PubMed:9834081 JSONTXT

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    jnlpba-st-training

    {"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":35,"end":61},"obj":"protein"},{"id":"T2","span":{"begin":87,"end":98},"obj":"DNA"},{"id":"T3","span":{"begin":106,"end":138},"obj":"DNA"},{"id":"T4","span":{"begin":140,"end":144},"obj":"protein"},{"id":"T5","span":{"begin":159,"end":166},"obj":"cell_type"},{"id":"T6","span":{"begin":209,"end":218},"obj":"protein"},{"id":"T7","span":{"begin":325,"end":348},"obj":"protein"},{"id":"T8","span":{"begin":350,"end":355},"obj":"protein"},{"id":"T9","span":{"begin":362,"end":382},"obj":"protein"},{"id":"T10","span":{"begin":403,"end":407},"obj":"protein"},{"id":"T11","span":{"begin":411,"end":420},"obj":"protein"},{"id":"T12","span":{"begin":542,"end":568},"obj":"DNA"},{"id":"T13","span":{"begin":570,"end":573},"obj":"DNA"},{"id":"T14","span":{"begin":593,"end":602},"obj":"DNA"},{"id":"T15","span":{"begin":637,"end":641},"obj":"protein"},{"id":"T16","span":{"begin":686,"end":690},"obj":"protein"},{"id":"T17","span":{"begin":715,"end":724},"obj":"protein"},{"id":"T18","span":{"begin":762,"end":767},"obj":"protein"},{"id":"T19","span":{"begin":771,"end":780},"obj":"protein"},{"id":"T20","span":{"begin":786,"end":795},"obj":"DNA"},{"id":"T21","span":{"begin":825,"end":829},"obj":"protein"},{"id":"T22","span":{"begin":831,"end":840},"obj":"protein"},{"id":"T23","span":{"begin":858,"end":870},"obj":"protein"},{"id":"T24","span":{"begin":885,"end":888},"obj":"protein"},{"id":"T25","span":{"begin":893,"end":896},"obj":"protein"},{"id":"T26","span":{"begin":939,"end":944},"obj":"protein"},{"id":"T27","span":{"begin":966,"end":970},"obj":"protein"},{"id":"T28","span":{"begin":974,"end":983},"obj":"protein"},{"id":"T29","span":{"begin":1025,"end":1043},"obj":"protein"},{"id":"T30","span":{"begin":1069,"end":1074},"obj":"protein"},{"id":"T31","span":{"begin":1194,"end":1199},"obj":"protein"}],"text":"Signaling pathways mediated by the TNF- and cytokine-receptor families target a common cis-element of the IFN regulatory factor 1 promoter.\nCD40 activation of B cells is strongly influenced by the presence of cytokines. However, the molecular basis for the interplay between these distinct stimuli is not clearly delineated. IFN regulatory factor 1 (IRF-1) is a transcription factor activated by either CD40 or cytokines. We have found that these different sets of signals target a common cis-acting element in the promoter of this gene, the IRF-1 gamma-activated site (GAS). Targeting of the IRF-1 GAS is not confined to activation via CD40 but extends to other stimuli that mimic the CD40 signaling cascade, like TNF-alpha and EBV. In contrast to induction of STATs by cytokines, the IRF-1 GAS-binding complex activated by CD40, TNF-alpha, or EBV contains Rel proteins, specifically p50 and p65. In this system, simultaneous exposure to CD40L together with either IL-4 or IFN-gamma does not lead to the activation of novel Rel/STAT complexes. Given the importance of IRF-1 in a variety of biologic functions from proliferation to apoptosis, our findings support the notion that modulation of IRF-1 levels may be a critical control point in B cell activation."}

