Covid19_manual_annotation  

2020PubMed@AikoHIRAKI:re32418532 JSONTXT

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue ForCovid19 Memo all_replicate correct/standard/original word tao:has_database_id
T63 0-18 NegativeRegulation denotes Counter-regulatory t
T25 19-45 Biological denotes 'Renin-Angiotensin' System
T26 52-67 Chemical denotes Candidate Drugs drug
T91 71-76 Therapy denotes Treat
T10 77-85 Disease denotes COVID-19 MESH:D000086382
T1 98-108 Species denotes SARS-CoV-2 t Tax:2697049
T28 109-117 Disease denotes infected t MESH:D007239
T31 118-126 Species denotes patients Tax:9606
T2 129-139 Species denotes SARS-CoV-2 Tax:2697049
T11 142-150 Disease denotes COVID-19 MESH:D000086382
T34 159-185 Biological denotes 'Renin-Angiotensin' System
T62 201-227 Biological denotes 'Renin-Angiotensin' system
T37 229-232 Biological denotes RAS
T65 255-293 Biological denotes 'Renin-Angiotensin-Aldosterone' system
T81 333-339 Species denotes humans Tax:9606
T72 355-364 Regulation denotes regulator
T67 368-373 Biological denotes renal
T70 375-389 Biological denotes cardiovascular
T71 394-407 Biological denotes innate immune
T66 408-417 Function denotes functions
T89 460-469 Chemical denotes vitamin D MESH:D014807
T82 524-543 NegativeRegulation denotes negative regulatory
T38 558-561 Biological denotes RAS
T93 571-582 NegativeRegulation denotes dysfunction
T92 589-604 PositiveRegulation denotes over-reactivity
T39 609-612 Biological denotes RAS
T94 628-645 Disease denotes hypovitaminosis D MESH:D014808
T68 693-698 Biological denotes renal
T83 700-707 Biological denotes cardiac
T84 709-717 Biological denotes vascular
T86 722-737 Biological denotes immune outcomes
T85 729-737 Biological denotes outcomes
T12 764-772 Disease denotes COVID-19 t MESH:D000086382
T32 773-781 Species denotes patients Tax:9606
T87 797-811 Disease denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T131 840-846 Biological denotes immune
T97 937-943 Die denotes lethal
T96 944-979 Disease denotes acute respiratory distress syndrome MESH:D012128
T3 998-1008 Species denotes SARS-CoV-2 Tax:2697049
T13 1040-1048 Disease denotes COVID-19 MESH:D000086382
T123 1072-1081 NegativeRegulation denotes interfere
T40 1091-1094 Biological denotes RAS
T100 1102-1113 Interact denotes interacting
T98 1123-1145 Gene denotes spike (S) glycoprotein Gene:43740568
T110 1173-1204 Gene denotes Angiotensin-Converting Enzyme 2 Gene:59272
T101 1206-1210 Gene denotes ACE2 Gene:59272
T111 1237-1246 Express denotes expressed
T113 1265-1281 Biological denotes epithelial cells
T114 1287-1300 Biological denotes blood vessels
T115 1302-1306 Biological denotes lung
T119 1308-1314 Biological denotes kidney
T69 1316-1329 Biological denotes renal tubules
T124 1332-1341 Biological denotes intestine
T118 1347-1352 Biological denotes heart
T125 1368-1384 Biological denotes cerebral neurons
T128 1389-1395 Biological denotes immune
T133 1389-1405 Biological denotes immune monocytes
T126 1406-1417 Biological denotes macrophages
T4 1436-1446 Species denotes SARS-CoV-2 Tax:2697049
T14 1455-1463 Disease denotes COVID-19 MESH:D000086382
T134 1504-1516 Disease denotes hypertension MESH:D006973
T135 1518-1533 Disease denotes atherosclerosis MESH:D050197
T136 1535-1545 Disease denotes thrombosis MESH:D013927
