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PubMed:23630944 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
23630944-1#44#52#gene6310 162-170 gene6310 denotes ataxin-1
23630944-1#44#52#gene6310 162-170 gene6310 denotes ataxin-1
23630944-1#132#158#diseaseC0524851 250-276 diseaseC0524851 denotes neurodegenerative disorder
23630944-1#176#182#diseaseC0004134 294-300 diseaseC0004134 denotes ataxia
23630944-1#176#182#diseaseC0007758 294-300 diseaseC0007758 denotes ataxia
23630944-0#20#28#gene6310 342-514 gene6310 denotes Although the mechanisms linking the mutation to the disease remain unclear, evidence indicates that it involves a combination of both gain and loss of functions of ataxin-1
23630944-3#61#67#gene8125 577-583 gene8125 denotes Anp32a
23630944-3#137#141#diseaseC0752120 653-657 diseaseC0752120 denotes SCA1
23630944-0#50#54#gene5524 722-975 gene5524 denotes Pp2a activity and the regulation of its holoenzyme composition, with the polyglutamine mutation within Atxn1 altering this function in the SCA1 mouse cerebellum before disease onset. We show that ataxin-1 enhances Pp2a-bβ expression and down-regulates A
23630944-0#87#116#diseaseC0752120 1387-1890 diseaseC0752120 denotes subunit, specifically bβ2, and of Anp32a occur at the transcriptional level. The Pp2a pathway alterations were confirmed by identified phosphorylation changes of the known Pp2a-substrates, Erk2 and Gsk3β. Similarly, mutant ataxin-1-expressing SH-SY5Y cells exhibit abnormal neuritic morphology, decreased levels of both PP2A-Bβ and ANP32A, and PP2A pathway alterations, all of which are ameliorated by overexpressing ANP32A. Our results point to dysregulation of this newly assigned function of ataxin-1
20#28#gene631087#116#diseaseC0752120 23630944-0#20#28#gene6310 23630944-0#87#116#diseaseC0752120 associated_with "Although the mechanisms linking the mutation to the disease remain unclear, evidence indicates that it involves a combination of both gain and loss of functions of ataxin-1","subunit, specifically bβ2, and of Anp32a occur at the transcriptional level. The Pp2a pathway alterations were confirmed by identified phosphorylation changes of the known Pp2a-substrates, Erk2 and Gsk3β. Similarly, mutant ataxin-1-expressing SH-SY5Y cells exhibit abnormal neuritic morphology, decreased levels of both PP2A-Bβ and ANP32A, and PP2A pathway alterations, all of which are ameliorated by overexpressing ANP32A. Our results point to dysregulation of this newly assigned function of ataxin-1"
44#52#gene6310132#158#diseaseC0524851 23630944-1#44#52#gene6310 23630944-1#132#158#diseaseC0524851 associated_with ataxin-1,neurodegenerative disorder
44#52#gene6310132#158#diseaseC0524851 23630944-1#44#52#gene6310 23630944-1#132#158#diseaseC0524851 associated_with ataxin-1,neurodegenerative disorder
44#52#gene6310176#182#diseaseC0004134 23630944-1#44#52#gene6310 23630944-1#176#182#diseaseC0004134 associated_with ataxin-1,ataxia
44#52#gene6310176#182#diseaseC0004134 23630944-1#44#52#gene6310 23630944-1#176#182#diseaseC0004134 associated_with ataxin-1,ataxia
44#52#gene6310176#182#diseaseC0007758 23630944-1#44#52#gene6310 23630944-1#176#182#diseaseC0007758 associated_with ataxin-1,ataxia
44#52#gene6310176#182#diseaseC0007758 23630944-1#44#52#gene6310 23630944-1#176#182#diseaseC0007758 associated_with ataxin-1,ataxia
50#54#gene552487#116#diseaseC0752120 23630944-0#50#54#gene5524 23630944-0#87#116#diseaseC0752120 associated_with "Pp2a activity and the regulation of its holoenzyme composition, with the polyglutamine mutation within Atxn1 altering this function in the SCA1 mouse cerebellum before disease onset. We show that ataxin-1 enhances Pp2a-bβ expression and down-regulates A","subunit, specifically bβ2, and of Anp32a occur at the transcriptional level. The Pp2a pathway alterations were confirmed by identified phosphorylation changes of the known Pp2a-substrates, Erk2 and Gsk3β. Similarly, mutant ataxin-1-expressing SH-SY5Y cells exhibit abnormal neuritic morphology, decreased levels of both PP2A-Bβ and ANP32A, and PP2A pathway alterations, all of which are ameliorated by overexpressing ANP32A. Our results point to dysregulation of this newly assigned function of ataxin-1"
61#67#gene8125137#141#diseaseC0752120 23630944-3#61#67#gene8125 23630944-3#137#141#diseaseC0752120 associated_with Anp32a,SCA1