PubMed:9390691
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-29 | protein | denotes | Phosphatidylinositol 3-kinase |
| T2 | 42-64 | protein | denotes | interleukin-2 receptor |
| T3 | 72-92 | protein | denotes | cell cycle regulator |
| T4 | 93-96 | protein | denotes | E2F |
| T5 | 134-147 | protein | denotes | interleukin-2 |
| T6 | 149-153 | protein | denotes | IL-2 |
| T7 | 158-165 | cell_type | denotes | T cells |
| T8 | 226-256 | protein | denotes | Phosphatidyl inositol 3-kinase |
| T9 | 258-262 | protein | denotes | PI3K |
| T10 | 280-284 | protein | denotes | IL-2 |
| T11 | 315-319 | protein | denotes | PI3K |
| T12 | 356-376 | protein | denotes | cell cycle regulator |
| T13 | 377-380 | protein | denotes | E2F |
| T14 | 387-391 | protein | denotes | IL-2 |
| T15 | 404-415 | cell_type | denotes | lymphocytes |
| T16 | 420-424 | protein | denotes | PI3K |
| T17 | 478-483 | protein | denotes | Stat5 |
| T18 | 488-491 | protein | denotes | Raf |
| T19 | 491-495 | protein | denotes | /MEK |
| T20 | 510-513 | protein | denotes | E2F |
| T21 | 526-542 | protein | denotes | Protein kinase B |
| T22 | 544-547 | protein | denotes | PKB |
| T23 | 565-569 | protein | denotes | IL-2 |
| T24 | 574-578 | protein | denotes | PI3K |
| T25 | 608-611 | protein | denotes | PKB |
| T26 | 636-639 | protein | denotes | E2F |
| T27 | 664-668 | protein | denotes | PI3K |
| T28 | 697-699 | protein | denotes | Rb |
| T29 | 714-723 | protein | denotes | cyclin D3 |
| T30 | 744-751 | protein | denotes | p27kip1 |
| T31 | 787-791 | protein | denotes | PI3K |
| T32 | 792-795 | protein | denotes | PKB |
| T33 | 822-835 | protein | denotes | IL-2 teceptor |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-97 | Sentence | denotes | Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. |
| S2 | 98-225 | Sentence | denotes | Cell cycle progression initiated by interleukin-2 (IL-2) in T cells is critical for lymphoproliferation and an immune response. |
| S3 | 226-285 | Sentence | denotes | Phosphatidyl inositol 3-kinase (PI3K) is activated by IL-2. |
| S4 | 286-334 | Sentence | denotes | However, nuclear targets for PI3K are not known. |
| S5 | 335-459 | Sentence | denotes | Here we identify the cell cycle regulator E2F as an IL-2 target in T lymphocytes and PI3K as the critical signaling pathway. |
| S6 | 460-525 | Sentence | denotes | We eliminate both Stat5 and Raf/MEK pathways from E2F regulation. |
| S7 | 526-579 | Sentence | denotes | Protein kinase B (PKB) is activated by IL-2 via PI3K. |
| S8 | 580-649 | Sentence | denotes | The expression of an active PKB is sufficient to induce E2F activity. |
| S9 | 650-752 | Sentence | denotes | Inhibition of PI3K inhibits phosphorylation of Rb, induction of cyclin D3, and degradation of p27kip1. |
| S10 | 753-865 | Sentence | denotes | These results establish a crucial PI3K/PKB-mediated link between the IL-2 teceptor and the cell cycle machinery. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 0-29 | NP | denotes | Phosphatidylinositol 3-kinase |
| C2 | 38-64 | NP | denotes | the interleukin-2 receptor |
| C3 | 68-96 | NP | denotes | the cell cycle regulator E2F |
| C4 | 158-165 | NP | denotes | T cells |
| C5 | 226-263 | NP | denotes | Phosphatidyl inositol 3-kinase (PI3K) |
