CORD-19-Sentences  

CORD-19:bfed3ce6a6df2d442d96d0cab07d4bc1f2347255 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-33 Sentence denotes Seattle Flu Study -Swab and Send:
TextSentencer_T1 0-33 Sentence denotes Seattle Flu Study -Swab and Send:
TextSentencer_T2 34-150 Sentence denotes Study Protocol for At-Home Surveillance Methods to Estimate the Burden of Respiratory Pathogens on a City-Wide Scale
TextSentencer_T2 34-150 Sentence denotes Study Protocol for At-Home Surveillance Methods to Estimate the Burden of Respiratory Pathogens on a City-Wide Scale
TextSentencer_T3 152-160 Sentence denotes Abstract
TextSentencer_T3 152-160 Sentence denotes Abstract
TextSentencer_T4 161-350 Sentence denotes While seasonal influenza and other respiratory pathogens cause significant morbidity and mortality each year, the community-based burden of these infections remains incompletely understood.
TextSentencer_T4 161-350 Sentence denotes While seasonal influenza and other respiratory pathogens cause significant morbidity and mortality each year, the community-based burden of these infections remains incompletely understood.
TextSentencer_T5 351-600 Sentence denotes Understanding the prevalence, epidemiology, and transmission dynamics of respiratory pathogen infections among community-dwelling individuals is essential during pandemic and epidemic settings and for developing pandemic-preparedness infrastructure.
TextSentencer_T5 351-600 Sentence denotes Understanding the prevalence, epidemiology, and transmission dynamics of respiratory pathogen infections among community-dwelling individuals is essential during pandemic and epidemic settings and for developing pandemic-preparedness infrastructure.
TextSentencer_T6 601-846 Sentence denotes We present the protocol for a novel, city-wide home-based cross-sectional study in the Seattle Metropolitan area, utilizing rapid delivery systems for self-collection of a nasal swab and return to the laboratory for respiratory pathogen testing.
TextSentencer_T6 601-846 Sentence denotes We present the protocol for a novel, city-wide home-based cross-sectional study in the Seattle Metropolitan area, utilizing rapid delivery systems for self-collection of a nasal swab and return to the laboratory for respiratory pathogen testing.
TextSentencer_T7 847-945 Sentence denotes All participation takes place electronically, including recruitment, consent, and data collection.
TextSentencer_T7 847-945 Sentence denotes All participation takes place electronically, including recruitment, consent, and data collection.
TextSentencer_T8 946-1084 Sentence denotes Within 48 hours of participants self-reporting respiratory symptoms, a nasal swab kit is delivered to the household via a courier service.
TextSentencer_T8 946-1084 Sentence denotes Within 48 hours of participants self-reporting respiratory symptoms, a nasal swab kit is delivered to the household via a courier service.
TextSentencer_T9 1085-1237 Sentence denotes Demographic and illness characteristics are collected at the time of sample collection and recovery and behavioral information collected one week later.
TextSentencer_T9 1085-1237 Sentence denotes Demographic and illness characteristics are collected at the time of sample collection and recovery and behavioral information collected one week later.
TextSentencer_T10 1238-1376 Sentence denotes Specimens are tested in the laboratory for multiple respiratory pathogens, and results are available on a public website for participants.
TextSentencer_T10 1238-1376 Sentence denotes Specimens are tested in the laboratory for multiple respiratory pathogens, and results are available on a public website for participants.
TextSentencer_T11 1377-1402 Sentence denotes Ethics and Dissemination.
TextSentencer_T11 1377-1402 Sentence denotes Ethics and Dissemination.
TextSentencer_T12 1403-1506 Sentence denotes The study was approved by the University of Washington Institutional Review Board (Protocol #00006181).
TextSentencer_T12 1403-1506 Sentence denotes The study was approved by the University of Washington Institutional Review Board (Protocol #00006181).
TextSentencer_T13 1507-1642 Sentence denotes Results will be disseminated through peer-reviewed publications, talks at conferences, and on the Study Website ( www.seattleflu.org ).
TextSentencer_T13 1507-1642 Sentence denotes Results will be disseminated through peer-reviewed publications, talks at conferences, and on the Study Website ( www.seattleflu.org ).
TextSentencer_T14 1643-1663 Sentence denotes All rights reserved.
TextSentencer_T14 1643-1663 Sentence denotes All rights reserved.
