PubMed:9360945 JSONTXT

{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":100},"obj":"Sentence"},{"id":"T2","span":{"begin":101,"end":280},"obj":"Sentence"},{"id":"T3","span":{"begin":281,"end":502},"obj":"Sentence"},{"id":"T4","span":{"begin":503,"end":585},"obj":"Sentence"},{"id":"T5","span":{"begin":586,"end":753},"obj":"Sentence"},{"id":"T6","span":{"begin":754,"end":976},"obj":"Sentence"},{"id":"T7","span":{"begin":977,"end":1137},"obj":"Sentence"},{"id":"T8","span":{"begin":1138,"end":1322},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":100},"obj":"Sentence"},{"id":"T2","span":{"begin":101,"end":280},"obj":"Sentence"},{"id":"T3","span":{"begin":281,"end":502},"obj":"Sentence"},{"id":"T4","span":{"begin":503,"end":585},"obj":"Sentence"},{"id":"T5","span":{"begin":586,"end":753},"obj":"Sentence"},{"id":"T6","span":{"begin":754,"end":976},"obj":"Sentence"},{"id":"T7","span":{"begin":977,"end":1137},"obj":"Sentence"},{"id":"T8","span":{"begin":1138,"end":1322},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Transcription factor NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes.\nThe POU transcription factors Oct-1 and Oct-2 regulate the activity of octamer-dependent promoters, including those that direct transcription from rearranged immunoglobulin genes. Unlike Oct-1, which is constitutively expressed in many cell types, Oct-2 expression is restricted primarily to B lymphocytes and can be induced in precursor B cells by stimulation with bacterial lipopolysaccharide (LPS). However, the precise factors that mediate this induction mechanism remain unknown. In the present study, we monitored Oct-2 expression in cells arrested for the activation of NF-kappaB, an LPS-responsive member of the Rel transcription factor family. Despite stimulation with LPS, disruption of the NF-kappaB signaling pathway in precursor B cells led to the loss of inducible Oct-2 DNA binding activity in vitro and the suppression of Oct-2-directed transcription in vivo. This biochemical defect correlated with a specific block to Oct-2 gene expression at the level of transcription, whereas the expression of Oct-1 was unaffected. The finding that Oct-2 is under NF-kappaB control highlights an important cross-talk mechanism involving two distinct transcription factor families that regulate B lymphocyte function."}

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":0,"end":20},"obj":"protein"},{"id":"T2","span":{"begin":21,"end":30},"obj":"protein"},{"id":"T3","span":{"begin":51,"end":61},"obj":"DNA"},{"id":"T4","span":{"begin":76,"end":99},"obj":"cell_type"},{"id":"T5","span":{"begin":105,"end":130},"obj":"protein"},{"id":"T6","span":{"begin":131,"end":136},"obj":"protein"},{"id":"T7","span":{"begin":141,"end":146},"obj":"protein"},{"id":"T8","span":{"begin":172,"end":199},"obj":"DNA"},{"id":"T9","span":{"begin":259,"end":279},"obj":"protein"},{"id":"T10","span":{"begin":288,"end":293},"obj":"protein"},{"id":"T11","span":{"begin":349,"end":354},"obj":"protein"},{"id":"T12","span":{"begin":393,"end":406},"obj":"cell_type"},{"id":"T13","span":{"begin":429,"end":446},"obj":"cell_type"},{"id":"T14","span":{"begin":621,"end":626},"obj":"protein"},{"id":"T15","span":{"begin":678,"end":687},"obj":"protein"},{"id":"T16","span":{"begin":692,"end":713},"obj":"protein"},{"id":"T17","span":{"begin":721,"end":752},"obj":"protein"},{"id":"T18","span":{"begin":802,"end":811},"obj":"protein"},{"id":"T19","span":{"begin":833,"end":850},"obj":"cell_type"},{"id":"T20","span":{"begin":880,"end":885},"obj":"protein"},{"id":"T21","span":{"begin":939,"end":944},"obj":"protein"},{"id":"T22","span":{"begin":1037,"end":1047},"obj":"DNA"},{"id":"T23","span":{"begin":1116,"end":1121},"obj":"protein"},{"id":"T24","span":{"begin":1155,"end":1160},"obj":"protein"},{"id":"T25","span":{"begin":1170,"end":1179},"obj":"protein"},{"id":"T26","span":{"begin":1256,"end":1285},"obj":"protein"},{"id":"T27","span":{"begin":1300,"end":1312},"obj":"cell_type"}],"text":"Transcription factor NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes.