PubMed:9988768
Annnotations
ggdb-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 356-361 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T2 | 557-562 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T3 | 597-604 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| T4 | 597-602 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T5 | 606-611 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T6 | 620-625 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T7 | 990-997 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| T8 | 990-995 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T9 | 999-1004 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T10 | 1013-1018 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T11 | 1220-1225 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T12 | 1233-1238 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T13 | 1338-1343 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T14 | 1425-1432 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| T15 | 1425-1430 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T16 | 1437-1442 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T17 | 1463-1470 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| T18 | 1463-1468 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T19 | 1475-1480 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T20 | 1596-1603 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| T21 | 1596-1601 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T22 | 1656-1661 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
GGDB-2020
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 356-361 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T2 | 557-562 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T3 | 597-604 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| T4 | 597-602 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T5 | 606-611 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T6 | 620-625 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T7 | 990-997 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| T8 | 990-995 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T9 | 999-1004 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T10 | 1013-1018 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T11 | 1220-1225 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T12 | 1233-1238 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T13 | 1338-1343 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T14 | 1425-1432 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| T15 | 1425-1430 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T16 | 1437-1442 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T17 | 1463-1470 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| T18 | 1463-1468 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T19 | 1475-1480 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T20 | 1596-1603 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| T21 | 1596-1601 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| T22 | 1656-1661 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-113 | Sentence | denotes | Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. |
| T2 | 114-233 | Sentence | denotes | The 3-O-sulfation of glucosamine residues is an important modification during the biosynthesis of heparan sulfate (HS). |
| T3 | 234-485 | Sentence | denotes | Our previous studies have led us to purify and molecularly clone the heparan sulfate D-glucosaminyl 3-O-sulfotransferase (3-OST-1), which is the key enzyme converting nonanticoagulant heparan sulfate (HSinact) to anticoagulant heparan sulfate (HSact). |
| T4 | 486-680 | Sentence | denotes | In this study, we expressed and characterized the full-length cDNAs of 3-OST-1 homologous genes, designated as 3-OST-2, 3-OST-3A, and 3-OST-3B as described in the accompanying paper (Shworak, N. |
| T5 | 681-704 | Sentence | denotes | W., Liu, J., Petros, L. |
| T6 | 705-747 | Sentence | denotes | M., Zhang, L., Kobayashi, M., Copeland, N. |
| T7 | 748-763 | Sentence | denotes | G., Jenkins, N. |
| T8 | 764-785 | Sentence | denotes | A., and Rosenberg, R. |
| T9 | 786-798 | Sentence | denotes | D. (1999) J. |
| T10 | 799-804 | Sentence | denotes | Biol. |
| T11 | 805-810 | Sentence | denotes | Chem. |
| T12 | 811-827 | Sentence | denotes | 274, 5170-5184). |
| T13 | 828-968 | Sentence | denotes | All these cDNAs were successfully expressed in COS-7 cells, and heparan sulfate sulfotransferase activities were found in the cell extracts. |
| T14 | 969-1219 | Sentence | denotes | We demonstrated that 3-OST-2, 3-OST-3A, and 3-OST-3B are heparan sulfate D-glucosaminyl 3-O-sulfotransferases because the enzymes transfer sulfate from adenosine 3'-phosphophate 5'-phospho-[35S]sulfate ([35S]PAPS) to the 3-OH position of glucosamine. |
| T15 | 1220-1276 | Sentence | denotes | 3-OST-3A and 3-OST-3B sulfate an identical disaccharide. |
| T16 | 1277-1502 | Sentence | denotes | HSact conversion activity in the cell extract transfected by 3-OST-1 was shown to be 300-fold greater than that in the cell extracts transfected by 3-OST-2 and 3-OST-3A, suggesting that 3-OST-2 and 3-OST-3A do not make HSact. |
| T17 | 1503-1699 | Sentence | denotes | The results of the disaccharide analysis of the nitrous acid-degraded [35S]HS suggested that 3-OST-2 transfers sulfate to GlcA2S-GlcNS and IdoA2S-GlcNS; 3-OST-3A transfers sulfate to IdoA2S-GlcNS. |
| T18 | 1700-1876 | Sentence | denotes | Our results demonstrate that the 3-O-sulfation of glucosamine is generated by different isoforms depending on the saccharide structures around the modified glucosamine residue. |
| T19 | 1877-2030 | Sentence | denotes | This discovery has provided evidence for a new cellular mechanism for generating a defined saccharide sequence in structurally complex HS polysaccharide. |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 14-29 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T2 | 212-227 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T3 | 229-231 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
| T4 | 303-318 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T5 | 418-433 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T6 | 461-476 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T7 | 892-907 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T8 | 1026-1041 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T9 | 1578-1580 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
| T10 | 2012-2014 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | HS |
glycogenes
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoGenes20190927-B_T1 | 356-361 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T2 | 557-562 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T3 | 583-593 | url | denotes | designated |
| PD-GlycoGenes20190927-B_T4 | 597-604 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| PD-GlycoGenes20190927-B_T5 | 597-602 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T6 | 606-611 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T7 | 620-625 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T8 | 990-997 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| PD-GlycoGenes20190927-B_T9 | 990-995 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T10 | 999-1004 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T11 | 1013-1018 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T12 | 1220-1225 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T13 | 1233-1238 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T14 | 1338-1343 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T15 | 1425-1432 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| PD-GlycoGenes20190927-B_T16 | 1425-1430 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T17 | 1437-1442 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T18 | 1463-1470 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| PD-GlycoGenes20190927-B_T19 | 1463-1468 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T20 | 1475-1480 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T21 | 1596-1603 | https://acgg.asia/db/ggdb/info/gg015 | denotes | 3-OST-2 |
| PD-GlycoGenes20190927-B_T22 | 1596-1601 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T23 | 1656-1661 | https://acgg.asia/db/ggdb/info/gg014 | denotes | 3-OST |
| PD-GlycoGenes20190927-B_T24 | 1892-1895 | https://acgg.asia/db/ggdb/info/gg135 | denotes | has |