CORD-19-Sentences  

CORD-19:b03c7f6241f74f5934ebec0287004bf9ff784922 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-26 Sentence denotes Epidemiology and Infection
TextSentencer_T1 0-26 Sentence denotes Epidemiology and Infection
TextSentencer_T2 28-36 Sentence denotes Abstract
TextSentencer_T2 28-36 Sentence denotes Abstract
TextSentencer_T3 39-210 Sentence denotes Influenza is a major public health problem [1] that brings an economic burden to patients and their families [2, 3] , and causes a great number of deaths [4] [5] [6] [7] .
TextSentencer_T3 39-210 Sentence denotes Influenza is a major public health problem [1] that brings an economic burden to patients and their families [2, 3] , and causes a great number of deaths [4] [5] [6] [7] .
TextSentencer_T4 211-480 Sentence denotes Interferon-induced transmembrane proteins (IFITM) are a family of proteins that function as virus restriction factors [8] [9] [10] , while IFITM3 is a cellular ongoing endosome-and lysosome-localised protein that protects cells from numerous viral infections [11, 12] .
TextSentencer_T4 211-480 Sentence denotes Interferon-induced transmembrane proteins (IFITM) are a family of proteins that function as virus restriction factors [8] [9] [10] , while IFITM3 is a cellular ongoing endosome-and lysosome-localised protein that protects cells from numerous viral infections [11, 12] .
TextSentencer_T5 481-669 Sentence denotes In recent years, animal [13] , in vitro [14] and human studies have evaluated the relationship between rs12252, a single-nucleotide polymorphism (SNP) in IFITM3, and the risk of influenza.
TextSentencer_T5 481-669 Sentence denotes In recent years, animal [13] , in vitro [14] and human studies have evaluated the relationship between rs12252, a single-nucleotide polymorphism (SNP) in IFITM3, and the risk of influenza.
TextSentencer_T6 670-832 Sentence denotes To date, two meta-analyses [15, 16] have summarised the results of previous articles published from 2012 to 2014, but there were defects in both of these studies.
TextSentencer_T6 670-832 Sentence denotes To date, two meta-analyses [15, 16] have summarised the results of previous articles published from 2012 to 2014, but there were defects in both of these studies.
TextSentencer_T7 833-938 Sentence denotes First, there were differences in the data extracted from the same articles between the two meta-analyses.
TextSentencer_T7 833-938 Sentence denotes First, there were differences in the data extracted from the same articles between the two meta-analyses.
TextSentencer_T8 939-1191 Sentence denotes Moreover, one of them [15] did not consider the homozygous comparison (CC vs. TT), since previous meta-analyses [15, 16] have showed an association between the minor C and severe influenza, it is imperative to analyse all data under this kind of model.
TextSentencer_T8 939-1191 Sentence denotes Moreover, one of them [15] did not consider the homozygous comparison (CC vs. TT), since previous meta-analyses [15, 16] have showed an association between the minor C and severe influenza, it is imperative to analyse all data under this kind of model.
TextSentencer_T9 1192-1385 Sentence denotes The quantity of the studies included in a meta-analysis plays a vital role; however, only four studies were included before, five additional studies of high quality were available at this time.
TextSentencer_T9 1192-1385 Sentence denotes The quantity of the studies included in a meta-analysis plays a vital role; however, only four studies were included before, five additional studies of high quality were available at this time.
TextSentencer_T10 1386-1482 Sentence denotes The latest studies were published in 2016 and 2017, indicating increased interest in this topic.
TextSentencer_T10 1386-1482 Sentence denotes The latest studies were published in 2016 and 2017, indicating increased interest in this topic.
TextSentencer_T11 1483-1666 Sentence denotes Moreover, although the previous meta-analyses reached a conclusion about the correlation between rs12252 and influenza, the newly published articles present more inconsistent results.
TextSentencer_T11 1483-1666 Sentence denotes Moreover, although the previous meta-analyses reached a conclusion about the correlation between rs12252 and influenza, the newly published articles present more inconsistent results.
TextSentencer_T12 1667-1790 Sentence denotes Hence, a new meta-analysis is urged to provide more confidence for the prevention and treatment of influenza in the future.
TextSentencer_T12 1667-1790 Sentence denotes Hence, a new meta-analysis is urged to provide more confidence for the prevention and treatment of influenza in the future.
TextSentencer_T13 1791-2016 Sentence denotes A comprehensive systematic search was performed based on the electronic databases, PubMed, the Cochrane library, OVID, EBSCO and the Web of Science to obtain related studies published from the initial date to 9 November 2017.
TextSentencer_T13 1791-2016 Sentence denotes A comprehensive systematic search was performed based on the electronic databases, PubMed, the Cochrane library, OVID, EBSCO and the Web of Science to obtain related studies published from the initial date to 9 November 2017.
TextSentencer_T14 2017-2175 Sentence denotes The following search terms were used to retrieve relevant literature: 'flu OR influenza OR grippe' AND 'IFITM OR interferon-induced transmembrane OR rs12252'.
TextSentencer_T14 2017-2175 Sentence denotes The following search terms were used to retrieve relevant literature: 'flu OR influenza OR grippe' AND 'IFITM OR interferon-induced transmembrane OR rs12252'.
TextSentencer_T15 2176-2210 Sentence denotes Only human studies were recruited.
TextSentencer_T15 2176-2210 Sentence denotes Only human studies were recruited.