\nThe POU transcription factors Oct-1 and Oct-2 regulate the activity of octamer-dependent promoters, including those that direct transcription from rearranged immunoglobulin genes. Unlike Oct-1, which is constitutively expressed in many cell types, Oct-2 expression is restricted primarily to B lymphocytes and can be induced in precursor B cells by stimulation with bacterial lipopolysaccharide (LPS). However, the precise factors that mediate this induction mechanism remain unknown. In the present study, we monitored Oct-2 expression in cells arrested for the activation of NF-kappaB, an LPS-responsive member of the Rel transcription factor family. Despite stimulation with LPS, disruption of the NF-kappaB signaling pathway in precursor B cells led to the loss of inducible Oct-2 DNA binding activity in vitro and the suppression of Oct-2-directed transcription in vivo. This biochemical defect correlated with a specific block to Oct-2 gene expression at the level of transcription, whereas the expression of Oct-1 was unaffected. The finding that Oct-2 is under NF-kappaB control highlights an important cross-talk mechanism involving two distinct transcription factor families that regulate B lymphocyte function."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":100},"obj":"Sentence"},{"id":"S2","span":{"begin":101,"end":280},"obj":"Sentence"},{"id":"S3","span":{"begin":281,"end":502},"obj":"Sentence"},{"id":"S4","span":{"begin":503,"end":585},"obj":"Sentence"},{"id":"S5","span":{"begin":586,"end":753},"obj":"Sentence"},{"id":"S6","span":{"begin":754,"end":976},"obj":"Sentence"},{"id":"S7","span":{"begin":977,"end":1137},"obj":"Sentence"},{"id":"S8","span":{"begin":1138,"end":1322},"obj":"Sentence"}],"text":"Transcription factor NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes.\nThe POU transcription factors Oct-1 and Oct-2 regulate the activity of octamer-dependent promoters, including those that direct transcription from rearranged immunoglobulin genes. Unlike Oct-1, which is constitutively expressed in many cell types, Oct-2 expression is restricted primarily to B lymphocytes and can be induced in precursor B cells by stimulation with bacterial lipopolysaccharide (LPS). However, the precise factors that mediate this induction mechanism remain unknown. In the present study, we monitored Oct-2 expression in cells arrested for the activation of NF-kappaB, an LPS-responsive member of the Rel transcription factor family. Despite stimulation with LPS, disruption of the NF-kappaB signaling pathway in precursor B cells led to the loss of inducible Oct-2 DNA binding activity in vitro and the suppression of Oct-2-directed transcription in vivo. This biochemical defect correlated with a specific block to Oct-2 gene expression at the level of transcription, whereas the expression of Oct-1 was unaffected. The finding that Oct-2 is under NF-kappaB control highlights an important cross-talk mechanism involving two distinct transcription factor families that regulate B lymphocyte function."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":30},"obj":"NP"},{"id":"C2","span":{"begin":76,"end":99},"obj":"NP"},{"id":"C3","span":{"begin":131,"end":136},"obj":"NP"},{"id":"C4","span":{"begin":141,"end":146},"obj":"NP"},{"id":"C5","span":{"begin":172,"end":199},"obj":"NP"},{"id":"C6","span":{"begin":211,"end":216},"obj":"NP"},{"id":"C7","span":{"begin":217,"end":221},"obj":"NP"},{"id":"C8","span":{"begin":288,"end":293},"obj":"NP"},{"id":"C9","span":{"begin":295,"end":300},"obj":"NP"},{"id":"C10","span":{"begin":349,"end":365},"obj":"NP"},{"id":"C11","span":{"begin":429,"end":446},"obj":"NP"},{"id":"C12","span":{"begin":450,"end":501},"obj":"NP"},{"id":"C13","span":{"begin":512,"end":531},"obj":"NP"},{"id":"C14","span":{"begin":532,"end":536},"obj":"NP"},{"id":"C15","span":{"begin":678,"end":687},"obj":"NP"},{"id":"C16","span":{"begin":689,"end":752},"obj":"NP"},{"id":"C17","span":{"begin":762,"end":782},"obj":"NP"},{"id":"C18","span":{"begin":833,"end":850},"obj":"NP"},{"id":"C19","span":{"begin":858,"end":975},"obj":"NP"},{"id":"C20","span":{"begin":977,"end":1000},"obj":"NP"},{"id":"C21","span":{"begin":1037,"end":1058},"obj":"NP"},{"id":"C22","span":{"begin":1116,"end":1121},"obj":"NP"},{"id":"C23","span":{"begin":1138,"end":1149},"obj":"NP"},{"id":"C24","span":{"begin":1150,"end":1154},"obj":"NP"},{"id":"C25","span":{"begin":1155,"end":1160},"obj":"NP"},{"id":"C26","span":{"begin":1243,"end":1285},"obj":"NP"},{"id":"C27","span":{"begin":1286,"end":1290},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-pron","subj":"C6","obj":"C5"},{"id":"R2","pred":"coref-relat","subj":"C7","obj":"C5"},{"id":"R3","pred":"coref-ident","subj":"C8","obj":"C3"},{"id":"R4","pred":"coref-relat","subj":"C9","obj":"C8"},{"id":"R5","pred":"coref-ident","subj":"C11","obj":"C2"},{"id":"R6","pred":"coref-relat","subj":"C14","obj":"C13"},{"id":"R7","pred":"coref-ident","subj":"C15","obj":"C1"},{"id":"R8","pred":"coref-appos","subj":"C16","obj":"C15"},{"id":"R9","pred":"coref-ident","subj":"C17","obj":"C12"},{"id":"R10","pred":"coref-ident","subj":"C18","obj":"C11"},{"id":"R11","pred":"coref-ident","subj":"C20","obj":"C19"},{"id":"R12","pred":"coref-ident","subj":"C21","obj":"C10"},{"id":"R13","pred":"coref-ident","subj":"C22","obj":"C8"},{"id":"R14","pred":"coref-relat","subj":"C24","obj":"C23"},{"id":"R15","pred":"coref-ident","subj":"C25","obj":"C4"},{"id":"R16","pred":"coref-relat","subj":"C27","obj":"C26"}],"text":"Transcription factor NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes.