PubMed:9390691 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/9390691","sourcedb":"PubMed","sourceid":"9390691","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/9390691","text":"Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F.\nCell cycle progression initiated by interleukin-2 (IL-2) in T cells is critical for lymphoproliferation and an immune response. Phosphatidyl inositol 3-kinase (PI3K) is activated by IL-2. However, nuclear targets for PI3K are not known. Here we identify the cell cycle regulator E2F as an IL-2 target in T lymphocytes and PI3K as the critical signaling pathway. We eliminate both Stat5 and Raf/MEK pathways from E2F regulation. Protein kinase B (PKB) is activated by IL-2 via PI3K. The expression of an active PKB is sufficient to induce E2F activity. Inhibition of PI3K inhibits phosphorylation of Rb, induction of cyclin D3, and degradation of p27kip1. These results establish a crucial PI3K/PKB-mediated link between the IL-2 teceptor and the cell cycle machinery.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":29},"obj":"NP"},{"id":"C2","span":{"begin":38,"end":64},"obj":"NP"},{"id":"C3","span":{"begin":68,"end":96},"obj":"NP"},{"id":"C4","span":{"begin":158,"end":165},"obj":"NP"},{"id":"C5","span":{"begin":226,"end":263},"obj":"NP"},{"id":"C6","span":{"begin":280,"end":284},"obj":"NP"},{"id":"C7","span":{"begin":315,"end":319},"obj":"NP"},{"id":"C8","span":{"begin":352,"end":380},"obj":"NP"},{"id":"C9","span":{"begin":402,"end":415},"obj":"NP"},{"id":"C10","span":{"begin":420,"end":424},"obj":"NP"},{"id":"C11","span":{"begin":565,"end":569},"obj":"NP"},{"id":"C12","span":{"begin":574,"end":578},"obj":"NP"},{"id":"C13","span":{"begin":664,"end":668},"obj":"NP"},{"id":"C14","span":{"begin":818,"end":835},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C5","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C7","obj":"C5"},{"id":"R3","pred":"coref-ident","subj":"C8","obj":"C3"},{"id":"R4","pred":"coref-ident","subj":"C9","obj":"C4"},{"id":"R5","pred":"coref-ident","subj":"C10","obj":"C7"},{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C6"},{"id":"R7","pred":"coref-ident","subj":"C12","obj":"C10"},{"id":"R8","pred":"coref-ident","subj":"C13","obj":"C12"},{"id":"R9","pred":"coref-ident","subj":"C14","obj":"C2"}],"attributes":[{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C10","pred":"source","obj":"genia-medco-coref"},{"subj":"C11","pred":"source","obj":"genia-medco-coref"},{"subj":"C12","pred":"source","obj":"genia-medco-coref"},{"subj":"C13","pred":"source","obj":"genia-medco-coref"},{"subj":"C14","pred":"source","obj":"genia-medco-coref"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":0,"end":29},"obj":"protein"},{"id":"T2","span":{"begin":42,"end":64},"obj":"protein"},{"id":"T3","span":{"begin":72,"end":92},"obj":"protein"},{"id":"T4","span":{"begin":93,"end":96},"obj":"protein"},{"id":"T5","span":{"begin":134,"end":147},"obj":"protein"},{"id":"T6","span":{"begin":149,"end":153},"obj":"protein"},{"id":"T7","span":{"begin":158,"end":165},"obj":"cell_type"},{"id":"T8","span":{"begin":226,"end":256},"obj":"protein"},{"id":"T9","span":{"begin":258,"end":262},"obj":"protein"},{"id":"T10","span":{"begin":280,"end":284},"obj":"protein"},{"id":"T11","span":{"begin":315,"end":319},"obj":"protein"},{"id":"T12","span":{"begin":356,"end":376},