    pubmed-sentences-benchmark

    {"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":139},"obj":"Sentence"},{"id":"S2","span":{"begin":140,"end":219},"obj":"Sentence"},{"id":"S3","span":{"begin":220,"end":324},"obj":"Sentence"},{"id":"S4","span":{"begin":325,"end":421},"obj":"Sentence"},{"id":"S5","span":{"begin":422,"end":575},"obj":"Sentence"},{"id":"S6","span":{"begin":576,"end":733},"obj":"Sentence"},{"id":"S7","span":{"begin":734,"end":897},"obj":"Sentence"},{"id":"S8","span":{"begin":898,"end":1044},"obj":"Sentence"},{"id":"S9","span":{"begin":1045,"end":1260},"obj":"Sentence"}],"text":"Signaling pathways mediated by the TNF- and cytokine-receptor families target a common cis-element of the IFN regulatory factor 1 promoter.\nCD40 activation of B cells is strongly influenced by the presence of cytokines. However, the molecular basis for the interplay between these distinct stimuli is not clearly delineated. IFN regulatory factor 1 (IRF-1) is a transcription factor activated by either CD40 or cytokines. We have found that these different sets of signals target a common cis-acting element in the promoter of this gene, the IRF-1 gamma-activated site (GAS). Targeting of the IRF-1 GAS is not confined to activation via CD40 but extends to other stimuli that mimic the CD40 signaling cascade, like TNF-alpha and EBV. In contrast to induction of STATs by cytokines, the IRF-1 GAS-binding complex activated by CD40, TNF-alpha, or EBV contains Rel proteins, specifically p50 and p65. In this system, simultaneous exposure to CD40L together with either IL-4 or IFN-gamma does not lead to the activation of novel Rel/STAT complexes. Given the importance of IRF-1 in a variety of biologic functions from proliferation to apoptosis, our findings support the notion that modulation of IRF-1 levels may be a critical control point in B cell activation."}

    genia-medco-coref

    {"project":"genia-medco-coref","denotations":[{"id":"C2","span":{"begin":102,"end":138},"obj":"NP"},{"id":"C1","span":{"begin":78,"end":138},"obj":"NP"},{"id":"C3","span":{"begin":209,"end":218},"obj":"NP"},{"id":"C4","span":{"begin":325,"end":356},"obj":"NP"},{"id":"C5","span":{"begin":403,"end":407},"obj":"NP"},{"id":"C6","span":{"begin":411,"end":420},"obj":"NP"},{"id":"C9","span":{"begin":527,"end":536},"obj":"NP"},{"id":"C8","span":{"begin":511,"end":536},"obj":"NP"},{"id":"C7","span":{"begin":480,"end":536},"obj":"NP"},{"id":"C10","span":{"begin":538,"end":574},"obj":"NP"},{"id":"C11","span":{"begin":589,"end":602},"obj":"NP"},{"id":"C12","span":{"begin":637,"end":641},"obj":"NP"},{"id":"C13","span":{"begin":657,"end":670},"obj":"NP"},{"id":"C14","span":{"begin":671,"end":675},"obj":"NP"},{"id":"C15","span":{"begin":715,"end":724},"obj":"NP"},{"id":"C16","span":{"begin":729,"end":732},"obj":"NP"},{"id":"C17","span":{"begin":771,"end":780},"obj":"NP"},{"id":"C18","span":{"begin":825,"end":829},"obj":"NP"},{"id":"C19","span":{"begin":831,"end":840},"obj":"NP"},{"id":"C20","span":{"begin":845,"end":848},"obj":"NP"},{"id":"C21","span":{"begin":1069,"end":1074},"obj":"NP"},{"id":"C22","span":{"begin":1164,"end":1174},"obj":"NP"},{"id":"C23","span":{"begin":1175,"end":1179},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C6","obj":"C3"},{"id":"R2","pred":"coref-ident","subj":"C9","obj":"C4"},{"id":"R3","pred":"coref-ident","subj":"C8","obj":"C2"},{"id":"R4","pred":"coref-ident","subj":"C7","obj":"C1"},{"id":"R5","pred":"coref-appos","subj":"C10","obj":"C7"},{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C7"},{"id":"R7","pred":"coref-ident","subj":"C12","obj":"C5"},{"id":"R8","pred":"coref-relat","subj":"C14","obj":"C13"},{"id":"R9","pred":"coref-ident","subj":"C17","obj":"C6"},{"id":"R10","pred":"coref-ident","subj":"C18","obj":"C12"},{"id":"R11","pred":"coref-ident","subj":"C19","obj":"C15"},{"id":"R12","pred":"coref-ident","subj":"C20","obj":"C16"},{"id":"R13","pred":"coref-ident","subj":"C21","obj":"C9"},{"id":"R14","pred":"coref-relat","subj":"C23","obj":"C22"}],"text":"Signaling pathways mediated by the TNF- and cytokine-receptor families target a common cis-element of the IFN regulatory factor 1 promoter.\nCD40 activation of B cells is strongly influenced by the presence of cytokines. However, the molecular basis for the interplay between these distinct stimuli is not clearly delineated. IFN regulatory factor 1 (IRF-1) is a transcription factor activated by either CD40 or cytokines. We have found that these different sets of signals target a common cis-acting element in the promoter of this gene, the IRF-1 gamma-activated site (GAS). Targeting of the IRF-1 GAS is not confined to activation via CD40 but extends to other stimuli that mimic the CD40 signaling cascade, like TNF-alpha and EBV. In contrast to induction of STATs by cytokines, the IRF-1 GAS-binding complex activated by CD40, TNF-alpha, or EBV contains Rel proteins, specifically p50 and p65. In this system, simultaneous exposure to CD40L together with either IL-4 or IFN-gamma does not lead to the activation of novel Rel/STAT complexes. Given the importance of IRF-1 in a variety of biologic functions from proliferation to apoptosis, our findings support the notion that modulation of IRF-1 levels may be a critical control point in B cell activation."}