\nThe POU transcription factors Oct-1 and Oct-2 regulate the activity of octamer-dependent promoters, including those that direct transcription from rearranged immunoglobulin genes. Unlike Oct-1, which is constitutively expressed in many cell types, Oct-2 expression is restricted primarily to B lymphocytes and can be induced in precursor B cells by stimulation with bacterial lipopolysaccharide (LPS). However, the precise factors that mediate this induction mechanism remain unknown. In the present study, we monitored Oct-2 expression in cells arrested for the activation of NF-kappaB, an LPS-responsive member of the Rel transcription factor family. Despite stimulation with LPS, disruption of the NF-kappaB signaling pathway in precursor B cells led to the loss of inducible Oct-2 DNA binding activity in vitro and the suppression of Oct-2-directed transcription in vivo. This biochemical defect correlated with a specific block to Oct-2 gene expression at the level of transcription, whereas the expression of Oct-1 was unaffected. The finding that Oct-2 is under NF-kappaB control highlights an important cross-talk mechanism involving two distinct transcription factor families that regulate B lymphocyte function."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":20},"obj":"protein_family_or_group"},{"id":"T2","span":{"begin":21,"end":30},"obj":"protein_complex"},{"id":"T3","span":{"begin":51,"end":56},"obj":"protein_molecule"},{"id":"T4","span":{"begin":76,"end":99},"obj":"cell_type"},{"id":"T5","span":{"begin":105,"end":130},"obj":"protein_family_or_group"},{"id":"T6","span":{"begin":131,"end":136},"obj":"protein_molecule"},{"id":"T7","span":{"begin":141,"end":146},"obj":"protein_molecule"},{"id":"T8","span":{"begin":172,"end":199},"obj":"DNA_domain_or_region"},{"id":"T9","span":{"begin":259,"end":279},"obj":"protein_family_or_group"},{"id":"T10","span":{"begin":288,"end":293},"obj":"protein_molecule"},{"id":"T11","span":{"begin":349,"end":354},"obj":"protein_molecule"},{"id":"T12","span":{"begin":393,"end":406},"obj":"cell_type"},{"id":"T13","span":{"begin":429,"end":446},"obj":"cell_type"},{"id":"T14","span":{"begin":467,"end":495},"obj":"lipid"},{"id":"T15","span":{"begin":497,"end":500},"obj":"lipid"},{"id":"T16","span":{"begin":621,"end":626},"obj":"protein_molecule"},{"id":"T17","span":{"begin":678,"end":687},"obj":"protein_complex"},{"id":"T18","span":{"begin":692,"end":695},"obj":"lipid"},{"id":"T19","span":{"begin":721,"end":752},"obj":"protein_family_or_group"},{"id":"T20","span":{"begin":779,"end":782},"obj":"lipid"},{"id":"T21","span":{"begin":802,"end":811},"obj":"protein_complex"},{"id":"T22","span":{"begin":833,"end":850},"obj":"cell_type"},{"id":"T23","span":{"begin":880,"end":885},"obj":"protein_molecule"},{"id":"T24","span":{"begin":939,"end":944},"obj":"protein_molecule"},{"id":"T25","span":{"begin":1037,"end":1042},"obj":"protein_molecule"},{"id":"T26","span":{"begin":1116,"end":1121},"obj":"protein_molecule"},{"id":"T27","span":{"begin":1155,"end":1160},"obj":"protein_molecule"},{"id":"T28","span":{"begin":1170,"end":1179},"obj":"protein_complex"},{"id":"T29","span":{"begin":1256,"end":1285},"obj":"protein_family_or_group"},{"id":"T30","span":{"begin":1291,"end":1299},"obj":"other_name"},{"id":"T31","span":{"begin":1300,"end":1312},"obj":"cell_type"}],"text":"Transcription factor NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes.