PubMed:9734661 JSONTXT

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{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":141},"obj":"Sentence"},{"id":"S2","span":{"begin":142,"end":390},"obj":"Sentence"},{"id":"S3","span":{"begin":391,"end":560},"obj":"Sentence"},{"id":"S4","span":{"begin":561,"end":745},"obj":"Sentence"},{"id":"S5","span":{"begin":746,"end":857},"obj":"Sentence"},{"id":"S6","span":{"begin":858,"end":1040},"obj":"Sentence"},{"id":"S7","span":{"begin":1041,"end":1146},"obj":"Sentence"},{"id":"S8","span":{"begin":1147,"end":1413},"obj":"Sentence"}],"text":"Establishment and characterization of EBV-positive and EBV-negative primary effusion lymphoma cell lines harbouring human herpesvirus type-8.\nIn this study we report on the establishment and characterization of two novel lymphoma cell lines (CRO-AP/3 and CRO-AP/5) which carry infection by human herpesvirus type-8 (HHV-8) and have derived from AIDS-related primary effusion lymphoma (PEL). These two cell lines are representative of different virologic subtypes of PEL, i.e. HHV-8+/EBV- PEL in the case of CRO-AP/3 and HHV-8+/EBV+ PEL in the case of CRO-AP/5. Consistent with the diagnosis of PEL, both CRO-AP/3 and CRO-AP/5 expressed indeterminate (i.e. non-B, non-T) phenotypes although immunogenotypic studies documented their B-cell origin. Both cell lines are devoid of genetic lesions of c-MYC, BCL-2 and p53 as well as gross rearrangements of BCL-6. Detailed histogenetic characterization of these novel PEL cell lines suggests that PEL may derive from a post-germinal centre B cell which has undergone pre-terminal differentiation. The CRO-AP/3 and CRO-AP/5 cell lines may provide a valuable model for clarifying the pathogenesis of PEL. In particular, these cell lines may help understand the relative contribution of HHV-8 and EBV to PEL growth and development and may facilitate the identification of recurrent cytogenetic abnormalities highlighting putative novel cancer related loci relevant to PEL."}

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{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":141},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":142,"end":390},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":391,"end":560},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":561,"end":745},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":746,"end":857},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":858,"end":1040},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":1041,"end":1146},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":1147,"end":1413},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":141},"obj":"Sentence"},{"id":"T2","span":{"begin":142,"end":390},"obj":"Sentence"},{"id":"T3","span":{"begin":391,"end":560},"obj":"Sentence"},{"id":"T4","span":{"begin":561,"end":745},"obj":"Sentence"},{"id":"T5","span":{"begin":746,"end":857},"obj":"Sentence"},{"id":"T6","span":{"begin":858,"end":1040},"obj":"Sentence"},{"id":"T7","span":{"begin":1041,"end":1146},"obj":"Sentence"},{"id":"T8","span":{"begin":1147,"end":1413},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Establishment and characterization of EBV-positive and EBV-negative primary effusion lymphoma cell lines harbouring human herpesvirus type-8.\nIn this study we report on the establishment and characterization of two novel lymphoma cell lines (CRO-AP/3 and CRO-AP/5) which carry infection by human herpesvirus type-8 (HHV-8) and have derived from AIDS-related primary effusion lymphoma (PEL). These two cell lines are representative of different virologic subtypes of PEL, i.e. HHV-8+/EBV- PEL in the case of CRO-AP/3 and HHV-8+/EBV+ PEL in the case of CRO-AP/5. Consistent with the diagnosis of PEL, both CRO-AP/3 and CRO-AP/5 expressed indeterminate (i.e. non-B, non-T) phenotypes although immunogenotypic studies documented their B-cell origin. Both cell lines are devoid of genetic lesions of c-MYC, BCL-2 and p53 as well as gross rearrangements of BCL-6. Detailed histogenetic characterization of these novel PEL cell lines suggests that PEL may derive from a post-germinal centre B cell which has undergone pre-terminal differentiation. The CRO-AP/3 and CRO-AP/5 cell lines may provide a valuable model for clarifying the pathogenesis of PEL. In particular, these cell lines may help understand the relative contribution of HHV-8 and EBV to PEL growth and development and may facilitate the identification of recurrent cytogenetic abnormalities highlighting putative novel cancer related loci relevant to PEL."}