    GENIAcorpus

    {"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":18},"obj":"other_name"},{"id":"T2","span":{"begin":87,"end":98},"obj":"DNA_domain_or_region"},{"id":"T3","span":{"begin":106,"end":138},"obj":"DNA_domain_or_region"},{"id":"T4","span":{"begin":140,"end":144},"obj":"protein_molecule"},{"id":"T5","span":{"begin":159,"end":166},"obj":"cell_type"},{"id":"T6","span":{"begin":209,"end":218},"obj":"protein_family_or_group"},{"id":"T7","span":{"begin":325,"end":348},"obj":"protein_molecule"},{"id":"T8","span":{"begin":350,"end":355},"obj":"protein_molecule"},{"id":"T9","span":{"begin":362,"end":382},"obj":"protein_family_or_group"},{"id":"T10","span":{"begin":403,"end":407},"obj":"protein_molecule"},{"id":"T11","span":{"begin":411,"end":420},"obj":"protein_family_or_group"},{"id":"T12","span":{"begin":542,"end":547},"obj":"protein_molecule"},{"id":"T13","span":{"begin":570,"end":573},"obj":"DNA_domain_or_region"},{"id":"T14","span":{"begin":593,"end":602},"obj":"DNA_domain_or_region"},{"id":"T15","span":{"begin":637,"end":641},"obj":"protein_molecule"},{"id":"T16","span":{"begin":686,"end":690},"obj":"protein_molecule"},{"id":"T17","span":{"begin":715,"end":724},"obj":"protein_molecule"},{"id":"T18","span":{"begin":729,"end":732},"obj":"virus"},{"id":"T19","span":{"begin":762,"end":767},"obj":"protein_family_or_group"},{"id":"T20","span":{"begin":771,"end":780},"obj":"protein_family_or_group"},{"id":"T21","span":{"begin":786,"end":795},"obj":"DNA_domain_or_region"},{"id":"T22","span":{"begin":825,"end":829},"obj":"protein_molecule"},{"id":"T23","span":{"begin":831,"end":840},"obj":"protein_molecule"},{"id":"T24","span":{"begin":845,"end":848},"obj":"virus"},{"id":"T25","span":{"begin":858,"end":870},"obj":"protein_family_or_group"},{"id":"T26","span":{"begin":885,"end":888},"obj":"protein_molecule"},{"id":"T27","span":{"begin":893,"end":896},"obj":"protein_molecule"},{"id":"T28","span":{"begin":939,"end":944},"obj":"protein_molecule"},{"id":"T29","span":{"begin":966,"end":970},"obj":"protein_molecule"},{"id":"T30","span":{"begin":974,"end":983},"obj":"protein_molecule"},{"id":"T31","span":{"begin":1025,"end":1043},"obj":"protein_complex"},{"id":"T32","span":{"begin":1069,"end":1074},"obj":"protein_molecule"},{"id":"T33","span":{"begin":1194,"end":1199},"obj":"protein_molecule"},{"id":"T34","span":{"begin":1242,"end":1259},"obj":"other_name"}],"text":"Signaling pathways mediated by the TNF- and cytokine-receptor families target a common cis-element of the IFN regulatory factor 1 promoter.\nCD40 activation of B cells is strongly influenced by the presence of cytokines. However, the molecular basis for the interplay between these distinct stimuli is not clearly delineated. IFN regulatory factor 1 (IRF-1) is a transcription factor activated by either CD40 or cytokines. We have found that these different sets of signals target a common cis-acting element in the promoter of this gene, the IRF-1 gamma-activated site (GAS). Targeting of the IRF-1 GAS is not confined to activation via CD40 but extends to other stimuli that mimic the CD40 signaling cascade, like TNF-alpha and EBV. In contrast to induction of STATs by cytokines, the IRF-1 GAS-binding complex activated by CD40, TNF-alpha, or EBV contains Rel proteins, specifically p50 and p65. In this system, simultaneous exposure to CD40L together with either IL-4 or IFN-gamma does not lead to the activation of novel Rel/STAT complexes. Given the importance of IRF-1 in a variety of biologic functions from proliferation to apoptosis, our findings support the notion that modulation of IRF-1 levels may be a critical control point in B cell activation."}