TextSentencer_T15 1664-1788 Sentence denotes No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T15 1664-1788 Sentence denotes No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T16 1789-2212 Sentence denotes • The findings of this study will inform whether a home-based approach to city-wide respiratory surveillance is possible in epidemic settings • A key strength of this study is that it is conducted across diverse neighborhoods spanning a major metropolitan area • Clinical findings may not be generalizable, as they are reliant on self-report (vaccination status, symptoms, healthcare utilization, etc.) All rights reserved.
TextSentencer_T16 1789-2212 Sentence denotes • The findings of this study will inform whether a home-based approach to city-wide respiratory surveillance is possible in epidemic settings • A key strength of this study is that it is conducted across diverse neighborhoods spanning a major metropolitan area • Clinical findings may not be generalizable, as they are reliant on self-report (vaccination status, symptoms, healthcare utilization, etc.) All rights reserved.
TextSentencer_T17 2213-2249 Sentence denotes No reuse allowed without permission.
TextSentencer_T17 2213-2249 Sentence denotes No reuse allowed without permission.
TextSentencer_T18 2250-2337 Sentence denotes author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T18 2250-2337 Sentence denotes author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T19 2339-2533 Sentence denotes Acute respiratory illnesses (ARIs) pose a significant burden on the healthcare system in the United States and represent an important cause of morbidity and mortality worldwide [1] [2] [3] [4] .
TextSentencer_T19 2339-2533 Sentence denotes Acute respiratory illnesses (ARIs) pose a significant burden on the healthcare system in the United States and represent an important cause of morbidity and mortality worldwide [1] [2] [3] [4] .
TextSentencer_T20 2534-2809 Sentence denotes In the United States, influenza is estimated to cause 9-45 million illnesses 140,000-810,000 hospitalizations, and 12,000-67,000 deaths while respiratory syncytial virus (RSV) is estimated to cause 2 million outpatient visits each year in children under the age of 5 [5, 6] .
TextSentencer_T20 2534-2809 Sentence denotes In the United States, influenza is estimated to cause 9-45 million illnesses 140,000-810,000 hospitalizations, and 12,000-67,000 deaths while respiratory syncytial virus (RSV) is estimated to cause 2 million outpatient visits each year in children under the age of 5 [5, 6] .
TextSentencer_T21 2810-3006 Sentence denotes Despite this burden, estimates about prevalence of the pathogens that result in ARIs rely on in-person healthcare visits or on aggregate counts from hospitalized individuals [6] [7] [8] [9] [10] .
TextSentencer_T21 2810-3006 Sentence denotes Despite this burden, estimates about prevalence of the pathogens that result in ARIs rely on in-person healthcare visits or on aggregate counts from hospitalized individuals [6] [7] [8] [9] [10] .
TextSentencer_T22 3007-3138 Sentence denotes Additionally, these estimates generally capture illnesses when specific symptoms are present, such as fever, cough, or sore throat.
TextSentencer_T22 3007-3138 Sentence denotes Additionally, these estimates generally capture illnesses when specific symptoms are present, such as fever, cough, or sore throat.
TextSentencer_T23 3139-3343 Sentence denotes Thus, they are likely a poor proxy for the prevalence of illness in community-dwelling individuals who may not necessarily seek care for their illness or have symptoms that fall outside of these criteria.
TextSentencer_T23 3139-3343 Sentence denotes Thus, they are likely a poor proxy for the prevalence of illness in community-dwelling individuals who may not necessarily seek care for their illness or have symptoms that fall outside of these criteria.
TextSentencer_T24 3344-3587 Sentence denotes Active, community-level surveillance for respiratory pathogens is essential to monitor the seasonal activity of these pathogens, as it may inform public health prevention strategies or influence treatment decisions made at the community level.
TextSentencer_T24 3344-3587 Sentence denotes Active, community-level surveillance for respiratory pathogens is essential to monitor the seasonal activity of these pathogens, as it may inform public health prevention strategies or influence treatment decisions made at the community level.
TextSentencer_T25 3588-3869 Sentence denotes Previous studies focused on respiratory pathogen surveillance only studied specific subsets of the population, such as households with children, or required a significant, coordinated effort to capture the community, which makes the approach difficult to replicate [11] [12] [13] .
TextSentencer_T25 3588-3869 Sentence denotes Previous studies focused on respiratory pathogen surveillance only studied specific subsets of the population, such as households with children, or required a significant, coordinated effort to capture the community, which makes the approach difficult to replicate [11] [12] [13] .
TextSentencer_T26 3870-4050 Sentence denotes Additionally, similar to traditional respiratory surveillance networks, these studies relied on in-person clinic visits which may contribute to potential spread of these pathogens.
