Id |
Subject |
Object |
Predicate |
Lexical cue |
ForCovid19 |
correct/standard/original word |
details |
tao:has_database_id |
typo |
T142 |
0-12 |
TrialDesign |
denotes |
Multi-centre |
|
|
|
|
|
T143 |
14-23 |
TrialDesign |
denotes |
three arm |
|
|
|
|
|
T144 |
25-46 |
TrialDesign |
denotes |
randomized controlled |
|
|
|
|
|
T223 |
60-63 |
TrialDesign |
denotes |
use |
|
|
|
|
|
6 |
67-85 |
Chemical |
denotes |
methylprednisolone |
drug |
|
|
MESH:D008775 |
|
7 |
90-112 |
Chemical |
denotes |
unfractionated heparin |
drug |
|
|
MESH:D006493 |
|
T64 |
116-130 |
Severity |
denotes |
critically ill |
|
|
|
|
|
T145 |
131-141 |
Status_of_Care |
denotes |
ventilated |
|
|
|
|
|
9 |
142-150 |
Species |
denotes |
patients |
|
|
|
Tax:9606 |
|
10 |
156-165 |
Disease |
denotes |
pneumonia |
|
|
|
MESH:D011014 |
|
11 |
171-181 |
Disease |
denotes |
SARS-CoV-2 |
|
|
|
MESH:D000086382 |
|
T147 |
182-191 |
Disease |
denotes |
infection |
|
|
|
MESH:MESH:D007239 |
|
T146 |
240-261 |
TrialDesign |
denotes |
randomised controlled |
|
|
|
|
|
T151 |
315-325 |
Type |
denotes |
adjunctive |
|
|
|
|
|
T150 |
326-333 |
Therapy |
denotes |
therapy |
|
|
|
|
|
T152 |
326-333 |
Therapy |
denotes |
therapy |
|
|
|
|
|
T155 |
326-333 |
Therapy |
denotes |
therapy |
|
|
|
|
|
122 |
339-357 |
Chemical |
denotes |
methylprednisolone |
drug |
|
|
MESH:D008775 |
|
123 |
362-384 |
Chemical |
denotes |
unfractionated heparin |
drug |
|
|
MESH:D006493 |
|
124 |
386-389 |
Chemical |
denotes |
UFH |
drug |
|
|
MESH:D006493 |
|
125 |
399-417 |
Chemical |
denotes |
methylprednisolone |
drug |
|
|
MESH:D008775 |
|
126 |
422-450 |
Chemical |
denotes |
low molecular weight heparin |
drug |
|
|
MESH:D006495 |
|
127 |
452-456 |
Chemical |
denotes |
LMWH |
drug |
|
|
MESH:D006495 |
|
T154 |
462-466 |
PositiveRegulation |
denotes |
more |
|
|
|
|
|
T153 |
480-488 |
NegativeRegulation |
denotes |
reducing |
|
|
|
|
|
128 |
499-508 |
Die |
denotes |
mortality |
|
|
|
MESH:D009026 |
|
T65 |
512-526 |
Severity |
denotes |
critically-ill |
|
|
|
|
|
T149 |
527-537 |
Status_of_Care |
denotes |
ventilated |
|
|
|
|
|
130 |
538-546 |
Species |
denotes |
patients |
|
|
|
Tax:9606 |
|
131 |
552-561 |
Disease |
denotes |
pneumonia |
|
|
|
MESH:D011014 |
|
132 |
567-577 |
Disease |
denotes |
SARS-CoV-2 |
|
|
|
MESH:D000086382 |
|
T148 |
578-587 |
Disease |
denotes |
infection |
|
|
|
MESH:MESH:D007239 |
|
133 |
600-604 |
Chemical |
denotes |
LMWH |
drug |
|
|
MESH:D006495 |
|
T156 |
654-666 |
TrialDesign |
denotes |
multi-centre |
|
|
|
|
|
T157 |
668-682 |
TrialDesign |
denotes |
interventional |
|
|
|
|
|
T158 |
684-698 |
TrialDesign |
denotes |
parallel group |
|
|
|
|
|
T159 |
700-711 |
TrialDesign |
denotes |
superiority |
|
|
|
|
|
T160 |
713-723 |
TrialDesign |
denotes |
randomized |
|
|
|
|
|
T161 |
725-747 |
TrialDesign |
denotes |
investigator sponsored |
|
|
|
|
|
T162 |
749-759 |
TrialDesign |
denotes |
three arms |
|
|
|
|
|
134 |
767-775 |
Species |
denotes |
Patients |
|
|
|
Tax:9606 |
|
T163 |
847-855 |
TrialDesign |
denotes |
randomly |
|
|
|
|
|
T165 |
913-918 |
Ratio |
denotes |
1:1:1 |
|
|
|
|
|
135 |
921-933 |
Species |
denotes |
PARTICIPANTS |
|
|
|
Tax:9606 |
|
T69 |
971-978 |
Area |
denotes |
Italian |
|
|
|
|
|
T224 |
1064-1072 |
Positive |
denotes |
Positive |
|
|
|
|
|
136 |
1073-1083 |
Species |
denotes |
SARS-CoV-2 |
|
|
|
Tax:2697049 |
|
T166 |
1099-1114 |
Method |
denotes |
pharyngeal swab |
|
|
|
|
|
T167 |
1118-1139 |
Biological |
denotes |
deep airways material |
|
|
|
|
|
T70 |
1153-1173 |
Therapy |
denotes |
pressure ventilation |
inclusion_criteria |
|
|
|
|
T71 |
1182-1194 |
Type |
denotes |
non-invasive |
inclusion_criteria |
|
|
|
|
T75 |
1198-1206 |
Type |
denotes |
invasive |
inclusion_criteria |
|
|
|
|
T84 |
1213-1223 |
Duration |
denotes |
> 24 hours |
inclusion_criteria |
|
|
|
|
T169 |