| C6 | 280-284 | NP | denotes | IL-2 |
| C7 | 315-319 | NP | denotes | PI3K |
| C8 | 352-380 | NP | denotes | the cell cycle regulator E2F |
| C9 | 402-415 | NP | denotes | T lymphocytes |
| C10 | 420-424 | NP | denotes | PI3K |
| C11 | 565-569 | NP | denotes | IL-2 |
| C12 | 574-578 | NP | denotes | PI3K |
| C13 | 664-668 | NP | denotes | PI3K |
| C14 | 818-835 | NP | denotes | the IL-2 teceptor |
| R1 | C5 | C1 | coref-ident | Phosphatidyl inositol 3-kinase (PI3K),Phosphatidylinositol 3-kinase |
| R2 | C7 | C5 | coref-ident | PI3K,Phosphatidyl inositol 3-kinase (PI3K) |
| R3 | C8 | C3 | coref-ident | the cell cycle regulator E2F,the cell cycle regulator E2F |
| R4 | C9 | C4 | coref-ident | T lymphocytes,T cells |
| R5 | C10 | C7 | coref-ident | PI3K,PI3K |
| R6 | C11 | C6 | coref-ident | IL-2,IL-2 |
| R7 | C12 | C10 | coref-ident | PI3K,PI3K |
| R8 | C13 | C12 | coref-ident | PI3K,PI3K |
| R9 | C14 | C2 | coref-ident | the IL-2 teceptor,the interleukin-2 receptor |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-29 | protein_molecule | denotes | Phosphatidylinositol 3-kinase |
| T2 | 42-64 | protein_molecule | denotes | interleukin-2 receptor |
| T3 | 72-92 | protein_family_or_group | denotes | cell cycle regulator |
| T4 | 93-96 | protein_molecule | denotes | E2F |
| T5 | 98-120 | other_name | denotes | Cell cycle progression |
| T6 | 134-147 | protein_molecule | denotes | interleukin-2 |
| T7 | 149-153 | protein_molecule | denotes | IL-2 |
| T8 | 158-165 | cell_type | denotes | T cells |
| T9 | 182-201 | other_name | denotes | lymphoproliferation |
| T10 | 209-224 | other_name | denotes | immune response |
| T11 | 226-256 | protein_molecule | denotes | Phosphatidyl inositol 3-kinase |
| T12 | 258-262 | protein_molecule | denotes | PI3K |
| T13 | 280-284 | protein_molecule | denotes | IL-2 |
| T14 | 315-319 | protein_molecule | denotes | PI3K |
| T15 | 356-376 | protein_family_or_group | denotes | cell cycle regulator |
| T16 | 377-380 | protein_molecule | denotes | E2F |
| T17 | 387-391 | protein_molecule | denotes | IL-2 |
| T18 | 404-415 | cell_type | denotes | lymphocytes |
| T19 | 420-424 | protein_molecule | denotes | PI3K |
| T20 | 432-458 | other_name | denotes | critical signaling pathway |
| T21 | 478-483 | protein_molecule | denotes | Stat5 |
| T22 | 488-491 | protein_molecule | denotes | Raf |
| T23 | 491-495 | protein_family_or_group | denotes | /MEK |
| T24 | 510-513 | protein_molecule | denotes | E2F |
| T25 | 526-542 | protein_molecule | denotes | Protein kinase B |
| T26 | 544-547 | protein_molecule | denotes | PKB |
| T27 | 565-569 | protein_molecule | denotes | IL-2 |
| T28 | 574-578 | protein_molecule | denotes | PI3K |
| T29 | 608-611 | protein_molecule | denotes | PKB |
| T30 | 636-639 | protein_molecule | denotes | E2F |
| T31 | 664-668 | protein_molecule | denotes | PI3K |
| T32 | 678-693 | other_name | denotes | phosphorylation |
| T33 | 697-699 | protein_molecule | denotes | Rb |
| T34 | 714-723 | protein_molecule | denotes | cyclin D3 |
| T35 | 744-751 | protein_molecule | denotes | p27kip1 |
| T36 | 787-791 | protein_molecule | denotes | PI3K |
| T37 | 792-795 | protein_molecule | denotes | PKB |
| T38 | 822-826 | protein_molecule | denotes | IL-2 |
| T39 | 844-864 | other_name | denotes | cell cycle machinery |