TextSentencer_T26 3870-4050 Sentence denotes Additionally, similar to traditional respiratory surveillance networks, these studies relied on in-person clinic visits which may contribute to potential spread of these pathogens.
TextSentencer_T27 4051-4270 Sentence denotes Nevertheless, community-wide surveillance studies provide an opportunity to better understand these pathogens among symptomatic individuals with wide-ranging illness severities and variable healthcare-seeking behaviors.
TextSentencer_T27 4051-4270 Sentence denotes Nevertheless, community-wide surveillance studies provide an opportunity to better understand these pathogens among symptomatic individuals with wide-ranging illness severities and variable healthcare-seeking behaviors.
TextSentencer_T28 4271-4505 Sentence denotes This manuscript describes the protocol for the Seattle Flu Study (SFS) Swab and Send sub-study, a novel, city-wide cross-sectional study of respiratory pathogens that yielded community-level surveillance through a home-based approach.
TextSentencer_T28 4271-4505 Sentence denotes This manuscript describes the protocol for the Seattle Flu Study (SFS) Swab and Send sub-study, a novel, city-wide cross-sectional study of respiratory pathogens that yielded community-level surveillance through a home-based approach.
TextSentencer_T29 4506-4843 Sentence denotes The objectives of this study are to gather data from the community to more accurately estimate the prevalence of respiratory illness, to examine whether an exclusively online and home-based mechanism for data collection is feasible in an epidemic setting, and to determine whether these methods are scalable in the context of a pandemic.
TextSentencer_T29 4506-4843 Sentence denotes The objectives of this study are to gather data from the community to more accurately estimate the prevalence of respiratory illness, to examine whether an exclusively online and home-based mechanism for data collection is feasible in an epidemic setting, and to determine whether these methods are scalable in the context of a pandemic.
TextSentencer_T30 4844-5177 Sentence denotes The primary aim of this study is to assess the feasibility of a novel, city-wide home-based cross-sectional study in the Seattle Metropolitan area, utilizing rapid delivery systems for self-collection of a nasal swab from individuals experiencing a new ARI with return of specimens to the laboratory for respiratory pathogen testing.
TextSentencer_T30 4844-5177 Sentence denotes The primary aim of this study is to assess the feasibility of a novel, city-wide home-based cross-sectional study in the Seattle Metropolitan area, utilizing rapid delivery systems for self-collection of a nasal swab from individuals experiencing a new ARI with return of specimens to the laboratory for respiratory pathogen testing.
TextSentencer_T31 5178-5438 Sentence denotes We hypothesize that novel, home-based surveillance of influenza and other respiratory pathogens can be utilized to monitor the epidemiology and transmission dynamics of influenza and other respiratory pathogens at a city-wide scale in Seattle, Washington, USA.
TextSentencer_T31 5178-5438 Sentence denotes We hypothesize that novel, home-based surveillance of influenza and other respiratory pathogens can be utilized to monitor the epidemiology and transmission dynamics of influenza and other respiratory pathogens at a city-wide scale in Seattle, Washington, USA.
TextSentencer_T32 5439-5559 Sentence denotes Study Design This is a prospective study of individuals residing within the Seattle Metropolitan area with ARI symptoms.
TextSentencer_T32 5439-5559 Sentence denotes Study Design This is a prospective study of individuals residing within the Seattle Metropolitan area with ARI symptoms.
TextSentencer_T33 5560-5719 Sentence denotes The study is nested within the Seattle Flu Study, a multi-armed influenza surveillance mechanism described, the protocol of which is described elsewhere [14] .
TextSentencer_T33 5560-5719 Sentence denotes The study is nested within the Seattle Flu Study, a multi-armed influenza surveillance mechanism described, the protocol of which is described elsewhere [14] .
TextSentencer_T34 5720-6030 Sentence denotes Individuals are eligible to participate in this study if they live within the Seattle Metropolitan area, experience a new or worsening cough and/or two ARI symptoms in the past seven days at time of enrollment (Table 1) , are English-speaking, and have a valid email address and access to the internet at home.
TextSentencer_T34 5720-6030 Sentence denotes Individuals are eligible to participate in this study if they live within the Seattle Metropolitan area, experience a new or worsening cough and/or two ARI symptoms in the past seven days at time of enrollment (Table 1) , are English-speaking, and have a valid email address and access to the internet at home.
TextSentencer_T35 6031-6113 Sentence denotes All individuals are consented to participate in the research study electronically.
TextSentencer_T35 6031-6113 Sentence denotes All individuals are consented to participate in the research study electronically.