TextSentencer_T16 2211-2841 Sentence denotes Eligible studies should comply with the following inclusion criteria: (1) regarding the association between rs12252 and influenza; (2) a cohort or case-control study; (3) influenza was diagnosed by polymerase chain reaction (PCR), patients should have been exposed to influenza virus in the past, developed clinical symptoms and with laboratory-confirmed influenza infection; (4) provide available genotype data to calculate the odds ratios (ORs) and 95% confidence intervals (CIs); (5) no deviation from HWE (Hardy-Weinberg equilibrium) of genotype distribution in the control group; (6) with full text; (7) published in English.
TextSentencer_T16 2211-2841 Sentence denotes Eligible studies should comply with the following inclusion criteria: (1) regarding the association between rs12252 and influenza; (2) a cohort or case-control study; (3) influenza was diagnosed by polymerase chain reaction (PCR), patients should have been exposed to influenza virus in the past, developed clinical symptoms and with laboratory-confirmed influenza infection; (4) provide available genotype data to calculate the odds ratios (ORs) and 95% confidence intervals (CIs); (5) no deviation from HWE (Hardy-Weinberg equilibrium) of genotype distribution in the control group; (6) with full text; (7) published in English.
TextSentencer_T17 2842-2897 Sentence denotes Exclusion criteria were as follows: (1) animal studies;
TextSentencer_T17 2842-2897 Sentence denotes Exclusion criteria were as follows: (1) animal studies;
TextSentencer_T18 2898-2980 Sentence denotes (2) abstracts, reviews or case reports; (3) containing insufficient genotype data.
TextSentencer_T18 2898-2980 Sentence denotes (2) abstracts, reviews or case reports; (3) containing insufficient genotype data.
TextSentencer_T19 2981-3097 Sentence denotes Eligible studies were identified independently by two researchers according to the inclusion and exclusion criteria.
TextSentencer_T19 2981-3097 Sentence denotes Eligible studies were identified independently by two researchers according to the inclusion and exclusion criteria.
TextSentencer_T20 3098-3223 Sentence denotes Any disagreement was discussed and if an agreement could not be reached, the differences were resolved by a third researcher.
TextSentencer_T20 3098-3223 Sentence denotes Any disagreement was discussed and if an agreement could not be reached, the differences were resolved by a third researcher.
TextSentencer_T21 3224-3643 Sentence denotes The following information was collected from each selected study: (1) first author's name; (2) year of publication; (3) country of the population in each study; (4) ethnicity of cases and controls; (5) type of influenza; (6) genotyping method; (7) age of cases and controls; (8) source of controls; (9) samples of controls and cases; (10) MAF (Minor Allele Frequency); (11) HWE; (12) Newcastle-Ottawa Scale (NOS) score.
TextSentencer_T21 3224-3643 Sentence denotes The following information was collected from each selected study: (1) first author's name; (2) year of publication; (3) country of the population in each study; (4) ethnicity of cases and controls; (5) type of influenza; (6) genotyping method; (7) age of cases and controls; (8) source of controls; (9) samples of controls and cases; (10) MAF (Minor Allele Frequency); (11) HWE; (12) Newcastle-Ottawa Scale (NOS) score.
TextSentencer_T22 3644-3855 Sentence denotes HWE was used to evaluate the quality of genotype data from the control group in each included study by the χ 2 test, and P > 0.05 was considered insignificant, indicating balanced distribution in the population.
TextSentencer_T22 3644-3855 Sentence denotes HWE was used to evaluate the quality of genotype data from the control group in each included study by the χ 2 test, and P > 0.05 was considered insignificant, indicating balanced distribution in the population.
TextSentencer_T23 3856-3978 Sentence denotes The quality of the studies was appraised by the NOS, which consists of three parts: selection, comparability and exposure.
TextSentencer_T23 3856-3978 Sentence denotes The quality of the studies was appraised by the NOS, which consists of three parts: selection, comparability and exposure.
TextSentencer_T24 3979-4008 Sentence denotes The score ranges from 0 to 9.
TextSentencer_T24 3979-4008 Sentence denotes The score ranges from 0 to 9.
TextSentencer_T25 4009-4182 Sentence denotes Scores for highquality articles were required to be 5 points at least in the NOS quality assessment, and studies with scores higher than 6 were adopted in our meta-analysis.
TextSentencer_T25 4009-4182 Sentence denotes Scores for highquality articles were required to be 5 points at least in the NOS quality assessment, and studies with scores higher than 6 were adopted in our meta-analysis.
TextSentencer_T26 4183-4252 Sentence denotes Studies with scores higher than 6 were adopted in this meta-analysis.
TextSentencer_T26 4183-4252 Sentence denotes Studies with scores higher than 6 were adopted in this meta-analysis.
TextSentencer_T27 4253-4444 Sentence denotes The statistical analysis of data was performed using Revman 5.0 (The Cochrane Collaboration, http://ims.cochrane.org/revman) and Stata 12.0 software (Stata Corp, College Station, Texas, USA).
TextSentencer_T27 4253-4444 Sentence denotes The statistical analysis of data was performed using Revman 5.0 (The Cochrane Collaboration, http://ims.cochrane.org/revman) and Stata 12.0 software (Stata Corp, College Station, Texas, USA).
TextSentencer_T28 4445-4680 Sentence denotes Pooled ORs and CIs were used to evaluate the association between rs12252 and influenza based on four genetic models, namely the allelic (C vs. T), homozygous (CC vs. TT), dominant (CC + CT vs. TT) and recessive (CC vs. CT + TT) models.