T137 1547-1559 Disease denotes coagulopathy MESH:D001778
T138 1562-1570 Disease denotes diarrhea MESH:D003967
T139 1572-1580 Disease denotes glaucoma MESH:D005901
T140 1582-1589 Disease denotes anosmia MESH:D000857
T141 1591-1598 Disease denotes ageusia MESH:D000370
T142 1600-1612 Disease denotes skin lesions MESH:D012871
T143 1614-1624 Disease denotes dermatitis MESH:D003872
T144 1627-1680 Disease denotes autoimmune inflammation of the central nervous system MESH:D020278
T145 1686-1693 Disease denotes damages
T116 1724-1728 Biological denotes lung
T117 1730-1735 Biological denotes heart
T120 1737-1743 Biological denotes kidney
T146 1749-1757 Biological denotes testicle
T147 1780-1787 Condition denotes diffuse
T15 1788-1796 Disease denotes COVID-19 MESH:D000086382
T148 1831-1844 PositiveRegulation denotes over-reaction
T41 1848-1851 Biological denotes RAS
T5 1855-1865 Species denotes SARS-CoV-2 t Tax:2697049
T29 1866-1874 Disease denotes infected t MESH:D007239
T30 1875-1882 Species denotes persons Tax:9606
T42 1891-1894 Biological denotes RAS
T149 1895-1904 PositiveRegulation denotes imbalance
T95 1930-1947 Disease denotes hypovitaminosis D MESH:D014808
T43 1965-1968 Biological denotes RAS
T16 1994-2002 Disease denotes COVID-19 MESH:D000086382
T44 2107-2110 Biological denotes RAS
T17 2132-2140 Disease denotes COVID-19 MESH:D000086382
T35 2152-2178 Biological denotes 'Renin-Angiotensin' System
T36 2180-2183 Biological denotes RAS
T64 2187-2205 NegativeRegulation denotes Counter-regulatory
T45 2206-2209 Biological denotes RAS
T46 2217-2220 Biological denotes RAS
T150 2238-2243 Gene denotes Renin Gene:5972
T121 2245-2251 Biological denotes kidney
T170 2253-2260 Cleave denotes cleaves
T151 2261-2276 Gene denotes Angiotensinogen Gene:183
T122 2278-2283 Biological denotes liver
T152 2293-2306 Gene denotes Angiotensin I peptide Gene:183|MESH:D000803
T166 2321-2331 Biological denotes DRVYIHPFHL peptide
T184 2338-2344 Gene denotes latter
T185 2348-2355 Cleave denotes cleaved
T173 2363-2392 Gene denotes Angiotensin-Converting Enzyme Gene:1636
T174 2394-2397 Gene denotes ACE Gene:1636
T153 2410-2424 Gene denotes Angiotensin II peptide Gene:183|MESH:D000804
T167 2439-2447 Biological denotes DRVYIHPF peptide
T102 2476-2480 Gene denotes ACE2 Gene:59272
T6 2482-2492 Species denotes SARS-CoV-2 Tax:2697049
T47 2525-2528 Biological denotes RAS
T196 2543-2550 Bind denotes targets
T154 2554-2568 Gene denotes Angiotensin II peptide Gene:183|MESH:D000804
T214 2593-2599 Gene denotes type 1 Gene:185
T198 2601-2605 Gene denotes AT1R Gene:185
T217 2625-2631 Gene denotes type 2 Gene:186
T202 2633-2637 Gene denotes AT2R Gene:186
T155 2639-2662 Gene denotes Angiotensin II receptor Gene:185
T216 2639-2662 Gene denotes Angiotensin II receptor Gene:186
T199 2665-2669 Gene denotes AT1R Gene:185
T112 2673-2682 Express denotes expressed
T218 2701-2710 Biological denotes monocytes
T127 2711-2722 Biological denotes macrophages
T219 2727-2734 Biological denotes T-cells
T48 2751-2754 Biological denotes RAS
T186 2794-2801 Cleave denotes cleaved
T103 2805-2809 Gene denotes ACE2 Gene:59272
T156 2811-2825 Gene denotes Angiotensin II peptide Gene:183|MESH:D000804
T190 2832-2847 Gene denotes Angiotensin 1-7 peptide Gene:183|MESH:C118790
T195 2862-2869 Biological denotes DRVYIHP peptide
T221 2872-2881 Bind denotes targeting