1227-1235 |
Type |
denotes |
Invasive |
inclusion_criteria |
|
|
|
|
T168 |
1236-1246 |
Type |
denotes |
mechanical |
inclusion_criteria |
|
|
|
|
T85 |
1247-1258 |
Therapy |
denotes |
ventilation |
inclusion_criteria |
|
|
|
|
T86 |
1264-1274 |
Duration |
denotes |
< 96 hours |
inclusion_criteria |
|
|
|
|
T89 |
1278-1293 |
Index |
denotes |
PaO2/FiO2 ratio |
inclusion_criteria |
|
|
|
|
T87 |
1294-1313 |
Value |
denotes |
lower than 150 mmHg |
inclusion_criteria |
|
|
|
|
T68 |
1317-1324 |
Index |
denotes |
D-dimer |
inclusion_criteria |
|
|
MESH:C036309 |
|
T88 |
1331-1340 |
Times |
denotes |
> 6 times |
inclusion_criteria |
|
|
|
|
T170 |
1341-1382 |
Value |
denotes |
the upper limit of normal reference range |
inclusion_criteria |
|
|
|
|
137 |
1386-1404 |
Gene |
denotes |
C-reactive Protein |
inclusion_criteria |
|
|
Gene:1401 |
|
T90 |
1405-1413 |
Times |
denotes |
> 6-fold |
inclusion_criteria |
|
|
|
|
T171 |
1414-1455 |
Value |
denotes |
upper the limit of normal reference range |
inclusion_criteria |
|
|
|
|
T135 |
1483-1493 |
Age |
denotes |
< 18 years |
exclusion_criteria |
|
|
|
|
T92 |
1506-1515 |
Therapy |
denotes |
treatment |
exclusion_criteria |
|
|
|
|
T174 |
1521-1540 |
Chemical |
denotes |
anticoagulant drugs |
notCovid19|drug |
|
|
|
|
T136 |
1544-1552 |
Biological |
denotes |
Platelet |
exclusion_criteria |
|
|
|
|
T172 |
1553-1558 |
Number |
denotes |
count |
exclusion_criteria |
|
|
|
|
T137 |
1559-1572 |
Value |
denotes |
< 100.000/mm3 |
exclusion_criteria |
|
|
|
|
T226 |
1576-1583 |
Chemical |
denotes |
History |
|
|
|
|
|
T227 |
1576-1583 |
Disease |
denotes |
History |
|
|
|
|
|
138 |
1587-1594 |
Chemical |
denotes |
heparin |
|
|
|
MESH:D006493 |
|
T173 |
1595-1602 |
Induce |
denotes |
induced |
|
|
|
|
|
T140 |
1603-1619 |
Disease |
denotes |
thrombocytopenia |
history|exclusion_criteria |
|
|
MESH:D013921 |
|
T96 |
1623-1630 |
Disease |
denotes |
Allergy |
exclusion_criteria |
|
|
http://purl.obolibrary.org/obo/HP_0012393 |
|
140 |
1634-1651 |
Chemical |
denotes |
sodium enoxaparin |
|
|
|
|
|
141 |
1661-1665 |
Chemical |
denotes |
LMWH |
drug |
|
|
MESH:D006495 |
|
142 |
1667-1670 |
Chemical |
denotes |
UFH |
|
|
|
MESH:D006493 |
|
143 |
1674-1692 |
Chemical |
denotes |
methylprednisolone |
|
|
|
MESH:D008775 |
|
T98 |
1696-1702 |
Condition |
denotes |
Active |
exclusion_criteria |
|
|
|
|
144 |
1703-1711 |
Disease |
denotes |
bleeding |
exclusion_criteria |
|
|
MESH:D006470 |
|
T176 |
1753-1762 |
PositiveRegulation |
denotes |
high risk |
|
|
|
|
|
145 |
1766-1774 |
Disease |
denotes |
bleeding |
exclusion_criteria |
|
|
MESH:D006470 |
|
T175 |
1775-1791 |
Negative |
denotes |
contraindicating |
|
|
|
|
|
T97 |
1792-1815 |
Therapy |
denotes |
anticoagulant treatment |
exclusion_criteria |
|
|
|
|
T177 |
1834-1846 |
Period |
denotes |
last 1 month |
|
|
|
|
|
T100 |
1871-1876 |
Biological |
denotes |
brain |
|
|
|
|
|
T101 |
1878-1884 |
Biological |
denotes |
spinal |
|
|
|
|
|
T102 |
1888-1898 |
Biological |
denotes |
ophthalmic |
|
|
|
|
|
T99 |
1899-1906 |
Therapy |
denotes |
surgery |
exclusion_criteria |
|
|
|
|
T105 |
1910-1917 |
Therapy |
denotes |
Chronic |
exclusion_criteria |
|
|
|
|
T104 |
1932-1952 |
Chemical |
denotes |
oral corticosteroids |
drug|exclusion_criteria |
|
|
|
|
T178 |
1937-1952 |
Therapy |
denotes |
corticosteroids |
exclusion_criteria |
|
|
|
|
T106 |
1956-1965 |
Condition |
denotes |
Pregnancy |
exclusion_criteria |
|
|
|
|
T107 |
1969-1982 |
Condition |
denotes |
breastfeeding |
exclusion_criteria |
|
|
|
|
T179 |
1986-1994 |
Positive |
denotes |
positive |
|
|
|
|
|
T108 |
1995-2009 |
Method |
denotes |
pregnancy test |
exclusion_criteria |
|
|
|
|
146 |
2031-2036 |
Species |
denotes |
women |
exclusion_criteria |
|
|
Tax:9606 |
|
T109 |
2058-2072 |
Method |
denotes |
pregnancy test |
exclusion_criteria |
|
|
|
|
