PubMed:9834055
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/9834055","sourcedb":"PubMed","sourceid":"9834055","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/9834055","text":"BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius.\nThe bursa of Fabricius is a gut-associated lymphoid organ that is essential for the generation of a diversified B cell repertoire in the chicken. We describe here a novel gene preferentially expressed in bursal B cells. The gene encodes an 85-kDa protein, designated BASH (B cell adaptor containing SH2 domain), that contains N-terminal acidic domains with SH2 domain-binding phosphotyrosine-based motifs, a proline-rich domain, and a C-terminal SH2 domain. BASH shows a substantial sequence similarity to SLP-76, an adaptor protein functioning in TCR-signal transduction. BASH becomes tyrosine-phosphorylated with the B cell Ag receptor (BCR) cross-link or by coexpression with Syk and Lyn and associates with signaling molecules including Syk and a putative chicken Shc homologue. Overexpression of BASH results in suppression of the NF-AT activation induced by BCR-cross-linking. These findings suggest that BASH is involved in BCR-mediated signal transduction and could play a critical role in B cell development in the bursa.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":4},"obj":"NP"},{"id":"C4","span":{"begin":72,"end":94},"obj":"NP"},{"id":"C3","span":{"begin":61,"end":94},"obj":"NP"},{"id":"C2","span":{"begin":6,"end":94},"obj":"NP"},{"id":"C5","span":{"begin":96,"end":118},"obj":"NP"},{"id":"C6","span":{"begin":122,"end":153},"obj":"NP"},{"id":"C7","span":{"begin":154,"end":158},"obj":"NP"},{"id":"C9","span":{"begin":300,"end":314},"obj":"NP"},{"id":"C8","span":{"begin":259,"end":314},"obj":"NP"},{"id":"C10","span":{"begin":316,"end":324},"obj":"NP"},{"id":"C11","span":{"begin":333,"end":350},"obj":"NP"},{"id":"C12","span":{"begin":363,"end":406},"obj":"NP"},{"id":"C13","span":{"begin":408,"end":412},"obj":"NP"},{"id":"C14","span":{"begin":554,"end":558},"obj":"NP"},{"id":"C15","span":{"begin":602,"end":608},"obj":"NP"},{"id":"C16","span":{"begin":610,"end":667},"obj":"NP"},{"id":"C17","span":{"begin":669,"end":673},"obj":"NP"},{"id":"C18","span":{"begin":775,"end":778},"obj":"NP"},{"id":"C19","span":{"begin":837,"end":840},"obj":"NP"},{"id":"C20","span":{"begin":897,"end":901},"obj":"NP"},{"id":"C21","span":{"begin":1007,"end":1011},"obj":"NP"},{"id":"C22","span":{"begin":1116,"end":1125},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-appos","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C5","obj":"C4"},{"id":"R3","pred":"coref-relat","subj":"C7","obj":"C6"},{"id":"R4","pred":"coref-ident","subj":"C9","obj":"C3"},{"id":"R5","pred":"coref-ident","subj":"C10","obj":"C8"},{"id":"R6","pred":"coref-ident","subj":"C12","obj":"C1"},{"id":"R7","pred":"coref-relat","subj":"C13","obj":"C11"},{"id":"R8","pred":"coref-ident","subj":"C14","obj":"C12"},{"id":"R9","pred":"coref-appos","subj":"C16","obj":"C15"},{"id":"R10","pred":"coref-ident","subj":"C17","obj":"C14"},{"id":"R11","pred":"coref-ident","subj":"C19","obj":"C18"},{"id":"R12","pred":"coref-ident","subj":"C20","obj":"C17"},{"id":"R13","pred":"coref-ident","subj":"C21","obj":"C20"},{"id":"R14","pred":"coref-ident","subj":"C22","obj":"C5"}],"attributes":[{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"},{"subj":"C10","pred":"source","obj":"genia