TextSentencer_T28 4445-4680 Sentence denotes Pooled ORs and CIs were used to evaluate the association between rs12252 and influenza based on four genetic models, namely the allelic (C vs. T), homozygous (CC vs. TT), dominant (CC + CT vs. TT) and recessive (CC vs. CT + TT) models.
TextSentencer_T29 4681-4870 Sentence denotes In addition, subgroup analyses were conducted according to different ethnic groups (Caucasian, Asian, African, Portuguese population) and severity of influenza (severe, mild), respectively.
TextSentencer_T29 4681-4870 Sentence denotes In addition, subgroup analyses were conducted according to different ethnic groups (Caucasian, Asian, African, Portuguese population) and severity of influenza (severe, mild), respectively.
TextSentencer_T30 4871-5017 Sentence denotes Heterogeneity was calculated by the P-value for heterogeneity (P h ) based on the Q test and the Thompson and Higgins classification index (I 2 ).
TextSentencer_T30 4871-5017 Sentence denotes Heterogeneity was calculated by the P-value for heterogeneity (P h ) based on the Q test and the Thompson and Higgins classification index (I 2 ).
TextSentencer_T31 5018-5136 Sentence denotes A random effect was implemented if P h < 0.05 or I 2 > 50%, otherwise, a fixed model was selected to pool the results.
TextSentencer_T31 5018-5136 Sentence denotes A random effect was implemented if P h < 0.05 or I 2 > 50%, otherwise, a fixed model was selected to pool the results.
TextSentencer_T32 5137-5371 Sentence denotes Sensitivity analysis was conducted by excluding a single study each time to validate the influence of the data attributes on the pooled OR, and low-quality studies that impact the stability of the results were deleted after this test.
TextSentencer_T32 5137-5371 Sentence denotes Sensitivity analysis was conducted by excluding a single study each time to validate the influence of the data attributes on the pooled OR, and low-quality studies that impact the stability of the results were deleted after this test.
TextSentencer_T33 5372-5498 Sentence denotes Possible publication bias was detected using Begg's and Egger's tests, a P value of <0.05 revealed potential publication bias.
TextSentencer_T33 5372-5498 Sentence denotes Possible publication bias was detected using Begg's and Egger's tests, a P value of <0.05 revealed potential publication bias.
TextSentencer_T34 5499-5594 Sentence denotes A flow diagram of the study selection process and the eligible results were shown in Figure 1 .
TextSentencer_T34 5499-5594 Sentence denotes A flow diagram of the study selection process and the eligible results were shown in Figure 1 .
TextSentencer_T35 5595-5792 Sentence denotes After excluding duplicate articles, a total of nine relevant studies, which include 10 sets of data, were extracted from the databases mentioned above based on our inclusion and exclusion criteria.
TextSentencer_T35 5595-5792 Sentence denotes After excluding duplicate articles, a total of nine relevant studies, which include 10 sets of data, were extracted from the databases mentioned above based on our inclusion and exclusion criteria.
TextSentencer_T36 5793-5868 Sentence denotes A total of 1365 cases and 5425 controls were included in the meta-analysis.
TextSentencer_T36 5793-5868 Sentence denotes A total of 1365 cases and 5425 controls were included in the meta-analysis.
TextSentencer_T37 5869-5950 Sentence denotes Different ethnic groups were defined as Caucasian, Asian, African and Portuguese.
TextSentencer_T37 5869-5950 Sentence denotes Different ethnic groups were defined as Caucasian, Asian, African and Portuguese.
TextSentencer_T38 5951-6174 Sentence denotes Four studies [17] [18] [19] [20] were conducted for Caucasian ethnicity, four studies [21] [22] [23] [24] for East Asian ethnicity, one [20] for African ethnicity and one study [25] was conducted for Portuguese mixed races.
TextSentencer_T38 5951-6174 Sentence denotes Four studies [17] [18] [19] [20] were conducted for Caucasian ethnicity, four studies [21] [22] [23] [24] for East Asian ethnicity, one [20] for African ethnicity and one study [25] was conducted for Portuguese mixed races.
TextSentencer_T39 6175-6338 Sentence denotes Of the nine studies, five [19, [20] [21] [22] 25] were new articles compared with earlier meta-analyses, and four of them were published in 2017 [21, 22, 24, 25] .
TextSentencer_T39 6175-6338 Sentence denotes Of the nine studies, five [19, [20] [21] [22] 25] were new articles compared with earlier meta-analyses, and four of them were published in 2017 [21, 22, 24, 25] .
TextSentencer_T40 6339-6439 Sentence denotes All eligible studies used a case-control design and patients' samples were genotyped by PCR methods.
TextSentencer_T40 6339-6439 Sentence denotes All eligible studies used a case-control design and patients' samples were genotyped by PCR methods.
TextSentencer_T41 6440-6568 Sentence denotes Some controls were from the general healthy population, while some were from the healthy population in the 1000 Genomes Project.
TextSentencer_T41 6440-6568 Sentence denotes Some controls were from the general healthy population, while some were from the healthy population in the 1000 Genomes Project.
TextSentencer_T42 6569-6591 Sentence denotes All controls meet HWE.
TextSentencer_T42 6569-6591 Sentence denotes All controls meet HWE.
TextSentencer_T43 6592-6746 Sentence denotes Subgroup analysis among the Caucasian population with 649 cases and 3875 controls while in the Asian population, 619 cases and 689 controls were included.
TextSentencer_T43 6592-6746 Sentence denotes Subgroup analysis among the Caucasian population with 649 cases and 3875 controls while in the Asian population, 619 cases and 689 controls were included.