T180 |
2142-2157 |
Status_of_Care |
denotes |
life-sustaining |
|
|
|
|
|
T110 |
2158-2167 |
Therapy |
denotes |
treatment |
exclusion_criteria |
|
|
|
|
T111 |
2172-2180 |
Condition |
denotes |
too sick |
exclusion_criteria |
|
|
|
|
T181 |
2215-2221 |
Severity |
denotes |
severe |
|
|
|
|
|
T112 |
2222-2230 |
Disease |
denotes |
diseases |
exclusion_criteria |
|
|
|
|
147 |
2263-2271 |
Species |
denotes |
patients |
|
|
|
Tax:9606 |
|
T182 |
2426-2436 |
TrialDesign |
denotes |
LMWH group |
drug |
|
|
MESH:D017984 |
|
149 |
2438-2446 |
Species |
denotes |
patients |
|
|
|
Tax:9606 |
|
T228 |
2469-2481 |
Dose |
denotes |
administered |
|
|
|
|
|
150 |
2482-2492 |
Chemical |
denotes |
enoxaparin |
drug |
|
|
MESH:D017984 |
|
T3 |
2496-2524 |
Amount |
denotes |
standard prophylactic dosage |
|
|
|
|
|
T188 |
2528-2548 |
TrialDesign |
denotes |
LMWH + steroid group |
drug |
|
|
MESH:D017984|MESH:D008775 |
|
153 |
2550-2558 |
Species |
denotes |
patients |
|
|
|
Tax:9606 |
|
T229 |
2578-2585 |
Dose |
denotes |
receive |
|
|
|
|
|
T230 |
2578-2585 |
Dose |
denotes |
receive |
|
|
|
|
|
154 |
2586-2596 |
Chemical |
denotes |
enoxaparin |
drug |
|
|
MESH:D017984 |
|
T4 |
2600-2628 |
Amount |
denotes |
standard prophylactic dosage |
|
|
|
|
|
155 |
2633-2651 |
Chemical |
denotes |
methylprednisolone |
drug |
|
|
MESH:D008775 |
|
T191 |
2655-2674 |
TrialDesign |
denotes |
UFH + steroid group |
drug |
|
|
MESH:D006493|MESH:D008775 |
|
158 |
2676-2684 |
Species |
denotes |
patients |
|
|
|
Tax:9606 |
|
T231 |
2704-2711 |
Dose |
denotes |
receive |
|
|
|
|
|
T232 |
2704-2711 |
Dose |
denotes |
receive |
|
|
|
|
|
159 |
2712-2715 |
Chemical |
denotes |
UFH |
drug |
|
|
MESH:D006493 |
|
T5 |
2719-2738 |
Amount |
denotes |
therapeutic dosages |
|
|
|
|
|
160 |
2743-2761 |
Chemical |
denotes |
methylprednisolone |
drug |
|
|
MESH:D008775 |
|
161 |
2763-2766 |
Chemical |
denotes |
UFH |
drug |
|
|
MESH:D006493 |
|
T7 |
2775-2787 |
Dose |
denotes |
administered |
|
|
|
|
|
T193 |
2788-2801 |
Biological |
denotes |
intravenously |
|
|
|
|
|
T192 |
2805-2824 |
TrialDesign |
denotes |
UFH + steroid group |
drug |
|
|
MESH:D006493|MESH:D008775 |
|
T6 |
2828-2845 |
Index |
denotes |
therapeutic doses |
|
|
|
|
|
T194 |
2882-2895 |
Index |
denotes |
infusion rate |
|
|
|
|
|
T8 |
2899-2912 |
Amount |
denotes |
18 UI/kg/hour |
|
|
|
|
|
T196 |
2922-2930 |
Change |
denotes |
modified |
|
|
|
|
|
T9 |
2941-2951 |
Index |
denotes |
aPTT Ratio |
|
|
|
|
|
T195 |
2976-2983 |
Ratio |
denotes |
1.5-2.0 |
|
|
|
|
|
T197 |
3032-3055 |
Interval |
denotes |
no longer than 12 hours |
|
|
|
|
|
164 |
3076-3079 |
Chemical |
denotes |
UFH |
drug |
|
|
MESH:D006493 |
|
T10 |
3101-3120 |
Duration |
denotes |
up to ICU discharge |
|
|
|
|
|
T201 |
3122-3141 |
Timing |
denotes |
After ICU discharge |
|
|
|
|
|
T198 |
3142-3163 |
Therapy |
denotes |
anticoagulant therapy |
|
|
|
|
|
T199 |
3171-3182 |
Interrupt |
denotes |
interrupted |
|
|
|
|
|
T200 |
3186-3194 |
Change |
denotes |
switched |
|
|
|
|
|
165 |
3215-3219 |
Chemical |
denotes |
LMWH |
drug |
|
|
MESH:D006495 |
|
166 |
3297-3307 |
Chemical |
denotes |
Enoxaparin |
drug |
|
|
MESH:D017984 |
|
T233 |
3316-3328 |
Dose |
denotes |
administered |
|
|
|
|
|
T234 |
3316-3328 |
Dose |
denotes |
administered |
|
|
|
|
|
T183 |
3337-3347 |
TrialDesign |
denotes |
LMWH group |
drug |
|
|
MESH:D017984 |
|
T189 |
3352-3372 |
TrialDesign |
denotes |
LMWH + steroid group |
drug |
|
|
MESH:D017984|MESH:D008775 |
|
T204 |
3376-3402 |
Amount |
denotes |
standard prophylactic dose |
|
|
|
|
|
T125 |
3410-3417 |
Amount |
denotes |
4000 UI |
|
|
|
|
|
T126 |
3418-3426 |
Interval |
denotes |
once day |
|
|
|
|
|
T124 |
3441-3448 |
Amount |
denotes |
6000 UI |
|
|
|
|
|
T127 |
3449-3457 |
Interval |
denotes |
once day |
|
|
|
|
|
170 |
3462-3470 |
Species |
denotes |
patients |
|
|
|
