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Background: Microphthalmia Transcription Factor Mitf plays a central role in melanocyte maturation and differentiation, as ell as tumorigenesis. We previously proved that Mitf expression of lt 50 percent Mitf lt 50 in primary melanoma can serve as a predictor of lymphatic dissemination. In this prospective study e aim to further assess the value of Mitf expression in the primary tumor, and hether it can serve as a predictor of hematogenous spread, hence a predictor of distant metastatic formation in cutaneous melanoma. Methods: This is a prospective study including 171 patients diagnosed ith primary cutaneous melanoma. All patients underent resection of the primary tumor ith either lymph node biopsies or dissections. Mitf expression in the primary melanoma as assessed via immunohistochemistry. Disease Free Survival DFS and Overall Survival OS curves ere generated using the Kaplan-Meier method. Mitf lt 50 as tested as an independent factor against age, location, histology, and thickness in a multivariate logistic regression model to predict distant metastasis. Results: 100 patients had Mitf lt 50 58.5 percent hereas 71 had Mitf 50 41.5 percent . Patients ith Mitf lt 50 had a significantly higher rate of distant metastases compared to those ho had Mitf 50 42 percent vs. 11.3 percent; p lt 0.0001 , and significantly shorter DFS 25.8 20.4 vs. 39.3 29.5 months; p lt 0.0001 and OS 32.2 22.2 vs. 41.0 31.1 months; p = 0.042 . In a multivariate logistic regression analysis, Mitf lt 50 as shon to be a significant predictor of distant metastatic disease, along ith thickness and dysplastic pathology. Conclusions: Mitf lt 50 in primary melanoma can serve as a predictor of hematogenous spread. The high expression of this molecular marker in the primary tumor is validated to be a favorable prognosticator of DFS and OS.,J Clin Oncol 34, 2016 suppl; abstr 9564 00:00.0,MelanomaSkin Cancers
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