TextSentencer_T36 6114-6265 Sentence denotes A parent or legally-authorized representative (LAR) will consent for individuals under 18 years, with assent for those between 7-18 years ( Figure 1 ).
TextSentencer_T36 6114-6265 Sentence denotes A parent or legally-authorized representative (LAR) will consent for individuals under 18 years, with assent for those between 7-18 years ( Figure 1 ).
TextSentencer_T37 6266-6490 Sentence denotes Individuals are excluded from participation if they are incarcerated, wards of the state, unable to comply with study procedures at the investigator's discretion, or previously enrolled in Swab & Send in the past seven days.
TextSentencer_T37 6266-6490 Sentence denotes Individuals are excluded from participation if they are incarcerated, wards of the state, unable to comply with study procedures at the investigator's discretion, or previously enrolled in Swab & Send in the past seven days.
TextSentencer_T38 6491-6898 Sentence denotes Recruitment of potential study participants is conducted using a combination of in-person referrals and internet advertisements, including: referral from a healthcare provider, travel clinic or immigrant/ refugee health screening, Seattle Flu Study community kiosk, school or place of work; printed flyers posted at community locations; and targeted online advertisements (e.g. Facebook, Instagram, Google).
TextSentencer_T38 6491-6898 Sentence denotes Recruitment of potential study participants is conducted using a combination of in-person referrals and internet advertisements, including: referral from a healthcare provider, travel clinic or immigrant/ refugee health screening, Seattle Flu Study community kiosk, school or place of work; printed flyers posted at community locations; and targeted online advertisements (e.g. Facebook, Instagram, Google).
TextSentencer_T39 6899-7042 Sentence denotes Recruitment materials direct eligible participants to the study website ( www.seattleflu.org , henceforth referenced as the " Study Website ").
TextSentencer_T39 6899-7042 Sentence denotes Recruitment materials direct eligible participants to the study website ( www.seattleflu.org , henceforth referenced as the " Study Website ").
TextSentencer_T40 7043-7238 Sentence denotes Individuals screen themselves for eligibility on the study website by providing their age, home zip code, information about presence and duration of symptoms, and confirming home internet access.
TextSentencer_T40 7043-7238 Sentence denotes Individuals screen themselves for eligibility on the study website by providing their age, home zip code, information about presence and duration of symptoms, and confirming home internet access.
TextSentencer_T41 7239-7384 Sentence denotes Individuals are informed about the study purpose, risks, and benefits, and sign an online form to provide consent to participate in the research.
TextSentencer_T41 7239-7384 Sentence denotes Individuals are informed about the study purpose, risks, and benefits, and sign an online form to provide consent to participate in the research.
TextSentencer_T42 7385-7480 Sentence denotes Numerous consent forms are available to accommodate the age range of participants ( Figure 1 ).
TextSentencer_T42 7385-7480 Sentence denotes Numerous consent forms are available to accommodate the age range of participants ( Figure 1 ).
TextSentencer_T43 7481-7565 Sentence denotes The study aims to enroll 3,000 participants over the course of the 2019-2020 season.
TextSentencer_T43 7481-7565 Sentence denotes The study aims to enroll 3,000 participants over the course of the 2019-2020 season.
TextSentencer_T44 7566-7782 Sentence denotes We estimate 2,400 (80%) participants will return their nasal swab kit to the laboratory for respiratory pathogen testing and that 240 (10%) of specimens will be positive for influenza by molecular testing (Table 2) .
TextSentencer_T44 7566-7782 Sentence denotes We estimate 2,400 (80%) participants will return their nasal swab kit to the laboratory for respiratory pathogen testing and that 240 (10%) of specimens will be positive for influenza by molecular testing (Table 2) .
TextSentencer_T45 7783-7800 Sentence denotes Primary Outcomes:
TextSentencer_T45 7783-7800 Sentence denotes Primary Outcomes:
TextSentencer_T46 7801-7821 Sentence denotes All rights reserved.
TextSentencer_T46 7801-7821 Sentence denotes All rights reserved.
TextSentencer_T47 7822-7858 Sentence denotes No reuse allowed without permission.
TextSentencer_T47 7822-7858 Sentence denotes No reuse allowed without permission.
TextSentencer_T48 7859-7946 Sentence denotes author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T48 7859-7946 Sentence denotes author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T49 7947-8024 Sentence denotes The copyright holder for this preprint (which was not peer-reviewed) is the .
TextSentencer_T49 7947-8024 Sentence denotes The copyright holder for this preprint (which was not peer-reviewed) is the .