"obj":"protein"},{"id":"T13","span":{"begin":377,"end":380},"obj":"protein"},{"id":"T14","span":{"begin":387,"end":391},"obj":"protein"},{"id":"T15","span":{"begin":404,"end":415},"obj":"cell_type"},{"id":"T16","span":{"begin":420,"end":424},"obj":"protein"},{"id":"T17","span":{"begin":478,"end":483},"obj":"protein"},{"id":"T18","span":{"begin":488,"end":491},"obj":"protein"},{"id":"T19","span":{"begin":491,"end":495},"obj":"protein"},{"id":"T20","span":{"begin":510,"end":513},"obj":"protein"},{"id":"T21","span":{"begin":526,"end":542},"obj":"protein"},{"id":"T22","span":{"begin":544,"end":547},"obj":"protein"},{"id":"T23","span":{"begin":565,"end":569},"obj":"protein"},{"id":"T24","span":{"begin":574,"end":578},"obj":"protein"},{"id":"T25","span":{"begin":608,"end":611},"obj":"protein"},{"id":"T26","span":{"begin":636,"end":639},"obj":"protein"},{"id":"T27","span":{"begin":664,"end":668},"obj":"protein"},{"id":"T28","span":{"begin":697,"end":699},"obj":"protein"},{"id":"T29","span":{"begin":714,"end":723},"obj":"protein"},{"id":"T30","span":{"begin":744,"end":751},"obj":"protein"},{"id":"T31","span":{"begin":787,"end":791},"obj":"protein"},{"id":"T32","span":{"begin":792,"end":795},"obj":"protein"},{"id":"T33","span":{"begin":822,"end":835},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"},{"subj":"T18","pred":"source","obj":"jnlpba-st-training"},{"subj":"T19","pred":"source","obj":"jnlpba-st-training"},{"subj":"T20","pred":"source","obj":"jnlpba-st-training"},{"subj":"T21","pred":"source","obj":"jnlpba-st-training"},{"subj":"T22","pred":"source","obj":"jnlpba-st-training"},{"subj":"T23","pred":"source","obj":"jnlpba-st-training"},{"subj":"T24","pred":"source","obj":"jnlpba-st-training"},{"subj":"T25","pred":"source","obj":"jnlpba-st-training"},{"subj":"T26","pred":"source","obj":"jnlpba-st-training"},{"subj":"T27","pred":"source","obj":"jnlpba-st-training"},{"subj":"T28","pred":"source","obj":"jnlpba-st-training"},{"subj":"T29","pred":"source","obj":"jnlpba-st-training"},{"subj":"T30","pred":"source","obj":"jnlpba-st-training"},{"subj":"T31","pred":"source","obj":"jnlpba-st-training"},{"subj":"T32","pred":"source","obj":"jnlpba-st-training"},{"subj":"T33","pred":"source","obj":"jnlpba-st-training"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":97},"obj":"Sentence"},{"id":"S2","span":{"begin":98,"end":225},"obj":"Sentence"},{"id":"S3","span":{"begin":226,"end":285},"obj":"Sentence"},{"id":"S4","span":{"begin":286,"end":334},"obj":"Sentence"},{"id":"S5","span":{"begin":335,"end":459},"obj":"Sentence"},{"id":"S6","span":{"begin":460,"end":525},"obj":"Sentence"},{"id":"S7","span":{"begin":526,"end":579},"obj":"Sentence"},{"id":"S8","span":{"begin":580,"end":649},"obj":"Sentence"},{"id":"S9","span":{"begin":650,"end":752},"obj":"Sentence"},{"id":"S10","span":{"begin":753,"end":865},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S7","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S8","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S9","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S10","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":29},"obj":"protein_molecule"},{"id":"T2","span":{"begin":42,"end":64},"obj":"protein_molecule"},{"id":"T3","span":{"begin":72,"end":92},"obj":"protein_family_or_group"},{"id":"T4","span":{"begin":93,"end":96},"obj":"protein_molecule