\nThe POU transcription factors Oct-1 and Oct-2 regulate the activity of octamer-dependent promoters, including those that direct transcription from rearranged immunoglobulin genes. Unlike Oct-1, which is constitutively expressed in many cell types, Oct-2 expression is restricted primarily to B lymphocytes and can be induced in precursor B cells by stimulation with bacterial lipopolysaccharide (LPS). However, the precise factors that mediate this induction mechanism remain unknown. In the present study, we monitored Oct-2 expression in cells arrested for the activation of NF-kappaB, an LPS-responsive member of the Rel transcription factor family. Despite stimulation with LPS, disruption of the NF-kappaB signaling pathway in precursor B cells led to the loss of inducible Oct-2 DNA binding activity in vitro and the suppression of Oct-2-directed transcription in vivo. This biochemical defect correlated with a specific block to Oct-2 gene expression at the level of transcription, whereas the expression of Oct-1 was unaffected. The finding that Oct-2 is under NF-kappaB control highlights an important cross-talk mechanism involving two distinct transcription factor families that regulate B lymphocyte function."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":86,"end":99},"obj":"Body_part"},{"id":"T2","span":{"begin":393,"end":406},"obj":"Body_part"},{"id":"T3","span":{"begin":429,"end":446},"obj":"Body_part"},{"id":"T4","span":{"begin":833,"end":850},"obj":"Body_part"},{"id":"T5","span":{"begin":1300,"end":1312},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000817"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0000817"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL_0000236"}],"text":"Transcription factor NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes.\nThe POU transcription factors Oct-1 and Oct-2 regulate the activity of octamer-dependent promoters, including those that direct transcription from rearranged immunoglobulin genes. Unlike Oct-1, which is constitutively expressed in many cell types, Oct-2 expression is restricted primarily to B lymphocytes and can be induced in precursor B cells by stimulation with bacterial lipopolysaccharide (LPS). However, the precise factors that mediate this induction mechanism remain unknown. In the present study, we monitored Oct-2 expression in cells arrested for the activation of NF-kappaB, an LPS-responsive member of the Rel transcription factor family. Despite stimulation with LPS, disruption of the NF-kappaB signaling pathway in precursor B cells led to the loss of inducible Oct-2 DNA binding activity in vitro and the suppression of Oct-2-directed transcription in vivo. This biochemical defect correlated with a specific block to Oct-2 gene expression at the level of transcription, whereas the expression of Oct-1 was unaffected. The finding that Oct-2 is under NF-kappaB control highlights an important cross-talk mechanism involving two distinct transcription factor families that regulate B lymphocyte function."}

{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":86,"end":99},"obj":"Cell"},{"id":"T2","span":{"begin":393,"end":406},"obj":"Cell"},{"id":"T3","span":{"begin":429,"end":446},"obj":"Cell"},{"id":"T4","span":{"begin":833,"end":850},"obj":"Cell"},{"id":"T5","span":{"begin":1300,"end":1312},"obj":"Cell"},{"id":"T6","span":{"begin":1302,"end":1312},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000236"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000236"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000817"},{"id":"A4","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0000817"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000236"},{"id":"A6","pred":"cl_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL:0000542"}],"text":"Transcription factor NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes.\nThe POU transcription factors Oct-1 and Oct-2 regulate the activity of octamer-dependent promoters, including those that direct transcription from rearranged immunoglobulin genes. Unlike Oct-1, which is constitutively expressed in many cell types, Oct-2 expression is restricted primarily to B lymphocytes and can be induced in precursor B cells by stimulation with bacterial lipopolysaccharide (LPS). However, the precise factors that mediate this induction mechanism remain unknown. In the present study, we monitored Oct-2 expression in cells arrested for the activation of NF-kappaB, an LPS-responsive member of the Rel transcription factor family. Despite stimulation with LPS, disruption of the NF-kappaB signaling pathway in precursor B cells led to the loss of inducible Oct-2 DNA binding activity in vitro and the suppression of Oct-2-directed transcription in vivo. This biochemical defect correlated with a specific block to Oct-2 gene expression at the level of transcription, whereas the expression of Oct-1 was unaffected. The finding that Oct-2 is under NF-kappaB control highlights an important cross-talk mechanism involving two distinct transcription factor families that regulate B lymphocyte function."}