TextSentencer_T50 8025-8111 Sentence denotes completion of questionnaire among those who test positive for respiratory pathogens 2.
TextSentencer_T50 8025-8111 Sentence denotes completion of questionnaire among those who test positive for respiratory pathogens 2.
TextSentencer_T51 8112-8253 Sentence denotes Usability and feasibility of self-collected nasal swabs for diagnosis of respiratory pathogens in symptomatic individuals Secondary Outcomes:
TextSentencer_T51 8112-8253 Sentence denotes Usability and feasibility of self-collected nasal swabs for diagnosis of respiratory pathogens in symptomatic individuals Secondary Outcomes:
TextSentencer_T52 8254-8256 Sentence denotes 1.
TextSentencer_T52 8254-8256 Sentence denotes 1.
TextSentencer_T53 8257-8440 Sentence denotes Clinical and sociodemographic characteristics of participants with respiratory pathogens who enrolled online through a home-based surveillance system and self-collected nasal swabs 2.
TextSentencer_T53 8257-8440 Sentence denotes Clinical and sociodemographic characteristics of participants with respiratory pathogens who enrolled online through a home-based surveillance system and self-collected nasal swabs 2.
TextSentencer_T54 8441-8567 Sentence denotes Variation in symptom presence, duration and severity between individuals testing positive for different respiratory viruses 3.
TextSentencer_T54 8441-8567 Sentence denotes Variation in symptom presence, duration and severity between individuals testing positive for different respiratory viruses 3.
TextSentencer_T55 8568-8742 Sentence denotes Behavioral and healthcare-seeking outcomes among individuals with and without respiratory pathogens detected, including healthcare utilization and work and school absenteeism
TextSentencer_T55 8568-8742 Sentence denotes Behavioral and healthcare-seeking outcomes among individuals with and without respiratory pathogens detected, including healthcare utilization and work and school absenteeism
TextSentencer_T56 8743-8909 Sentence denotes After consent, participants complete an online Enrollment Questionnaire , provide their home address and contact information such as an email address or phone number.
TextSentencer_T56 8743-8909 Sentence denotes After consent, participants complete an online Enrollment Questionnaire , provide their home address and contact information such as an email address or phone number.
TextSentencer_T57 8910-9342 Sentence denotes Participants are mailed a swab kit within 48 hours of submitting the Enrollment Questionnaire, which includes a Quick Start Instruction Card , a UTM tube (Becton, Dickinson and Company, Sparks, MD), a nylon flocked swab (COPAN Diagnostics Inc., Murietta, CA), and a return box with affixed Category B UN3373 label, as required by International Air Transport Association (IATA) guidelines [15] , and a pre-paid return shipping label.
TextSentencer_T57 8910-9342 Sentence denotes Participants are mailed a swab kit within 48 hours of submitting the Enrollment Questionnaire, which includes a Quick Start Instruction Card , a UTM tube (Becton, Dickinson and Company, Sparks, MD), a nylon flocked swab (COPAN Diagnostics Inc., Murietta, CA), and a return box with affixed Category B UN3373 label, as required by International Air Transport Association (IATA) guidelines [15] , and a pre-paid return shipping label.
TextSentencer_T58 9343-9422 Sentence denotes Pediatric nasal swabs are available for participants 5 years of age or younger.
TextSentencer_T58 9343-9422 Sentence denotes Pediatric nasal swabs are available for participants 5 years of age or younger.
TextSentencer_T59 9423-9568 Sentence denotes Upon kit receipt, participants complete an online Illness Questionnaire to ascertain demographics, illness characteristics, and health behaviors.
TextSentencer_T59 9423-9568 Sentence denotes Upon kit receipt, participants complete an online Illness Questionnaire to ascertain demographics, illness characteristics, and health behaviors.
TextSentencer_T60 9569-9754 Sentence denotes At the end of the Illness Questionnaire , participants are prompted to self-collect a mid-nasal swab using the instructions provided on an instruction card included in the swab kit box.
TextSentencer_T60 9569-9754 Sentence denotes At the end of the Illness Questionnaire , participants are prompted to self-collect a mid-nasal swab using the instructions provided on an instruction card included in the swab kit box.
TextSentencer_T61 9755-9895 Sentence denotes Participants are instructed to place their self-collected nasal swabs directly into the UTM tube which is pre-labeled with a unique barcode.
TextSentencer_T61 9755-9895 Sentence denotes Participants are instructed to place their self-collected nasal swabs directly into the UTM tube which is pre-labeled with a unique barcode.
