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PubMed:9351829 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 19-44 protein denotes latent membrane protein-1
T2 54-58 protein denotes AP-1
T3 76-81 protein denotes c-Jun
T4 132-157 protein denotes latent membrane protein-1
T5 159-164 protein denotes LMP-1
T6 172-197 protein denotes integral membrane protein
T7 215-226 cell_type denotes fibroblasts
T8 285-290 protein denotes LMP-1
T9 326-336 protein denotes NF-kappa B
T10 410-415 protein denotes LMP-1
T11 435-440 protein denotes LMP-1
T12 469-494 protein denotes AP-1 transcription factor
T13 507-534 protein denotes Jun/Jun or Jun/Fos proteins
T14 536-541 protein denotes LMP-1
T15 553-557 protein denotes AP-1
T16 597-602 protein denotes c-Jun
T17 622-625 protein denotes JNK
T18 648-685 protein denotes extracellular signal-regulated kinase
T19 687-690 protein denotes Erk
T20 715-720 protein denotes LMP-1
T21 750-789 protein denotes c-Jun N-terminal transactivation domain
T22 826-829 protein denotes JNK
T23 896-918 protein denotes C-terminal amino acids
T24 926-940 protein denotes LMP-1 molecule
T25 954-977 protein denotes TRAF interaction domain
T26 997-1001 protein denotes AP-1
T27 1014-1017 protein denotes JNK
T28 1057-1061 protein denotes AP-1
T29 1086-1089 protein denotes LMP
T30 1138-1150 protein denotes LMP-1 mutant
T31 1160-1195 DNA denotes tetracycline-regulated LMP-1 allele
T32 1217-1220 protein denotes JNK
T33 1258-1263 protein denotes LMP-1
T34 1277-1284 cell_type denotes B cells
T35 1373-1378 protein denotes LMP-1
T36 1388-1391 protein denotes JNK
T37 1392-1397 protein denotes c-Jun
T38 1398-1402 protein denotes AP-1
T39 1502-1507 protein denotes LMP-1

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-108 Sentence denotes Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade.
S2 109-284 Sentence denotes The Epstein-Barr virus latent membrane protein-1 (LMP-1) is an integral membrane protein which transforms fibroblasts and is essential for EBV-mediated B-cell immortalization.
S3 285-416 Sentence denotes LMP-1 has been shown to trigger cellular NF-kappa B activity which, however, cannot fully explain the oncogenic potential of LMP-1.
S4 417-535 Sentence denotes Here we show that LMP-1 induces the activity of the AP-1 transcription factor, a dimer of Jun/Jun or Jun/Fos proteins.
S5 536-700 Sentence denotes LMP-1 effects on AP-1 are mediated through activation of the c-Jun N-terminal kinase (JNK) cascade, but not the extracellular signal-regulated kinase (Erk) pathway.
S6 701-855 Sentence denotes Consequently, LMP-1 triggers the activity of the c-Jun N-terminal transactivation domain which is known to be activated upon JNK-mediated phosphorylation.
S7 856-1013 Sentence denotes Deletion analysis indicates that the 55 C-terminal amino acids of the LMP-1 molecule, but not its TRAF interaction domain, are essential for AP-1 activation.
S8 1014-1151 Sentence denotes JNK-mediated transcriptional activation of AP-1 is the direct output of LMP-1-triggered signaling, as shown by an inducible LMP-1 mutant.
S9 1152-1324 Sentence denotes Using a tetracycline-regulated LMP-1 allele, we demonstrate that JNK is also an effector of non-cytotoxic LMP-1 signaling in B cells, the physiological target cells of EBV.