T220 2929-2933 Gene denotes MasR Gene:116511
T191 2936-2951 Gene denotes Angiotensin 1-7 peptide Gene:183|MESH:C118790
T223 2967-2978 Cleave denotes transformed
T222 2982-2992 Biological denotes Alamandine peptide MESH:C581752
T213 3007-3014 Biological denotes ARVYIHP peptide
T224 3022-3045 Biological denotes aspartate decarboxylase MESH:C019747
T228 3047-3057 Biological denotes Alamandine peptide MESH:C581752
T229 3064-3068 Bind denotes bind
T225 3090-3137 Gene denotes Mas-related G protein-coupled receptor member D Gene:116512
T226 3139-3143 Gene denotes MRGD Gene:116512
T192 3172-3187 Gene denotes Angiotensin 1-7 peptide Gene:183|MESH:C118790
T157 3202-3216 Gene denotes Angiotensin II peptide Gene:183|MESH:D000804
T231 3221-3228 Produce denotes produce
T230 3229-3242 Biological denotes Angiotensin A peptide MESH:C516880
T209 3257-3265 Biological denotes ARVYIHPF peptide
T232 3274-3297 Biological denotes aspartate decarboxylase MESH:C019747
T234 3303-3313 Biological denotes Alamandine peptide MESH:C581752
T104 3332-3336 Gene denotes ACE2 Gene:59272
T233 3337-3345 Cleave denotes cleavage
T105 3347-3351 Gene denotes ACE2 Gene:59272
T236 3361-3367 Cleave denotes cleave
T158 3368-3381 Gene denotes Angiotensin I peptide Gene:183|MESH:D000803
T235 3390-3405 Gene denotes Angiotensin 1-9 peptide Gene:183|MESH:C506331
T169 3420-3429 Biological denotes DRVYIHPFH peptide
T197 3438-3445 Bind denotes targets
T203 3446-3450 Gene denotes AT2R Gene:186
T49 3459-3462 Biological denotes RAS
T159 3506-3521 Gene denotes Angiotensin III peptide Gene:183|MESH:D000805
T206 3536-3543 Biological denotes RVYIHPF peptide
T160 3549-3563 Gene denotes Angiotensin IV peptide Gene:183|MESH:C496150
T210 3578-3584 Biological denotes VYIHPF peptide
T237 3595-3604 Bind denotes targeting
T239 3595-3604 Bind denotes targeting
T200 3609-3613 Gene denotes AT1R Gene:185
T238 3632-3636 Biological denotes AT4R May be MESH:C090830?
T50 3696-3699 Biological denotes RAS
T243 3701-3712 Gene denotes Angiotensin peptide MESH:D000803|Gene:183
T247 3701-3712 Gene denotes Angiotensin peptide MESH:D000804|Gene:183
T241 3714-3715 Gene denotes I peptide MESH:D000803|Gene:183
T245 3720-3722 Gene denotes II peptide MESH:D000804|Gene:183
T161 3730-3745 Gene denotes Angiotensin III peptide Gene:183|MESH:D000805
T51 3792-3795 Biological denotes RAS
T18 3834-3842 Disease denotes COVID-19 MESH:D000086382
T78 3885-3905 NegativeRegulation denotes 'counter-regulatory'
T52 3906-3909 Biological denotes RAS
T262 3940-3951 Biological denotes homeostasis
T193 3966-3981 Gene denotes Angiotensin 1-7 peptide Gene:183|MESH:C118790
T248 3983-3998 Gene denotes Angiotensin 1-9 peptide Gene:183|MESH:C506331
T251 4000-4010 Biological denotes Alamandine peptide MESH:C581752
T252 4012-4025 Biological denotes Angiotensin A peptide MESH:C516880
T162 4031-4045 Gene denotes Angiotensin IV peptide Gene:183|MESH:C496150
T254 4057-4066 Bind denotes targeting
T258 4057-4066 Bind denotes targeting
T259 4057-4066 Bind denotes targeting
T260 4057-4066 Bind denotes targeting
T261 4057-4066 Bind denotes targeting
T255 4071-4075 Gene denotes MasR Gene:116511
T204 4077-4081 Gene denotes AT2R Gene:186
T256 4083-4087 Gene denotes MRGD Gene:116512
T106 4089-4093 Gene denotes ACE2 Gene:59272
T257 4098-4102 Biological denotes AT4R May be MESH:C090830?