Tax:9606 |
|
T203 |
3471-3480 |
Index |
denotes |
weighting |
|
|
|
|
|
T202 |
3481-3496 |
Value |
denotes |
more than 90 kg |
|
|
|
|
|
T14 |
3521-3533 |
Dose |
denotes |
administered |
|
|
|
|
|
T205 |
3534-3548 |
Biological |
denotes |
subcutaneously |
|
|
|
|
|
T15 |
3549-3559 |
Interval |
denotes |
once a day |
|
|
|
|
|
T13 |
3560-3579 |
Duration |
denotes |
up to ICU discharge |
|
|
|
|
|
171 |
3713-3731 |
Chemical |
denotes |
Methylprednisolone |
drug |
|
|
MESH:D008775 |
|
T210 |
3740-3752 |
Dose |
denotes |
administered |
|
|
|
|
|
T211 |
3740-3752 |
Dose |
denotes |
administered |
|
|
|
|
|
T212 |
3740-3752 |
Dose |
denotes |
administered |
|
|
|
|
|
T213 |
3740-3752 |
Dose |
denotes |
administered |
|
|
|
|
|
T190 |
3761-3781 |
TrialDesign |
denotes |
LMWH + steroid group |
drug |
|
|
MESH:D017984|MESH:D008775 |
|
T206 |
3786-3805 |
TrialDesign |
denotes |
UHF + steroid group |
drug |
UFH + steroid group |
|
MESH:D006493|MESH:D008775 |
t |
T16 |
3806-3819 |
Biological |
denotes |
intravenously |
|
|
|
|
|
T17 |
3828-3841 |
Timing |
denotes |
initial bolus |
|
|
|
|
|
T209 |
3845-3854 |
Amount |
denotes |
0,5 mg/kg |
|
|
|
|
|
T131 |
3885-3894 |
Amount |
denotes |
0,5 mg/kg |
|
|
|
|
|
T18 |
3895-3908 |
Interval |
denotes |
4 times daily |
|
|
|
|
|
T19 |
3909-3919 |
Timing |
denotes |
for 7 days |
|
|
|
|
|
T132 |
3921-3930 |
Amount |
denotes |
0,5 mg/kg |
|
|
|
|
|
T21 |
3931-3944 |
Interval |
denotes |
3 times daily |
|
|
|
|
|
T22 |
3945-3965 |
Timing |
denotes |
from day 8 to day 10 |
|
|
|
|
|
T133 |
3967-3976 |
Amount |
denotes |
0,5 mg/kg |
|
|
|
|
|
T24 |
3977-3990 |
Interval |
denotes |
2 times daily |
|
|
|
|
|
T25 |
3991-4008 |
Timing |
denotes |
at days 11 and 12 |
|
|
|
|
|
T134 |
4013-4022 |
Amount |
denotes |
0,5 mg/kg |
|
|
|
|
|
T27 |
4023-4033 |
Interval |
denotes |
once daily |
|
|
|
|
|
T28 |
4034-4051 |
Timing |
denotes |
at days 13 and 14 |
|
|
|
|
|
176 |
4106-4115 |
Die |
denotes |
mortality |
|
|
|
MESH:D009026 |
|
T113 |
4158-4169 |
Therapy |
denotes |
Ventilation |
|
|
|
|
|
T214 |
4170-4174 |
Prevent |
denotes |
free |
|
|
|
|
|
178 |
4239-4246 |
Species |
denotes |
patient |
|
|
|
Tax:9606 |
|
T216 |
4260-4264 |
Prevent |
denotes |
free |
|
|
|
|
|
T115 |
4268-4279 |
Therapy |
denotes |
ventilation |
|
|
|
|
|
T77 |
4288-4296 |
Type |
denotes |
invasive |
|
|
|
|
|
T72 |
4300-4312 |
Type |
denotes |
non-invasive |
|
|
|
|
|
T217 |
4398-4412 |
Dose |
denotes |
administration |
|
|
|
|
|
T235 |
4398-4412 |
Dose |
denotes |
administration |
|
|
|
|
|
T31 |
4416-4425 |
Amount |
denotes |
high-dose |
|
|
|
|
|
179 |
4426-4434 |
Chemical |
denotes |
steroids |
drug |
|
|
MESH:D013256 |
|
T30 |
4438-4461 |
Chemical |
denotes |
immune-modulatory drugs |
drug |
|
|
|
|
T73 |
4491-4503 |
Type |
denotes |
non-invasive |
|
|
|
|
|
T219 |
4507-4526 |
Type |
denotes |
invasive mechanical |
|
|
|
|
|
T116 |
4516-4526 |
Type |
denotes |
mechanical |
|
|
|
|
|
T218 |
4527-4538 |
Therapy |
denotes |
ventilation |
|
|
|
|
|
T221 |
4578-4590 |
Type |
denotes |
non-invasive |
|
|
|
|
|
T74 |
4591-4602 |
Therapy |
denotes |
ventilation |
|
|
|
|
|
T220 |
4616-4624 |
Type |
denotes |
invasive |
|
|
|
|
|
T82 |
4625-4636 |
Therapy |
denotes |
ventilation |
|
|
|
|
|
180 |
4650-4659 |
Die |
denotes |
mortality |
|
|
|
MESH:D009026 |
|
182 |
4825-4835 |
Disease |
denotes |
infections |
|
|
|
MESH:D007239 |
|
183 |
4876-4886 |
Disease |
denotes |
infections |
|
|
|
MESH:D007239 |
|
T34 |
4890-4897 |
Species |
denotes |
Candida |
|
|
|
Tax:1535326 |
|
T35 |
4890-4897 |
Species |
denotes |
Candida |
|
|
|
Tax:5475 |
|
T37 |
4899-4910 |
Species |
denotes |
Aspergillus |
|
|
|
Tax:5052 |
|
184 |
4912-4922 |
Species |
denotes |
Adenovirus |
|
|
|
Tax:10508 |
|
T38 |
4924-4954 |
Species |
denotes |
Herpes Virus e Cytomegalovirus |
|
|
|
|
|
185 |
4975-4992 |
Disease |
