Covid19_manual_annotation  

PubMed:32744052 JSONTXT 24 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue ForCovid19 Memo correct/standard/original word tao:has_database_id typo
7 0-4 Gene denotes IL-1 Gene:3552
T93 5-12 Induce denotes induces
8 13-26 Biological denotes throboxane-A2 MESH:D013928
9 28-32 Biological denotes TxA2 MESH:D013928
10 37-45 Disease denotes COVID-19 MESH:C000657245
11 54-66 Disease denotes inflammation MESH:D007249
T1 71-84 Disease denotes micro-thrombi
T95 86-96 Negative denotes inhibitory
T94 97-103 Result denotes effect
12 111-135 Gene denotes IL-1 receptor antagonist Gene:3557
13 137-143 Gene denotes IL-1Ra Gene:3557
89 146-150 Gene denotes IL-1 Gene:3552
T96 151-158 Induce denotes induces
T4 183-192 Biological denotes metabolic
T3 197-210 Biological denotes hematological
T2 211-218 Change denotes changes
T97 223-243 Species denotes experimental animals
T99 245-249 Gene denotes IL-1 Gene:3552
T7 250-260 Therapy denotes treatments
91 267-278 Disease denotes hypotension MESH:D007022
T101 286-291 Severity denotes rapid
T100 292-301 Decrease denotes reduction
T5 305-328 Biological denotes systemic blood pressure
T102 330-337 Decrease denotes reduced
T6 338-357 Biological denotes vascular resistance
T103 359-368 Increase denotes increased
T8 369-379 Biological denotes heart rate
T9 384-406 Biological denotes leukocyte aggregations
92 408-412 Gene denotes IL-1 Gene:3552
93 420-443 Disease denotes endothelial dysfunction MESH:C536439
T105 515-523 Species denotes pathogen
T104 524-533 Disease denotes infection MESH:D007239
T12 535-551 Disease denotes This dysfunction MESH:C536439
T15 568-578 Biological denotes macrophage
T108 579-591 Function denotes intervention
T16 596-605 Increase denotes increased
T106 606-613 Biological denotes protein
T107 614-626 Property denotes permeability MESH:D010539
T13 673-682 Biological denotes cytokines
T14 687-712 Biological denotes arachidonic acid products
T114 714-719 Disease denotes These
T113 720-727 Result denotes effects
T112 746-755 Induce denotes induction
96 759-763 Gene denotes IL-1 Gene:3552
T111 767-786 Disease denotes various pathologies
T110 814-830 Species denotes pathogenic viral
T109 831-841 Disease denotes infections MESH:D007239
98 853-863 Species denotes SARS-CoV-2 Tax:2697049
99 879-887 Disease denotes COVID-19 MESH:C000657245
T115 889-899 Activate denotes Activation
T116 903-914 Biological denotes macrophages
100 918-932 Species denotes coronavirus-19 Tax:2697049
T17 946-953 Increase denotes release
T18 957-973 Type denotes pro-inflammatory
T117 974-983 Biological denotes cytokines
T19 985-1003 Biological denotes metalloproteinases
T20 1008-1033 Biological denotes other proteolytic enzymes
T22 1049-1066 Disease denotes thrombi formation
T21 1071-1077 Severity denotes severe
101 1078-1101 Disease denotes respiratory dysfunction MESH:D012131
102 1103-1111 Species denotes Patients Tax:9606
103 1117-1125 Disease denotes COVID-19 MESH:C000657245
T23 1127-1140 Severity denotes seriously ill
T118 1145-1175 Severity denotes hospitalized in intensive care
T119 1177-1184 Show denotes present
T24 1185-1193 Severity denotes systemic
104 1194-1206 Disease denotes inflammation MESH:D007249
105 1208-1234 Disease denotes intravascular coagulopathy MESH:D004211
T25 1240-1249 BecomeSevere denotes high risk
106 1253-1277 Disease denotes thrombotic complications MESH:D013927
