PubMed:9811966
Annnotations
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Analysis of the predicted amino acid sequence suggests that overall protein structure is conserved, but the receptor binding sites are not. A number of potential regulatory sequences similar to those found in mammals have been identified in the promoter. These include (5'-3') a composite NF-AT/ \"AP-1\" element, a CD28 response element, an AP-1 element, an NF-AT element, and the AP-1 part of an AP-1/octamer composite element. The mammalian NF-kappaB and octamer binding sites seem to be absent, although there are alternative potential NF-kappaB and octamer-binding elements in the chicken IL2 promoter, in close proximity to their mammalian homologues. Sequence comparisons also predict other potential transcription factor binding sites as yet undescribed in mammalian IL2 promoters. A Taq I polymorphism was identified which enabled chicken IL2 to be mapped to chromosome 4, linked to ANX5, with synteny with mouse chromosome 3 and human chromosome 4. 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