denotes |
organ dysfunction |
|
|
|
|
|
186 |
5059-5081 |
Disease |
denotes |
venous thromboembolism |
|
|
|
MESH:D054556 |
|
187 |
5083-5089 |
Disease |
denotes |
stroke |
|
|
|
MESH:D020521 |
|
188 |
5093-5114 |
Disease |
denotes |
myocardial infarction |
|
|
|
MESH:D009203 |
|
189 |
5156-5164 |
Disease |
denotes |
bleeding |
|
|
|
MESH:D006470 |
|
T41 |
5177-5188 |
Method |
denotes |
transfusion |
|
|
|
|
|
T43 |
5192-5217 |
Amount |
denotes |
2 or more units of packed |
|
|
|
|
|
T44 |
5218-5233 |
Biological |
denotes |
red blood cells |
|
|
|
|
|
T42 |
5234-5242 |
Timing |
denotes |
in a day |
|
|
|
|
|
190 |
5244-5252 |
Disease |
denotes |
bleeding |
|
|
|
MESH:D020300 |
|
T121 |
5244-5252 |
Disease |
denotes |
bleeding |
|
|
|
|
|
T236 |
5244-5252 |
Disease |
denotes |
bleeding |
|
|
|
|
|
T45 |
5314-5326 |
Disease |
denotes |
intracranial |
|
|
|
|
|
T46 |
5328-5340 |
Biological |
denotes |
intra-spinal |
|
|
|
|
|
191 |
5342-5353 |
Biological |
denotes |
intraocular |
|
|
|
|
|
T122 |
5380-5383 |
Biological |
denotes |
eye |
|
|
|
|
|
T123 |
5393-5411 |
Disease |
denotes |
conjunctival bleed |
|
|
|
|
|
T222 |
5415-5418 |
Negative |
denotes |
not |
|
|
|
|
|
T49 |
5442-5453 |
Biological |
denotes |
pericardial |
|
|
|
|
|
T51 |
5455-5470 |
Biological |
denotes |
intra-articular |
|
|
|
|
|
T52 |
5472-5485 |
Biological |
denotes |
intramuscular |
|
|
|
|
|
194 |
5491-5511 |
Disease |
denotes |
compartment syndrome |
|
|
|
MESH:D003161 |
|
T120 |
5516-5531 |
Biological |
denotes |
retroperitoneal |
|
|
|
|
|
195 |
5534-5542 |
Disease |
denotes |
bleeding |
|
|
|
|
|
T55 |
5561-5582 |
Therapy |
denotes |
surgical intervention |
|
|
|
|
|
196 |
5587-5595 |
Disease |
denotes |
bleeding |
|
|
|
|
|
197 |
5624-5632 |
Disease |
denotes |
bleeding |
|
|
|
MESH:D006470 |
|
198 |
5669-5674 |
Die |
denotes |
death |
|
|
|
MESH:D003643 |
|
199 |
5702-5707 |
Die |
denotes |
death |
|
|
|
MESH:D003643 |
|
200 |
5746-5764 |
Disease |
denotes |
non-major bleeding |
|
|
|
|
|
201 |
5777-5808 |
Disease |
denotes |
acute clinically overt bleeding |
|
|
|
|
|
202 |
5871-5904 |
Disease |
denotes |
bleeding compromising hemodynamic |
|
|
|
|
|
203 |
5906-5926 |
Disease |
denotes |
spontaneous hematoma |
|
|
|
HP:0007420 |
|
T57 |
5927-5945 |
Size |
denotes |
larger than 25 cm2 |
|
|
|
|
|
204 |
5947-5969 |
Disease |
denotes |
intramuscular hematoma |
|
|
|
HP:0012233 |
|
205 |
6001-6011 |
Disease |
denotes |
haematuria |
|
|
|
MESH:D006417 |
|
T59 |
6113-6124 |
Disease |
denotes |
haemoptysis |
|
hemoptysis |
synonym |
MESH:D006469 |
|
206 |
6126-6137 |
Disease |
denotes |
hematemesis |
|
|
|
MESH:D006396 |
|
207 |
6141-6168 |
Disease |
denotes |
spontaneous rectal bleeding |
|
|
|
|
|
208 |
6222-6240 |
Disease |
denotes |
any other bleeding |
|
|
|
|
|
T60 |
6251-6286 |
Disease |
denotes |
temporary cessation of a study drug |
|
|
|
|
|
T237 |
6306-6325 |
TrialDesign |
denotes |
block randomisation |
|
|
|
|
|
T245 |
6344-6364 |
TrialDesign |
denotes |
variable block sizes |
|
|
|
|
|
T244 |
6366-6376 |
TrialDesign |
denotes |
block size |
|
|
|
|
|
T238 |
6377-6382 |
Ratio |
denotes |
4-6-8 |
|
|
|
|
|
T239 |
6410-6416 |
TrialDesign |
denotes |
Centre |
|
|
|
|
|
T243 |
6418-6421 |
Index |
denotes |
BMI |
inclusion_criteria |
|
|
|
|
T246 |
6423-6426 |
Value |
denotes |
<30 |
|
|
|
|
|
T247 |
6427-6430 |
Value |
denotes |
≥30 |
|
|
|
|
|
T240 |
6436-6439 |
Age |
denotes |
Age |
inclusion_criteria |
|
|
|
|
T241 |
6441-6444 |
Age |
denotes |
<75 |
|
|
|
|
|
T242 |
6445-6448 |
Age |
denotes |
≥75 |
|
|
|
|
|
T248 |
6451-6472 |
TrialDesign |
denotes |
Central randomisation |
|
|
|
|
|
T249 |
6567-6572 |
Ratio |
denotes |
1:1:1 |
|
|
|
|
|
209 |
6704-6716 |
Species |
denotes |
Participants |
|
|
|
Tax:9606 |
|
T258 |
6738-6745 |
TrialDesign |
denotes |
blinded |
|
|
|
|
|
T61 |
6883-6898 |
TrialDesign |
