CORD-19-Sentences  

CORD-19:bf39a81c9aab9e0569f33d93d5e203d320dac024 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-45 Sentence denotes Gender differences in patients with COVID-19:
TextSentencer_T1 0-45 Sentence denotes Gender differences in patients with COVID-19:
TextSentencer_T2 46-77 Sentence denotes Focus on severity and mortality
TextSentencer_T2 46-77 Sentence denotes Focus on severity and mortality
TextSentencer_T3 79-87 Sentence denotes Abstract
TextSentencer_T3 79-87 Sentence denotes Abstract
TextSentencer_T4 88-104 Sentence denotes medRxiv preprint
TextSentencer_T4 88-104 Sentence denotes medRxiv preprint
TextSentencer_T5 105-114 Sentence denotes Question:
TextSentencer_T5 105-114 Sentence denotes Question:
TextSentencer_T6 115-175 Sentence denotes Are men more susceptible to getting and dying from Findings:
TextSentencer_T6 115-175 Sentence denotes Are men more susceptible to getting and dying from Findings:
TextSentencer_T7 176-235 Sentence denotes In the case series, men tend to be more serious than women.
TextSentencer_T7 176-235 Sentence denotes In the case series, men tend to be more serious than women.
TextSentencer_T8 236-394 Sentence denotes In the public data set, the percentage of men were higher in the deceased group than in the survived group, although age was comparable between men and women.
TextSentencer_T8 236-394 Sentence denotes In the public data set, the percentage of men were higher in the deceased group than in the survived group, although age was comparable between men and women.
TextSentencer_T9 395-403 Sentence denotes Meaning:
TextSentencer_T9 395-403 Sentence denotes Meaning:
TextSentencer_T10 404-512 Sentence denotes Male gender is a risk factor for worse outcome in patients with COVID independent of age and susceptibility.
TextSentencer_T10 404-512 Sentence denotes Male gender is a risk factor for worse outcome in patients with COVID independent of age and susceptibility.
TextSentencer_T11 513-524 Sentence denotes Importance:
TextSentencer_T11 513-524 Sentence denotes Importance:
TextSentencer_T12 525-676 Sentence denotes The recent outbreak of Novel Coronavirus (SARS-CoV-2) Disease has put the world on alert, that is reminiscent of the SARS outbreak seventeen years ago.
TextSentencer_T12 525-676 Sentence denotes The recent outbreak of Novel Coronavirus (SARS-CoV-2) Disease has put the world on alert, that is reminiscent of the SARS outbreak seventeen years ago.
TextSentencer_T13 677-687 Sentence denotes Objective:
TextSentencer_T13 677-687 Sentence denotes Objective:
TextSentencer_T14 688-871 Sentence denotes We aim to compare the severity and mortality between male and female patients with both COVID-19 and SARS, to explore the most useful prognostic factors for individualized assessment.
TextSentencer_T14 688-871 Sentence denotes We aim to compare the severity and mortality between male and female patients with both COVID-19 and SARS, to explore the most useful prognostic factors for individualized assessment.
TextSentencer_T15 872-906 Sentence denotes Design, Setting, and Participants:
TextSentencer_T15 872-906 Sentence denotes Design, Setting, and Participants:
TextSentencer_T16 907-1111 Sentence denotes We extracted the data from a case series of 43 hospitalized patients we treated, a public data set of the first 37 cases died of COVID-19 in Wuhan city and 1019 survived patients from six cities in China.
TextSentencer_T16 907-1111 Sentence denotes We extracted the data from a case series of 43 hospitalized patients we treated, a public data set of the first 37 cases died of COVID-19 in Wuhan city and 1019 survived patients from six cities in China.
TextSentencer_T17 1112-1219 Sentence denotes We also analyzed the data of 524 patients with SARS, including 139 deaths, from Beijing city in early 2003.
TextSentencer_T17 1112-1219 Sentence denotes We also analyzed the data of 524 patients with SARS, including 139 deaths, from Beijing city in early 2003.
TextSentencer_T18 1220-1247 Sentence denotes Main Outcomes and Measures:
TextSentencer_T18 1220-1247 Sentence denotes Main Outcomes and Measures:
TextSentencer_T19 1248-1271 Sentence denotes Severity and mortality.
TextSentencer_T19 1248-1271 Sentence denotes Severity and mortality.
TextSentencer_T20 1272-1280 Sentence denotes Results:
TextSentencer_T20 1272-1280 Sentence denotes Results:
TextSentencer_T21 1281-1415 Sentence denotes Older age and high number of comorbidities were associated with higher severity and mortality in patients with both COVID-19 and SARS.
TextSentencer_T21 1281-1415 Sentence denotes Older age and high number of comorbidities were associated with higher severity and mortality in patients with both COVID-19 and SARS.