T263 4142-4156 Biological denotes These peptides
T264 4179-4195 Biological denotes cardioprotective
T265 4197-4207 Biological denotes vasoactive
T266 4209-4226 Biological denotes anti-hypertensive
T267 4229-4246 Biological denotes anti-hypertrophic
T268 4254-4271 Biological denotes anti-inflammatory
T189 4289-4322 Biological denotes Such naturally-produced molecules
T53 4330-4333 Biological denotes RAS
T269 4350-4360 NegativeRegulation denotes counteract
T7 4365-4375 Species denotes SARS-CoV-2 Tax:2697049
T270 4384-4399 PositiveRegulation denotes over-activation
T54 4403-4406 Biological denotes RAS
T271 4411-4418 BecomeReduce denotes reverse
T19 4451-4459 Disease denotes COVID-19 MESH:D000086382
T55 4519-4533 Chemical denotes RAS inhibitors inhibitor|drug
T20 4594-4602 Disease denotes COVID-19 MESH:D000086382
T33 4603-4611 Species denotes patients Tax:9606
T56 4633-4645 Chemical denotes RAS blockers inhibitor|drug
T21 4669-4677 Disease denotes COVID-19 MESH:D000086382
T57 4712-4726 Chemical denotes RAS inhibitors inhibitor|drug
T272 4734-4741 Chemical denotes prevent
T88 4746-4760 Disease denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T58 4764-4767 Biological denotes RAS
T275 4783-4790 NegativeRegulation denotes control
T274 4795-4802 Release denotes release
T273 4806-4832 Biological denotes pro-inflammatory cytokines
T22 4857-4865 Disease denotes COVID-19 MESH:D000086382
T8 4879-4889 Species denotes SARS-CoV-2 Tax:2697049
T27 4890-4898 Disease denotes infected MESH:D007239
T80 4899-4905 Species denotes humans Tax:9606
T59 4920-4923 Biological denotes RAS
T276 4924-4936 PositiveRegulation denotes over-reacted
T107 4945-4949 Gene denotes ACE2 Gene:59272
T277 4961-4966 Species denotes viral
T279 4967-4976 Disease denotes infection MESH:D007239
T90 4981-5001 Disease denotes vitamin D deficiency http://purl.obolibrary.org/obo/HP_0100512
T23 5028-5036 Disease denotes COVID-19 MESH:D000086382
T60 5066-5069 Biological denotes RAS
T280 5076-5117 Chemical denotes specific candidate chemotherapeutic drugs drug
T289 5123-5141 Chemical denotes proposed molecules
T182 5155-5169 Chemical denotes ACE inhibitors inhibitor|drug
T282 5174-5181 NegativeRegulation denotes prevent
T281 5186-5196 Cleave denotes production
T163 5200-5214 Gene denotes Angiotensin II peptide MESH:D000804|Gene:183
T164 5220-5233 Gene denotes Angiotensin I peptide MESH:D000803|Gene:183
T283 5240-5248 Chemical denotes blockers inhibitor|drug
T284 5249-5260 Chemical denotes antagonists inhibitor|drug
T201 5264-5268 Gene denotes AT1R Gene:185
T285 5277-5285 Chemical denotes Losartan inhibitor|drug
T286 5277-5285 Chemical denotes Losartan inhibitor|drug
T288 5290-5301 Chemical denotes derivatives inhibitor|drug
T290 5303-5314 Recombinant denotes Recombinant
T108 5315-5319 Gene denotes ACE2 Gene:59272
T292 5398-5409 NegativeRegulation denotes competitive
T291 5410-5417 Bind denotes binding
T99 5425-5447 Gene denotes spike (S) glycoprotein Gene:43740568
T9 5451-5461 Species denotes SARS-CoV-2 Tax:2697049
T293 5501-5524 Chemical denotes candidate peptide drugs drug
T79 5544-5564 NegativeRegulation denotes 'counter-regulatory'
T61 5565-5568 Biological denotes RAS
T194 5575-5590 Gene denotes Angiotensin 1-7 peptide Gene:183|MESH:C118790
T249 5592-5607 Gene denotes Angiotensin 1-9 peptide Gene:183|MESH:C506331
T250 5609-5619 Biological denotes Alamandine peptide MESH:C581752
T253 5621-5634 Biological denotes Angiotensin A peptide MESH:C516880
T165 5642-5656 Gene denotes Angiotensin IV peptide MESH:C496150|Gene:183
T24 5666-5674 Disease denotes COVID-19 MESH:D000086382
T297 5690-5698 Bind denotes targeted
T298 5690-5698 Bind denotes targeted
T299 5690-5698 Bind denotes targeted
T300 5690-5698 Bind denotes targeted
T301 5690-5698 Bind denotes targeted
T294 5723-5727 Gene denotes MasR Gene:116511
T205 5729-5733 Gene denotes AT2R Gene:186
T295 5735-5739 Gene denotes MRGD Gene:116512
T109 5741-5745 Gene denotes ACE2 Gene:59272
T296 5750-5754 Biological denotes AT4R May be MESH:C090830?
