PubMed:9346236 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/9346236","sourcedb":"PubMed","sourceid":"9346236","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/9346236","text":"The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation.\nThe homeobox gene GBX2 was identified as a target gene of the v-Myb oncoprotein encoded by the avian myeloblastosis virus (AMV). GBX2 activation by c-Myb requires signal transduction emanating from the cell surface while the leukemogenic AMV v-Myb constitutively induces the GBX2 gene. Mutations in the DNA binding domain of AMV-Myb render it independent of signaling events and concomitantly abrogate the collaboration between Myb and CCAAT Enhancer Binding Proteins (C/EBP), which are involved in granulocyte differentiation. Ectopic expression of GBX2 in growth factor-dependent myeloblasts induces monocytic features and independence from exogenous cytokines, reflecting distinct features of AMV-transformed cells. Our results suggest that Myb or factors it interacts with contribute to hematopoietic lineage choice and differentiation in a signal transduction-dependent 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