107 1283-1305 Disease denotes venous thromboembolism MESH:D054556
108 1334-1338 Gene denotes IL-1 Gene:3552
T120 1343-1348 Disease denotes these
109 1349-1357 Species denotes patients Tax:9606
T26 1362-1367 Biological denotes lungs
T122 1390-1402 Target denotes target organ
T121 1424-1432 Increase denotes increase
T30 1440-1460 Biological denotes degradation products
T31 1464-1470 Biological denotes fibrin
110 1472-1482 Gene denotes fibrinogen Gene:2244
T28 1487-1494 Biological denotes D-dimer MESH:C036309
T27 1501-1514 Disease denotes organ lesions
111 1519-1538 Disease denotes respiratory failure MESH:D012131
112 1562-1566 Gene denotes IL-1 Gene:3552
T123 1567-1574 Induce denotes induces
T125 1575-1581 Gene denotes itself Gene:3552
T126 1609-1625 Type denotes pro-inflammatory
T32 1626-1634 Biological denotes cytokine
113 1636-1639 Gene denotes TNF Gene:7124
114 1698-1712 Disease denotes shock syndrome MESH:D012769
115 1716-1724 Disease denotes COVID-19 MESH:C000657245
116 1731-1735 Gene denotes IL-1 Gene:3552
117 1740-1743 Gene denotes TNF Gene:7124
118 1750-1765 Disease denotes pulmonary edema MESH:D011654
T34 1767-1777 Disease denotes thrombosis MESH:D013927
T36 1782-1790 Disease denotes bleeding MESH:D006470
120 1807-1818 Disease denotes hypotension MESH:D007022
T37 1823-1860 Disease denotes resistance of systemic blood pressure May be "http://purl.obolibrary.org/obo/HP_0030972".
121 1862-1866 Gene denotes IL-1 Gene:3552
122 1874-1884 Disease denotes leukopenia MESH:D007970
123 1889-1905 Disease denotes thrombocytopenia MESH:D013921
T38 1911-1931 Disease denotes formation of thrombi
T127 1944-1956 Disease denotes complication comorbidity
T128 1964-1982 Biological denotes circulatory system
T129 1987-2000 Function denotes functionality
T130 2008-2013 Biological denotes organ
T42 2052-2061 Index denotes morbidity MESH:D009017
124 2066-2075 Die denotes mortality MESH:D009026
125 2077-2081 Gene denotes IL-1 Gene:3552
T131 2089-2097 Biological denotes platelet
T132 2098-2106 Biological denotes vascular
T133 2107-2122 Function denotes thrombogenicity
T43 2131-2152 Biological denotes non-endothelial cells
T135 2156-2167 Induce denotes stimulating
T134 2172-2181 Function denotes formation
127 2185-2199 Biological denotes thromboxane A2 MESH:D013928
T136 2209-2217 Release denotes released
T44 2227-2247 Biological denotes inflamed environment
128 2249-2253 Gene denotes IL-1 Gene:3552
T137 2295-2303 Induce denotes inducing
129 2304-2309 Disease denotes fever MESH:D005334
T139 2339-2349 Metabolism denotes metabolism
130 2353-2369 Biological denotes arachidonic acid MESH:D016718
T138 2376-2385 Chemical denotes increases
T46 2391-2418 Biological denotes vascular endothelial organs
T45 2426-2438 Biological denotes hypothalamus
132 2460-2470 Disease denotes thrombosis MESH:D013927
T51 2472-2480 Biological denotes vascular
133 2481-2493 Disease denotes inflammation MESH:D007249
T49 2498-2509 Biological denotes angigenesis angiogenesis t
T50 2540-2550 Activate denotes activation
T47 2569-2592 Gene denotes thromboxane A2 receptor Gene:6915
T68 2697-2705 Condition denotes In vitro
T141 2706-2714 Increase denotes enhanced
134 2715-2729 Chemical denotes thromboxane B2 MESH:D013929
T140 2730-2737 Release denotes release
T62 2741-2769 Biological denotes polymorphonuclear leukocytes
T61 2774-2785 Biological denotes macrophages
