CORD-19:d05ba19fb87837ac31ae8501669bb7f74fd5739f JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-122 Sentence denotes Complete Genome Sequences of Four Novel Human Coronavirus OC43 Isolates Associated with Severe Acute Respiratory Infection
TextSentencer_T1 0-122 Sentence denotes Complete Genome Sequences of Four Novel Human Coronavirus OC43 Isolates Associated with Severe Acute Respiratory Infection
TextSentencer_T2 124-132 Sentence denotes Abstract
TextSentencer_T2 124-132 Sentence denotes Abstract
TextSentencer_T3 133-343 Sentence denotes We report here the complete genome sequences of four human coronavirus (HCoV) OC43 isolates generated using targeted viral nucleic acid capture and next-generation sequencing; the isolates were collected in New
TextSentencer_T3 133-343 Sentence denotes We report here the complete genome sequences of four human coronavirus (HCoV) OC43 isolates generated using targeted viral nucleic acid capture and next-generation sequencing; the isolates were collected in New
TextSentencer_T4 345-472 Sentence denotes H uman coronaviruses are enveloped positive-sense single-stranded RNA viruses with the largest genomes of any RNA viruses (1) .
TextSentencer_T4 345-472 Sentence denotes H uman coronaviruses are enveloped positive-sense single-stranded RNA viruses with the largest genomes of any RNA viruses (1) .
TextSentencer_T5 473-596 Sentence denotes Coronaviruses cause up to one-third of common colds, with epidemiology peaking in the winter and early spring (2) (3) (4) .
TextSentencer_T5 473-596 Sentence denotes Coronaviruses cause up to one-third of common colds, with epidemiology peaking in the winter and early spring (2) (3) (4) .
TextSentencer_T6 597-700 Sentence denotes Symptoms can range from subclinical to more severe lower-respiratory-tract involvement in infants (5) .
TextSentencer_T6 597-700 Sentence denotes Symptoms can range from subclinical to more severe lower-respiratory-tract involvement in infants (5) .
TextSentencer_T7 701-812 Sentence denotes There are three groups of coronaviruses which are classified based on genetic and serologic relationships (6) .
TextSentencer_T7 701-812 Sentence denotes There are three groups of coronaviruses which are classified based on genetic and serologic relationships (6) .
TextSentencer_T8 813-907 Sentence denotes Coronavirus OC43 (HCoV OC43) belongs to the Betacoronavirus genus of the Coronoviridae family.
TextSentencer_T8 813-907 Sentence denotes Coronavirus OC43 (HCoV OC43) belongs to the Betacoronavirus genus of the Coronoviridae family.
TextSentencer_T9 908-1043 Sentence denotes Nasopharyngeal swabs were collected after consent through studies approved by the institutional review board (IRB) at each institution.
TextSentencer_T9 908-1043 Sentence denotes Nasopharyngeal swabs were collected after consent through studies approved by the institutional review board (IRB) at each institution.
TextSentencer_T10 1044-1306 Sentence denotes An Illumina stranded RNA sequencing library was created from isolated RNA, and hybridization-based enrichment was performed using a respiratory viral panel probe set, which contains 5,683 hybridization probes designed to capture 24 human respiratory viruses (7).
TextSentencer_T10 1044-1306 Sentence denotes An Illumina stranded RNA sequencing library was created from isolated RNA, and hybridization-based enrichment was performed using a respiratory viral panel probe set, which contains 5,683 hybridization probes designed to capture 24 human respiratory viruses (7).
TextSentencer_T11 1307-1402 Sentence denotes Next-generation sequencing was performed on an Illumina MiSeq platform with paired 75-bp reads.
TextSentencer_T11 1307-1402 Sentence denotes Next-generation sequencing was performed on an Illumina MiSeq platform with paired 75-bp reads.
TextSentencer_T12 1403-1511 Sentence denotes Genome sequences were generated by reference-guided alignment to the HCoV OC43 genome (GenBank accession no.
TextSentencer_T12 1403-1511 Sentence denotes Genome sequences were generated by reference-guided alignment to the HCoV OC43 genome (GenBank accession no.
TextSentencer_T13 1512-1630 Sentence denotes AY391777) and de novo assembly (CLC Genomics) with manual corrections to any discrepancies from the two methodologies.