S10 1325-1508 Sentence denotes In summary, our data reveal a novel effector of LMP-1, the SEK/JNK/c-Jun/AP-1 pathway, which contributes to our understanding of the immortalizing and transforming potential of LMP-1.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-44 NP denotes Epstein-Barr virus latent membrane protein-1
C2 54-67 NP denotes AP-1 activity
C3 72-107 NP denotes the c-Jun N-terminal kinase cascade
C4 109-165 NP denotes The Epstein-Barr virus latent membrane protein-1 (LMP-1)
C5 169-197 NP denotes an integral membrane protein
C6 198-203 NP denotes which
C7 285-290 NP denotes LMP-1
C8 317-345 NP denotes cellular NF-kappa B activity
C9 346-351 NP denotes which
C10 410-415 NP denotes LMP-1
C11 435-440 NP denotes LMP-1
C13 465-494 NP denotes the AP-1 transcription factor
C12 449-494 NP denotes the activity of the AP-1 transcription factor
C14 536-541 NP denotes LMP-1
C15 553-557 NP denotes AP-1
C16 593-634 NP denotes the c-Jun N-terminal kinase (JNK) cascade
C17 715-720 NP denotes LMP-1
C18 730-789 NP denotes the activity of the c-Jun N-terminal transactivation domain
C19 790-795 NP denotes which
C20 922-940 NP denotes the LMP-1 molecule
C21 950-953 NP denotes its
C22 1057-1061 NP denotes AP-1
C23 1244-1284 NP denotes non-cytotoxic LMP-1 signaling in B cells
C24 1286-1323 NP denotes the physiological target cells of EBV
C26 1373-1378 NP denotes LMP-1
C25 1353-1378 NP denotes a novel effector of LMP-1
C27 1380-1410 NP denotes the SEK/JNK/c-Jun/AP-1 pathway
C28 1412-1417 NP denotes which
C29 1502-1507 NP denotes LMP-1
R1 C4 C1 coref-ident The Epstein-Barr virus latent membrane protein-1 (LMP-1),Epstein-Barr virus latent membrane protein-1
R2 C6 C5 coref-relat which,an integral membrane protein
R3 C9 C8 coref-relat which,cellular NF-kappa B activity
R4 C10 C7 coref-ident LMP-1,LMP-1
R5 C11 C10 coref-ident LMP-1,LMP-1
R6 C12 C2 coref-ident the activity of the AP-1 transcription factor,AP-1 activity
R7 C14 C11 coref-ident LMP-1,LMP-1
R8 C15 C13 coref-ident AP-1,the AP-1 transcription factor
R9 C16 C3 coref-ident the c-Jun N-terminal kinase (JNK) cascade,the c-Jun N-terminal kinase cascade
R10 C17 C14 coref-ident LMP-1,LMP-1
R11 C19 C18 coref-relat which,the activity of the c-Jun N-terminal transactivation domain
R12 C21 C20 coref-pron its,the LMP-1 molecule
R13 C22 C15 coref-ident AP-1,AP-1
R14 C24 C23 coref-appos the physiological target cells of EBV,non-cytotoxic LMP-1 signaling in B cells
R15 C26 C17 coref-ident LMP-1,LMP-1
R16 C27 C25 coref-appos the SEK/JNK/c-Jun/AP-1 pathway,a novel effector of LMP-1
R17 C28 C27 coref-relat which,the SEK/JNK/c-Jun/AP-1 pathway
R18 C29 C26 coref-ident LMP-1,LMP-1

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-18 virus denotes Epstein-Barr virus
T2 19-44 protein_molecule denotes latent membrane protein-1
T3 54-58 protein_molecule denotes AP-1
T4 76-81 protein_molecule denotes c-Jun
T5 113-131 virus denotes Epstein-Barr virus
T6 132-157 protein_molecule denotes latent membrane protein-1
T7 159-164 protein_molecule denotes LMP-1
T8 172-197 protein_family_or_group denotes integral membrane protein
T9 215-226 cell_type denotes fibroblasts
T10 248-283 other_name denotes EBV-mediated B-cell immortalization
T11 285-290 protein_molecule denotes LMP-1
T12 326-336 protein_complex denotes NF-kappa B
T13 387-406 other_name denotes oncogenic potential
T14 410-415 protein_molecule denotes LMP-1
T15 435-440 protein_molecule denotes LMP-1
T16 469-473 protein_molecule denotes AP-1
T17 507-514 protein_complex denotes Jun/Jun
T18 518-525 protein_complex denotes Jun/Fos
T19 536-541 protein_molecule denotes LMP-1
T20 553-557 protein_molecule denotes AP-1
T21 597-602 protein_molecule denotes c-Jun
T22 622-625 protein_molecule denotes JNK
T23 648-685 protein_molecule denotes extracellular signal-regulated kinase
T24 687-690 protein_molecule denotes Erk
T25 715-720 protein_molecule denotes LMP-1
T26 750-755 protein_molecule denotes c-Jun
T27 826-829 protein_molecule denotes JNK
T28 896-918 protein_domain_or_region denotes C-terminal amino acids
T29 926-931 protein_molecule denotes LMP-1
T30 954-977 protein_domain_or_region denotes TRAF interaction domain
T31 997-1001 protein_molecule denotes AP-1
T32 1014-1017 protein_molecule denotes JNK
T33 1057-1061 protein_molecule denotes AP-1
T34 1086-1089 protein_family_or_group denotes LMP
T35 1138-1143 protein_molecule denotes LMP-1
T36 1160-1182 DNA_domain_or_region denotes tetracycline-regulated
T37 1183-1188 protein_molecule denotes LMP-1
T38 1217-1220 protein_molecule denotes JNK
T39 1244-1257 other_name denotes non-cytotoxic
T40 1258-1263 protein_molecule denotes LMP-1
T41 1277-1284 cell_type denotes B cells
T42 1320-1323 virus denotes EBV
T43 1373-1378 protein_molecule denotes LMP-1
T44 1384-1388 other_name denotes SEK/
T45 1388-1391 protein_molecule denotes JNK
T46 1392-1397 protein_molecule denotes c-Jun
T47 1398-1402 protein_molecule denotes AP-1
T48 1476-1498 other_name denotes transforming potential
T49 1502-1507 protein_molecule denotes LMP-1