TextSentencer_T44 6747-6971 Sentence denotes Since the World Health Organization (WHO) reported the change of the A (H1N1) because of the pandemic and replacement caused by A (H1N1) pdm09 after 2009 [26] , we renamed the type of influenza of some study according to it.
TextSentencer_T44 6747-6971 Sentence denotes Since the World Health Organization (WHO) reported the change of the A (H1N1) because of the pandemic and replacement caused by A (H1N1) pdm09 after 2009 [26] , we renamed the type of influenza of some study according to it.
TextSentencer_T45 6972-7083 Sentence denotes The detailed characteristics and allele distribution of the selected studies were presented in Tables 1 and 2 .
TextSentencer_T45 6972-7083 Sentence denotes The detailed characteristics and allele distribution of the selected studies were presented in Tables 1 and 2 .
TextSentencer_T46 7084-7254 Sentence denotes Overall analysis The article of Randolph et al. contained two sets of data, which were retrieved from a white, non-Hispanic population and an African American population.
TextSentencer_T46 7084-7254 Sentence denotes Overall analysis The article of Randolph et al. contained two sets of data, which were retrieved from a white, non-Hispanic population and an African American population.
TextSentencer_T47 7255-7439 Sentence denotes To distinguish the two sets of data, the former was named Randolph 1 when the data were analysed using Revman 5.0 software, while the latter was called Randolph 2 in the meta-analysis.
TextSentencer_T47 7255-7439 Sentence denotes To distinguish the two sets of data, the former was named Randolph 1 when the data were analysed using Revman 5.0 software, while the latter was called Randolph 2 in the meta-analysis.
TextSentencer_T48 7440-7758 Sentence denotes Significant association between rs12252 and influenza was found in all four genetic models (C vs. T: OR = 1.54, 95% CI (1.34-1.77), P < 0.00001; CC vs. CT + TT: OR = 2.80, 95% CI (2.03-3.85), P < 0.00001; CC vs. TT: OR = 2.39, 95% CI (1.85-3.09), P < 0.00001; CC + CT vs. TT: OR = 1.38, 95% CI (1.14-1.67), P = 0.001).
TextSentencer_T48 7440-7758 Sentence denotes Significant association between rs12252 and influenza was found in all four genetic models (C vs. T: OR = 1.54, 95% CI (1.34-1.77), P < 0.00001; CC vs. CT + TT: OR = 2.80, 95% CI (2.03-3.85), P < 0.00001; CC vs. TT: OR = 2.39, 95% CI (1.85-3.09), P < 0.00001; CC + CT vs. TT: OR = 1.38, 95% CI (1.14-1.67), P = 0.001).
TextSentencer_T49 7759-7862 Sentence denotes The fixed model was applied to all allelic models because no obvious heterogeneity was found (Fig. 2 ).
TextSentencer_T49 7759-7862 Sentence denotes The fixed model was applied to all allelic models because no obvious heterogeneity was found (Fig. 2 ).
TextSentencer_T50 7863-7971 Sentence denotes The 10 sets of data were stratified into different subgroups by ethnicity and degrees of patients' symptoms.
TextSentencer_T50 7863-7971 Sentence denotes The 10 sets of data were stratified into different subgroups by ethnicity and degrees of patients' symptoms.
TextSentencer_T51 7972-8097 Sentence denotes Subgroup analysis among the Caucasian population showed significant association in the allelic model ( Table 3 and Figure 3 .
TextSentencer_T51 7972-8097 Sentence denotes Subgroup analysis among the Caucasian population showed significant association in the allelic model ( Table 3 and Figure 3 .
TextSentencer_T52 8098-8120 Sentence denotes Table 3 and Figure 4 .
TextSentencer_T52 8098-8120 Sentence denotes Table 3 and Figure 4 .
TextSentencer_T53 8121-8258 Sentence denotes We also made a comparison between severe and mild influenza patients, and for this analysis, we used the mild group as the control group.
TextSentencer_T53 8121-8258 Sentence denotes We also made a comparison between severe and mild influenza patients, and for this analysis, we used the mild group as the control group.
TextSentencer_T54 8259-8419 Sentence denotes A total of five studies [18, 19, 22, 25] were included in this analysis, which included 312 patients with severe influenza and 468 patients with mild influenza.
TextSentencer_T54 8259-8419 Sentence denotes A total of five studies [18, 19, 22, 25] were included in this analysis, which included 312 patients with severe influenza and 468 patients with mild influenza.
TextSentencer_T55 8420-8580 Sentence denotes Significant difference was shown in CC vs. TT (OR = 3.11, 95% CI (1.58-6.13), P = 0.001) and CC vs. CT + TT models (OR = 3.90, 95% CI (2.44-6.21), P < 0.00001).
TextSentencer_T55 8420-8580 Sentence denotes Significant difference was shown in CC vs. TT (OR = 3.11, 95% CI (1.58-6.13), P = 0.001) and CC vs. CT + TT models (OR = 3.90, 95% CI (2.44-6.21), P < 0.00001).
TextSentencer_T56 8581-8642 Sentence denotes The main results of our meta-analysis were shown in Table 3 .
TextSentencer_T56 8581-8642 Sentence denotes The main results of our meta-analysis were shown in Table 3 .
TextSentencer_T57 8643-8717 Sentence denotes Sensitivity analysis was conducted by omitting the data of a single study.
TextSentencer_T57 8643-8717 Sentence denotes Sensitivity analysis was conducted by omitting the data of a single study.
TextSentencer_T58 8718-8765 Sentence denotes For each omission, the results remained stable.