TextSentencer_T13 1512-1630 Sentence denotes AY391777) and de novo assembly (CLC Genomics) with manual corrections to any discrepancies from the two methodologies.
TextSentencer_T14 1631-1718 Sentence denotes Annotations were completed using the Genome Annotation Transfer Utility from ViPR (8) .
TextSentencer_T14 1631-1718 Sentence denotes Annotations were completed using the Genome Annotation Transfer Utility from ViPR (8) .
TextSentencer_T15 1719-1969 Sentence denotes Isolate HCoV-OC43/USA/ACRI_0052/2016 (ACRI_0052) was obtained from a 14month-old patient who presented to the Arkansas Children's Hospital emergency department in Little Rock, AR, in March 2016 with a 5-day history of fever, congestion, and wheezing.
TextSentencer_T15 1719-1969 Sentence denotes Isolate HCoV-OC43/USA/ACRI_0052/2016 (ACRI_0052) was obtained from a 14month-old patient who presented to the Arkansas Children's Hospital emergency department in Little Rock, AR, in March 2016 with a 5-day history of fever, congestion, and wheezing.
TextSentencer_T16 1970-2212 Sentence denotes Isolates HCoV-OC43/USA/TCNP_0070/2016 (TCNP_070), HCoV-OC43/ USA/TCNP_00204/2017 (TCNP_00204), and HCoV-OC43/USA/TCNP_00212/2017 (TCNP_ 00212) were obtained from children presenting to the University of New Mexico Children's Hospital (UNMCH).
TextSentencer_T16 1970-2212 Sentence denotes Isolates HCoV-OC43/USA/TCNP_0070/2016 (TCNP_070), HCoV-OC43/ USA/TCNP_00204/2017 (TCNP_00204), and HCoV-OC43/USA/TCNP_00212/2017 (TCNP_ 00212) were obtained from children presenting to the University of New Mexico Children's Hospital (UNMCH).
TextSentencer_T17 2213-2356 Sentence denotes TCNP_0070 was isolated from a 9-month-old patient who presented to UNMCH in February 2016 with a 3-day history of fever, cough, and congestion.
TextSentencer_T17 2213-2356 Sentence denotes TCNP_0070 was isolated from a 9-month-old patient who presented to UNMCH in February 2016 with a 3-day history of fever, cough, and congestion.
TextSentencer_T18 2357-2579 Sentence denotes TCNP_00204 was obtained from a 4-month-old who presented with a 1-day history of cough and congestion to UNMCH in January 2017, was admitted to the hospital, and required an 8-day stay in the pediatric intensive care unit.
TextSentencer_T18 2357-2579 Sentence denotes TCNP_00204 was obtained from a 4-month-old who presented with a 1-day history of cough and congestion to UNMCH in January 2017, was admitted to the hospital, and required an 8-day stay in the pediatric intensive care unit.
TextSentencer_T19 2580-2764 Sentence denotes Isolate TCNP_00212 was obtained from a 5-month-old with preexisting lung disease who presented with a history of 6 days of cough and wheezing and was admitted to UNMCH in January 2017.
TextSentencer_T19 2580-2764 Sentence denotes Isolate TCNP_00212 was obtained from a 5-month-old with preexisting lung disease who presented with a history of 6 days of cough and wheezing and was admitted to UNMCH in January 2017.
TextSentencer_T20 2765-2939 Sentence denotes Sample ACRI_0052 had 1,191,015 sequencing reads align to the HCoV OC43 RefSeq genome (GenBank accession number AY_391777), which resulted in a mean genome coverage of 2,329ϫ.
TextSentencer_T20 2765-2939 Sentence denotes Sample ACRI_0052 had 1,191,015 sequencing reads align to the HCoV OC43 RefSeq genome (GenBank accession number AY_391777), which resulted in a mean genome coverage of 2,329ϫ.
TextSentencer_T21 2940-3131 Sentence denotes The genomes of samples TCNP_0070, TCNP_00204, and TCNP_00212 had 293,026, 96,808, and 250,215 aligned sequencing reads, which resulted in mean coverages of 717ϫ, 236ϫ, and 611ϫ, respectively.
TextSentencer_T21 2940-3131 Sentence denotes The genomes of samples TCNP_0070, TCNP_00204, and TCNP_00212 had 293,026, 96,808, and 250,215 aligned sequencing reads, which resulted in mean coverages of 717ϫ, 236ϫ, and 611ϫ, respectively.
