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sentences

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Transcription factor NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes.
T2 101-280 Sentence denotes The POU transcription factors Oct-1 and Oct-2 regulate the activity of octamer-dependent promoters, including those that direct transcription from rearranged immunoglobulin genes.
T3 281-502 Sentence denotes Unlike Oct-1, which is constitutively expressed in many cell types, Oct-2 expression is restricted primarily to B lymphocytes and can be induced in precursor B cells by stimulation with bacterial lipopolysaccharide (LPS).
T4 503-585 Sentence denotes However, the precise factors that mediate this induction mechanism remain unknown.
T5 586-753 Sentence denotes In the present study, we monitored Oct-2 expression in cells arrested for the activation of NF-kappaB, an LPS-responsive member of the Rel transcription factor family.
T6 754-976 Sentence denotes Despite stimulation with LPS, disruption of the NF-kappaB signaling pathway in precursor B cells led to the loss of inducible Oct-2 DNA binding activity in vitro and the suppression of Oct-2-directed transcription in vivo.
T7 977-1137 Sentence denotes This biochemical defect correlated with a specific block to Oct-2 gene expression at the level of transcription, whereas the expression of Oct-1 was unaffected.
T8 1138-1322 Sentence denotes The finding that Oct-2 is under NF-kappaB control highlights an important cross-talk mechanism involving two distinct transcription factor families that regulate B lymphocyte function.
T1 0-100 Sentence denotes Transcription factor NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes.
T2 101-280 Sentence denotes The POU transcription factors Oct-1 and Oct-2 regulate the activity of octamer-dependent promoters, including those that direct transcription from rearranged immunoglobulin genes.
T3 281-502 Sentence denotes Unlike Oct-1, which is constitutively expressed in many cell types, Oct-2 expression is restricted primarily to B lymphocytes and can be induced in precursor B cells by stimulation with bacterial lipopolysaccharide (LPS).
T4 503-585 Sentence denotes However, the precise factors that mediate this induction mechanism remain unknown.
T5 586-753 Sentence denotes In the present study, we monitored Oct-2 expression in cells arrested for the activation of NF-kappaB, an LPS-responsive member of the Rel transcription factor family.
T6 754-976 Sentence denotes Despite stimulation with LPS, disruption of the NF-kappaB signaling pathway in precursor B cells led to the loss of inducible Oct-2 DNA binding activity in vitro and the suppression of Oct-2-directed transcription in vivo.
T7 977-1137 Sentence denotes This biochemical defect correlated with a specific block to Oct-2 gene expression at the level of transcription, whereas the expression of Oct-1 was unaffected.
T8 1138-1322 Sentence denotes The finding that Oct-2 is under NF-kappaB control highlights an important cross-talk mechanism involving two distinct transcription factor families that regulate B lymphocyte function.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-20 protein denotes Transcription factor
T2 21-30 protein denotes NF-kappaB
T3 51-61 DNA denotes Oct-2 gene
T4 76-99 cell_type denotes precursor B lymphocytes
T5 105-130 protein denotes POU transcription factors
T6 131-136 protein denotes Oct-1
T7 141-146 protein denotes Oct-2
T8 172-199 DNA denotes octamer-dependent promoters
T9 259-279 protein denotes immunoglobulin genes
T10 288-293 protein denotes Oct-1
T11 349-354 protein denotes Oct-2
T12 393-406 cell_type denotes B lymphocytes
T13 429-446 cell_type denotes precursor B cells
T14 621-626 protein denotes Oct-2
T15 678-687 protein denotes NF-kappaB
T16 692-713 protein denotes LPS-responsive member
T17 721-752 protein denotes Rel transcription factor family
T18 802-811 protein denotes NF-kappaB
T19 833-850 cell_type denotes precursor B cells
T20 880-885 protein denotes Oct-2
T21 939-944 protein denotes Oct-2
T22 1037-1047 DNA denotes Oct-2 gene
T23 1116-1121 protein denotes Oct-1
T24 1155-1160 protein denotes Oct-2
T25 1170-1179 protein denotes NF-kappaB
T26 1256-1285 protein denotes transcription factor families
T27 1300-1312 cell_type denotes B lymphocyte