denotes |
UHF and steroid |
drug |
UFH and steroid |
|
MESH:D006493|MESH:D008775 |
t |
T184 |
6910-6920 |
TrialDesign |
denotes |
LMWH group |
drug |
|
|
MESH:D017984 |
|
T253 |
6915-6920 |
TrialDesign |
denotes |
group |
|
|
|
|
|
213 |
6959-6964 |
Die |
denotes |
death |
|
|
|
MESH:D003643 |
|
T254 |
6988-6999 |
TrialDesign |
denotes |
sample size |
|
|
|
|
|
T257 |
7032-7035 |
Number |
denotes |
210 |
inclusion_criteria |
|
|
|
|
T255 |
7043-7056 |
TrialDesign |
denotes |
randomization |
|
|
|
|
|
T256 |
7057-7062 |
Ratio |
denotes |
1:1:1 |
|
|
|
|
|
T260 |
7067-7074 |
Number |
denotes |
seventy |
inclusion_criteria |
|
|
|
|
214 |
7075-7083 |
Species |
denotes |
patients |
|
|
|
Tax:9606 |
|
215 |
7142-7151 |
Die |
denotes |
mortality |
|
|
|
MESH:D009026 |
|
T185 |
7160-7170 |
TrialDesign |
denotes |
LMWH group |
drug |
|
|
MESH:D017984 |
|
217 |
7220-7228 |
Species |
denotes |
patients |
|
|
|
Tax:9606 |
|
218 |
7323-7328 |
Die |
denotes |
death |
|
|
|
MESH:D003643 |
|
T251 |
7341-7361 |
TrialDesign |
denotes |
LMHW + steroid group |
drug |
LMWH + steroid group |
|
MESH:D017984|MESH:D008775 |
t |
T186 |
7366-7376 |
TrialDesign |
denotes |
LMWH group |
drug |
|
|
MESH:D017984 |
|
T207 |
7383-7402 |
TrialDesign |
denotes |
UHF + steroid group |
drug |
UFH + steroid group |
|
MESH:D006493|MESH:D008775 |
t |
T187 |
7407-7417 |
TrialDesign |
denotes |
LMWH group |
drug |
|
|
MESH:D017984 |
|
224 |
7481-7501 |
TrialDesign |
denotes |
LMHW + steroid group |
drug |
LMWH + steroid group |
|
MESH:D017984|MESH:D008775 |
t |
T208 |
7506-7525 |
TrialDesign |
denotes |
UHF + steroid group |
drug |
UFH + steroid group |
|
MESH:D006493|MESH:D008775 |
t |
T259 |
7735-7756 |
TrialDesign |
denotes |
8 participating sites |
|
|
|
|
|
228 |
7788-7796 |
Species |
denotes |
patients |
|
|
|
Tax:9606 |
|
229 |
7822-7830 |
Species |
denotes |
patients |
|
|
|
Tax:9606 |
|
230 |
7870-7878 |
Species |
denotes |
patients |
|
|
|
Tax:9606 |
|
T141 |
7908-7911 |
Number |
denotes |
210 |
inclusion_criteria |
|
|
|
|
231 |
7912-7924 |
Species |
denotes |
participants |
|
|
|
Tax:9606 |
|
R1 |
11 |
T147 |
of_a |
SARS-CoV-2,infection |
R10 |
T151 |
T152 |
of_a |
adjunctive,therapy |
R100 |
T126 |
T233 |
of_a |
once day,administered |
R101 |
T124 |
T234 |
of_a |
6000 UI,administered |
R102 |
T127 |
T234 |
of_a |
once day,administered |
R103 |
T202 |
T203 |
of_a |
more than 90 kg,weighting |
R104 |
T203 |
170 |
of_a |
weighting,patients |
R105 |
170 |
T234 |
of_a |
patients,administered |
R106 |
T233 |
T182 |
of_a |
administered,LMWH group |
R107 |
T233 |
T188 |
of_a |
administered,LMWH + steroid group |
R108 |
T234 |
T182 |
of_a |
administered,LMWH group |
R109 |
T234 |
T188 |
of_a |
administered,LMWH + steroid group |
R11 |
T151 |
T155 |
of_a |
adjunctive,therapy |
R110 |
T15 |
T233 |
of_a |
once a day,administered |
R111 |
T15 |
T234 |
of_a |
once a day,administered |
R112 |
T13 |
T233 |
in |
up to ICU discharge,administered |
R113 |
T13 |
T234 |
in |
up to ICU discharge,administered |
R114 |
T205 |
T233 |
in |
subcutaneously,administered |
R115 |
T205 |
T234 |
in |
subcutaneously,administered |
R116 |
T209 |
T210 |
of_a |
"0,5 mg/kg",administered |
R117 |
T17 |
T210 |
of_a |
initial bolus,administered |
R118 |
T18 |
T210 |
of_a |
4 times daily,administered |
R119 |
171 |
T210 |
of_a |
Methylprednisolone,administered |
R12 |
122 |
T150 |
using |
methylprednisolone,therapy |
R120 |
T19 |
T210 |
of_a |
for 7 days,administered |
R121 |
T132 |
T211 |
of_a |
"0,5 mg/kg",administered |
R122 |
T21 |
T211 |
of_a |
3 times daily,administered |
R123 |
T22 |
T211 |
of_a |
from day 8 to day 10,administered |
R124 |
171 |
T211 |
of_a |
Methylprednisolone,administered |
R125 |
T16 |
T210 |
in |
intravenously,administered |
R126 |
T16 |
T211 |
in |
intravenously,administered |
R127 |
T133 |
T212 |
of_a |
