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PMC:17821 / 40653-53021 JSONTXT 2 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T73 1170-1172 1605310 denotes 35
T64 1556-1558 2456387 denotes 42
T49 1996-1998 8214013 denotes 19
T50 1999-2001 8814067 denotes 20
T51 2002-2004 9797567 denotes 21
T65 2038-2040 9632077 denotes 23
T72 2277-2279 9797567 denotes 21
T82 2280-2282 8317332 denotes 43
T56 2598-2600 10366105 denotes 44
T76 3872-3874 1605310 denotes 35
T61 4124-4125 9461440 denotes 8
T63 4677-4678 7621075 denotes 6
T77 5040-5042 1605310 denotes 35
T69 5043-5045 6501574 denotes 39
T80 6675-6677 9808201 denotes 45
T68 6861-6863 7401630 denotes 46
T62 7875-7877 10623430 denotes 34
T66 7875-7877 10623430 denotes 34
T79 8118-8120 10366105 denotes 44
T57 8711-8713 1828823 denotes 47
T58 8714-8716 8157973 denotes 48
T59 8790-8792 2784682 denotes 49
T60 8793-8795 1578447 denotes 50
T52 8843-8845 8569187 denotes 51
T53 8846-8848 9742213 denotes 52
T81 8922-8924 10366105 denotes 44
T48 9047-9049 10037754 denotes 53
T67 9048-9856 1605310 denotes 3]. Aggrecanase neoepitopes were abundantly found during the first phase of this arthritis [44]. Injection of zymosan into the knee joints of the three strains we studied was followed by a comparable depletion of PG; this finding suggests that the three strains have similar potencies to produce aggrecanase. Severe cartilage destruction, like chondrocyte death and cartilage erosion, was found only in DBA/1 mice. During the acute phase, PMNs constitute the dominant cell type present in the joint, whereas during the chronic phase, macrophages are the predominant cell type present in the synovium and synovial cavity. FcγR activation on both PMNs and macrophages may lead to the release of oxygen and nitrogen radicals, which in high concentrations can kill chondrocytes either by necrosis or apoptosis [5
T78 9140-9142 10366105 denotes 44
T70 9855-9857 7856740 denotes 54
T71 9858-9860 10403282 denotes 55
T74 10148-10150 1846914 denotes 56
T75 10151-10153 7575726 denotes 57
T55 10542-10874 9874574 denotes 1 joint. This attachment to the cartilage surface may cause release of enzymes that directly penetrate the cartilage matrix thus escaping from their inhibitors (manuscript in preparation). The present findings partly underline the findings in our previous study, in which an antigen-induced arthritis was produced in FcR γ-/-mice [5
T54 10873-10875 10765918 denotes 58