135 2807-2812 Species denotes human Tax:9606
T58 2813-2824 Recombinant denotes recombinant
T57 2825-2838 Gene denotes interleukin 1 Gene:3552
137 2915-2919 Gene denotes IL-1 Gene:3552
T142 2920-2927 Induce denotes induces
138 2928-2942 Biological denotes thromboxane B2 MESH:D013929
139 2944-2948 Biological denotes TxB2 MESH:D013929
T143 2950-2958 Release denotes releases
T52 2962-2971 Activate denotes activated
T53 2972-2983 Biological denotes neutrophils
T54 2988-2999 Biological denotes macrophages
T146 3004-3012 Increase denotes increase
140 3016-3027 Chemical denotes thromboxane MESH:D013931
T145 3032-3038 Induce denotes induce
T144 3039-3060 Biological denotes leukocyte aggregation
T64 3065-3073 Severity denotes systemic
141 3074-3086 Disease denotes inflammation MESH:D007249
T65 3116-3124 Severity denotes dramatic
T39 3125-3142 Disease denotes thrombi formation
142 3147-3164 Disease denotes organ dysfunction MESH:D009102
143 3173-3177 Gene denotes IL-1 Gene:3552
T147 3178-3188 Induce denotes stimulates
T148 3189-3205 Biological denotes endothelial cell
T149 3206-3215 Biological denotes leukocyte
T66 3216-3224 Bind denotes adhesion
T150 3230-3234 Biological denotes TxB2 MESH:D013929
T151 3235-3245 Produce denotes production
T155 3291-3299 Increase denotes increase
T69 3303-3314 Biological denotes neutrophils
T156 3320-3326 Bind denotes adhere
T154 3334-3338 Biological denotes lung
T153 3347-3355 Decrease denotes decrease
T70 3359-3370 Biological denotes lymphocytes
144 3383-3393 Biological denotes ecosanoids
145 3402-3406 Biological denotes TxA2 MESH:D013928
T159 3408-3416 Detect denotes detected
T152 3420-3424 Biological denotes TxB2 MESH:D013929
T71 3452-3460 Biological denotes vascular
146 3461-3473 Disease denotes inflammation MESH:D007249
147 3478-3498 Biological denotes platelet aggregation
T157 3514-3523 Produce denotes formation
T40 3527-3534 Biological denotes thrombi
T74 3540-3554 Biological denotes thrombogenesis May be MESH:D013927?
148 3570-3578 Disease denotes COVID-19 MESH:C000657245
T75 3588-3596 Biological denotes platelet
T158 3601-3617 Biological denotes cell aggregation
T76 3606-3617 Biological denotes aggregation
149 3623-3645 Biological denotes clotting abnormalities
T78 3651-3681 Chemical denotes anti-clotting inhibitor agents inhibitor|drug
T160 3698-3708 Prevent denotes prevention
150 3724-3743 Disease denotes thrombotic diseases MESH:D013927
T162 3745-3755 Prevent denotes Prevention
T163 3762-3771 Induce denotes induction
T73 3775-3779 Biological denotes TxA2 MESH:D013928
T164 3780-3786 Prevent denotes avoids
T41 3787-3804 Biological denotes thrombi formation
T161 3805-3812 Induce denotes induced
151 3816-3820 Gene denotes IL-1 Gene:3552
T172 3839-3846 Severity denotes serious
T171 3847-3862 Biological denotes vascular events
152 3869-3873 Biological denotes TxA2 MESH:D013928
T84 3874-3883 Increase denotes increases
T83 3884-3897 Severity denotes significantly
T165 3905-3914 Difficult denotes difficult
T166 3918-3925 Prevent denotes inhibit
T173 3950-3961 Easy denotes much better
T167 3965-3972 Prevent denotes prevent
T168 3977-3986 Induce denotes induction
T169 3991-4001 Produce denotes generation
T82 4005-4013 Prevent denotes blocking
T170 4018-4027 Induce denotes inductors
153 4038-4042 Gene denotes IL-1 Gene:3552
T86 4048-4058 Prevent denotes inhibition