"0,5 mg/kg",administered |
R128 |
T24 |
T212 |
of_a |
2 times daily,administered |
R129 |
T25 |
T212 |
of_a |
at days 11 and 12,administered |
R13 |
123 |
T150 |
using |
unfractionated heparin,therapy |
R130 |
T134 |
T213 |
of_a |
"0,5 mg/kg",administered |
R131 |
T27 |
T213 |
of_a |
once daily,administered |
R132 |
T28 |
T213 |
of_a |
at days 13 and 14,administered |
R133 |
171 |
T212 |
of_a |
Methylprednisolone,administered |
R134 |
171 |
T213 |
of_a |
Methylprednisolone,administered |
R135 |
T16 |
T212 |
in |
intravenously,administered |
R136 |
T16 |
T213 |
in |
intravenously,administered |
R137 |
T210 |
T188 |
of_a |
administered,LMWH + steroid group |
R138 |
T211 |
T188 |
of_a |
administered,LMWH + steroid group |
R139 |
T212 |
T188 |
of_a |
administered,LMWH + steroid group |
R14 |
124 |
123 |
abbreviation |
UFH,unfractionated heparin |
R140 |
T213 |
T188 |
of_a |
administered,LMWH + steroid group |
R141 |
T210 |
T191 |
of_a |
administered,UFH + steroid group |
R142 |
T211 |
T191 |
of_a |
administered,UFH + steroid group |
R143 |
T212 |
T191 |
of_a |
administered,UFH + steroid group |
R144 |
T213 |
T191 |
of_a |
administered,UFH + steroid group |
R145 |
T115 |
T77 |
of_a |
ventilation,invasive |
R146 |
T115 |
T72 |
of_a |
ventilation,non-invasive |
R147 |
T31 |
T217 |
of_a |
high-dose,administration |
R148 |
T31 |
T235 |
of_a |
high-dose,administration |
R149 |
179 |
T217 |
of_a |
steroids,administration |
R15 |
127 |
126 |
abbreviation |
LMWH,low molecular weight heparin |
R150 |
T30 |
T235 |
of_a |
immune-modulatory drugs,administration |
R151 |
T43 |
T41 |
of_a |
2 or more units of packed,transfusion |
R152 |
T44 |
T41 |
of_a |
red blood cells,transfusion |
R153 |
T42 |
T41 |
of_a |
in a day,transfusion |
R154 |
190 |
T45 |
- |
bleeding,intracranial |
R155 |
T122 |
191 |
of_a |
eye,intraocular |
R156 |
T46 |
T121 |
in |
intra-spinal,bleeding |
R157 |
191 |
T121 |
in |
intraocular,bleeding |
R158 |
T222 |
T123 |
of_a |
not,conjunctival bleed |
R159 |
T49 |
T121 |
in |
pericardial,bleeding |
R16 |
125 |
T152 |
using |
methylprednisolone,therapy |
R160 |
T51 |
T121 |
in |
intra-articular,bleeding |
R161 |
T120 |
T121 |
in |
retroperitoneal,bleeding |
R162 |
194 |
T236 |
with |
compartment syndrome,bleeding |
R163 |
T52 |
T236 |
in |
intramuscular,bleeding |
R164 |
196 |
198 |
cause_of |
bleeding,death |
R165 |
195 |
T55 |
against |
bleeding,surgical intervention |
R166 |
T57 |
203 |
of_a |
larger than 25 cm2,spontaneous hematoma |
R167 |
T238 |
T244 |
of_a |
4-6-8,block size |
R168 |
T240 |
T241 |
- |
Age,<75 |
R169 |
T240 |
T242 |
- |
Age,≥75 |
R17 |
126 |
T152 |
using |
low molecular weight heparin,therapy |
R170 |
T246 |
T243 |
of_a |
<30,BMI |
R171 |
T247 |
T243 |
of_a |
≥30,BMI |
R172 |
T249 |
T248 |
of_a |
1:1:1,Central randomisation |
R173 |
T61 |
T253 |
- |
UHF and steroid,group |
R174 |
231 |
T141 |
of_a |
participants,210 |
R175 |
T257 |
T254 |
of_a |
210,sample size |
R176 |
T256 |
T255 |
of_a |
1:1:1,randomization |
R177 |
214 |
T260 |
of_a |
patients,seventy |
R18 |
133 |
T155 |
using |
LMWH,therapy |
R19 |
T65 |
131 |
of_a |
critically-ill,pneumonia |
R2 |
T147 |
9 |
has_a |
infection,patients |
R20 |
130 |
T149 |
has_status |
patients,ventilated |
R21 |
132 |
T148 |
of_a |
SARS-CoV-2,infection |
R22 |
T148 |
130 |
has_a |
infection,patients |
R23 |
131 |
130 |
has_a |
pneumonia,patients |
R24 |
T150 |
T154 |
is_a |
therapy,more |
R25 |
T152 |
T154 |
is_a |
therapy,more |
R26 |
T155 |
T154 |
against |
therapy,more |
R27 |
130 |
T153 |
is_a |
patients,reducing |
R28 |
T153 |
128 |
is_a |
reducing,mortality |
R29 |
T154 |
T153 |
is_a |
more,reducing |
R3 |
10 |
9 |
has_a |
pneumonia,patients |
R30 |
T73 |
T116 |
- |
non-invasive,mechanical |
R31 |
T219 |
T218 |
of_a |
invasive mechanical,ventilation |
R32 |
T73 |
T218 |
of_a |
non-invasive,ventilation |
R33 |
T221 |
T74 |