R1 T25 T26 for 'Renin-Angiotensin' System,Candidate Drugs
R10 T67 T66 of_a renal,functions
R100 T184 T152 coreference latter,Angiotensin I
R101 T184 T185 is_a latter,cleaved
R102 T151 T170 is_a Angiotensinogen,cleaves
R103 T170 T152 into cleaves,Angiotensin I
R104 T170 T166 into cleaves,DRVYIHPFHL
R105 T185 T153 into cleaved,Angiotensin II
R106 T185 T167 into cleaved,DRVYIHPF
R107 T173 T185 using Angiotensin-Converting Enzyme,cleaved
R108 T156 T186 is_a Angiotensin II,cleaved
R109 T186 T190 into cleaved,Angiotensin 1-7
R11 T70 T66 of_a cardiovascular,functions
R110 T103 T186 using ACE2,cleaved
R111 T186 T195 into cleaved,DRVYIHP
R112 T214 T155 - type 1,Angiotensin II receptor
R113 T217 T216 - type 2,Angiotensin II receptor
R114 T154 T196 is_a Angiotensin II,targets
R115 T196 T214 to targets,type 1
R116 T196 T217 to targets,type 2
R117 T198 T214 abbreviation AT1R,type 1
R118 T202 T217 abbreviation AT2R,type 2
R119 T199 T112 is_a AT1R,expressed
R12 T71 T66 of_a innate immune,functions
R120 T218 T112 on monocytes,expressed
R121 T127 T112 on macrophages,expressed
R122 T219 T112 on T-cells,expressed
R123 T190 T221 is_a Angiotensin 1-7,targeting
R124 T221 T220 to targeting,MasR
R125 T191 T223 is_a Angiotensin 1-7,transformed
R126 T223 T222 into transformed,Alamandine
R127 T223 T213 into transformed,ARVYIHP
R128 T224 T223 using aspartate decarboxylase,transformed
R129 T226 T225 abbreviation MRGD,Mas-related G protein-coupled receptor member D
R13 T12 T32 has_a COVID-19,patients
R130 T228 T229 is_a Alamandine,bind
R131 T229 T225 to bind,Mas-related G protein-coupled receptor member D
R132 T157 T231 is_a Angiotensin II,produce
R133 T231 T230 is_a produce,Angiotensin A
R134 T231 T209 is_a produce,ARVYIHPF
R135 T232 T231 using aspartate decarboxylase,produce
R136 T230 T233 is_a Angiotensin A,cleavage
R137 T233 T234 into cleavage,Alamandine
R138 T104 T234 using ACE2,Alamandine
R139 T158 T236 is_a Angiotensin I,cleave
R14 T5 T29 cause_of SARS-CoV-2,infected
R140 T236 T235 into cleave,Angiotensin 1-9
R141 T105 T236 using ACE2,cleave
R142 T236 T169 into cleave,DRVYIHPFH
R143 T235 T197 is_a Angiotensin 1-9,targets
R145 T159 T237 is_a Angiotensin III,targeting
R146 T206 T237 is_a RVYIHPF,targeting
R147 T237 T200 to targeting,AT1R
R148 T160 T239 is_a Angiotensin IV,targeting
R149 T210 T239 is_a VYIHPF,targeting
R15 T29 T30 has_a infected,persons
R150 T239 T238 to targeting,AT4R
R151 T243 T241 - Angiotensin,I
R152 T247 T245 - Angiotensin,II
R153 T193 T254 is_a Angiotensin 1-7,targeting
R154 T254 T255 to targeting,MasR
R155 T197 T203 to targets,AT2R
R156 T248 T258 is_a Angiotensin 1-9,targeting
R157 T258 T204 to targeting,AT2R
R158 T251 T259 is_a Alamandine,targeting
R159 T259 T256 to targeting,MRGD
R16 T64 T45 is_a Counter-regulatory,RAS
R160 T252 T260 is_a Angiotensin A,targeting
R161 T260 T106 to targeting,ACE2
R162 T162 T261 is_a Angiotensin IV,targeting
R163 T261 T257 to targeting,AT4R
R164 T263 T193 coreference These peptides,Angiotensin 1-7
R165 T263 T248 coreference These peptides,Angiotensin 1-9
R166 T263 T251 coreference These peptides,Alamandine
R167 T263 T252 coreference These peptides,Angiotensin A