-medco-coref"},{"subj":"C11","pred":"source","obj":"genia-medco-coref"},{"subj":"C12","pred":"source","obj":"genia-medco-coref"},{"subj":"C13","pred":"source","obj":"genia-medco-coref"},{"subj":"C14","pred":"source","obj":"genia-medco-coref"},{"subj":"C15","pred":"source","obj":"genia-medco-coref"},{"subj":"C16","pred":"source","obj":"genia-medco-coref"},{"subj":"C17","pred":"source","obj":"genia-medco-coref"},{"subj":"C18","pred":"source","obj":"genia-medco-coref"},{"subj":"C19","pred":"source","obj":"genia-medco-coref"},{"subj":"C20","pred":"source","obj":"genia-medco-coref"},{"subj":"C21","pred":"source","obj":"genia-medco-coref"},{"subj":"C22","pred":"source","obj":"genia-medco-coref"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":0,"end":4},"obj":"protein"},{"id":"T2","span":{"begin":8,"end":32},"obj":"protein"},{"id":"T3","span":{"begin":61,"end":68},"obj":"cell_type"},{"id":"T4","span":{"begin":208,"end":225},"obj":"cell_type"},{"id":"T5","span":{"begin":300,"end":314},"obj":"cell_type"},{"id":"T6","span":{"begin":336,"end":350},"obj":"protein"},{"id":"T7","span":{"begin":363,"end":367},"obj":"protein"},{"id":"T8","span":{"begin":369,"end":405},"obj":"protein"},{"id":"T9","span":{"begin":422,"end":447},"obj":"protein"},{"id":"T10","span":{"begin":453,"end":500},"obj":"protein"},{"id":"T11","span":{"begin":504,"end":523},"obj":"protein"},{"id":"T12","span":{"begin":531,"end":552},"obj":"protein"},{"id":"T13","span":{"begin":554,"end":558},"obj":"protein"},{"id":"T14","span":{"begin":602,"end":608},"obj":"protein"},{"id":"T15","span":{"begin":644,"end":647},"obj":"protein"},{"id":"T16","span":{"begin":669,"end":673},"obj":"protein"},{"id":"T17","span":{"begin":715,"end":733},"obj":"protein"},{"id":"T18","span":{"begin":735,"end":738},"obj":"protein"},{"id":"T19","span":{"begin":775,"end":778},"obj":"protein"},{"id":"T20","span":{"begin":783,"end":786},"obj":"protein"},{"id":"T21","span":{"begin":807,"end":826},"obj":"protein"},{"id":"T22","span":{"begin":837,"end":840},"obj":"protein"},{"id":"T23","span":{"begin":847,"end":877},"obj":"protein"},{"id":"T24","span":{"begin":897,"end":901},"obj":"protein"},{"id":"T25","span":{"begin":932,"end":937},"obj":"protein"},{"id":"T26","span":{"begin":960,"end":963},"obj":"protein"},{"id":"T27","span":{"begin":1007,"end":1011},"obj":"protein"},{"id":"T28","span":{"begin":1027,"end":1030},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"},{"subj":"T18","pred":"source","obj":"jnlpba-st-training"},{"subj":"T19","pred":"source","obj":"jnlpba-st-training"},{"subj":"T20","pred":"source","obj":"jnlpba-st-training"},{"subj":"T21","pred":"source","obj":"jnlpba-st-training"},{"subj":"T22","pred":"source","obj":"jnlpba-st-training"},{"subj":"T23","pred":"source","obj":"jnlpba-st-training"},{"subj":"T24","pred":"source","obj":"jnlpba-st-training"},{"subj":"T25","pred":"source","obj":"jnlpba-st-training"},{"subj":"T26","pred":"source","obj":"jnlpba-st-training"},{"subj":"T27","pred":"source","obj":"jnlpba-st-training"},{"subj":"T28","pred":"source","obj":"jnlpba-st-training"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":95},"obj":"Sentence"},{"id":"S2","span":{"begin":96,"end":241},"obj":"Sentence"},{"id":"S3","span":{"begin":242,"end":315},"obj":"Sentence"},{"id":"S4","span":{"begin":316,"end":553},"obj":"Sentence"},{"id":"S5","span":{"begin":554,"end":668},"obj":"Sentence"},{"id":"S6","span":{"begin":669,"end