T87 4062-4066 Cleave denotes lack
T85 4070-4079 Structure denotes formation
154 4083-4087 Gene denotes IL-1 Gene:3552
T174 4088-4094 Prevent denotes avoids
155 4147-4152 Die denotes death MESH:D003643
156 4160-4167 Species denotes patient Tax:9606
T178 4173-4182 Therapy denotes treatment
T175 4186-4205 Biological denotes innate immune cells
T176 4206-4215 Produce denotes producing
157 4216-4220 Gene denotes IL-1 negative Gene:3552
158 4226-4250 Gene denotes IL-1 receptor antagonist inhibitor Gene:3557
159 4252-4258 Gene denotes IL-1Ra inhibitor Gene:3557
T177 4264-4269 Prevent denotes avoid
T90 4270-4289 Biological denotes hemodynamic changes
160 4291-4303 Disease denotes septic shock MESH:D012772
T88 4308-4313 Biological denotes organ
161 4314-4326 Disease denotes inflammation MESH:D007249
162 4373-4381 Disease denotes COVID-19 MESH:C000657245
163 4393-4403 Species denotes SARS-CoV-2 Tax:2697049
R1 T4 T2 of_a metabolic,changes
R100 12 T94 of_a IL-1 receptor antagonist,effect
R101 13 12 abbreviation IL-1Ra,IL-1 receptor antagonist
R102 89 T96 is_a IL-1,induces
R103 T96 T2 is_a induces,changes
R104 T3 T2 of_a hematological,changes
R105 T99 T7 of_a IL-1,treatments
R106 T101 T100 of_a rapid,reduction
R107 T100 T5 is_a reduction,systemic blood pressure
R108 T102 T6 is_a reduced,vascular resistance
R109 T100 91 cause_of reduction,hypotension
R110 T102 91 cause_of reduced,hypotension
R111 T103 T8 is_a increased,heart rate
R112 T103 T9 is_a increased,leukocyte aggregations
R113 T103 91 cause_of increased,hypotension
R114 T7 T100 cause_of treatments,reduction
R115 T7 T102 cause_of treatments,reduced
R116 T7 T103 of_a treatments,increased
R117 T97 T7 for experimental animals,treatments
R118 92 93 cause_of IL-1,endothelial dysfunction
R119 T105 T104 of_a pathogen,infection
R120 T12 93 coreference This dysfunction,endothelial dysfunction
R121 T13 T12 relates cytokines,This dysfunction
R122 T14 T12 relates arachidonic acid products,This dysfunction
R123 T16 T107 is_a increased,permeability
R124 T106 T107 of_a protein,permeability
R125 T15 T108 of_a macrophage,intervention
R126 T108 T12 is_a intervention,This dysfunction
R127 T107 T12 is_a permeability,This dysfunction
R128 T110 T109 by pathogenic viral,infections
R129 98 99 by SARS-CoV-2,COVID-19
R130 T109 T111 is_a infections,various pathologies
R131 99 T109 is_a COVID-19,infections
R132 T114 T12 coreference These,This dysfunction
R133 T114 T113 of_a These,effects
R134 T111 T112 in various pathologies,induction
R135 T112 T113 cause_of induction,effects
R136 96 T112 of_a IL-1,induction
R137 T17 T22 cause_of release,thrombi formation
R138 T17 101 cause_of release,respiratory dysfunction
R139 T115 T17 is_a Activation,release
R140 T17 T117 is_a release,cytokines
R141 T17 T20 is_a release,other proteolytic enzymes
R142 T17 T19 is_a release,metalloproteinases
R143 T115 T116 of_a Activation,macrophages
R144 100 T115 by coronavirus-19,Activation
R145 T21 101 of_a severe,respiratory dysfunction
R146 103 102 has_a COVID-19,Patients
R147 T23 103 of_a seriously ill,COVID-19
R148 T118 103 of_a hospitalized in intensive care,COVID-19
R149 T24 104 of_a systemic,inflammation
R150 102 T119 is_a Patients,present
R151 T119 104 is_a present,inflammation
R152 T119 107 is_a present,venous thromboembolism
R153 T119 105 is_a present,intravascular coagulopathy
R154 105 T25 is_a intravascular coagulopathy,high risk