TextSentencer_T62 9896-10122 Sentence denotes Next, participants are instructed to place the UTM tube containing the self-collected nasal swab into a specimen bag, pre-packaged with an absorbent sheet, and then place the specimen bag into the provided return shipping box.
TextSentencer_T62 9896-10122 Sentence denotes Next, participants are instructed to place the UTM tube containing the self-collected nasal swab into a specimen bag, pre-packaged with an absorbent sheet, and then place the specimen bag into the provided return shipping box.
TextSentencer_T63 10123-10250 Sentence denotes United States Postal Service (USPS) return postage and Category B UN3373 stickers are affixed to the outside of the return box.
TextSentencer_T63 10123-10250 Sentence denotes United States Postal Service (USPS) return postage and Category B UN3373 stickers are affixed to the outside of the return box.
TextSentencer_T64 10251-10454 Sentence denotes Although previous testing has demonstrated that respiratory viral RNA is stable in room-temperature UTM for up to one week [16] , participants are encouraged to mail their nasal swab as soon as possible.
TextSentencer_T64 10251-10454 Sentence denotes Although previous testing has demonstrated that respiratory viral RNA is stable in room-temperature UTM for up to one week [16] , participants are encouraged to mail their nasal swab as soon as possible.
TextSentencer_T65 10455-10583 Sentence denotes Returned samples are estimated to arrive at the laboratory approximately 24 hours after deposit at a US Postal Service facility.
TextSentencer_T65 10455-10583 Sentence denotes Returned samples are estimated to arrive at the laboratory approximately 24 hours after deposit at a US Postal Service facility.
TextSentencer_T66 10584-10695 Sentence denotes When kits are received in the study laboratory, contents of the box and errors in swab collection are recorded.
TextSentencer_T66 10584-10695 Sentence denotes When kits are received in the study laboratory, contents of the box and errors in swab collection are recorded.
TextSentencer_T67 10696-10898 Sentence denotes Swabs are removed and viral transport media aliquoted, subjected to RNA amplification using a MagNA Pure 96 System, and tested for respiratory pathogens using TaqMan Open Array RT-PCR (Table 5 ) [17] .
TextSentencer_T67 10696-10898 Sentence denotes Swabs are removed and viral transport media aliquoted, subjected to RNA amplification using a MagNA Pure 96 System, and tested for respiratory pathogens using TaqMan Open Array RT-PCR (Table 5 ) [17] .
TextSentencer_T68 10899-10967 Sentence denotes These methods are described in the Seattle Flu Study protocol [14] .
TextSentencer_T68 10899-10967 Sentence denotes These methods are described in the Seattle Flu Study protocol [14] .
TextSentencer_T69 10968-11241 Sentence denotes Seven days after the nasal swab collection, participants are re-contacted to complete a One Week Follow-Up Questionnaire to assess the impact of their illness on behavioral outcomes such as absenteeism and healthcare-seeking behaviors (provider visits, antiviral use, etc).
TextSentencer_T69 10968-11241 Sentence denotes Seven days after the nasal swab collection, participants are re-contacted to complete a One Week Follow-Up Questionnaire to assess the impact of their illness on behavioral outcomes such as absenteeism and healthcare-seeking behaviors (provider visits, antiviral use, etc).
TextSentencer_T70 11242-11262 Sentence denotes All rights reserved.
TextSentencer_T70 11242-11262 Sentence denotes All rights reserved.
TextSentencer_T71 11263-11299 Sentence denotes No reuse allowed without permission.
TextSentencer_T71 11263-11299 Sentence denotes No reuse allowed without permission.
TextSentencer_T72 11300-11387 Sentence denotes author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T72 11300-11387 Sentence denotes author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T73 11388-11769 Sentence denotes The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.04.20031211 doi: medRxiv preprint Participants receive a $5 digital gift card for completing the Illness Questionnaire and returning their self-collected swab; an additional $5 gift card will be provided to participants who completed the One Week Follow-Up Questionnaire.
TextSentencer_T73 11388-11769 Sentence denotes The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.04.20031211 doi: medRxiv preprint Participants receive a $5 digital gift card for completing the Illness Questionnaire and returning their self-collected swab; an additional $5 gift card will be provided to participants who completed the One Week Follow-Up Questionnaire.
TextSentencer_T74 11770-11956 Sentence denotes Participants are able to view their test results for influenza A and B and RSV on the Study Website within 3 months of when the swab is collected by entering their unique sample barcode.
TextSentencer_T74 11770-11956 Sentence denotes Participants are able to view their test results for influenza A and B and RSV on the Study Website within 3 months of when the swab is collected by entering their unique sample barcode.