TextSentencer_T22 1416-1597 Sentence denotes The percentages of older age (≥65 years) were much higher in the deceased group than in the survived group in patients with both COVID-19 (83.8 vs. 13.2, P<0.001) and SARS (37.4 vs.
TextSentencer_T22 1416-1597 Sentence denotes The percentages of older age (≥65 years) were much higher in the deceased group than in the survived group in patients with both COVID-19 (83.8 vs. 13.2, P<0.001) and SARS (37.4 vs.
TextSentencer_T23 1598-1612 Sentence denotes 4.9, P<0.001).
TextSentencer_T23 1598-1612 Sentence denotes 4.9, P<0.001).
TextSentencer_T24 1613-1733 Sentence denotes In the case series, men tend to be more serious than women (P=0.035), although age was comparable between men and women.
TextSentencer_T24 1613-1733 Sentence denotes In the case series, men tend to be more serious than women (P=0.035), although age was comparable between men and women.
TextSentencer_T25 1734-1874 Sentence denotes In the public data set, age was also comparable between men and women in the deceased group or the survived group in patients with COVID-19.
TextSentencer_T25 1734-1874 Sentence denotes In the public data set, age was also comparable between men and women in the deceased group or the survived group in patients with COVID-19.
TextSentencer_T26 1875-1964 Sentence denotes Meanwhile, gender distribution was exactly symmetrical in the 1019 survivors of COVID-19.
TextSentencer_T26 1875-1964 Sentence denotes Meanwhile, gender distribution was exactly symmetrical in the 1019 survivors of COVID-19.
TextSentencer_T27 1965-2083 Sentence denotes However, the percentage of male were higher in the deceased group than in the survived group (70.3 vs. 50.0, P=0.015).
TextSentencer_T27 1965-2083 Sentence denotes However, the percentage of male were higher in the deceased group than in the survived group (70.3 vs. 50.0, P=0.015).
TextSentencer_T28 2084-2148 Sentence denotes The gender role in mortality was also observed in SARS patients.
TextSentencer_T28 2084-2148 Sentence denotes The gender role in mortality was also observed in SARS patients.
TextSentencer_T29 2149-2240 Sentence denotes Survival analysis showed that men (hazard ratio [95% CI] 1.47 [1.05-2.06, P= 0.025) had a .
TextSentencer_T29 2149-2240 Sentence denotes Survival analysis showed that men (hazard ratio [95% CI] 1.47 [1.05-2.06, P= 0.025) had a .
TextSentencer_T30 2241-2395 Sentence denotes CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T30 2241-2395 Sentence denotes CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T31 2396-2493 Sentence denotes is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.
TextSentencer_T31 2396-2493 Sentence denotes is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.
TextSentencer_T32 2494-2568 Sentence denotes 1101 significantly higher mortality rate than women in patients with SARS.
TextSentencer_T32 2494-2568 Sentence denotes 1101 significantly higher mortality rate than women in patients with SARS.
TextSentencer_T33 2569-2653 Sentence denotes Older age and male gender are risk factors for worse outcome in patients with COVID.
TextSentencer_T33 2569-2653 Sentence denotes Older age and male gender are risk factors for worse outcome in patients with COVID.
TextSentencer_T34 2654-2834 Sentence denotes While men and women have the same susceptibility to both SARS-CoV-2 and SARS-CoV, men may be more prone to have higher severity and mortality independent of age and susceptibility.
TextSentencer_T34 2654-2834 Sentence denotes While men and women have the same susceptibility to both SARS-CoV-2 and SARS-CoV, men may be more prone to have higher severity and mortality independent of age and susceptibility.
TextSentencer_T35 2836-2984 Sentence denotes In early December 2019, an outbreak of a novel coronavirus disease in Wuhan city and the rapidly spread throughout China has put the world on alert.
TextSentencer_T35 2836-2984 Sentence denotes In early December 2019, an outbreak of a novel coronavirus disease in Wuhan city and the rapidly spread throughout China has put the world on alert.
TextSentencer_T36 2985-3216 Sentence denotes High-throughput sequencing has revealed a novel β -coronavirus that is currently named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 1 , which resembled severe acute respiratory syndrome coronavirus (SARS-CoV) 2 .
TextSentencer_T36 2985-3216 Sentence denotes High-throughput sequencing has revealed a novel β -coronavirus that is currently named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 1 , which resembled severe acute respiratory syndrome coronavirus (SARS-CoV) 2 .
TextSentencer_T37 3217-3255 Sentence denotes Most patients with COVID-19 were mild.
TextSentencer_T37 3217-3255 Sentence denotes Most patients with COVID-19 were mild.
TextSentencer_T38 3256-3315 Sentence denotes Moderate patients often experienced dyspnea after one week.
TextSentencer_T38 3256-3315 Sentence denotes Moderate patients often experienced dyspnea after one week.