R168 T263 T162 coreference These peptides,Angiotensin IV
R169 T263 T264 cause_of These peptides,cardioprotective
R17 T78 T52 is_a 'counter-regulatory',RAS
R170 T263 T265 cause_of These peptides,vasoactive
R171 T263 T266 cause_of These peptides,anti-hypertensive
R172 T263 T267 cause_of These peptides,anti-hypertrophic
R173 T263 T268 cause_of These peptides,anti-inflammatory
R174 T271 T19 is_a reverse,COVID-19
R175 T189 T263 coreference Such naturally-produced molecules,These peptides
R176 T189 T269 is_a Such naturally-produced molecules,counteract
R177 T269 T270 is_a counteract,over-activation
R178 T270 T54 is_a over-activation,RAS
R179 T53 T189 of_a RAS,Such naturally-produced molecules
R18 T20 T33 has_a COVID-19,patients
R180 T189 T271 is_a Such naturally-produced molecules,reverse
R181 T7 T270 cause_of SARS-CoV-2,over-activation
R182 T57 T275 is_a RAS inhibitors,control
R183 T275 T274 is_a control,release
R184 T274 T273 is_a release,pro-inflammatory cytokines
R185 T274 T88 cause_of release,cytokine storm
R186 T277 T279 of_a viral,infection
R187 T277 T8 coreference viral,SARS-CoV-2
R188 T279 T276 is_a infection,over-reacted
R189 T90 T276 is_a vitamin D deficiency,over-reacted
R19 T8 T27 cause_of SARS-CoV-2,infected
R190 T276 T59 is_a over-reacted,RAS
R191 T276 T22 cause_of over-reacted,COVID-19
R192 T107 T279 via ACE2,infection
R193 T164 T281 is_a Angiotensin I,production
R194 T281 T163 to production,Angiotensin II
R195 T282 T281 is_a prevent,production
R196 T182 T282 is_a ACE inhibitors,prevent
R197 T286 T288 - Losartan,derivatives
R198 T289 T280 coreference proposed molecules,specific candidate chemotherapeutic drugs
R199 T182 T289 is_a ACE inhibitors,proposed molecules
R2 T28 T31 has_a infected,patients
R20 T27 T80 has_a infected,humans
R200 T285 T289 is_a Losartan,proposed molecules
R201 T286 T289 is_a Losartan,proposed molecules
R202 T201 T284 of_a AT1R,antagonists
R203 T201 T283 of_a AT1R,blockers
R204 T283 T289 is_a blockers,proposed molecules
R205 T284 T289 is_a antagonists,proposed molecules
R206 T290 T108 is_a Recombinant,ACE2
R207 T108 T292 is_a ACE2,competitive
R208 T292 T291 is_a competitive,binding
R209 T291 T99 to binding,spike (S) glycoprotein
R21 T79 T61 is_a 'counter-regulatory',RAS
R210 T9 T99 of_a SARS-CoV-2,spike (S) glycoprotein
R211 T194 T293 is_a Angiotensin 1-7,candidate peptide drugs
R212 T249 T293 is_a Angiotensin 1-9,candidate peptide drugs
R213 T250 T293 is_a Alamandine,candidate peptide drugs
R214 T253 T293 is_a Angiotensin A,candidate peptide drugs
R215 T165 T293 is_a Angiotensin IV,candidate peptide drugs
R216 T24 T293 for COVID-19,candidate peptide drugs
R217 T194 T297 is_a Angiotensin 1-7,targeted
R218 T297 T294 to targeted,MasR
R219 T249 T298 is_a Angiotensin 1-9,targeted
R22 T68 T85 of_a renal,outcomes
R220 T298 T205 to targeted,AT2R
R221 T250 T299 is_a Alamandine,targeted
R222 T299 T295 to targeted,MRGD
R223 T253 T300 is_a Angiotensin A,targeted
R224 T300 T109 to targeted,ACE2
R225 T301 T296 to targeted,AT4R
R226 T165 T301 is_a Angiotensin IV,targeted
R23 T83 T85 of_a cardiac,outcomes
R24 T84 T85 of_a vascular,outcomes
R25 T26 T91 using Candidate Drugs,Treat
R26 T10 T91 for COVID-19,Treat