TextSentencer_T58 8718-8765 Sentence denotes For each omission, the results remained stable.
TextSentencer_T59 8766-8909 Sentence denotes Begg's funnel plot and Egger's linear regression were conducted using Stata 12.0 to assess possible publication bias from the included studies.
TextSentencer_T59 8766-8909 Sentence denotes Begg's funnel plot and Egger's linear regression were conducted using Stata 12.0 to assess possible publication bias from the included studies.
TextSentencer_T60 8910-8986 Sentence denotes No obvious publication bias was observed in any model (Table 4 and Fig. 5) .
TextSentencer_T60 8910-8986 Sentence denotes No obvious publication bias was observed in any model (Table 4 and Fig. 5) .
TextSentencer_T61 8987-8989 Sentence denotes T.
TextSentencer_T61 8987-8989 Sentence denotes T.
TextSentencer_T62 8990-9001 Sentence denotes Chen et al.
TextSentencer_T62 8990-9001 Sentence denotes Chen et al.
TextSentencer_T63 9002-9197 Sentence denotes In 2009, Huang et al. [8] reported the immune response to influenza A H1N1 virus mediated by IFITM proteins and it is now widely accepted that IFITM3 functions as restriction of viral infections.
TextSentencer_T63 9002-9197 Sentence denotes In 2009, Huang et al. [8] reported the immune response to influenza A H1N1 virus mediated by IFITM proteins and it is now widely accepted that IFITM3 functions as restriction of viral infections.
TextSentencer_T64 9198-9310 Sentence denotes An early research [17] reported the influence of host genetic determinants for some diseases, such as influenza.
TextSentencer_T64 9198-9310 Sentence denotes An early research [17] reported the influence of host genetic determinants for some diseases, such as influenza.
TextSentencer_T65 9311-9431 Sentence denotes SNPs are the most common type of human genetic variation, and multiple SNPs exist in the IFITM3 gene, including rs12252.
TextSentencer_T65 9311-9431 Sentence denotes SNPs are the most common type of human genetic variation, and multiple SNPs exist in the IFITM3 gene, including rs12252.
TextSentencer_T66 9432-9511 Sentence denotes Following the 2009 flu pandemic, many studies focused on influenza and rs12252.
TextSentencer_T66 9432-9511 Sentence denotes Following the 2009 flu pandemic, many studies focused on influenza and rs12252.
TextSentencer_T67 9512-9624 Sentence denotes Everitt et al. [17] first reported reduction of morbidity and mortality associated with influenza due to IFITM3.
TextSentencer_T67 9512-9624 Sentence denotes Everitt et al. [17] first reported reduction of morbidity and mortality associated with influenza due to IFITM3.
TextSentencer_T68 9625-9736 Sentence denotes This association has been verified by this meta-analysis with half the data coming from 2016 and 2017 articles.
TextSentencer_T68 9625-9736 Sentence denotes This association has been verified by this meta-analysis with half the data coming from 2016 and 2017 articles.
TextSentencer_T69 9737-9797 Sentence denotes However, some different conclusions were found in our study.
TextSentencer_T69 9737-9797 Sentence denotes However, some different conclusions were found in our study.
TextSentencer_T70 9798-10112 Sentence denotes Most of the eligible articles in our study found a connection between rs12252 and influenza, yet the connection was not replicated in the studies reported by Mills et al. [18] and David et al. [25] , while Randolph et al. [20] found rs12252 was not associated with susceptibility to paediatric influenza infection.
TextSentencer_T70 9798-10112 Sentence denotes Most of the eligible articles in our study found a connection between rs12252 and influenza, yet the connection was not replicated in the studies reported by Mills et al. [18] and David et al. [25] , while Randolph et al. [20] found rs12252 was not associated with susceptibility to paediatric influenza infection.
TextSentencer_T71 10113-10294 Sentence denotes Despite the fact that a study with negative results was selected [18] in the earlier meta-analysis [15, 16] , more articles with negative results were included in our meta-analysis.
TextSentencer_T71 10113-10294 Sentence denotes Despite the fact that a study with negative results was selected [18] in the earlier meta-analysis [15, 16] , more articles with negative results were included in our meta-analysis.
TextSentencer_T72 10295-10395 Sentence denotes The two previous meta-analyses [15, 16] only included four articles published between 2012 and 2014.
TextSentencer_T72 10295-10395 Sentence denotes The two previous meta-analyses [15, 16] only included four articles published between 2012 and 2014.
TextSentencer_T73 10396-10561 Sentence denotes In addition, Xuan et al. [15] found that one study [23] showed a departure from HWE in the control group, while we showed that this study actually accorded with HWE.
TextSentencer_T73 10396-10561 Sentence denotes In addition, Xuan et al. [15] found that one study [23] showed a departure from HWE in the control group, while we showed that this study actually accorded with HWE.
TextSentencer_T74 10562-10672 Sentence denotes Our meta-analysis showed that discrepancies in host genetic factors may influence susceptibility to influenza.
TextSentencer_T74 10562-10672 Sentence denotes Our meta-analysis showed that discrepancies in host genetic factors may influence susceptibility to influenza.
TextSentencer_T75 10673-10827 Sentence denotes This is similar to the results of two previous meta-analyses, which suggested that the minor rs12252-C allele may protect people from influenza infection.
TextSentencer_T75 10673-10827 Sentence denotes This is similar to the results of two previous meta-analyses, which suggested that the minor rs12252-C allele may protect people from influenza infection.