TextSentencer_T39 3316-3506 Sentence denotes Severe patients progressed rapidly to critical conditions including acute respiratory distress syndrome (ARDS), acute respiratory failure, coagulopathy, septic shock, and metabolic acidosis.
TextSentencer_T39 3316-3506 Sentence denotes Severe patients progressed rapidly to critical conditions including acute respiratory distress syndrome (ARDS), acute respiratory failure, coagulopathy, septic shock, and metabolic acidosis.
TextSentencer_T40 3507-3808 Sentence denotes Early identification of risk factors for critical conditions is urgently warranted not only to identify the defining clinical and epidemiological characteristics with greater precision, but also facilitated appropriate supportive care and promptly access to the intensive care unit (ICU) if necessary.
TextSentencer_T40 3507-3808 Sentence denotes Early identification of risk factors for critical conditions is urgently warranted not only to identify the defining clinical and epidemiological characteristics with greater precision, but also facilitated appropriate supportive care and promptly access to the intensive care unit (ICU) if necessary.
TextSentencer_T41 3809-3992 Sentence denotes The Chinese health authority has announced that the total number of confirmed cases on the Chinese mainland has reached 76,936, and 2,442 people have died of the disease as of Feb 23.
TextSentencer_T41 3809-3992 Sentence denotes The Chinese health authority has announced that the total number of confirmed cases on the Chinese mainland has reached 76,936, and 2,442 people have died of the disease as of Feb 23.
TextSentencer_T42 3993-4119 Sentence denotes Among the 2,442 deceased patients, most were old and two-thirds were males, though the detailed data has not been reported 3 .
TextSentencer_T42 3993-4119 Sentence denotes Among the 2,442 deceased patients, most were old and two-thirds were males, though the detailed data has not been reported 3 .
TextSentencer_T43 4120-4143 Sentence denotes This raises a question:
TextSentencer_T43 4120-4143 Sentence denotes This raises a question:
TextSentencer_T44 4144-4204 Sentence denotes Are men more susceptible to getting and dying from COVID-19?
TextSentencer_T44 4144-4204 Sentence denotes Are men more susceptible to getting and dying from COVID-19?
TextSentencer_T45 4205-4508 Sentence denotes Here, we reported the clinical characteristics of a recent case series of 43 patients with 2019 SARS-CoV-2 infection we treated, a public data set of the first 37 cases died of SARS-CoV-2 in Wuhan city and the 1019 survived patients with SARS-CoV-2 from six cities with a high prevalence of the disease.
TextSentencer_T45 4205-4508 Sentence denotes Here, we reported the clinical characteristics of a recent case series of 43 patients with 2019 SARS-CoV-2 infection we treated, a public data set of the first 37 cases died of SARS-CoV-2 in Wuhan city and the 1019 survived patients with SARS-CoV-2 from six cities with a high prevalence of the disease.
TextSentencer_T46 4509-4674 Sentence denotes We aimed to compare the severity and mortality in male and female patients with COVID-19, to explore the most useful prognostic factor for individualized assessment.
TextSentencer_T46 4509-4674 Sentence denotes We aimed to compare the severity and mortality in male and female patients with COVID-19, to explore the most useful prognostic factor for individualized assessment.
TextSentencer_T47 4675-4700 Sentence denotes SARS-CoV-2 infection is .
TextSentencer_T47 4675-4700 Sentence denotes SARS-CoV-2 infection is .
TextSentencer_T48 4701-4855 Sentence denotes CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T48 4701-4855 Sentence denotes CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T49 4856-4931 Sentence denotes is the (which was not peer-reviewed) The copyright holder for this preprint
TextSentencer_T49 4856-4931 Sentence denotes is the (which was not peer-reviewed) The copyright holder for this preprint
TextSentencer_T50 4933-5139 Sentence denotes In the case series analysis, a recent case series of 43 patients with COVID-19 was treated at Wuhan Union Hospital by the medical team of Beijing Tongren Hospital from January 29, 2020 to February 15, 2020.
TextSentencer_T50 4933-5139 Sentence denotes In the case series analysis, a recent case series of 43 patients with COVID-19 was treated at Wuhan Union Hospital by the medical team of Beijing Tongren Hospital from January 29, 2020 to February 15, 2020.
TextSentencer_T51 5140-5313 Sentence denotes Respiratory specimens were collected by local center for disease control and prevention (CDC) and then shipped to designated authoritative laboratories to detect SARS-CoV-2.
TextSentencer_T51 5140-5313 Sentence denotes Respiratory specimens were collected by local center for disease control and prevention (CDC) and then shipped to designated authoritative laboratories to detect SARS-CoV-2.
TextSentencer_T52 5314-5407 Sentence denotes The presence of SARS-CoV-2 in respiratory specimens was detected by real-time RT-PCR methods.
