asco@alo33:164600 JSONTXT

Background: Young rectum presents a peculiar situation ith patients presenting ith adverse histologies and more advanced stage hen compared to older rectal cancer patients. Methods: We evaluated patient records of young carcinoma rectum[less than 35 years] treated radically in our unit in the department of Radiotherapy from 2007 to 2013.Patients ith early stage disease ere taken up for upfront surgery, Patients ith locally advanced disease underent surgery after short course of radiation 25 Gray in 5 fractions or after the long course radio-chemotherapy 45 Gray in 25 fractions ith concurrent capecitabine.Adjuvant chemotherapy capecitabine plus oxalliplatinx002A;6 cycles after preoperative radio or radio-chemotherapy as planned as planned for patients ith high risk feature T4 primary, node positive, margin positive .Progression free survival PFS as calculated from the time to progression or death. Kaplan Meier method as used for survival analysis. Results: A total of 38 patients of young rectal cancer ere registered during this period. Family history of cancer as present in 2 patients. Median age at presentation as 27 years [range 16-34]. Male to female ratio as 1.23:1. The median karnofsky performance status as 70[range 30-100]. 29 [76.3 percent] patients presented in advanced stage of the disease stage III and IV . Mucinous, signet, and other poor risk histology as seen in 19 [50 percent] patients. Median CEA as 12.6 [range 0.9-200]. 34 89.5 percent patients recieved radiotherapy 24 patients preop and 10 patients postop and 24 patients recieved adjuvant radiotherapy. Median follo-up as 10 months. 9 patients had progression of disease. Distant metastasis as the most common type of failure seen in 7 [77.7 percent] patients. The 1 yearand 3 year progression free survival [PFS] as 74.1 percent and 57.1 percent respectively. Conclusions: There is a higher proportion of poor histology subtypes among young rectal cancer patients hen compared to adult patients. The high incidence of poor histological subtypesconfer poor prognosis these patients.,J Clin Oncol 34, 2016 suppl; abstr e15151 ,Publication Only Gastrointestinal Colorectal Cancer