TextSentencer_T76 10828-10980 Sentence denotes In the allelic model, the comprehensive result showed people who carry the C gene were 1.54-fold more likely to succumb to influenza infection (C vs. T:
TextSentencer_T76 10828-10980 Sentence denotes In the allelic model, the comprehensive result showed people who carry the C gene were 1.54-fold more likely to succumb to influenza infection (C vs. T:
TextSentencer_T77 10981-10994 Sentence denotes P < 0.00001).
TextSentencer_T77 10981-10994 Sentence denotes P < 0.00001).
TextSentencer_T78 10995-11142 Sentence denotes In the dominant model, the risk of illness of people with the CC or CT genotype was 1.38-fold higher than those with a TT genotype (CC + CT vs. TT:
TextSentencer_T78 10995-11142 Sentence denotes In the dominant model, the risk of illness of people with the CC or CT genotype was 1.38-fold higher than those with a TT genotype (CC + CT vs. TT:
TextSentencer_T79 11143-11154 Sentence denotes P = 0.001).
TextSentencer_T79 11143-11154 Sentence denotes P = 0.001).
TextSentencer_T80 11155-11238 Sentence denotes The risk of influenza was 2.38-fold greater in the recessive model (CC vs. CT + TT:
TextSentencer_T80 11155-11238 Sentence denotes The risk of influenza was 2.38-fold greater in the recessive model (CC vs. CT + TT:
TextSentencer_T81 11239-11385 Sentence denotes P < 0.00001) and the risk of influenza even increased 2.80-fold when comparing people with CC and TT genotypes in the homozygote model (CC vs. TT:
TextSentencer_T81 11239-11385 Sentence denotes P < 0.00001) and the risk of influenza even increased 2.80-fold when comparing people with CC and TT genotypes in the homozygote model (CC vs. TT:
TextSentencer_T82 11386-11399 Sentence denotes P < 0.00001).
TextSentencer_T82 11386-11399 Sentence denotes P < 0.00001).
TextSentencer_T83 11400-11448 Sentence denotes People infected with influenza during the period
TextSentencer_T83 11400-11448 Sentence denotes People infected with influenza during the period
TextSentencer_T84 11450-11537 Sentence denotes of viral circulation each year account for a large part of the entire population [27] .
TextSentencer_T84 11450-11537 Sentence denotes of viral circulation each year account for a large part of the entire population [27] .
TextSentencer_T85 11538-11748 Sentence denotes Most people just have moderate respiratory symptoms and can recover within a week; however, a small number of people can develop severe respiratory distress or other illnesses and even rare complications [28] .
TextSentencer_T85 11538-11748 Sentence denotes Most people just have moderate respiratory symptoms and can recover within a week; however, a small number of people can develop severe respiratory distress or other illnesses and even rare complications [28] .
TextSentencer_T86 11749-11822 Sentence denotes This variation in response may result from variation in host genes [29] .
TextSentencer_T86 11749-11822 Sentence denotes This variation in response may result from variation in host genes [29] .
TextSentencer_T87 11823-12016 Sentence denotes In the severe vs. mild group, we found people who carry the CC genotype are three times more likely to catch severe influenza than mild influenza compared with people carrying non-CC genotypes.
TextSentencer_T87 11823-12016 Sentence denotes In the severe vs. mild group, we found people who carry the CC genotype are three times more likely to catch severe influenza than mild influenza compared with people carrying non-CC genotypes.
TextSentencer_T88 12017-12072 Sentence denotes New discoveries are reflected in the subgroup analysis.
TextSentencer_T88 12017-12072 Sentence denotes New discoveries are reflected in the subgroup analysis.
TextSentencer_T89 12073-12236 Sentence denotes When the data were stratified by ethnicity, we found a significant association between the risk of the disease and rs12252 both in Asian and Caucasian populations.
TextSentencer_T89 12073-12236 Sentence denotes When the data were stratified by ethnicity, we found a significant association between the risk of the disease and rs12252 both in Asian and Caucasian populations.
TextSentencer_T90 12237-12508 Sentence denotes Four studies [21] [22] [23] [24] were included in the Asian group, double the number compared with the previous meta-analyses; and the results turned out to be significant in all four models, which showed rs12252-C increases the risk of influenza in the Asian population.
TextSentencer_T90 12237-12508 Sentence denotes Four studies [21] [22] [23] [24] were included in the Asian group, double the number compared with the previous meta-analyses; and the results turned out to be significant in all four models, which showed rs12252-C increases the risk of influenza in the Asian population.
TextSentencer_T91 12509-12625 Sentence denotes In the Caucasian subgroup, we found significant differences except in the dominant model (CC + CT vs. TT, P = 0.22).
TextSentencer_T91 12509-12625 Sentence denotes In the Caucasian subgroup, we found significant differences except in the dominant model (CC + CT vs. TT, P = 0.22).
TextSentencer_T92 12626-12788 Sentence denotes However, previous meta-analyses [15, 16] found no significant connection between the SNP and influenza in the allelic (C vs. T) and homozygote models (CC vs. TT).
TextSentencer_T92 12626-12788 Sentence denotes However, previous meta-analyses [15, 16] found no significant connection between the SNP and influenza in the allelic (C vs. T) and homozygote models (CC vs. TT).
TextSentencer_T93 12789-12864 Sentence denotes Hence, our results may be more convincing in explaining the role of Gene C.
TextSentencer_T93 12789-12864 Sentence denotes Hence, our results may be more convincing in explaining the role of Gene C.
TextSentencer_T94 12865-12933 Sentence denotes We also identified a new association by the degree of the infection.