TextSentencer_T52 5314-5407 Sentence denotes The presence of SARS-CoV-2 in respiratory specimens was detected by real-time RT-PCR methods.
TextSentencer_T53 5408-5516 Sentence denotes The RT-PCR assay was conducted in accordance with the protocol established by the World Health Organization.
TextSentencer_T53 5408-5516 Sentence denotes The RT-PCR assay was conducted in accordance with the protocol established by the World Health Organization.
TextSentencer_T54 5517-5755 Sentence denotes In the public data set, the first 37 cases died of COVID-19 in Wuhan city and the 1019 survived patients with COVID-19 from six cities with a high prevalence of the disease were obtained from the Chinese Public Health Science Data Center.
TextSentencer_T54 5517-5755 Sentence denotes In the public data set, the first 37 cases died of COVID-19 in Wuhan city and the 1019 survived patients with COVID-19 from six cities with a high prevalence of the disease were obtained from the Chinese Public Health Science Data Center.
TextSentencer_T55 5756-5929 Sentence denotes Case data included basic demographic information, classification, date of symptom onset, date of diagnosis, date of hospitalization, date of discharge or date of death, etc.
TextSentencer_T55 5756-5929 Sentence denotes Case data included basic demographic information, classification, date of symptom onset, date of diagnosis, date of hospitalization, date of discharge or date of death, etc.
TextSentencer_T56 5930-6042 Sentence denotes The study protocol was approved by the Ethics Committee of Beijing Tongren Hospital, Capital Medical University.
TextSentencer_T56 5930-6042 Sentence denotes The study protocol was approved by the Ethics Committee of Beijing Tongren Hospital, Capital Medical University.
TextSentencer_T57 6043-6142 Sentence denotes Data were expressed as mean ± SD, median (interquartile range (IQR)) or percentage, as appropriate.
TextSentencer_T57 6043-6142 Sentence denotes Data were expressed as mean ± SD, median (interquartile range (IQR)) or percentage, as appropriate.
TextSentencer_T58 6143-6326 Sentence denotes Compared the differences between the two groups, mean values and percentages were compared between the two groups by the Student t-test, Mann-Whitney U test or chi-square (χ 2 ) test.
TextSentencer_T58 6143-6326 Sentence denotes Compared the differences between the two groups, mean values and percentages were compared between the two groups by the Student t-test, Mann-Whitney U test or chi-square (χ 2 ) test.
TextSentencer_T59 6327-6438 Sentence denotes Kaplan-Meier survival curves and the log-rank test was used for testing the survival between males and females.
TextSentencer_T59 6327-6438 Sentence denotes Kaplan-Meier survival curves and the log-rank test was used for testing the survival between males and females.
TextSentencer_T60 6439-6512 Sentence denotes Statistical analyses were performed using the SAS software (version 9.4).
TextSentencer_T60 6439-6512 Sentence denotes Statistical analyses were performed using the SAS software (version 9.4).
TextSentencer_T61 6513-6581 Sentence denotes P< 0.05 (two-tailed) was considered to be statistically significant.
TextSentencer_T61 6513-6581 Sentence denotes P< 0.05 (two-tailed) was considered to be statistically significant.
TextSentencer_T62 6582-6649 Sentence denotes The demographic and clinical characteristics are shown in Table 1 .
TextSentencer_T62 6582-6649 Sentence denotes The demographic and clinical characteristics are shown in Table 1 .
TextSentencer_T63 6650-6694 Sentence denotes The median age was 62 years (IQR, 51 to 70).
TextSentencer_T63 6650-6694 Sentence denotes The median age was 62 years (IQR, 51 to 70).
TextSentencer_T64 6695-6795 Sentence denotes Fever (95.3%) and cough (65.1%) were the most common symptoms, while diarrhea (16.3) was not common.
TextSentencer_T64 6695-6795 Sentence denotes Fever (95.3%) and cough (65.1%) were the most common symptoms, while diarrhea (16.3) was not common.
TextSentencer_T65 6796-6933 Sentence denotes 37.2% of patients had at least one underlying disorder (i.e., hypertension, diabetes, cardiovascular diseases and chronic lung diseases).
TextSentencer_T65 6796-6933 Sentence denotes 37.2% of patients had at least one underlying disorder (i.e., hypertension, diabetes, cardiovascular diseases and chronic lung diseases).
TextSentencer_T66 6934-7005 Sentence denotes Ages, symptoms and comorbidities were comparable between men and women.
TextSentencer_T66 6934-7005 Sentence denotes Ages, symptoms and comorbidities were comparable between men and women.
TextSentencer_T67 7006-7056 Sentence denotes As expected, men had a higher level of hemoglobin.
