PubMed:9419430
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 24-53 | protein | denotes | CD40-specific single-chain Fv |
| T2 | 75-91 | protein | denotes | variable regions |
| T3 | 95-104 | protein | denotes | mAb G28-5 |
| T4 | 108-123 | protein | denotes | single-chain Fv |
| T5 | 125-128 | protein | denotes | sFv |
| T6 | 153-169 | protein | denotes | variable regions |
| T7 | 191-200 | protein | denotes | mAb G28-5 |
| T8 | 221-225 | protein | denotes | CD40 |
| T9 | 301-310 | protein | denotes | G28-5 sFv |
| T10 | 324-336 | protein | denotes | CD40 agonist |
| T11 | 362-366 | protein | denotes | CD40 |
| T12 | 409-416 | protein | denotes | CD40-Ig |
| T13 | 430-439 | protein | denotes | G28-5 sFv |
| T14 | 471-480 | protein | denotes | G28-5 IgG |
| T15 | 507-511 | protein | denotes | CD40 |
| T16 | 525-532 | cell_type | denotes | B cells |
| T17 | 548-557 | protein | denotes | G28-5 IgG |
| T18 | 585-594 | protein | denotes | G28-5 sFv |
| T19 | 605-609 | protein | denotes | CD40 |
| T20 | 644-658 | protein | denotes | natural ligand |
| T21 | 660-683 | protein | denotes | gp39-CD8 fusion protein |
| T22 | 764-776 | protein | denotes | binding site |
| T23 | 780-785 | protein | denotes | G28-5 |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 221-225 | NP | denotes | CD40 |
| C2 | 277-285 | NP | denotes | solution |
| C3 | 301-310 | NP | denotes | G28-5 sFv |
| C4 | 315-336 | NP | denotes | a potent CD40 agonist |
| C5 | 337-341 | NP | denotes | that |
| C6 | 362-366 | NP | denotes | CD40 |
| C7 | 370-386 | NP | denotes | the cell surface |
| C8 | 420-428 | NP | denotes | solution |
| C9 | 430-439 | NP | denotes | G28-5 sFv |
| C10 | 471-480 | NP | denotes | G28-5 IgG |
| C11 | 507-521 | NP | denotes | CD40 responses |
| C12 | 548-557 | NP | denotes | G28-5 IgG |
| C13 | 585-594 | NP | denotes | G28-5 sFv |
| C14 | 605-619 | NP | denotes | CD40 responses |
| C15 | 868-876 | NP | denotes | solution |
| C16 | 884-901 | NP | denotes | the cell surfaces |
| R1 | C5 | C4 | coref-relat | that,a potent CD40 agonist |
| R2 | C6 | C1 | coref-ident | CD40,CD40 |
| R3 | C8 | C2 | coref-ident | solution,solution |
| R4 | C9 | C3 | coref-ident | G28-5 sFv,G28-5 sFv |
| R5 | C12 | C10 | coref-ident | G28-5 IgG,G28-5 IgG |
| R6 | C13 | C9 | coref-ident | G28-5 sFv,G28-5 sFv |
| R7 | C14 | C11 | coref-ident | CD40 responses,CD40 responses |
| R8 | C15 | C8 | coref-ident | solution,solution |
| R9 | C16 | C7 | coref-ident | the cell surfaces,the cell surface |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-105 | Sentence | denotes | Agonistic activity of a CD40-specific single-chain Fv constructed from the variable regions of mAb G28-5. |
| S2 | 106-201 | Sentence | denotes | A single-chain Fv (sFv) was expressed from the variable regions of the CD40-specific mAb G28-5. |
| S3 | 202-286 | Sentence | denotes | The molecule bound CD40 with a high affinity (2.2 nM) and was a monomer in solution. |
| S4 | 287-429 | Sentence | denotes | Surprisingly, G28-5 sFv was a potent CD40 agonist that rapidly crosslinked CD40 on the cell surface but did not crosslink CD40-Ig in solution. |
| S5 | 430-547 | Sentence | denotes | G28-5 sFv was a more potent agonist than G28-5 IgG and was able to stimulate CD40 responses by B cells and monocytes. |
| S6 | 548-685 | Sentence | denotes | G28-5 IgG partially blocked, whereas G28-5 sFv augmented CD40 responses during stimulation with natural ligand (gp39-CD8 fusion protein). |
| S7 | 686-902 | Sentence | denotes | These results indicate that the functional activity of ligands built from the binding site of G28-5 is highly dependent upon the size and physical properties of the molecule both in solution and on the cell surfaces. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-18 | other_name | denotes | Agonistic activity |
| T2 | 24-53 | protein_molecule | denotes | CD40-specific single-chain Fv |
| T3 | 75-91 | protein_domain_or_region | denotes | variable regions |
| T4 | 95-104 | protein_molecule | denotes | mAb G28-5 |
| T5 | 108-123 | protein_molecule | denotes | single-chain Fv |
| T6 | 125-128 | protein_molecule | denotes | sFv |
| T7 | 153-169 | protein_domain_or_region | denotes | variable regions |
| T8 | 191-200 | protein_molecule | denotes | mAb G28-5 |
| T9 | 221-225 | protein_molecule | denotes | CD40 |
| T10 | 301-310 | protein_molecule | denotes | G28-5 sFv |
| T11 | 324-328 | protein_molecule | denotes | CD40 |
| T12 | 362-366 | protein_molecule | denotes | CD40 |
| T13 | 374-386 | cell_component | denotes | cell surface |
| T14 | 409-413 | protein_molecule | denotes | CD40 |
| T15 | 430-439 | protein_molecule | denotes | G28-5 sFv |
| T16 | 471-480 | protein_molecule | denotes | G28-5 IgG |
| T17 | 507-511 | protein_molecule | denotes | CD40 |
| T18 | 525-532 | cell_type | denotes | B cells |
| T19 | 548-557 | protein_molecule | denotes | G28-5 IgG |
| T20 | 585-594 | protein_molecule | denotes | G28-5 sFv |
| T21 | 605-609 | protein_molecule | denotes | CD40 |
| T22 | 644-658 | protein_family_or_group | denotes | natural ligand |
| T23 | 660-683 | protein_molecule | denotes | gp39-CD8 fusion protein |
| T24 | 718-737 | other_name | denotes | functional activity |
| T25 | 764-776 | protein_domain_or_region | denotes | binding site |
| T26 | 780-785 | protein_molecule | denotes | G28-5 |
| T27 | 888-901 | cell_component | denotes | cell surfaces |