TextSentencer_T75 11957-12184 Sentence denotes Participant information is kept confidential, and questionnaire and sample data are linked to participants using a unique identification number assigned at enrollment; only the direct study team will have access to the linkage.
TextSentencer_T75 11957-12184 Sentence denotes Participant information is kept confidential, and questionnaire and sample data are linked to participants using a unique identification number assigned at enrollment; only the direct study team will have access to the linkage.
TextSentencer_T76 12185-12286 Sentence denotes All study questionnaires are collected through REDCap, which is Title 21 CFR Part 11 compliant [18] .
TextSentencer_T76 12185-12286 Sentence denotes All study questionnaires are collected through REDCap, which is Title 21 CFR Part 11 compliant [18] .
TextSentencer_T77 12287-12400 Sentence denotes Access to de-identified, aggregate study data and analysis code will be publicly available on the Study Website .
TextSentencer_T77 12287-12400 Sentence denotes Access to de-identified, aggregate study data and analysis code will be publicly available on the Study Website .
TextSentencer_T78 12401-12550 Sentence denotes Descriptive statistics of frequency/percentage and mean/standard deviation will be performed for categorical and continuous covariates, respectively.
TextSentencer_T78 12401-12550 Sentence denotes Descriptive statistics of frequency/percentage and mean/standard deviation will be performed for categorical and continuous covariates, respectively.
TextSentencer_T79 12551-12693 Sentence denotes Bivariate analyses will be conducted using parametric and nonparametric tests as appropriate, with statistical significance defined as p<0.05.
TextSentencer_T79 12551-12693 Sentence denotes Bivariate analyses will be conducted using parametric and nonparametric tests as appropriate, with statistical significance defined as p<0.05.
TextSentencer_T80 12694-12831 Sentence denotes Respiratory pathogen prevalence is defined as the total number of cases of a pathogen detected out of the total number of tested samples.
TextSentencer_T80 12694-12831 Sentence denotes Respiratory pathogen prevalence is defined as the total number of cases of a pathogen detected out of the total number of tested samples.
TextSentencer_T81 12832-12966 Sentence denotes Odds ratios and 95% confidence intervals will be estimated using negative binomial or Poisson regressions with robust standard errors.
TextSentencer_T81 12832-12966 Sentence denotes Odds ratios and 95% confidence intervals will be estimated using negative binomial or Poisson regressions with robust standard errors.
TextSentencer_T82 12967-13062 Sentence denotes Additional analyses will occur, as described elsewhere in the Seattle Flu Study protocol [14] .
TextSentencer_T82 12967-13062 Sentence denotes Additional analyses will occur, as described elsewhere in the Seattle Flu Study protocol [14] .
TextSentencer_T83 13063-13128 Sentence denotes Ethical approval was granted by the University of Washington IRB.
TextSentencer_T83 13063-13128 Sentence denotes Ethical approval was granted by the University of Washington IRB.
TextSentencer_T84 13129-13228 Sentence denotes Additionally, the Seattle Flu Study has a scientific advisory board to whom it reports bi-annually.
TextSentencer_T84 13129-13228 Sentence denotes Additionally, the Seattle Flu Study has a scientific advisory board to whom it reports bi-annually.
TextSentencer_T85 13229-13322 Sentence denotes These reports include updates on enrollment, preliminary results, and protocol modifications.
TextSentencer_T85 13229-13322 Sentence denotes These reports include updates on enrollment, preliminary results, and protocol modifications.
TextSentencer_T86 13323-13508 Sentence denotes Our study group will present the results of the Swab and Send sub-study at national and international research conferences, through peer-reviewed publications, and on the study website.
TextSentencer_T86 13323-13508 Sentence denotes Our study group will present the results of the Swab and Send sub-study at national and international research conferences, through peer-reviewed publications, and on the study website.
TextSentencer_T87 13509-13629 Sentence denotes Any changes to the study protocol will be communicated to journals in accordance with that journal's reporting policies.
TextSentencer_T87 13509-13629 Sentence denotes Any changes to the study protocol will be communicated to journals in accordance with that journal's reporting policies.
TextSentencer_T88 13630-13765 Sentence denotes We will follow STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) reporting guidelines, as applicable [19] .
TextSentencer_T88 13630-13765 Sentence denotes We will follow STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) reporting guidelines, as applicable [19] .
TextSentencer_T89 13766-13929 Sentence denotes Study materials, including the Quick Start Instruction Card , kit design, and study questionnaires, will be available upon request with approval of the study team.