TextSentencer_T67 7006-7056 Sentence denotes As expected, men had a higher level of hemoglobin.
TextSentencer_T68 7057-7072 Sentence denotes However, male .
TextSentencer_T68 7057-7072 Sentence denotes However, male .
TextSentencer_T69 7073-7227 Sentence denotes CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T69 7073-7227 Sentence denotes CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T70 7228-7451 Sentence denotes is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.02.23.20026864 doi: medRxiv preprint patients also had elevated serum creatinine, white blood cells and neutrophils.
TextSentencer_T70 7228-7451 Sentence denotes is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.02.23.20026864 doi: medRxiv preprint patients also had elevated serum creatinine, white blood cells and neutrophils.
TextSentencer_T71 7452-7625 Sentence denotes Among the 43-case series, 13 (30.2%) were diagnosed with mild or common pneumonia, 14 (32.6%) and 16 (37.2%) were diagnosed with severe and critical pneumonia, respectively.
TextSentencer_T71 7452-7625 Sentence denotes Among the 43-case series, 13 (30.2%) were diagnosed with mild or common pneumonia, 14 (32.6%) and 16 (37.2%) were diagnosed with severe and critical pneumonia, respectively.
TextSentencer_T72 7626-7789 Sentence denotes Chi-square (χ 2 ) test for trend indicated that men tend to be more serious than women (P=0.035) according to the clinical classification of severity ( Figure 1 ).
TextSentencer_T72 7626-7789 Sentence denotes Chi-square (χ 2 ) test for trend indicated that men tend to be more serious than women (P=0.035) according to the clinical classification of severity ( Figure 1 ).
TextSentencer_T73 7790-7897 Sentence denotes In the deceased patients, fever (86.5%) and cough (67.6%) were common, while diarrhea was uncommon (18.9%).
TextSentencer_T73 7790-7897 Sentence denotes In the deceased patients, fever (86.5%) and cough (67.6%) were common, while diarrhea was uncommon (18.9%).
TextSentencer_T74 7898-7985 Sentence denotes The median period from symptom onset to death was 13 days (ranging from 11 to 18 days).
TextSentencer_T74 7898-7985 Sentence denotes The median period from symptom onset to death was 13 days (ranging from 11 to 18 days).
TextSentencer_T75 7986-8226 Sentence denotes Of these deceased patients, 64.9% had at least one underlying disorder (i.e., hypertension, diabetes, cardiovascular disease, or chronic obstructive pulmonary disease) ( Table 2 ). and 52.4% (Hefei city, n=103) respectively in these cities.
TextSentencer_T75 7986-8226 Sentence denotes Of these deceased patients, 64.9% had at least one underlying disorder (i.e., hypertension, diabetes, cardiovascular disease, or chronic obstructive pulmonary disease) ( Table 2 ). and 52.4% (Hefei city, n=103) respectively in these cities.
TextSentencer_T76 8227-8270 Sentence denotes In total, 50.0% were men in survived cases.
TextSentencer_T76 8227-8270 Sentence denotes In total, 50.0% were men in survived cases.
TextSentencer_T77 8271-8329 Sentence denotes However, of the 37 deceased patients, 26 (70.3%) were men.
TextSentencer_T77 8271-8329 Sentence denotes However, of the 37 deceased patients, 26 (70.3%) were men.
TextSentencer_T78 8330-8442 Sentence denotes While men and women had the same susceptibility, men were more prone to dying (χ 2 test, P=0.016) ( Figure 2C ).
TextSentencer_T78 8330-8442 Sentence denotes While men and women had the same susceptibility, men were more prone to dying (χ 2 test, P=0.016) ( Figure 2C ).
TextSentencer_T79 8443-8444 Sentence denotes .
TextSentencer_T79 8443-8444 Sentence denotes .
TextSentencer_T80 8445-8599 Sentence denotes CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T80 8445-8599 Sentence denotes CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T81 8600-8743 Sentence denotes is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.02.23.20026864 doi: medRxiv preprint
TextSentencer_T81 8600-8743 Sentence denotes is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.02.23.20026864 doi: medRxiv preprint
TextSentencer_T82 8744-8889 Sentence denotes Between March 25 and May 22, 2003, a total of 139 patients died of SARS in Beijing area reported from 29 hospitals were enrolled in our analysis.
TextSentencer_T82 8744-8889 Sentence denotes Between March 25 and May 22, 2003, a total of 139 patients died of SARS in Beijing area reported from 29 hospitals were enrolled in our analysis.
TextSentencer_T83 8890-8990 Sentence denotes Fever (98.4%) and cough (76.9%) were the most common symptoms, while diarrhea (6.7%) was not common.
TextSentencer_T83 8890-8990 Sentence denotes Fever (98.4%) and cough (76.9%) were the most common symptoms, while diarrhea (6.7%) was not common.
