asco@alo33:162299
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Background: Mutational status in colorectal cancer CRC impacts response to EGFR inhibition, prognosis, and may affect response to chemoradiation. It is unclear if obesity or other clinical characteristics, including smoking and diabetes, increases the predilection for certain genotypes. The purpose of the folloing study as to explore the relationship beteen clinical factors, codon-specific mutations and overall survival OS . Methods: Metastatic colorectal cancer patients ere retrospectively analyzed; clinical characteristics including smoking, diabetes, and body mass index BMI ere extracted from medical records. Genotyping as performed for 150 mutations across 15 commonly mutated cancer genes including NRAS, KRAS, PIK3CA, BRAF, and PTEN as part of their clinical management and recorded. Logistic regression as used to establish associations beteen clinical characteristics and genotypes. Results: 394 metastatic CRC patients ere identified. Median age as 58 range 25-89 . 219 56 percent ere male. 202 51 percent ere non-smokers. 61 had diabetes. 272 patients had a BMI 25. 136 patients had KRAS mutations, the most common of hich as G12D 37 percent . Diabetes as associated ith a higher incidence of KRAS odds ratio [OR] 1.9 95 percent CI 1.1-1.3; p = 0.02 and PIK3CA mutations OR 2.4 95 percent CI 1.1-5.0; p = 0.02 , but not OS. KRAS mutations ere not significantly associated ith BMI 25 nor OS. BRAF mutations ere significantly associated ith poorer OS hazard ratio [HR] 1.9 95 percent CI 1.3-2.7; p lt 0.001 . Current smokers ere more likely to have CTNNB1 mutations OR 11.3 95 percent CI 1.5-83.2; p = 0.02 and G12D KRAS mutations OR 5.6 95 percent CI 1.0-30.3 . Current smokers ere less likely to have BMI 25 OR 0.44; p = 0.02 . Patients ith BMI x2264; 18.5 have an association ith poor OS HR 2.6 95 percent CI 1.1-6.4; p = 0.03 , although this needs to be corroborated ith a larger sample size. Conclusions: A statistically significant association as found beteen diabetes and KRAS and PIK3CA mutations. The association of BRAF mutations and decreased overall survival as significant, concordant ith previous reports. Smokers ere more likely to harbor G12D KRAS mutations, and lo BMI x2264; 18.5 trended toard poorer overall survival.,J Clin Oncol 34, 2016 suppl; abstr 3596 00:00.0,Gastrointestinal Colorectal Cancer
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