PubMed:9351829
Annnotations
jnlpba-st-training
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pubmed-sentences-benchmark
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genia-medco-coref
{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":44},"obj":"NP"},{"id":"C2","span":{"begin":54,"end":67},"obj":"NP"},{"id":"C3","span":{"begin":72,"end":107},"obj":"NP"},{"id":"C4","span":{"begin":109,"end":165},"obj":"NP"},{"id":"C5","span":{"begin":169,"end":197},"obj":"NP"},{"id":"C6","span":{"begin":198,"end":203},"obj":"NP"},{"id":"C7","span":{"begin":285,"end":290},"obj":"NP"},{"id":"C8","span":{"begin":317,"end":345},"obj":"NP"},{"id":"C9","span":{"begin":346,"end":351},"obj":"NP"},{"id":"C10","span":{"begin":410,"end":415},"obj":"NP"},{"id":"C11","span":{"begin":435,"end":440},"obj":"NP"},{"id":"C13","span":{"begin":465,"end":494},"obj":"NP"},{"id":"C12","span":{"begin":449,"end":494},"obj":"NP"},{"id":"C14","span":{"begin":536,"end":541},"obj":"NP"},{"id":"C15","span":{"begin":553,"end":557},"obj":"NP"},{"id":"C16","span":{"begin":593,"end":634},"obj":"NP"},{"id":"C17","span":{"begin":715,"end":720},"obj":"NP"},{"id":"C18","span":{"begin":730,"end":789},"obj":"NP"},{"id":"C19","span":{"begin":790,"end":795},"obj":"NP"},{"id":"C20","span":{"begin":922,"end":940},"obj":"NP"},{"id":"C21","span":{"begin":950,"end":953},"obj":"NP"},{"id":"C22","span":{"begin":1057,"end":1061},"obj":"NP"},{"id":"C23","span":{"begin":1244,"end":1284},"obj":"NP"},{"id":"C24","span":{"begin":1286,"end":1323},"obj":"NP"},{"id":"C26","span":{"begin":1373,"end":1378},"obj":"NP"},{"id":"C25","span":{"begin":1353,"end":1378},"obj":"NP"},{"id":"C27","span":{"begin":1380,"end":1410},"obj":"NP"},{"id":"C28","span":{"begin":1412,"end":1417},"obj":"NP"},{"id":"C29","span":{"begin":1502,"end":1507},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C4","obj":"C1"},{"id":"R2","pred":"coref-relat","subj":"C6","obj":"C5"},{"id":"R3","pred":"coref-relat","subj":"C9","obj":"C8"},{"id":"R4","pred":"coref-ident","subj":"C10","obj":"C7"},{"id":"R5","pred":"coref-ident","subj":"C11","obj":"C10"},{"id":"R6","pred":"coref-ident","subj":"C12","obj":"C2"},{"id":"R7","pred":"coref-ident","subj":"C14","obj":"C11"},{"id":"R8","pred":"coref-ident","subj":"C15","obj":"C13"},{"id":"R9","pred":"coref-ident","subj":"C16","obj":"C3"},{"id":"R10","pred":"coref-ident","subj":"C17","obj":"C14"},{"id":"R11","pred":"coref-relat","subj":"C19","obj":"C18"},{"id":"R12","pred":"coref-pron","subj":"C21","obj":"C20"},{"id":"R13","pred":"coref-ident","subj":"C22","obj":"C15"},{"id":"R14","pred":"coref-appos","subj":"C24","obj":"C23"},{"id":"R15","pred":"coref-ident","subj":"C26","obj":"C17"},{"id":"R16","pred":"coref-appos","subj":"C27","obj":"C25"},{"id":"R17","pred":"coref-relat","subj":"C28","obj":"C27"},{"id":"R18","pred":"coref-ident","subj":"C29","obj":"C26"}],"text":"Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade.\nThe Epstein-Barr virus latent membrane protein-1 (LMP-1) is an integral membrane protein which transforms fibroblasts and is essential for EBV-mediated B-cell immortalization. LMP-1 has been shown to trigger cellular NF-kappa B activity which, however, cannot fully explain the oncogenic potential of LMP-1. Here we show that LMP-1 induces the activity of the AP-1 transcription factor, a dimer of Jun/Jun or Jun/Fos proteins. LMP-1 effects on AP-1 are mediated through activation of the c-Jun N-terminal kinase (JNK) cascade, but not the extracellular signal-regulated kinase (Erk) pathway. Consequently, LMP-1 triggers the activity of the c-Jun N-terminal transactivation domain which is known to be activated upon JNK-mediated phosphorylation. Deletion analysis indicates that the 55 C-terminal amino acids of the LMP-1 molecule, but not its TRAF interaction domain, are essential for AP-1 activation. JNK-mediated transcriptional activation of AP-1 is the direct output of LMP-1-triggered signaling, as shown by an inducible LMP-1 mutant. Using a tetracycline-regulated LMP-1 allele, we demonstrate that JNK is also an effector of non-cytotoxic LMP-1 signaling in B cells, the physiological target cells of EBV. In summary, our data reveal a novel effector of LMP-1, the SEK/JNK/c-Jun/AP-1 pathway, which contributes to our understanding of the immortalizing and transforming potential of LMP-1."}
GENIAcorpus
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