R155 T25 106 is_a high risk,thrombotic complications
R156 108 104 relates IL-1,inflammation
R157 108 105 relates IL-1,intravascular coagulopathy
R158 108 107 relates IL-1,venous thromboembolism
R159 T120 109 has_a these,patients
R160 T120 104 coreference these,inflammation
R161 T120 105 coreference these,intravascular coagulopathy
R162 T120 107 coreference these,venous thromboembolism
R163 T31 T30 of_a fibrin,degradation products
R164 110 T30 of_a fibrinogen,degradation products
R165 T28 T30 of_a D-dimer,degradation products
R166 T30 T121 is_a degradation products,increase
R167 T26 T121 at lungs,increase
R168 T26 109 of_a lungs,patients
R169 T121 111 cause_of increase,respiratory failure
R170 T121 T27 cause_of increase,organ lesions
R171 T122 T26 is_a target organ,lungs
R172 112 T123 is_a IL-1,induces
R173 T123 T125 is_a induces,itself
R174 T125 112 coreference itself,IL-1
R175 T123 113 is_a induces,TNF
R176 T18 T117 of_a pro-inflammatory,cytokines
R177 T126 T32 of_a pro-inflammatory,cytokine
R178 T32 113 is_a cytokine,TNF
R179 113 114 relates TNF,shock syndrome
R180 115 114 in COVID-19,shock syndrome
R181 T127 T38 is_a complication,formation of thrombi
R182 T130 T129 of_a organ,functionality
R183 T128 T127 of_a circulatory system,complication
R184 T129 T127 of_a functionality,complication
R185 127 T136 is_a thromboxane A2,released
R186 T136 T44 into released,inflamed environment
R187 127 T134 of_a thromboxane A2,formation
R188 T135 T134 is_a stimulating,formation
R189 125 T135 is_a IL-1,stimulating
R190 T134 T133 is_a formation,thrombogenicity
R191 T131 T133 of_a platelet,thrombogenicity
R192 T132 T133 on vascular,thrombogenicity
R193 T43 T133 on non-endothelial cells,thrombogenicity
R195 T137 129 is_a inducing,fever
R196 T45 T46 of_a hypothalamus,vascular endothelial organs
R197 130 T138 is_a arachidonic acid,increases
R198 T46 T138 from vascular endothelial organs,increases
R199 130 T139 of_a arachidonic acid,metabolism
R200 T139 T137 cause_of metabolism,inducing
R201 128 T139 relates IL-1,metabolism
R202 128 T137 is_a IL-1,inducing
R203 T50 T49 cause_of activation,angigenesis
R204 T51 133 of_a vascular,inflammation
R205 T47 T50 of_a thromboxane A2 receptor,activation
R206 139 138 abbreviation TxB2,thromboxane B2
R207 T58 T57 is_a recombinant,interleukin 1
R208 T57 135 of_a interleukin 1,human
R209 134 T140 is_a thromboxane B2,release
R210 T141 T140 is_a enhanced,release
R211 T57 T140 cause_of interleukin 1,release
R212 T62 T140 by polymorphonuclear leukocytes,release
R213 T61 T140 by macrophages,release
R214 T68 T140 of_a In vitro,release
R215 137 T142 is_a IL-1,induces
R216 T142 T143 is_a induces,releases
R217 138 T143 is_a thromboxane B2,releases
R218 T52 T54 is_a activated,macrophages
R219 T52 T53 is_a activated,neutrophils
R220 T52 T143 in activated,releases
R221 T64 141 of_a systemic,inflammation
R222 140 T146 is_a thromboxane,increase
R223 T146 T145 is_a increase,induce
R224 T145 T144 is_a induce,leukocyte aggregation
R225 T145 141 is_a induce,inflammation
R226 T65 T39 of_a dramatic,thrombi formation
R227 T65 142 of_a dramatic,organ dysfunction
R228 T144 T39 cause_of leukocyte aggregation,thrombi formation
R229 T144 142 cause_of leukocyte aggregation,organ dysfunction
R230 T64 T39 cause_of systemic,thrombi formation
R231 141 142 cause_of inflammation,organ dysfunction
R232 T149 T66 of_a leukocyte,adhesion