of_a |
non-invasive,ventilation |
R34 |
T220 |
T82 |
of_a |
invasive,ventilation |
R35 |
T34 |
183 |
cause_of |
Candida,infections |
R36 |
T35 |
183 |
cause_of |
Candida,infections |
R37 |
T37 |
183 |
cause_of |
Aspergillus,infections |
R38 |
184 |
183 |
cause_of |
Adenovirus,infections |
R39 |
T38 |
183 |
cause_of |
Herpes Virus e Cytomegalovirus,infections |
R4 |
9 |
T145 |
has_status |
patients,ventilated |
R40 |
T70 |
T71 |
of_a |
pressure ventilation,non-invasive |
R41 |
T70 |
T75 |
of_a |
pressure ventilation,invasive |
R42 |
T84 |
T70 |
in |
> 24 hours,pressure ventilation |
R43 |
T85 |
T169 |
of_a |
ventilation,Invasive |
R44 |
T85 |
T168 |
of_a |
ventilation,mechanical |
R45 |
T86 |
T85 |
in |
< 96 hours,ventilation |
R46 |
T87 |
T89 |
of_a |
lower than 150 mmHg,PaO2/FiO2 ratio |
R47 |
T88 |
T68 |
of_a |
> 6 times,D-dimer |
R48 |
T170 |
T88 |
of_a |
the upper limit of normal reference range,> 6 times |
R49 |
T171 |
T90 |
of_a |
upper the limit of normal reference range,> 6-fold |
R5 |
T64 |
10 |
of_a |
critically ill,pneumonia |
R50 |
T90 |
137 |
of_a |
> 6-fold,C-reactive Protein |
R51 |
T166 |
T224 |
using |
pharyngeal swab,Positive |
R52 |
T167 |
T166 |
of_a |
deep airways material,pharyngeal swab |
R53 |
T224 |
136 |
is_a |
Positive,SARS-CoV-2 |
R54 |
T137 |
T172 |
of_a |
< 100.000/mm3,count |
R55 |
T174 |
T92 |
using |
anticoagulant drugs,treatment |
R56 |
T136 |
T172 |
of_a |
Platelet,count |
R57 |
140 |
T96 |
against |
sodium enoxaparin,Allergy |
R58 |
141 |
T96 |
against |
LMWH,Allergy |
R59 |
142 |
T96 |
against |
UFH,Allergy |
R6 |
6 |
T223 |
using |
methylprednisolone,use |
R60 |
143 |
T96 |
against |
methylprednisolone,Allergy |
R61 |
138 |
T173 |
is_a |
heparin,induced |
R62 |
T173 |
T140 |
is_a |
induced,thrombocytopenia |
R63 |
T100 |
T99 |
of_a |
brain,surgery |
R64 |
T101 |
T99 |
of_a |
spinal,surgery |
R65 |
T102 |
T99 |
of_a |
ophthalmic,surgery |
R66 |
T177 |
T99 |
in |
last 1 month,surgery |
R67 |
T176 |
145 |
is_a |
high risk,bleeding |
R68 |
144 |
T98 |
has_status |
bleeding,Active |
R69 |
T175 |
T97 |
is_a |
contraindicating,anticoagulant treatment |
R7 |
7 |
T223 |
using |
unfractionated heparin,use |
R70 |
T97 |
145 |
for |
anticoagulant treatment,bleeding |
R71 |
T105 |
T178 |
- |
Chronic,corticosteroids |
R72 |
T108 |
T179 |
using |
pregnancy test,positive |
R73 |
T110 |
T180 |
has_status |
treatment,life-sustaining |
R74 |
146 |
T109 |
for |
women,pregnancy test |
R75 |
T181 |
T112 |
of_a |
severe,diseases |
R76 |
T3 |
T228 |
of_a |
standard prophylactic dosage,administered |
R77 |
150 |
T228 |
of_a |
enoxaparin,administered |
R78 |
T228 |
T182 |
of_a |
administered,LMWH group |
R79 |
T4 |
T229 |
of_a |
standard prophylactic dosage,receive |
R8 |
T223 |
9 |
for |
use,patients |
R80 |
154 |
T229 |
of_a |
enoxaparin,receive |
R81 |
155 |
T230 |
of_a |
methylprednisolone,receive |
R82 |
T229 |
T188 |
of_a |
receive,LMWH + steroid group |
R83 |
T230 |
T188 |
of_a |
receive,LMWH + steroid group |
R84 |
159 |
T231 |
of_a |
UFH,receive |
R85 |
T5 |
T231 |
of_a |
therapeutic dosages,receive |
R86 |
T193 |
T231 |
in |
intravenously,receive |
R87 |
160 |
T232 |
of_a |
methylprednisolone,receive |
R88 |
T232 |
T191 |
of_a |
receive,UFH + steroid group |
R89 |
T231 |
T191 |
of_a |
receive,UFH + steroid group |
R9 |
T151 |
T150 |
of_a |
adjunctive,therapy |
R90 |
T195 |
T9 |
of_a |
1.5-2.0,aPTT Ratio |
R91 |
T8 |
T194 |
of_a |
18 UI/kg/hour,infusion rate |
R92 |
T194 |
T231 |
of_a |
infusion rate,receive |
R93 |
T231 |
T196 |
is_a |
receive,modified |
R94 |
T196 |
T9 |
is_a |
modified,aPTT Ratio |
R95 |
T197 |
T196 |
in |
no longer than 12 hours,modified |
R96 |
T10 |
T231 |
in |
up to ICU discharge,receive |
R97 |
166 |
T233 |
of_a |
Enoxaparin,administered |
R98 |
166 |
T234 |
of_a |
Enoxaparin,administered |
R99 |
T125 |
T233 |
of_a |
4000 UI,administered |