TextSentencer_T22 3132-3369 Sentence denotes The genomes of isolates ACRI_0052, TCNP_0070, TCNP_00204, and TCNP_00212 varied from the AY_391777 genome by 346, 334, 550, and 565 nucleotides (nt), of which 137, 150, 99, and 98 were predicted to cause amino acid changes, respectively.
TextSentencer_T22 3132-3369 Sentence denotes The genomes of isolates ACRI_0052, TCNP_0070, TCNP_00204, and TCNP_00212 varied from the AY_391777 genome by 346, 334, 550, and 565 nucleotides (nt), of which 137, 150, 99, and 98 were predicted to cause amino acid changes, respectively.
TextSentencer_T23 3370-3553 Sentence denotes In comparison with each other at the genome level, TCNP_00204 and TCNP_00212 from New Mexico were 99.8% identical to each other and 99.5% identical to TCNP_0070, also from New Mexico.
TextSentencer_T23 3370-3553 Sentence denotes In comparison with each other at the genome level, TCNP_00204 and TCNP_00212 from New Mexico were 99.8% identical to each other and 99.5% identical to TCNP_0070, also from New Mexico.
TextSentencer_T24 3554-3957 Sentence denotes Yet, phylogenetic comparison through nearest-neighbor joining revealed that two of the isolates from New Mexico, TCNP_00204 and TCNP_00212, grouped closely to each other and with strains with accession numbers KY369907 and SC9741, whereas the other New Mexican isolate, TCNP_0070, grouped together with ACRI_0052 and was most closely related to the isolates with accession numbers KX538976 and KY967360.
TextSentencer_T24 3554-3957 Sentence denotes Yet, phylogenetic comparison through nearest-neighbor joining revealed that two of the isolates from New Mexico, TCNP_00204 and TCNP_00212, grouped closely to each other and with strains with accession numbers KY369907 and SC9741, whereas the other New Mexican isolate, TCNP_0070, grouped together with ACRI_0052 and was most closely related to the isolates with accession numbers KX538976 and KY967360.
TextSentencer_T25 3958-3978 Sentence denotes Accession number(s).
TextSentencer_T25 3958-3978 Sentence denotes Accession number(s).
TextSentencer_T26 3979-4194 Sentence denotes The whole-genome sequences of the isolates have been deposited in GenBank under the accession numbers MF314143 (HCoV-OC43/USA/ ACRI_0052/2016), MF374983 (TCNP_0070), MF374984 (TCNP_00204), and MF374985 (TCNP_00212).
TextSentencer_T26 3979-4194 Sentence denotes The whole-genome sequences of the isolates have been deposited in GenBank under the accession numbers MF314143 (HCoV-OC43/USA/ ACRI_0052/2016), MF374983 (TCNP_0070), MF374984 (TCNP_00204), and MF374985 (TCNP_00212).
TextSentencer_T27 4195-4531 Sentence denotes This project was supported in part by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health (NIH) through grants UL1TR000041, KL2TR000089, UL1TR000039, and KL2TR000063, as well as the Centers for Translational Science Award Western Consortium Grant.
TextSentencer_T27 4195-4531 Sentence denotes This project was supported in part by the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health (NIH) through grants UL1TR000041, KL2TR000089, UL1TR000039, and KL2TR000063, as well as the Centers for Translational Science Award Western Consortium Grant.
TextSentencer_T28 4532-4534 Sentence denotes J.
TextSentencer_T28 4532-4534 Sentence denotes J.
TextSentencer_T29 4535-4537 Sentence denotes L.
TextSentencer_T29 4535-4537 Sentence denotes L.
TextSentencer_T30 4538-4683 Sentence denotes Kennedy has support from the NIH National Institute of Allergy and Infectious Disease (grant K08AI121345) and the Arkansas Biosciences Institute.
TextSentencer_T30 4538-4683 Sentence denotes Kennedy has support from the NIH National Institute of Allergy and Infectious Disease (grant K08AI121345) and the Arkansas Biosciences Institute.
TextSentencer_T31 4684-4821 Sentence denotes The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
TextSentencer_T31 4684-4821 Sentence denotes The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.