{"project":"PubCasesHPO","denotations":[{"id":"AB1","span":{"begin":221,"end":229},"obj":"HP:0002665"},{"id":"TI1","span":{"begin":85,"end":93},"obj":"HP:0002665"},{"id":"AB2","span":{"begin":375,"end":383},"obj":"HP:0002665"}],"text":"Establishment and characterization of EBV-positive and EBV-negative primary effusion lymphoma cell lines harbouring human herpesvirus type-8.\nIn this study we report on the establishment and characterization of two novel lymphoma cell lines (CRO-AP/3 and CRO-AP/5) which carry infection by human herpesvirus type-8 (HHV-8) and have derived from AIDS-related primary effusion lymphoma (PEL). These two cell lines are representative of different virologic subtypes of PEL, i.e. HHV-8+/EBV- PEL in the case of CRO-AP/3 and HHV-8+/EBV+ PEL in the case of CRO-AP/5. Consistent with the diagnosis of PEL, both CRO-AP/3 and CRO-AP/5 expressed indeterminate (i.e. non-B, non-T) phenotypes although immunogenotypic studies documented their B-cell origin. Both cell lines are devoid of genetic lesions of c-MYC, BCL-2 and p53 as well as gross rearrangements of BCL-6. Detailed histogenetic characterization of these novel PEL cell lines suggests that PEL may derive from a post-germinal centre B cell which has undergone pre-terminal differentiation. The CRO-AP/3 and CRO-AP/5 cell lines may provide a valuable model for clarifying the pathogenesis of PEL. In particular, these cell lines may help understand the relative contribution of HHV-8 and EBV to PEL growth and development and may facilitate the identification of recurrent cytogenetic abnormalities highlighting putative novel cancer related loci relevant to PEL."}

{"project":"PubCasesORDO","denotations":[{"id":"TI1","span":{"begin":68,"end":93},"obj":"ORDO:48686"},{"id":"AB1","span":{"begin":358,"end":383},"obj":"ORDO:48686"},{"id":"AB2","span":{"begin":385,"end":388},"obj":"ORDO:48686"},{"id":"AB3","span":{"begin":466,"end":469},"obj":"ORDO:48686"},{"id":"AB4","span":{"begin":488,"end":491},"obj":"ORDO:48686"},{"id":"AB5","span":{"begin":532,"end":535},"obj":"ORDO:48686"},{"id":"AB6","span":{"begin":594,"end":597},"obj":"ORDO:48686"},{"id":"AB7","span":{"begin":912,"end":915},"obj":"ORDO:48686"},{"id":"AB8","span":{"begin":941,"end":944},"obj":"ORDO:48686"},{"id":"AB9","span":{"begin":1142,"end":1145},"obj":"ORDO:48686"},{"id":"AB10","span":{"begin":1245,"end":1248},"obj":"ORDO:48686"},{"id":"AB11","span":{"begin":1409,"end":1412},"obj":"ORDO:48686"}],"namespaces":[{"prefix":"ORDO","uri":"http://www.orpha.net/ORDO/Orphanet_"}],"text":"Establishment and characterization of EBV-positive and EBV-negative primary effusion lymphoma cell lines harbouring human herpesvirus type-8.\nIn this study we report on the establishment and characterization of two novel lymphoma cell lines (CRO-AP/3 and CRO-AP/5) which carry infection by human herpesvirus type-8 (HHV-8) and have derived from AIDS-related primary effusion lymphoma (PEL). These two cell lines are representative of different virologic subtypes of PEL, i.e. HHV-8+/EBV- PEL in the case of CRO-AP/3 and HHV-8+/EBV+ PEL in the case of CRO-AP/5. Consistent with the diagnosis of PEL, both CRO-AP/3 and CRO-AP/5 expressed indeterminate (i.e. non-B, non-T) phenotypes although immunogenotypic studies documented their B-cell origin. Both cell lines are devoid of genetic lesions of c-MYC, BCL-2 and p53 as well as gross rearrangements of BCL-6. Detailed histogenetic characterization of these novel PEL cell lines suggests that PEL may derive from a post-germinal centre B cell which has undergone pre-terminal differentiation. The CRO-AP/3 and CRO-AP/5 cell lines may provide a valuable model for clarifying the pathogenesis of PEL. In particular, these cell lines may help understand the relative contribution of HHV-8 and EBV to PEL growth and development and may facilitate the identification of recurrent cytogenetic abnormalities highlighting putative novel cancer related loci relevant to PEL."}