R233 T148 T66 of_a endothelial cell,adhesion
R234 143 T147 is_a IL-1,stimulates
R235 T147 T66 is_a stimulates,adhesion
R236 T147 T151 is_a stimulates,production
R237 T150 T151 of_a TxB2,production
R238 T69 T156 is_a neutrophils,adhere
R239 T156 T154 to adhere,lung
R240 T153 T70 is_a decrease,lymphocytes
R241 T155 T69 is_a increase,neutrophils
R242 T71 146 of_a vascular,inflammation
R243 145 144 is_a TxA2,ecosanoids
R245 T157 T40 is_a formation,thrombi
R246 144 T157 relates ecosanoids,formation
R247 144 146 cause_of ecosanoids,inflammation
R248 144 147 cause_of ecosanoids,platelet aggregation
R249 T75 T76 - platelet,aggregation
R250 T152 T159 is_a TxB2,detected
R251 T159 145 is_a detected,TxA2
R252 T75 T74 is_a platelet,thrombogenesis
R253 T158 T74 is_a cell aggregation,thrombogenesis
R254 149 T74 is_a clotting abnormalities,thrombogenesis
R255 T78 T160 is_a anti-clotting inhibitor agents,prevention
R256 T160 150 is_a prevention,thrombotic diseases
R257 151 T161 is_a IL-1,induced
R258 T161 T41 is_a induced,thrombi formation
R259 T73 T162 of_a TxA2,Prevention
R260 T73 T163 of_a TxA2,induction
R261 T162 T164 is_a Prevention,avoids
R262 T163 T164 is_a induction,avoids
R263 T164 T41 is_a avoids,thrombi formation
R264 T84 152 is_a increases,TxA2
R265 T83 T84 of_a significantly,increases
R266 T172 T171 of_a serious,vascular events
R267 T171 T41 coreference vascular events,thrombi formation
R269 T165 T166 is_a difficult,inhibit
R270 T84 T165 is_a increases,difficult
R271 T84 T173 is_a increases,much better
R272 T173 T167 is_a much better,prevent
R273 T167 T168 is_a prevent,induction
R274 T167 T169 is_a prevent,generation
R275 153 T170 is_a IL-1,inductors
R276 T82 T170 is_a blocking,inductors
R277 T168 T82 is_a induction,blocking
R278 T169 T82 is_a generation,blocking
R279 T171 152 in vascular events,TxA2
R280 155 156 is_a death,patient
R282 T174 155 is_a avoids,death
R283 T86 T174 is_a inhibition,avoids
R284 T87 T174 is_a lack,avoids
R285 T87 T85 is_a lack,formation
R286 T85 154 of_a formation,IL-1
R287 T86 T85 is_a inhibition,formation
R288 T175 T176 is_a innate immune cells,producing
R289 T176 157 is_a producing,IL-1
R290 159 158 abbreviation IL-1Ra,IL-1 receptor antagonist
R291 T178 T177 is_a treatment,avoid
R292 T177 T90 is_a avoid,hemodynamic changes
R293 T177 160 is_a avoid,septic shock
R294 T177 161 is_a avoid,inflammation
R296 T178 T175 of_a treatment,innate immune cells
R297 158 T178 with IL-1 receptor antagonist,treatment
R298 163 162 by SARS-CoV-2,COVID-19
R299 T88 161 is_a organ,inflammation
R31 121 120 cause_of IL-1,hypotension
R32 121 T37 cause_of IL-1,resistance of systemic blood pressure
R33 121 122 cause_of IL-1,leukopenia
R34 121 123 cause_of IL-1,thrombocytopenia
R35 T38 T42 cause_of formation of thrombi,morbidity
R36 T38 124 cause_of formation of thrombi,mortality
R50 T50 132 cause_of activation,thrombosis
R51 T50 133 cause_of activation,inflammation
R88 116 118 cause_of IL-1,pulmonary edema
R89 116 T34 cause_of IL-1,thrombosis
R90 116 T36 cause_of IL-1,bleeding
R91 117 118 cause_of TNF,pulmonary edema
R92 117 T34 cause_of TNF,thrombosis
R93 117 T36 cause_of TNF,bleeding
R94 9 8 abbreviation TxA2,throboxane-A2
R95 8 11 cause_of throboxane-A2,inflammation
R96 8 T1 cause_of throboxane-A2,micro-thrombi
R97 7 T93 is_a IL-1,induces
R98 T93 8 is_a induces,throboxane-A2
R99 T95 T94 is_a inhibitory,effect