R27 T10 T31 has_a COVID-19,patients
R28 T89 T82 is_a vitamin D,negative regulatory
R29 T82 T38 is_a negative regulatory,RAS
R3 T1 T28 cause_of SARS-CoV-2,infected
R30 T93 T39 is_a dysfunction,RAS
R31 T92 T39 is_a over-reactivity,RAS
R32 T39 T86 cause_of RAS,immune outcomes
R33 T39 T85 cause_of RAS,outcomes
R34 T94 T86 cause_of hypovitaminosis D,immune outcomes
R35 T94 T85 cause_of hypovitaminosis D,outcomes
R36 T86 T32 has_a immune outcomes,patients
R37 T85 T32 has_a outcomes,patients
R4 T36 T35 abbreviation RAS,'Renin-Angiotensin' System
R41 T96 T97 has_status acute respiratory distress syndrome,lethal
R42 T94 T87 cause_of hypovitaminosis D,cytokine storm
R43 T94 T96 cause_of hypovitaminosis D,acute respiratory distress syndrome
R44 T39 T87 cause_of RAS,cytokine storm
R45 T39 T96 cause_of RAS,acute respiratory distress syndrome
R46 T96 T32 has_a acute respiratory distress syndrome,patients
R47 T87 T32 has_a cytokine storm,patients
R48 T101 T110 abbreviation ACE2,Angiotensin-Converting Enzyme 2
R49 T3 T13 cause_of SARS-CoV-2,COVID-19
R5 T37 T62 abbreviation RAS,'Renin-Angiotensin' system
R50 T3 T100 is_a SARS-CoV-2,interacting
R51 T100 T110 with interacting,Angiotensin-Converting Enzyme 2
R52 T98 T100 via spike (S) glycoprotein,interacting
R53 T100 T123 is_a interacting,interfere
R54 T123 T40 is_a interfere,RAS
R55 T128 T126 - immune,macrophages
R56 T114 T113 of_a blood vessels,epithelial cells
R57 T115 T113 of_a lung,epithelial cells
R58 T119 T113 of_a kidney,epithelial cells
R59 T69 T113 of_a renal tubules,epithelial cells
R6 T63 T25 is_a Counter-regulatory,'Renin-Angiotensin' System
R60 T124 T113 of_a intestine,epithelial cells
R61 T118 T113 of_a heart,epithelial cells
R62 T113 T111 on epithelial cells,expressed
R63 T125 T111 on cerebral neurons,expressed
R64 T133 T111 on immune monocytes,expressed
R65 T128 T111 on immune,expressed
R66 T4 T14 cause_of SARS-CoV-2,COVID-19
R67 T134 T14 is_a hypertension,COVID-19
R68 T135 T14 is_a atherosclerosis,COVID-19
R69 T136 T14 is_a thrombosis,COVID-19
R7 T65 T62 synonym 'Renin-Angiotensin-Aldosterone' system,'Renin-Angiotensin' system
R70 T137 T14 is_a coagulopathy,COVID-19
R71 T138 T14 is_a diarrhea,COVID-19
R72 T139 T14 is_a glaucoma,COVID-19
R73 T140 T14 is_a anosmia,COVID-19
R74 T141 T14 is_a ageusia,COVID-19
R75 T142 T14 is_a skin lesions,COVID-19
R76 T143 T14 is_a dermatitis,COVID-19
R77 T144 T14 is_a autoimmune inflammation of the central nervous system,COVID-19
R78 T145 T14 is_a damages,COVID-19
R79 T116 T145 to lung,damages
R8 T62 T72 is_a 'Renin-Angiotensin' system,regulator
R80 T117 T145 to heart,damages
R81 T120 T145 to kidney,damages
R82 T146 T145 to testicle,damages
R83 T148 T41 is_a over-reaction,RAS
R84 T148 T15 cause_of over-reaction,COVID-19
R85 T15 T147 has_status COVID-19,diffuse
R86 T30 T41 in persons,RAS
R87 T149 T42 is_a imbalance,RAS
R88 T149 T95 cause_of imbalance,hypovitaminosis D
R89 T149 T148 coreference imbalance,over-reaction
R9 T72 T66 is_a regulator,functions
R90 T121 T150 in kidney,Renin
R91 T122 T151 in liver,Angiotensinogen
R92 T150 T170 using Renin,cleaves
R97 T174 T173 abbreviation ACE,Angiotensin-Converting Enzyme