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Background: Nipple-sparing mastectomy NSM improved patientsx2019; mental and aesthetics results and shoed safe oncologic outcomes. Hoever, there ere still controversies about the indications for NSM, especially tumor-to-nipple distance TND and multicentricity and there as limited evidence about predictive factors of local recurrence LR . Methods: A systematic revie as conducted according to the PRISMA guidelines. Studies reported on the association of TND or multicentricity and occult NAC involvement ere included in the meta-analysis. Studies reported on TND or multicentricity and LR in the setting of NSM ere included in the systematic revie. We computed the Relative Risks RRs ith 95 percent confidence intervals CIs from the original studies. Results: 1544 articles ere identified from electronic search. Ultimately, seventeen clinical studies published from 1985 to 2015 ith 4099 patients met selection criteria. Seven studies reported TND and occult NAC involvement. The Relative Risk RR for the groups of x201C;TND 1cmx201D;, x201C;TND 2cmx201D;, x201C;TND 3cmx201D; and x201C;TND 4cmx201D; ere 7.95,3.79, 2.71 and 3.43 respectively and the outcomes ere all statistically significant. Six studies reported multicentricity and occult NAC involvement and shoed no statistically significant difference. Eight studies reported specific inclusion criteria for TND in patients underent NSM ere included in the systematic revie. Studies of TND 1cm and TND 2cm had mean LR rate of 3.3 percent and 5.3 percent respectively. Conclusions: This meta-analysis and systematic revie shoed that TND = 1cm could be considered as a cutoff to select NSM candidates for decreasing risk of occult NAC involvement. Besides, selecting patients of TND 1cm or TND 2cm for NSM may not increase LR. We also found that multicentricity as not associated ith occult NAC involvement.,J Clin Oncol 34, 2016 suppl; abstr 1041 00:00.0,Breast CancerTriple-NegativeCytotoxicsLocal Therapy
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