| Id |
Subject |
Object |
Predicate |
Lexical cue |
| BEL:20034564 |
935-1133 |
complex(p(MGI:Il23a),p(MGI:Il1b)) decreases r(MGI:Tbx21) |
denotes |
: In CD4+ T cells from naive DBA/1 mice, IL-23 alone hardly induced retinoic acid-related orphan receptor gammat (RORgammat), Th17 polarization, and Th17 cytokines, but it inhibited T-bet expression |
| BEL:20034550 |
1291-1427 |
complex(p(MGI:Il12b),p(MGI:Il23a)) increases r(MGI:Il22) |
denotes |
In contrast to TGFbeta1/IL-6, IL-23 was critical for the induction of IL-22 in CD4+ T cells from both naive and CII-immunized DBA/1 mice |
| BEL:20034538 |
1574-1884 |
complex(p(MGI:Il12b),p(MGI:Il23a)) decreases r(MGI:Foxp3) |
denotes |
However, in CD4+ T cells from naive mice, IL-23 significantly increased the TGFbeta1/IL-6-induced Th17 polarization, including elevated levels of IL-17A and IL-17F and decreased expression of T-bet and FoxP3. Of note, the IL-23-induced increase in IL-17A and IL-17F levels was prevented in T-bet-deficient mice |
| BEL:20034542 |
1574-1884 |
complex(p(MGI:Il12b),p(MGI:Il23a)) increases r(MGI:Il17a) |
denotes |
However, in CD4+ T cells from naive mice, IL-23 significantly increased the TGFbeta1/IL-6-induced Th17 polarization, including elevated levels of IL-17A and IL-17F and decreased expression of T-bet and FoxP3. Of note, the IL-23-induced increase in IL-17A and IL-17F levels was prevented in T-bet-deficient mice |
| BEL:20034546 |
1574-1884 |
complex(p(MGI:Il12b),p(MGI:Il23a)) increases r(MGI:Il17f) |
denotes |
However, in CD4+ T cells from naive mice, IL-23 significantly increased the TGFbeta1/IL-6-induced Th17 polarization, including elevated levels of IL-17A and IL-17F and decreased expression of T-bet and FoxP3. Of note, the IL-23-induced increase in IL-17A and IL-17F levels was prevented in T-bet-deficient mice |