TextSentencer_T89 13766-13929 Sentence denotes Study materials, including the Quick Start Instruction Card , kit design, and study questionnaires, will be available upon request with approval of the study team.
TextSentencer_T90 13930-13997 Sentence denotes The Seattle Flu Study is funded through the Brotman Baty Institute.
TextSentencer_T90 13930-13997 Sentence denotes The Seattle Flu Study is funded through the Brotman Baty Institute.
TextSentencer_T91 13998-14162 Sentence denotes The funder is not involved in the design of the study, does not have any ownership over the management and conduct of the study, the data, or the rights to publish.
TextSentencer_T91 13998-14162 Sentence denotes The funder is not involved in the design of the study, does not have any ownership over the management and conduct of the study, the data, or the rights to publish.
TextSentencer_T92 14163-14172 Sentence denotes Table 1 .
TextSentencer_T92 14163-14172 Sentence denotes Table 1 .
TextSentencer_T93 14173-14271 Sentence denotes List of symptoms that will be used in online questionnaires to screen individuals for eligibility.
TextSentencer_T93 14173-14271 Sentence denotes List of symptoms that will be used in online questionnaires to screen individuals for eligibility.
TextSentencer_T94 14272-14470 Sentence denotes Selecting either acute cough or two or more concurrent qualifying symptoms will be considered an acute illness episode and will make an individual eligible for enrollment in the Swab and Send study.
TextSentencer_T94 14272-14470 Sentence denotes Selecting either acute cough or two or more concurrent qualifying symptoms will be considered an acute illness episode and will make an individual eligible for enrollment in the Swab and Send study.
TextSentencer_T95 14471-15180 Sentence denotes Feeling feverish or warm * Runny/stuffy nose or sneezing * Headache * Feeling more tired than usual * New or worsening cough ** Muscle or body aches * Chills or shivering X Increased trouble with breathing * Sweats X Diarrhea + Sore throat or itchy/scratchy throat * Ear pain/ear discharge + Nausea or vomiting * Rash + * a qualifying symptom for study eligibility for individuals of any age ** a qualifying symptom that is sufficient on its own for study eligibility for individuals of any age X not a qualifying symptom for study eligibility + a qualifying symptom for study eligibility for individuals <18 years of age author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T95 14471-15180 Sentence denotes Feeling feverish or warm * Runny/stuffy nose or sneezing * Headache * Feeling more tired than usual * New or worsening cough ** Muscle or body aches * Chills or shivering X Increased trouble with breathing * Sweats X Diarrhea + Sore throat or itchy/scratchy throat * Ear pain/ear discharge + Nausea or vomiting * Rash + * a qualifying symptom for study eligibility for individuals of any age ** a qualifying symptom that is sufficient on its own for study eligibility for individuals of any age X not a qualifying symptom for study eligibility + a qualifying symptom for study eligibility for individuals <18 years of age author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T96 15181-15346 Sentence denotes The copyright holder for this preprint (which was not peer-reviewed) is the . author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T96 15181-15346 Sentence denotes The copyright holder for this preprint (which was not peer-reviewed) is the . author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T97 15347-15577 Sentence denotes If the participant is unable to provide informed consent due to cognitive impairment or because they have not attained the legal age for consent, a legally-authorized representative (LAR) may sign the consent form on their behalf.
TextSentencer_T97 15347-15577 Sentence denotes If the participant is unable to provide informed consent due to cognitive impairment or because they have not attained the legal age for consent, a legally-authorized representative (LAR) may sign the consent form on their behalf.
TextSentencer_T98 15578-15754 Sentence denotes Participants enrolled by Seattle Children's Hospital staff or participants enrolled into the prospective clinical cohort sign a HIPAA Agreement in addition to the main consent.
TextSentencer_T98 15578-15754 Sentence denotes Participants enrolled by Seattle Children's Hospital staff or participants enrolled into the prospective clinical cohort sign a HIPAA Agreement in addition to the main consent.
TextSentencer_T99 15755-15775 Sentence denotes All rights reserved.
TextSentencer_T99 15755-15775 Sentence denotes All rights reserved.
TextSentencer_T100 15776-15812 Sentence denotes No reuse allowed without permission.
TextSentencer_T100 15776-15812 Sentence denotes No reuse allowed without permission.
TextSentencer_T101 15813-15900 Sentence denotes author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T101 15813-15900 Sentence denotes author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T102 15901-16044 Sentence denotes The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.04.20031211 doi: medRxiv preprint
TextSentencer_T102 15901-16044 Sentence denotes The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.04.20031211 doi: medRxiv preprint