| T34310 |
0-647 |
Sentence |
denotes |
Here, we present a novel model for chronic "complex" EAE associated with well defined multiple pathogenic anti-myelin autoreactivities induced in (SJL/JxC57Bl/6J)F1 mice by immunization with the "mouse multi-epitope encephalitogenic protein" (mMEP), a protein product of synthetic gene encoding in tandem only the disease-related epitopes of MBP, PLP, MOG, MOBP and OSP. "Complex" EAE induced by mMEP is associated with pathogenic autoreactivities against multiple myelin antigens that result in severe chronic clinical manifestation, accompanied by massive inflammation, extensive demyelination and neuronal damage in the CNS and the optic nerve. |