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-100 Sentence denotes Transcription factor NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes.
S2 101-280 Sentence denotes The POU transcription factors Oct-1 and Oct-2 regulate the activity of octamer-dependent promoters, including those that direct transcription from rearranged immunoglobulin genes.
S3 281-502 Sentence denotes Unlike Oct-1, which is constitutively expressed in many cell types, Oct-2 expression is restricted primarily to B lymphocytes and can be induced in precursor B cells by stimulation with bacterial lipopolysaccharide (LPS).
S4 503-585 Sentence denotes However, the precise factors that mediate this induction mechanism remain unknown.
S5 586-753 Sentence denotes In the present study, we monitored Oct-2 expression in cells arrested for the activation of NF-kappaB, an LPS-responsive member of the Rel transcription factor family.
S6 754-976 Sentence denotes Despite stimulation with LPS, disruption of the NF-kappaB signaling pathway in precursor B cells led to the loss of inducible Oct-2 DNA binding activity in vitro and the suppression of Oct-2-directed transcription in vivo.
S7 977-1137 Sentence denotes This biochemical defect correlated with a specific block to Oct-2 gene expression at the level of transcription, whereas the expression of Oct-1 was unaffected.
S8 1138-1322 Sentence denotes The finding that Oct-2 is under NF-kappaB control highlights an important cross-talk mechanism involving two distinct transcription factor families that regulate B lymphocyte function.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-30 NP denotes Transcription factor NF-kappaB
C2 76-99 NP denotes precursor B lymphocytes
C3 131-136 NP denotes Oct-1
C4 141-146 NP denotes Oct-2
C5 172-199 NP denotes octamer-dependent promoters
C6 211-216 NP denotes those
C7 217-221 NP denotes that
C8 288-293 NP denotes Oct-1
C9 295-300 NP denotes which
C10 349-365 NP denotes Oct-2 expression
C11 429-446 NP denotes precursor B cells
C12 450-501 NP denotes stimulation with bacterial lipopolysaccharide (LPS)
C13 512-531 NP denotes the precise factors
C14 532-536 NP denotes that
C15 678-687 NP denotes NF-kappaB
C16 689-752 NP denotes an LPS-responsive member of the Rel transcription factor family
C17 762-782 NP denotes stimulation with LPS
C18 833-850 NP denotes precursor B cells
C19 858-975 NP denotes the loss of inducible Oct-2 DNA binding activity in vitro and the suppression of Oct-2-directed transcription in vivo
C20 977-1000 NP denotes This biochemical defect
C21 1037-1058 NP denotes Oct-2 gene expression
C22 1116-1121 NP denotes Oct-1
C23 1138-1149 NP denotes The finding
C24 1150-1154 NP denotes that
C25 1155-1160 NP denotes Oct-2
C26 1243-1285 NP denotes two distinct transcription factor families
C27 1286-1290 NP denotes that
R1 C6 C5 coref-pron those,octamer-dependent promoters
R2 C7 C5 coref-relat that,octamer-dependent promoters
R3 C8 C3 coref-ident Oct-1,Oct-1
R4 C9 C8 coref-relat which,Oct-1
R5 C11 C2 coref-ident precursor B cells,precursor B lymphocytes
R6 C14 C13 coref-relat that,the precise factors
R7 C15 C1 coref-ident NF-kappaB,Transcription factor NF-kappaB
R8 C16 C15 coref-appos an LPS-responsive member of the Rel transcription factor family,NF-kappaB
R9 C17 C12 coref-ident stimulation with LPS,stimulation with bacterial lipopolysaccharide (LPS)
R10 C18 C11 coref-ident precursor B cells,precursor B cells
R11 C20 C19 coref-ident This biochemical defect,the loss of inducible Oct-2 DNA binding activity in vitro and the suppression of Oct-2-directed transcription in vivo
R12 C21 C10 coref-ident Oct-2 gene expression,Oct-2 expression
R13 C22 C8 coref-ident Oct-1,Oct-1
R14 C24 C23 coref-relat that,The finding
R15 C25 C4 coref-ident Oct-2,Oct-2
R16 C27 C26 coref-relat that,two distinct transcription factor families

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-20 protein_family_or_group denotes Transcription factor
T2 21-30 protein_complex denotes NF-kappaB
T3 51-56 protein_molecule denotes Oct-2
T4 76-99 cell_type denotes precursor B lymphocytes
T5 105-130 protein_family_or_group denotes POU transcription factors
T6 131-136 protein_molecule denotes Oct-1
T7 141-146 protein_molecule denotes Oct-2
T8 172-199 DNA_domain_or_region denotes octamer-dependent promoters
T9 259-279 protein_family_or_group denotes immunoglobulin genes
T10 288-293 protein_molecule denotes Oct-1
T11 349-354 protein_molecule denotes Oct-2
T12 393-406 cell_type denotes B lymphocytes
T13 429-446 cell_type denotes precursor B cells
T14 467-495 lipid denotes bacterial lipopolysaccharide
T15 497-500 lipid denotes LPS
T16 621-626 protein_molecule denotes Oct-2
T17 678-687 protein_complex denotes NF-kappaB
T18 692-695 lipid denotes LPS
T19 721-752 protein_family_or_group denotes Rel transcription factor family
T20 779-782 lipid denotes LPS
T21 802-811 protein_complex denotes NF-kappaB
T22 833-850 cell_type denotes precursor B cells
T23 880-885 protein_molecule denotes Oct-2
T24 939-944 protein_molecule denotes Oct-2
T25 1037-1042 protein_molecule denotes Oct-2
T26 1116-1121 protein_molecule denotes Oct-1
T27 1155-1160 protein_molecule denotes Oct-2
T28 1170-1179 protein_complex denotes NF-kappaB
T29 1256-1285 protein_family_or_group denotes transcription factor families
T30 1291-1299 other_name denotes regulate
T31 1300-1312 cell_type denotes B lymphocyte

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 86-99 Body_part denotes B lymphocytes http://purl.obolibrary.org/obo/CL_0000236
T2 393-406 Body_part denotes B lymphocytes http://purl.obolibrary.org/obo/CL_0000236
T3 429-446 Body_part denotes precursor B cells http://purl.obolibrary.org/obo/CL_0000817
T4 833-850 Body_part denotes precursor B cells http://purl.obolibrary.org/obo/CL_0000817
T5 1300-1312 Body_part denotes B lymphocyte http://purl.obolibrary.org/obo/CL_0000236

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 86-99 Cell denotes B lymphocytes http://purl.obolibrary.org/obo/CL:0000236
T2 393-406 Cell denotes B lymphocytes http://purl.obolibrary.org/obo/CL:0000236
T3 429-446 Cell denotes precursor B cells http://purl.obolibrary.org/obo/CL:0000817
T4 833-850 Cell denotes precursor B cells http://purl.obolibrary.org/obo/CL:0000817
T5 1300-1312 Cell denotes B lymphocyte http://purl.obolibrary.org/obo/CL:0000236
T6 1302-1312 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542