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PubMed:17001622 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
17001622-0#24#37#diseaseC0006142 24-37 diseaseC0006142 denotes breast cancer
17001622-0#24#37#diseaseC0678222 24-37 diseaseC0678222 denotes breast cancer
17001622-0#49#52#gene472 49-52 gene472 denotes ATM
17001622-1#13#16#gene472 228-231 gene472 denotes ATM
17001622-1#41#69#diseaseC3899988 681-1102 diseaseC3899988 denotes ariant is likely to interfere with function. To elucidate the consequences of this mutation, we expression profiled wild-type, heterozygous, and homozygous lymphoblastoid cell lines (LCLs) from Scottish and Australian families using an oligonucleotide microarray. Cluster analysis revealed 77 genes that were differentially expressed in homozygous and heterozygous V2424G cells (compared to wild-type) and 11 genes differ
17001622-1#70#91#diseaseC0004135 1149-1556 diseaseC0004135 denotes also evaluated the profiles of LCLs after exposure to ionizing radiation (IR) and identified 77 genes that were differentially expressed in wild-type cells, but not in homozygous or heterozygous V2424G cells. We validated the expression differences by RT-PCR in additional heterozygous V2424G LCLs from another breast cancer family. We found no consistent cytotoxicity or abrogation of ATM kinase activity a
17001622-10#53#56#gene472 1535-1538 gene472 denotes ATM
17001622-10#187#210#diseaseC0008626 1669-1692 diseaseC0008626 denotes chromosomal aberrations
13#16#gene47241#69#diseaseC3899988 17001622-1#13#16#gene472 17001622-1#41#69#diseaseC3899988 associated_with ATM,"ariant is likely to interfere with function. To elucidate the consequences of this mutation, we expression profiled wild-type, heterozygous, and homozygous lymphoblastoid cell lines (LCLs) from Scottish and Australian families using an oligonucleotide microarray. Cluster analysis revealed 77 genes that were differentially expressed in homozygous and heterozygous V2424G cells (compared to wild-type) and 11 genes differ"
13#16#gene47270#91#diseaseC0004135 17001622-1#13#16#gene472 17001622-1#70#91#diseaseC0004135 associated_with ATM,"also evaluated the profiles of LCLs after exposure to ionizing radiation (IR) and identified 77 genes that were differentially expressed in wild-type cells, but not in homozygous or heterozygous V2424G cells. We validated the expression differences by RT-PCR in additional heterozygous V2424G LCLs from another breast cancer family. We found no consistent cytotoxicity or abrogation of ATM kinase activity a"
49#52#gene47224#37#diseaseC0006142 17001622-0#49#52#gene472 17001622-0#24#37#diseaseC0006142 associated_with ATM,breast cancer
49#52#gene47224#37#diseaseC0678222 17001622-0#49#52#gene472 17001622-0#24#37#diseaseC0678222 associated_with ATM,breast cancer
53#56#gene472187#210#diseaseC0008626 17001622-10#53#56#gene472 17001622-10#187#210#diseaseC0008626 associated_with ATM,chromosomal aberrations