TextSentencer_T84 8991-9142 Sentence denotes 57.0% of the patients had at least one of the concomitant diseases including hypertension, diabetes, cardiovascular diseases and chronic lung diseases.
TextSentencer_T84 8991-9142 Sentence denotes 57.0% of the patients had at least one of the concomitant diseases including hypertension, diabetes, cardiovascular diseases and chronic lung diseases.
TextSentencer_T85 9143-9209 Sentence denotes The mean duration from self-reported symptom to death was 15 (IQR:
TextSentencer_T85 9143-9209 Sentence denotes The mean duration from self-reported symptom to death was 15 (IQR:
TextSentencer_T86 9210-9222 Sentence denotes 10-19) days.
TextSentencer_T86 9210-9222 Sentence denotes 10-19) days.
TextSentencer_T87 9223-9308 Sentence denotes Table 2 summarizes the clinical and biochemical characteristics of all SARS patients.
TextSentencer_T87 9223-9308 Sentence denotes Table 2 summarizes the clinical and biochemical characteristics of all SARS patients.
TextSentencer_T88 9309-9421 Sentence denotes The median age of the deceased patients was much higher than that of the survived patients (57 vs. 32, P<0.001).
TextSentencer_T88 9309-9421 Sentence denotes The median age of the deceased patients was much higher than that of the survived patients (57 vs. 32, P<0.001).
TextSentencer_T89 9422-9562 Sentence denotes The rate of the concomitant diseases in the deceased patients was also higher than that of the survived patients (57.0% vs. 17.9%, P<0.001).
TextSentencer_T89 9422-9562 Sentence denotes The rate of the concomitant diseases in the deceased patients was also higher than that of the survived patients (57.0% vs. 17.9%, P<0.001).
TextSentencer_T90 9563-9766 Sentence denotes While the deceased patients were significantly older than the survived patients ( Figure 3A ), ages were comparable between men and women in both deceased and survived patients with SARS ( Figure 3B ).
TextSentencer_T90 9563-9766 Sentence denotes While the deceased patients were significantly older than the survived patients ( Figure 3A ), ages were comparable between men and women in both deceased and survived patients with SARS ( Figure 3B ).
TextSentencer_T91 9767-9885 Sentence denotes The proportion of males was higher in the deceased group than in the survived group (χ 2 test, P=0.016) ( Figure 3C ).
TextSentencer_T91 9767-9885 Sentence denotes The proportion of males was higher in the deceased group than in the survived group (χ 2 test, P=0.016) ( Figure 3C ).
TextSentencer_T92 9886-10038 Sentence denotes Survival analysis showed that men (hazard ratio [95% CI] 1.47 [1.05-2.06], P= 0.025) had a significantly higher mortality rate than women ( Figure 3D ).
TextSentencer_T92 9886-10038 Sentence denotes Survival analysis showed that men (hazard ratio [95% CI] 1.47 [1.05-2.06], P= 0.025) had a significantly higher mortality rate than women ( Figure 3D ).
TextSentencer_T93 10039-10244 Sentence denotes Coronavirus is a large family of viruses that cause illness ranging from the common cold to severe pneumonia such as SARS 2 Older age and the high number of comorbidities were associated with severity in .
TextSentencer_T93 10039-10244 Sentence denotes Coronavirus is a large family of viruses that cause illness ranging from the common cold to severe pneumonia such as SARS 2 Older age and the high number of comorbidities were associated with severity in .
TextSentencer_T94 10245-10399 Sentence denotes CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T94 10245-10399 Sentence denotes CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T95 10400-10582 Sentence denotes is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.02.23.20026864 doi: medRxiv preprint patients with COVID-19 [9] [10] [11] .
TextSentencer_T95 10400-10582 Sentence denotes is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.02.23.20026864 doi: medRxiv preprint patients with COVID-19 [9] [10] [11] .
TextSentencer_T96 10583-10748 Sentence denotes Wang et al. reported that compared with patients not treated in the ICU (n=102) patients treated in the ICU (n=36) were older (median age, 66 years vs 51 years) 11 .
TextSentencer_T96 10583-10748 Sentence denotes Wang et al. reported that compared with patients not treated in the ICU (n=102) patients treated in the ICU (n=36) were older (median age, 66 years vs 51 years) 11 .
TextSentencer_T97 10749-10915 Sentence denotes Consistent with previous reports, older patients (≥65 years old), were more likely to have a severe type of COVID-19 in the case series patients in the present study.
TextSentencer_T97 10749-10915 Sentence denotes Consistent with previous reports, older patients (≥65 years old), were more likely to have a severe type of COVID-19 in the case series patients in the present study.
TextSentencer_T98 10916-11137 Sentence denotes In the public data set, we also found that the percentage of older age (≥65 years) was much higher in the deceased patient than in the survived patients (83.8% in 37 deceased patients vs. 13.2% in 1019 survived patients).