TextSentencer_T94 12865-12933 Sentence denotes We also identified a new association by the degree of the infection.
TextSentencer_T95 12934-13079 Sentence denotes Neither of the meta-analyses of Yang et al. [16] and Xuan et al. [15] found any association between SNP rs12252 and patients with mild infection.
TextSentencer_T95 12934-13079 Sentence denotes Neither of the meta-analyses of Yang et al. [16] and Xuan et al. [15] found any association between SNP rs12252 and patients with mild infection.
TextSentencer_T96 13080-13188 Sentence denotes However, we found that people with rs12252-C are at higher risk of influenza compared with healthy controls.
TextSentencer_T96 13080-13188 Sentence denotes However, we found that people with rs12252-C are at higher risk of influenza compared with healthy controls.
TextSentencer_T97 13189-13458 Sentence denotes These discrepancies may be due to: (1) sample sizes were increased in our study; (2) control group data from the 1000 Genomes Project (http://www.internationalgenome.org) were updated in 2013; therefore, more controls were included in the improved 1000 Genomes Project.
TextSentencer_T97 13189-13458 Sentence denotes These discrepancies may be due to: (1) sample sizes were increased in our study; (2) control group data from the 1000 Genomes Project (http://www.internationalgenome.org) were updated in 2013; therefore, more controls were included in the improved 1000 Genomes Project.
TextSentencer_T98 13459-13631 Sentence denotes With more eligible articles and participants, there is more confidence in the conclusions from subgroup analysis. (3) Representation of ethnicity was improved in our study.
TextSentencer_T98 13459-13631 Sentence denotes With more eligible articles and participants, there is more confidence in the conclusions from subgroup analysis. (3) Representation of ethnicity was improved in our study.
TextSentencer_T99 13632-13757 Sentence denotes Previously, only a UK population was used to represent the Caucasian race, yet we added a Spanish population to the analysis.
TextSentencer_T99 13632-13757 Sentence denotes Previously, only a UK population was used to represent the Caucasian race, yet we added a Spanish population to the analysis.
TextSentencer_T100 13758-13836 Sentence denotes Similarly, we added people from other regions in China to improve reliability.
TextSentencer_T100 13758-13836 Sentence denotes Similarly, we added people from other regions in China to improve reliability.
TextSentencer_T101 13837-13916 Sentence denotes Our study included new studies that include African and Portuguese populations.
TextSentencer_T101 13837-13916 Sentence denotes Our study included new studies that include African and Portuguese populations.
TextSentencer_T102 13917-14061 Sentence denotes Although the number of relevant articles is not sufficient to draw conclusions for these two populations, it shows the importance of this topic.
TextSentencer_T102 13917-14061 Sentence denotes Although the number of relevant articles is not sufficient to draw conclusions for these two populations, it shows the importance of this topic.
TextSentencer_T103 14062-14189 Sentence denotes The heterogeneity of the four genetic models in our meta-analysis is low; however, slight heterogeneities exist (allelic model:
TextSentencer_T103 14062-14189 Sentence denotes The heterogeneity of the four genetic models in our meta-analysis is low; however, slight heterogeneities exist (allelic model:
TextSentencer_T104 14190-14216 Sentence denotes I 2 = 46%; dominant model:
TextSentencer_T104 14190-14216 Sentence denotes I 2 = 46%; dominant model:
TextSentencer_T105 14217-14244 Sentence denotes I 2 = 30%; recessive model:
TextSentencer_T105 14217-14244 Sentence denotes I 2 = 30%; recessive model:
TextSentencer_T106 14245-14273 Sentence denotes I 2 = 32%; homozygote model:
TextSentencer_T106 14245-14273 Sentence denotes I 2 = 32%; homozygote model:
TextSentencer_T107 14274-14285 Sentence denotes I 2 = 43%).
TextSentencer_T107 14274-14285 Sentence denotes I 2 = 43%).
TextSentencer_T108 14286-14791 Sentence denotes The following reasons may explain these findings: (1) genotyping methods were not exactly the same among the nine included articles, despite all of them using PCR for genotyping; (2) the source of the control group varied; although we tried to get the most comparable data with the case group, some studies used control group data from other databases; (3) varying types of influenza were involved in the meta-analysis; (4) differences in social demographic characteristics existed in our primary studies.
TextSentencer_T108 14286-14791 Sentence denotes The following reasons may explain these findings: (1) genotyping methods were not exactly the same among the nine included articles, despite all of them using PCR for genotyping; (2) the source of the control group varied; although we tried to get the most comparable data with the case group, some studies used control group data from other databases; (3) varying types of influenza were involved in the meta-analysis; (4) differences in social demographic characteristics existed in our primary studies.
TextSentencer_T109 14792-14946 Sentence denotes Random models were only used when data were stratified by degree of illness; heterogeneity was found in the severe subgroup, but not in the mild subgroup.
TextSentencer_T109 14792-14946 Sentence denotes Random models were only used when data were stratified by degree of illness; heterogeneity was found in the severe subgroup, but not in the mild subgroup.
TextSentencer_T110 14947-15055 Sentence denotes We consider that slight differences in the definition of the severe subgroup is one of the reasons for this.
TextSentencer_T110 14947-15055 Sentence denotes We consider that slight differences in the definition of the severe subgroup is one of the reasons for this.
TextSentencer_T111 15056-15182 Sentence denotes The definition of severe patients was similarly or clearly described as hospitalised patients in most of our eligible studies.
TextSentencer_T111 15056-15182 Sentence denotes The definition of severe patients was similarly or clearly described as hospitalised patients in most of our eligible studies.
