PubMed:9854680 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":18,"end":41},"obj":"protein"},{"id":"T2","span":{"begin":87,"end":114},"obj":"cell_type"},{"id":"T3","span":{"begin":127,"end":151},"obj":"protein"},{"id":"T4","span":{"begin":153,"end":155},"obj":"protein"},{"id":"T5","span":{"begin":220,"end":242},"obj":"cell_type"},{"id":"T6","span":{"begin":244,"end":247},"obj":"cell_type"},{"id":"T7","span":{"begin":447,"end":450},"obj":"cell_type"},{"id":"T8","span":{"begin":1348,"end":1350},"obj":"protein"},{"id":"T9","span":{"begin":1555,"end":1557},"obj":"protein"},{"id":"T10","span":{"begin":1578,"end":1581},"obj":"cell_type"}],"text":"The modulation of glucocorticoid receptor content by 3-O-methyl-D-glucose transport in human mononuclear leukocyte in obesity.\nGlucocorticoid receptors (GR) and 3-O-methyl-D glucose (3-O-MG) transport were determined in mononuclear leukocytes (MNL) from 11 abdominal obese subjects, 10 pituitary-dependent Cushing's syndrome (Cushing's disease) and 10 healthy controls. Using a whole-cell competitive binding assay and 3H-dexamethasone as tracer, MNL of abdominal obese subjects were found to have 4855 +/- 1389 sites/cell which was significantly lower (p \u003c 0.05) than controls (6234 +/- 1568 sites/cell), although no significant difference was found in the mean serum cortisol level. Their mean Kd (affinity) was also significantly lower than that found in the healthy controls (obese Kd:2.92 +/- 0.84 nmol/l, control Kd: 4.55 +/- 0.67 nM, p \u003c 0.05). On the other hand, the receptor characteristics in Cushing's disease patients were within the normal range. At the same time, 3-O-MG transport was determined in the same subjects. In Cushing's disease, 3-O-MG transport was within the normal range, whereas in abdominal obesity this value was significantly lower than the healthy controls (abdominal obese: 31.90 +/- 8.20; control: 46.26 +/- 12.91 fmol/10(6) cell, min, p \u003c 0.05). We also found a positive correlation between 3-O-MG transport and GR binding capacity in abdominal subjects (r = 0.89, p \u003c 0.001), however we did not find such a correlation in Cushing's disease (r = 0.60, p \u003e 0.05). These results indicated that, in abdominal obesity, the GR binding capacity in MNL is influenced by the changes in glucose transport."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":126},"obj":"Sentence"},{"id":"S2","span":{"begin":127,"end":369},"obj":"Sentence"},{"id":"S3","span":{"begin":370,"end":684},"obj":"Sentence"},{"id":"S4","span":{"begin":685,"end":851},"obj":"Sentence"},{"id":"S5","span":{"begin":852,"end":959},"obj":"Sentence"},{"id":"S6","span":{"begin":960,"end":1031},"obj":"Sentence"},{"id":"S7","span":{"begin":1032,"end":1281},"obj":"Sentence"},{"id":"S8","span":{"begin":1282,"end":1498},"obj":"Sentence"},{"id":"S9","span":{"begin":1499,"end":1632},"obj":"Sentence"}],"text":"The modulation of glucocorticoid receptor content by 3-O-methyl-D-glucose transport in human mononuclear leukocyte in obesity.\nGlucocorticoid receptors (GR) and 3-O-methyl-D glucose (3-O-MG) transport were determined in mononuclear leukocytes (MNL) from 11 abdominal obese subjects, 10 pituitary-dependent Cushing's syndrome (Cushing's disease) and 10 healthy controls. Using a whole-cell competitive binding assay and 3H-dexamethasone as tracer, MNL of abdominal obese subjects were found to have 4855 +/- 1389 sites/cell which was significantly lower (p \u003c 0.05) than controls (6234 +/- 1568 sites/cell), although no significant difference was found in the mean serum cortisol level. Their mean Kd (affinity) was also significantly lower than that found in the healthy controls (obese Kd:2.92 +/- 0.84 nmol/l, control Kd: 4.55 +/- 0.67 nM, p \u003c 0.05). On the other hand, the receptor characteristics in Cushing's disease patients were within the normal range. At the same time, 3-O-MG transport was determined in the same subjects. In Cushing's disease, 3-O-MG transport was within the normal range, whereas in abdominal obesity this value was significantly lower than the healthy controls (abdominal obese: 31.90 +/- 8.20; control: 46.26 +/- 12.91 fmol/10(6) cell, min, p \u003c 0.05). We also found a positive correlation between 3-O-MG transport and GR binding capacity in abdominal subjects (r = 0.89, p \u003c 0.001), however we did not find such a correlation in Cushing's disease (r = 0.60, p \u003e 0.05). These results indicated that, in abdominal obesity, the GR binding capacity in MNL is influenced by the changes in glucose transport."}

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