TextSentencer_T98 10916-11137 Sentence denotes In the public data set, we also found that the percentage of older age (≥65 years) was much higher in the deceased patient than in the survived patients (83.8% in 37 deceased patients vs. 13.2% in 1019 survived patients).
TextSentencer_T99 11138-11228 Sentence denotes The results indicated that older age was associated with a high mortality in patients with
TextSentencer_T99 11138-11228 Sentence denotes The results indicated that older age was associated with a high mortality in patients with
TextSentencer_T100 11229-11346 Sentence denotes This is the first preliminary study investigating the gender role in morbidity and mortality of SARS-CoV-2 infection.
TextSentencer_T100 11229-11346 Sentence denotes This is the first preliminary study investigating the gender role in morbidity and mortality of SARS-CoV-2 infection.
TextSentencer_T101 11347-11512 Sentence denotes It is suggested that COVID-19 is more likely to affect older males with comorbidities, and can result in severe and even fatal respiratory diseases such as ARDS 10 .
TextSentencer_T101 11347-11512 Sentence denotes It is suggested that COVID-19 is more likely to affect older males with comorbidities, and can result in severe and even fatal respiratory diseases such as ARDS 10 .
TextSentencer_T102 11513-11554 Sentence denotes Among the 425 patients with COVID-19, 56%
TextSentencer_T102 11513-11554 Sentence denotes Among the 425 patients with COVID-19, 56%
TextSentencer_T103 11555-11647 Sentence denotes were male, indicating males may be more susceptible to SARS-CoV-2 infection than females 6 .
TextSentencer_T103 11555-11647 Sentence denotes were male, indicating males may be more susceptible to SARS-CoV-2 infection than females 6 .
TextSentencer_T104 11648-11769 Sentence denotes In 140 hospitalized patients with COVID-19, an approximately 1:1 ratio of male (50.7%) and female patients was found 10 .
TextSentencer_T104 11648-11769 Sentence denotes In 140 hospitalized patients with COVID-19, an approximately 1:1 ratio of male (50.7%) and female patients was found 10 .
TextSentencer_T105 11770-11875 Sentence denotes In four case series reports, 30 of 41(73%), 67 of 99 (68%), 25 of 51(49%) and 75 of 138 (54.3%) were men.
TextSentencer_T105 11770-11875 Sentence denotes In four case series reports, 30 of 41(73%), 67 of 99 (68%), 25 of 51(49%) and 75 of 138 (54.3%) were men.
TextSentencer_T106 11876-12110 Sentence denotes In the present study, however, a similar susceptible to SARS-CoV-2 between males and females was observed in 1019 survived patients (50.0% males) collected from six cities and in a case series of 43 hospitalized patient (51.2% males).
TextSentencer_T106 11876-12110 Sentence denotes In the present study, however, a similar susceptible to SARS-CoV-2 between males and females was observed in 1019 survived patients (50.0% males) collected from six cities and in a case series of 43 hospitalized patient (51.2% males).
TextSentencer_T107 12111-12317 Sentence denotes Although the deceased patients were significantly older than the survived patients with COVID-19 in this study, ages were comparable between males and females in both the deceased and the survived patients.
TextSentencer_T107 12111-12317 Sentence denotes Although the deceased patients were significantly older than the survived patients with COVID-19 in this study, ages were comparable between males and females in both the deceased and the survived patients.
TextSentencer_T108 12318-12472 Sentence denotes Consistent with this predominance, we also found that the proportion of male was higher in the deceased group than in the survived group in SARS patients.
TextSentencer_T108 12318-12472 Sentence denotes Consistent with this predominance, we also found that the proportion of male was higher in the deceased group than in the survived group in SARS patients.
TextSentencer_T109 12473-12514 Sentence denotes Survival analysis showed that men had a .
TextSentencer_T109 12473-12514 Sentence denotes Survival analysis showed that men had a .
TextSentencer_T110 12515-12669 Sentence denotes CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T110 12515-12669 Sentence denotes CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T111 12670-12878 Sentence denotes is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.02.23.20026864 doi: medRxiv preprint significantly higher mortality rate than women in SARS patients.
TextSentencer_T111 12670-12878 Sentence denotes is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.02.23.20026864 doi: medRxiv preprint significantly higher mortality rate than women in SARS patients.
TextSentencer_T112 12879-13026 Sentence denotes Therefore, Gender is a risk factor for higher severity and mortality in patients with both COVID-19 and SARS independent of age and susceptibility.
TextSentencer_T112 12879-13026 Sentence denotes Therefore, Gender is a risk factor for higher severity and mortality in patients with both COVID-19 and SARS independent of age and susceptibility.