TextSentencer_T112 15183-15341 Sentence denotes However, in our newly selected articles, patients with severe influenza in the study of López-Rodríguez et al. [19] were patients Epidemiology and Infection 7
TextSentencer_T112 15183-15341 Sentence denotes However, in our newly selected articles, patients with severe influenza in the study of López-Rodríguez et al. [19] were patients Epidemiology and Infection 7
TextSentencer_T113 15342-15503 Sentence denotes hospitalised with PVP, while in Pan et al. [22] , severe patients were described as those with severe acute respiratory infection with influenza virus infection.
TextSentencer_T113 15342-15503 Sentence denotes hospitalised with PVP, while in Pan et al. [22] , severe patients were described as those with severe acute respiratory infection with influenza virus infection.
TextSentencer_T114 15504-15569 Sentence denotes Furthermore, the larger sample size may contribute to the result.
TextSentencer_T114 15504-15569 Sentence denotes Furthermore, the larger sample size may contribute to the result.
TextSentencer_T115 15570-15728 Sentence denotes Although we tried our best to optimise our process, there are some limitations in our study. (1) Only nine English studies were included in our meta-analysis.
TextSentencer_T115 15570-15728 Sentence denotes Although we tried our best to optimise our process, there are some limitations in our study. (1) Only nine English studies were included in our meta-analysis.
TextSentencer_T116 15729-16040 Sentence denotes For instance, although we found some eligible studies based on the title and abstract, we had to exclude a study because it was published in Russian; (2) most of the included studies were on Asian and Caucasian populations, while only one study included Portuguese [25] and one studied African [20] populations.
TextSentencer_T116 15729-16040 Sentence denotes For instance, although we found some eligible studies based on the title and abstract, we had to exclude a study because it was published in Russian; (2) most of the included studies were on Asian and Caucasian populations, while only one study included Portuguese [25] and one studied African [20] populations.
TextSentencer_T117 16041-16606 Sentence denotes More studies in different ethnic groups are needed; (3) the definitions of severe influenza in the eligible studies are not exactly the same, which may increase the heterogeneity of our meta-analysis; (4) different kinds of influenza are analysed together which may contribute to the heterogeneity; (5) some studies were multi-arm studies, in subgroup meta-analysis was classified according to degree of patients symptoms; however, the data of control group were repeatedly used, which would enlarge the sample size by mistake and increase the risk of type I error.
TextSentencer_T117 16041-16606 Sentence denotes More studies in different ethnic groups are needed; (3) the definitions of severe influenza in the eligible studies are not exactly the same, which may increase the heterogeneity of our meta-analysis; (4) different kinds of influenza are analysed together which may contribute to the heterogeneity; (5) some studies were multi-arm studies, in subgroup meta-analysis was classified according to degree of patients symptoms; however, the data of control group were repeatedly used, which would enlarge the sample size by mistake and increase the risk of type I error.
TextSentencer_T118 16607-16734 Sentence denotes In conclusion, our meta-analysis indicates significant association between rs12252 and not only severe but also mild influenza.
TextSentencer_T118 16607-16734 Sentence denotes In conclusion, our meta-analysis indicates significant association between rs12252 and not only severe but also mild influenza.
TextSentencer_T119 16735-16834 Sentence denotes Meanwhile, Asians and Caucasians carrying the C allele are more susceptible to influenza infection.
TextSentencer_T119 16735-16834 Sentence denotes Meanwhile, Asians and Caucasians carrying the C allele are more susceptible to influenza infection.
TextSentencer_T120 16835-16992 Sentence denotes The challenge we met was about the extraction of data of 1000 Genomes Project; fortunately, finally we extracted the data with the help of Huada Corporation.
TextSentencer_T120 16835-16992 Sentence denotes The challenge we met was about the extraction of data of 1000 Genomes Project; fortunately, finally we extracted the data with the help of Huada Corporation.
TextSentencer_T121 16993-17482 Sentence denotes By including recent high-quality data, we provide a reasonable biological reference for further prevention and control strategies; however, some challenges of our results still exist, which were mainly reflected in the limitations discussed in our paper; if more original articles were included, and more subgroup analyses were carried out according to sexes, ages or virus strains, the result would be better; due to the limitations in our meta-analysis, further studies are still needed.
TextSentencer_T121 16993-17482 Sentence denotes By including recent high-quality data, we provide a reasonable biological reference for further prevention and control strategies; however, some challenges of our results still exist, which were mainly reflected in the limitations discussed in our paper; if more original articles were included, and more subgroup analyses were carried out according to sexes, ages or virus strains, the result would be better; due to the limitations in our meta-analysis, further studies are still needed.
TextSentencer_T122 17483-17501 Sentence denotes Financial support.
TextSentencer_T122 17483-17501 Sentence denotes Financial support.
TextSentencer_T123 17502-17703 Sentence denotes This study was supported by the National Mega-projects for Infectious Diseases (2014ZX10004001 to YS) and grants from the National Science Fund for Distinguished Young Scholars (grant number 81525017).
TextSentencer_T123 17502-17703 Sentence denotes This study was supported by the National Mega-projects for Infectious Diseases (2014ZX10004001 to YS) and grants from the National Science Fund for Distinguished Young Scholars (grant number 81525017).
TextSentencer_T124 17704-17725 Sentence denotes Conflict of interest.
TextSentencer_T124 17704-17725 Sentence denotes Conflict of interest.
TextSentencer_T125 17726-17731 Sentence denotes None.
TextSentencer_T125 17726-17731 Sentence denotes None.