":878},"obj":"Sentence"},{"id":"S7","span":{"begin":879,"end":978},"obj":"Sentence"},{"id":"S8","span":{"begin":979,"end":1126},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S7","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S8","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":4},"obj":"protein_molecule"},{"id":"T2","span":{"begin":8,"end":32},"obj":"protein_molecule"},{"id":"T3","span":{"begin":61,"end":68},"obj":"cell_type"},{"id":"T4","span":{"begin":76,"end":94},"obj":"body_part"},{"id":"T5","span":{"begin":100,"end":118},"obj":"body_part"},{"id":"T6","span":{"begin":124,"end":153},"obj":"body_part"},{"id":"T7","span":{"begin":208,"end":225},"obj":"cell_type"},{"id":"T8","span":{"begin":233,"end":240},"obj":"multi_cell"},{"id":"T9","span":{"begin":300,"end":306},"obj":"cell_type"},{"id":"T10","span":{"begin":307,"end":314},"obj":"cell_type"},{"id":"T11","span":{"begin":336,"end":350},"obj":"protein_molecule"},{"id":"T12","span":{"begin":363,"end":367},"obj":"protein_molecule"},{"id":"T13","span":{"begin":369,"end":405},"obj":"protein_molecule"},{"id":"T14","span":{"begin":422,"end":447},"obj":"protein_domain_or_region"},{"id":"T15","span":{"begin":504,"end":511},"obj":"amino_acid_monomer"},{"id":"T16","span":{"begin":531,"end":552},"obj":"protein_domain_or_region"},{"id":"T17","span":{"begin":554,"end":558},"obj":"protein_molecule"},{"id":"T18","span":{"begin":602,"end":608},"obj":"protein_molecule"},{"id":"T19","span":{"begin":644,"end":647},"obj":"protein_family_or_group"},{"id":"T20","span":{"begin":669,"end":673},"obj":"protein_molecule"},{"id":"T21","span":{"begin":682,"end":690},"obj":"amino_acid_monomer"},{"id":"T22","span":{"begin":715,"end":733},"obj":"protein_molecule"},{"id":"T23","span":{"begin":735,"end":738},"obj":"protein_molecule"},{"id":"T24","span":{"begin":775,"end":778},"obj":"protein_molecule"},{"id":"T25","span":{"begin":783,"end":786},"obj":"protein_molecule"},{"id":"T26","span":{"begin":807,"end":826},"obj":"protein_family_or_group"},{"id":"T27","span":{"begin":837,"end":840},"obj":"protein_molecule"},{"id":"T28","span":{"begin":847,"end":877},"obj":"protein_family_or_group"},{"id":"T29","span":{"begin":897,"end":901},"obj":"protein_molecule"},{"id":"T30","span":{"begin":932,"end":937},"obj":"protein_molecule"},{"id":"T31","span":{"begin":960,"end":963},"obj":"protein_molecule"},{"id":"T32","span":{"begin":1007,"end":1011},"obj":"protein_molecule"},{"id":"T33","span":{"begin":1027,"end":1030},"obj":"protein_molecule"},{"id":"T34","span":{"begin":1094,"end":1112},"obj":"other_name"},{"id":"T35","span":{"begin":1120,"end":1125},"obj":"tissue"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"},{"subj":"T26","pred":"source","obj":"GENIAcorpus"},{"subj":"T27","pred":"source","obj":"GENIAcorpus"},{"subj":"T28","pred":"source","obj":"GENIAcorpus"},{"subj":"T29","pred":"source","obj":"GENIAcorpus"},{"subj":"T30","pred":"source","obj":"GENIAcorpus"},{"subj":"T31","pred":"source","obj":"GENIAcorpus"},{"subj":"T32","pred":"source","obj":"GENIAcorpus"},{"subj":"T33","pred":"source","obj":"GENIAcorpus"},{"subj":"T34","pred":"source","obj":"GENIAcorpus"},{"subj":"T35","pred":"source","obj":"GENIAcorpus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#a8ec93","default":true},{"id":"jnlpba-st-training","color":"#ec93c2"},{"id":"pubmed-sentences-benchmark","color":"#93dcec"},{"id":"GENIAcorpus","color":"#ece293"}]}]}}