TextSentencer_T113 13027-13113 Sentence denotes In early 2003, we participated in the Beijing Municipal Medical Taskforce of SARS 12 .
TextSentencer_T113 13027-13113 Sentence denotes In early 2003, we participated in the Beijing Municipal Medical Taskforce of SARS 12 .
TextSentencer_T114 13114-13355 Sentence denotes Here, we re-analyzed the data of a large population of 520 SARS patients including 135 deaths in Beijing, and summarized the experience and lessons for present use, because SARS-CoV-2 and SARS-CoV attack cells via the same receptor, ACE2 3 .
TextSentencer_T114 13114-13355 Sentence denotes Here, we re-analyzed the data of a large population of 520 SARS patients including 135 deaths in Beijing, and summarized the experience and lessons for present use, because SARS-CoV-2 and SARS-CoV attack cells via the same receptor, ACE2 3 .
TextSentencer_T115 13356-13560 Sentence denotes We have previously reported that high protein expression of ACE2 receptor in specific organs correlated with specific organ failures indicated by corresponding clinical parameters in SARS patients 12,13 .
TextSentencer_T115 13356-13560 Sentence denotes We have previously reported that high protein expression of ACE2 receptor in specific organs correlated with specific organ failures indicated by corresponding clinical parameters in SARS patients 12,13 .
TextSentencer_T116 13561-13765 Sentence denotes Interestingly, the ACE2 gene is located on the X-chromosome and it has been shown that circulating ACE2 levels are higher in men than in women and in patients with diabetes or cardiovascular diseases 14 .
TextSentencer_T116 13561-13765 Sentence denotes Interestingly, the ACE2 gene is located on the X-chromosome and it has been shown that circulating ACE2 levels are higher in men than in women and in patients with diabetes or cardiovascular diseases 14 .
TextSentencer_T117 13766-13923 Sentence denotes Therefore, male patients may be more prone to die from SARS-CoV-2 because of the high expression of ACE2, though further research on the mechanism is needed.
TextSentencer_T117 13766-13923 Sentence denotes Therefore, male patients may be more prone to die from SARS-CoV-2 because of the high expression of ACE2, though further research on the mechanism is needed.
TextSentencer_T118 13924-13956 Sentence denotes This study has some limitations.
TextSentencer_T118 13924-13956 Sentence denotes This study has some limitations.
TextSentencer_T119 13957-14169 Sentence denotes First, for severity analysis only a case series of 43 patients with SARS-CoV-2 were included, because detailed patient information, particularly regarding clinical outcomes was unavailable in the public data set;
TextSentencer_T119 13957-14169 Sentence denotes First, for severity analysis only a case series of 43 patients with SARS-CoV-2 were included, because detailed patient information, particularly regarding clinical outcomes was unavailable in the public data set;
TextSentencer_T120 14170-14271 Sentence denotes Second, for mortality analysis only the first 37cases died of SARS-CoV-2 in Wuhan city were included.
TextSentencer_T120 14170-14271 Sentence denotes Second, for mortality analysis only the first 37cases died of SARS-CoV-2 in Wuhan city were included.
TextSentencer_T121 14272-14401 Sentence denotes However, this is the first preliminary data investigating the gender role in morbidity and mortality in patients with SARS-CoV-2.
TextSentencer_T121 14272-14401 Sentence denotes However, this is the first preliminary data investigating the gender role in morbidity and mortality in patients with SARS-CoV-2.
TextSentencer_T122 14402-14549 Sentence denotes More clinical and basic research regarding gender and other prognostic factors for individualized assessment and treatment is needed in the future.
TextSentencer_T122 14402-14549 Sentence denotes More clinical and basic research regarding gender and other prognostic factors for individualized assessment and treatment is needed in the future.
TextSentencer_T123 14550-14635 Sentence denotes In conclusion, older age is a predominant risk factor for severity and morbidity in .
TextSentencer_T123 14550-14635 Sentence denotes In conclusion, older age is a predominant risk factor for severity and morbidity in .
TextSentencer_T124 14636-14790 Sentence denotes CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T124 14636-14790 Sentence denotes CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T125 14791-14980 Sentence denotes Chi-square (χ 2 ) test for trend indicated that males tend to be more serious than females according to the clinical classification of severity including Mild+Common, Severe and Critical. .
TextSentencer_T125 14791-14980 Sentence denotes Chi-square (χ 2 ) test for trend indicated that males tend to be more serious than females according to the clinical classification of severity including Mild+Common, Severe and Critical. .
TextSentencer_T126 14981-15135 Sentence denotes CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T126 14981-15135 Sentence denotes CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
TextSentencer_T127 15136-15279 Sentence denotes is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.02.23.20026864 doi: medRxiv preprint
TextSentencer_T127 15136-15279 Sentence denotes is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.02.23.20026864 doi: medRxiv preprint