2000; Weisberger et al., 2006) .
T5 4384-4475 Epistemic_statement denotes These results could possibly have been related to recent administration of glucocorticoids.
T6 5300-5412 Epistemic_statement denotes However, the cat died of cardiorespiratory failure postoperatively, probably due to unclassified cardiomyopathy.
T7 7382-7728 Epistemic_statement denotes Although central nervous system (CNS) lymphoma and stage IV lymphoma/lymphoid leukaemia could readily metastasize to the peripheral nerves, there was no evidence of CNS lymphoma in this case from the imaging findings; furthermore, polyneuropathy was the only observed clinical sign, highly indicative of primary lymphoma of the peripheral nerves.
T8 7729-7878 Epistemic_statement denotes Neurolymphomatosis is often associated with neurological deficits related to the affected spinal cord roots, nerve or trunk (Linzmann et al., 2009 ).
T9 8322-8505 Epistemic_statement denotes In cats, immune-mediated and infectious polyradiculoneuritis should be considered in the differential diagnoses (Flecknell and Lucke, 1978; Henke et al., 2009; Mandara et al., 2016) .
T10 8694-8969 Epistemic_statement denotes The other immune-mediated disorder is its chronic counterpart, chronic inflammatory demyelinating polyneuropathy (CIDP), or feline chronic relapsing polyneuropathy, which progresses slowly and tends to be associated with spontaneous recovery and relapse (Mari et al., 2016) .
T11 9169-9262 Epistemic_statement denotes Molecular and serological tests and immunolabelling can help identify infectious aetiologies.
T12 9338-9585 Epistemic_statement denotes 4) , which could play a critical role in the pathogenesis of neurolymphomatosis, because neurotropism (nerve invasion) of neoplastic cells has been presumed to result from the adhesion of CD56 molecules to the nerve processes (Kern et al., 1992) .
T13 9586-9699 Epistemic_statement denotes Unfortunately, the expression of CD56 with respect to neoplastic B-cell ontogeny has not been fully investigated.
T14 9700-10033 Epistemic_statement denotes In previous studies, human B-cell lymphomas with CD56 positivity were reportedly associated with a propensity for extranodal involvement and assumed to preferentially arise from the germinal centre stage, where B cells undergo neoplastic transformation with aberrant expression of CD56 (Weisberger et al., 2006; Isobe et al., 2007) .
T15 10034-10229 Epistemic_statement denotes To date, CD56 has not been detected in human primary B-cell neurolymphomatosis and further insight into the pathogenesis of primary B-cell neurolymphomatosis is required (Baehring et al., 2003) .
T16 11002-11014 Epistemic_statement denotes For further
T17 11015-11137 Epistemic_statement denotes investigation of the pathogenesis in neurolymphomatosis, the chicken is believed to be an ideal experimental animal model.
T18 11570-11739 Epistemic_statement denotes Additionally, concurrent CSF examination might be useful in demonstrating a lymphocytic pleocytosis, which could provide the prospective evidence for neurolymphomatosis.
T19 11740-11893 Epistemic_statement denotes For definite diagnosis, nerve biopsies directed by imaging techniques with IHC studies should be performed in suspected cases (Kelly and Karcher, 2005) .
T20 12838-12993 Epistemic_statement denotes Half of these cases (4/8) were of the B-cell lineage, one was of T-cell lineage, one was non-B and non-T cell in origin, while the others remained unknown.
T21 13255-13391 Epistemic_statement denotes In man, primary lymphoma of the peripheral nervous system appears to be aggressive, but may respond to therapy (Misdraji et al., 2000) .
T22 13392-13554 Epistemic_statement denotes The overall survival time is similar to that of large B-cell lymphoma of nodal sites and may be better than that of primary CNS lymphoma (Misdraji et al., 2000) .