"},{"id":"T5","span":{"begin":98,"end":120},"obj":"other_name"},{"id":"T6","span":{"begin":134,"end":147},"obj":"protein_molecule"},{"id":"T7","span":{"begin":149,"end":153},"obj":"protein_molecule"},{"id":"T8","span":{"begin":158,"end":165},"obj":"cell_type"},{"id":"T9","span":{"begin":182,"end":201},"obj":"other_name"},{"id":"T10","span":{"begin":209,"end":224},"obj":"other_name"},{"id":"T11","span":{"begin":226,"end":256},"obj":"protein_molecule"},{"id":"T12","span":{"begin":258,"end":262},"obj":"protein_molecule"},{"id":"T13","span":{"begin":280,"end":284},"obj":"protein_molecule"},{"id":"T14","span":{"begin":315,"end":319},"obj":"protein_molecule"},{"id":"T15","span":{"begin":356,"end":376},"obj":"protein_family_or_group"},{"id":"T16","span":{"begin":377,"end":380},"obj":"protein_molecule"},{"id":"T17","span":{"begin":387,"end":391},"obj":"protein_molecule"},{"id":"T18","span":{"begin":404,"end":415},"obj":"cell_type"},{"id":"T19","span":{"begin":420,"end":424},"obj":"protein_molecule"},{"id":"T20","span":{"begin":432,"end":458},"obj":"other_name"},{"id":"T21","span":{"begin":478,"end":483},"obj":"protein_molecule"},{"id":"T22","span":{"begin":488,"end":491},"obj":"protein_molecule"},{"id":"T23","span":{"begin":491,"end":495},"obj":"protein_family_or_group"},{"id":"T24","span":{"begin":510,"end":513},"obj":"protein_molecule"},{"id":"T25","span":{"begin":526,"end":542},"obj":"protein_molecule"},{"id":"T26","span":{"begin":544,"end":547},"obj":"protein_molecule"},{"id":"T27","span":{"begin":565,"end":569},"obj":"protein_molecule"},{"id":"T28","span":{"begin":574,"end":578},"obj":"protein_molecule"},{"id":"T29","span":{"begin":608,"end":611},"obj":"protein_molecule"},{"id":"T30","span":{"begin":636,"end":639},"obj":"protein_molecule"},{"id":"T31","span":{"begin":664,"end":668},"obj":"protein_molecule"},{"id":"T32","span":{"begin":678,"end":693},"obj":"other_name"},{"id":"T33","span":{"begin":697,"end":699},"obj":"protein_molecule"},{"id":"T34","span":{"begin":714,"end":723},"obj":"protein_molecule"},{"id":"T35","span":{"begin":744,"end":751},"obj":"protein_molecule"},{"id":"T36","span":{"begin":787,"end":791},"obj":"protein_molecule"},{"id":"T37","span":{"begin":792,"end":795},"obj":"protein_molecule"},{"id":"T38","span":{"begin":822,"end":826},"obj":"protein_molecule"},{"id":"T39","span":{"begin":844,"end":864},"obj":"other_name"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"},{"subj":"T26","pred":"source","obj":"GENIAcorpus"},{"subj":"T27","pred":"source","obj":"GENIAcorpus"},{"subj":"T28","pred":"source","obj":"GENIAcorpus"},{"subj":"T29","pred":"source","obj":"GENIAcorpus"},{"subj":"T30","pred":"source","obj":"GENIAcorpus"},{"subj":"T31","pred":"source","obj":"GENIAcorpus"},{"subj":"T32","pred":"source","obj":"GENIAcorpus"},{"subj":"T33","pred":"source","obj":"GENIAcorpus"},{"subj":"T34","pred":"source","obj":"GENIAcorpus"},{"subj":"T35","pred":"source","obj":"GENIAcorpus"},{"subj":"T36","pred":"source","obj":"GENIAcorpus"},{"subj":"T37","pred":"source","obj":"GENIAcorpus"},{"subj":"T38","pred":"source","obj":"GENIAcorpus"},{"subj":"T39","pred":"source","obj":"GENIAcorpus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#9393ec","default":true},{"id":"jnlpba-st-training","color":"#acec93"},{"id":"pubmed-sentences-benchmark","color":"#ec93c6"},{"id":"GENIAcorpus","color":"#93e0ec"}]}]}}