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PubMed:9834081 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 35-61 protein denotes TNF- and cytokine-receptor
T2 87-98 DNA denotes cis-element
T3 106-138 DNA denotes IFN regulatory factor 1 promoter
T4 140-144 protein denotes CD40
T5 159-166 cell_type denotes B cells
T6 209-218 protein denotes cytokines
T7 325-348 protein denotes IFN regulatory factor 1
T8 350-355 protein denotes IRF-1
T9 362-382 protein denotes transcription factor
T10 403-407 protein denotes CD40
T11 411-420 protein denotes cytokines
T12 542-568 DNA denotes IRF-1 gamma-activated site
T13 570-573 DNA denotes GAS
T14 593-602 DNA denotes IRF-1 GAS
T15 637-641 protein denotes CD40
T16 686-690 protein denotes CD40
T17 715-724 protein denotes TNF-alpha
T18 762-767 protein denotes STATs
T19 771-780 protein denotes cytokines
T20 786-795 DNA denotes IRF-1 GAS
T21 825-829 protein denotes CD40
T22 831-840 protein denotes TNF-alpha
T23 858-870 protein denotes Rel proteins
T24 885-888 protein denotes p50
T25 893-896 protein denotes p65
T26 939-944 protein denotes CD40L
T27 966-970 protein denotes IL-4
T28 974-983 protein denotes IFN-gamma
T29 1025-1043 protein denotes Rel/STAT complexes
T30 1069-1074 protein denotes IRF-1
T31 1194-1199 protein denotes IRF-1

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-139 Sentence denotes Signaling pathways mediated by the TNF- and cytokine-receptor families target a common cis-element of the IFN regulatory factor 1 promoter.
S2 140-219 Sentence denotes CD40 activation of B cells is strongly influenced by the presence of cytokines.
S3 220-324 Sentence denotes However, the molecular basis for the interplay between these distinct stimuli is not clearly delineated.
S4 325-421 Sentence denotes IFN regulatory factor 1 (IRF-1) is a transcription factor activated by either CD40 or cytokines.
S5 422-575 Sentence denotes We have found that these different sets of signals target a common cis-acting element in the promoter of this gene, the IRF-1 gamma-activated site (GAS).
S6 576-733 Sentence denotes Targeting of the IRF-1 GAS is not confined to activation via CD40 but extends to other stimuli that mimic the CD40 signaling cascade, like TNF-alpha and EBV.
S7 734-897 Sentence denotes In contrast to induction of STATs by cytokines, the IRF-1 GAS-binding complex activated by CD40, TNF-alpha, or EBV contains Rel proteins, specifically p50 and p65.
S8 898-1044 Sentence denotes In this system, simultaneous exposure to CD40L together with either IL-4 or IFN-gamma does not lead to the activation of novel Rel/STAT complexes.
S9 1045-1260 Sentence denotes Given the importance of IRF-1 in a variety of biologic functions from proliferation to apoptosis, our findings support the notion that modulation of IRF-1 levels may be a critical control point in B cell activation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 102-138 NP denotes the IFN regulatory factor 1 promoter
C1 78-138 NP denotes a common cis-element of the IFN regulatory factor 1 promoter
C3 209-218 NP denotes cytokines
C4 325-356 NP denotes IFN regulatory factor 1 (IRF-1)
C5 403-407 NP denotes CD40
C6 411-420 NP denotes cytokines
C9 527-536 NP denotes this gene
C8 511-536 NP denotes the promoter of this gene
C7 480-536 NP denotes a common cis-acting element in the promoter of this gene
C10 538-574 NP denotes the IRF-1 gamma-activated site (GAS)
C11 589-602 NP denotes the IRF-1 GAS
C12 637-641 NP denotes CD40
C13 657-670 NP denotes other stimuli
C14 671-675 NP denotes that
C15 715-724 NP denotes TNF-alpha
C16 729-732 NP denotes EBV
C17 771-780 NP denotes cytokines
C18 825-829 NP denotes CD40
C19 831-840 NP denotes TNF-alpha
C20 845-848 NP denotes EBV
C21 1069-1074 NP denotes IRF-1
C22 1164-1174 NP denotes the notion
C23 1175-1179 NP denotes that
R1 C6 C3 coref-ident cytokines,cytokines
R2 C9 C4 coref-ident this gene,IFN regulatory factor 1 (IRF-1)
R3 C8 C2 coref-ident the promoter of this gene,the IFN regulatory factor 1 promoter
R4 C7 C1 coref-ident a common cis-acting element in the promoter of this gene,a common cis-element of the IFN regulatory factor 1 promoter
R5 C10 C7 coref-appos the IRF-1 gamma-activated site (GAS),a common cis-acting element in the promoter of this gene
R6 C11 C7 coref-ident the IRF-1 GAS,a common cis-acting element in the promoter of this gene
R7 C12 C5 coref-ident CD40,CD40
R8 C14 C13 coref-relat that,other stimuli
R9 C17 C6 coref-ident cytokines,cytokines
R10 C18 C12 coref-ident CD40,CD40
R11 C19 C15 coref-ident TNF-alpha,TNF-alpha
R12 C20 C16 coref-ident EBV,EBV
R13 C21 C9 coref-ident IRF-1,this gene
R14 C23 C22 coref-relat that,the notion

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-18 other_name denotes Signaling pathways
T2 87-98 DNA_domain_or_region denotes cis-element
T3 106-138 DNA_domain_or_region denotes IFN regulatory factor 1 promoter
T4 140-144 protein_molecule denotes CD40
T5 159-166 cell_type denotes B cells
T6 209-218 protein_family_or_group denotes cytokines
T7 325-348 protein_molecule denotes IFN regulatory factor 1
T8 350-355 protein_molecule denotes IRF-1
T9 362-382 protein_family_or_group denotes transcription factor
T10 403-407 protein_molecule denotes CD40
T11 411-420 protein_family_or_group denotes cytokines
T12 542-547 protein_molecule denotes IRF-1
T13 570-573 DNA_domain_or_region denotes GAS
T14 593-602 DNA_domain_or_region denotes IRF-1 GAS
T15 637-641 protein_molecule denotes CD40
T16 686-690 protein_molecule denotes CD40
T17 715-724 protein_molecule denotes TNF-alpha
T18 729-732 virus denotes EBV
T19 762-767 protein_family_or_group denotes STATs
T20 771-780 protein_family_or_group denotes cytokines
T21 786-795 DNA_domain_or_region denotes IRF-1 GAS
T22 825-829 protein_molecule denotes CD40
T23 831-840 protein_molecule denotes TNF-alpha
T24 845-848 virus denotes EBV
T25 858-870 protein_family_or_group denotes Rel proteins
T26 885-888 protein_molecule denotes p50
T27 893-896 protein_molecule denotes p65
T28 939-944 protein_molecule denotes CD40L
T29 966-970 protein_molecule denotes IL-4
T30 974-983 protein_molecule denotes IFN-gamma
T31 1025-1043 protein_complex denotes Rel/STAT complexes
T32 1069-1074 protein_molecule denotes IRF-1
T33 1194-1199 protein_molecule denotes IRF-1
T34 1242-1259 other_name denotes B cell activation