| Id |
Subject |
Object |
Predicate |
Lexical cue |
| 25914168-4#62#66#gene3456 |
552-556 |
gene3456 |
denotes |
IFNβ |
| 25914168-4#76#78#diseaseC0026769 |
566-568 |
diseaseC0026769 |
denotes |
MS |
| 25914168-0#35#41#gene285195 |
824-1168 |
gene285195 |
denotes |
SULTS: We found an association between rs9828519(G) and nonresponse to IFNβ (pdiscovery = 4.43 × 10(-8)) and confirmed it in a meta-analysis across 3 replication data sets (preplication = 7.78 × 10(-4)). Only 1 gene is found in the linkage disequilibrium block containing rs9828519: SLC9A9. Exploring the function of this gene, we see that SLC9 |
| 25914168-0#45#63#diseaseC0026769 |
1192-1657 |
diseaseC0026769 |
denotes |
minished in MS subjects who are more likely to have relapses. Moreover, SLC9A9 knockdown in T cells in vitro leads an increase in expression of IFNγ, which is a proinflammatory molecule.
INTERPRETATION: This study identifies and validates the role of rs9828519, an intronic variant in SLC9A9, in IFNβ-treated subjects, demonstrating a successful pharmacogenetic screen in MS. Functional characterization suggests that SLC9A9, an Na(+) -H(+) exchanger found in endos |
| 25914168-10#169#171#gene4397 |
1564-1566 |
gene4397 |
denotes |
MS |
| 25914168-10#377#379#diseaseC0026769 |
1772-1774 |
diseaseC0026769 |
denotes |
MS |
| 169#171#gene4397377#379#diseaseC0026769 |
25914168-10#169#171#gene4397 |
25914168-10#377#379#diseaseC0026769 |
associated_with |
MS,MS |
| 35#41#gene28519545#63#diseaseC0026769 |
25914168-0#35#41#gene285195 |
25914168-0#45#63#diseaseC0026769 |
associated_with |
"SULTS: We found an association between rs9828519(G) and nonresponse to IFNβ (pdiscovery = 4.43 × 10(-8)) and confirmed it in a meta-analysis across 3 replication data sets (preplication = 7.78 × 10(-4)). Only 1 gene is found in the linkage disequilibrium block containing rs9828519: SLC9A9. Exploring the function of this gene, we see that SLC9","minished in MS subjects who are more likely to have relapses. Moreover, SLC9A9 knockdown in T cells in vitro leads an increase in expression of IFNγ, which is a proinflammatory molecule.
INTERPRETATION: This study identifies and validates the role of rs9828519, an intronic variant in SLC9A9, in IFNβ-treated subjects, demonstrating a successful pharmacogenetic screen in MS. Functional characterization suggests that SLC9A9, an Na(+) -H(+) exchanger found in endos" |
| 62#66#gene345676#78#diseaseC0026769 |
25914168-4#62#66#gene3456 |
25914168-4#76#78#diseaseC0026769 |
associated_with |
IFNβ,MS |
