PubMed:9346236 JSONTXT

{"project":"bionlp-st-gro-2013-development","denotations":[{"id":"T3","span":{"begin":40,"end":52},"obj":"Gene"},{"id":"T10","span":{"begin":160,"end":164},"obj":"Gene"},{"id":"T11","span":{"begin":172,"end":189},"obj":"Protein"},{"id":"T12","span":{"begin":205,"end":231},"obj":"Virus"},{"id":"T13","span":{"begin":233,"end":236},"obj":"Virus"},{"id":"T14","span":{"begin":239,"end":243},"obj":"Gene"},{"id":"T16","span":{"begin":258,"end":263},"obj":"Protein"},{"id":"T17","span":{"begin":348,"end":351},"obj":"Virus"},{"id":"T18","span":{"begin":352,"end":357},"obj":"Protein"},{"id":"T20","span":{"begin":385,"end":394},"obj":"Gene"},{"id":"T22","span":{"begin":413,"end":431},"obj":"DNABindingDomainOfProtein"},{"id":"T23","span":{"begin":435,"end":438},"obj":"Virus"},{"id":"T24","span":{"begin":439,"end":442},"obj":"Protein"},{"id":"T27","span":{"begin":538,"end":541},"obj":"Protein"},{"id":"T28","span":{"begin":546,"end":577},"obj":"Protein"},{"id":"T29","span":{"begin":579,"end":584},"obj":"Protein"},{"id":"T32","span":{"begin":660,"end":664},"obj":"Protein"},{"id":"T33","span":{"begin":668,"end":681},"obj":"Protein"},{"id":"T34","span":{"begin":692,"end":703},"obj":"Cell"},{"id":"T36","span":{"begin":712,"end":721},"obj":"Cell"},{"id":"T37","span":{"begin":722,"end":730},"obj":"Function"},{"id":"T38","span":{"begin":763,"end":772},"obj":"Protein"},{"id":"T39","span":{"begin":806,"end":809},"obj":"Virus"},{"id":"T40","span":{"begin":822,"end":827},"obj":"Cell"},{"id":"T41","span":{"begin":854,"end":857},"obj":"Protein"},{"id":"T42","span":{"begin":861,"end":868},"obj":"Gene"},{"id":"T43","span":{"begin":869,"end":871},"obj":"Protein"},{"id":"T1","span":{"begin":4,"end":17},"obj":"Gene"},{"id":"T2","span":{"begin":18,"end":22},"obj":"Gene"},{"id":"T7","span":{"begin":114,"end":127},"obj":"Gene"},{"id":"T8","span":{"begin":128,"end":132},"obj":"Gene"},{"id":"E1","span":{"begin":54,"end":62},"obj":"RegulatoryProcess"},{"id":"E2","span":{"begin":63,"end":79},"obj":"CellGrowth"},{"id":"E3","span":{"begin":84,"end":108},"obj":"CellDifferentiation"},{"id":"E5","span":{"begin":244,"end":254},"obj":"PositiveRegulationOfGeneExpression"},{"id":"E6","span":{"begin":373,"end":380},"obj":"PositiveRegulationOfGeneExpression"},{"id":"E7","span":{"begin":396,"end":405},"obj":"Mutation"},{"id":"E8","span":{"begin":503,"end":511},"obj":"NegativeRegulation"},{"id":"E10","span":{"begin":609,"end":636},"obj":"CellDifferentiation"},{"id":"E11","span":{"begin":638,"end":656},"obj":"GeneExpression"},{"id":"E12","span":{"begin":704,"end":711},"obj":"PositiveRegulation"},{"id":"E13","span":{"begin":872,"end":881},"obj":"BindingToProtein"},{"id":"E14","span":{"begin":901,"end":929},"obj":"CellFateDetermination"},{"id":"E15","span":{"begin":934,"end":949},"obj":"CellDifferentiation"},{"id":"E16","span":{"begin":955,"end":974},"obj":"SignalingPathway"},{"id":"E4","span":{"begin":273,"end":292},"obj":"SignalingPathway"},{"id":"E9","span":{"begin":54,"end":62},"obj":"RegulatoryProcess"}],"relations":[{"id":"R4","pred":"fromSpecies","subj":"T18","obj":"T17"},{"id":"R5","pred":"fromSpecies","subj":"T24","obj":"T23"},{"id":"R6","pred":"hasPart","subj":"T24","obj":"T22"},{"id":"R7","pred":"locatedIn","subj":"E11","obj":"T34"},{"id":"R8","pred":"hasFunction","subj":"T36","obj":"T37"},{"id":"R1","pred":"fromSpecies","subj":"T11","obj":"T13"},{"id":"R3","pred":"hasAgent","subj":"T2","obj":"E1"},{"id":"R4","pred":"hasPatient","subj":"E2","obj":"E1"},{"id":"R5","pred":"hasAgent","subj":"T16","obj":"E5"},{"id":"R6","pred":"hasPatient","subj":"T14","obj":"E5"},{"id":"R7","pred":"hasAgent","subj":"T18","obj":"E6"},{"id":"R8","pred":"hasPatient","subj":"T20","obj":"E6"},{"id":"R9","pred":"hasPatient","subj":"T22","obj":"E7"},{"id":"R10","pred":"hasAgent","subj":"E7","obj":"E8"},{"id":"R11","pred":"hasPatient","subj":"T32","obj":"E11"},{"id":"R12","pred":"hasAgent","subj":"E11","obj":"E12"},{"id":"R13","pred":"hasPatient","subj":"T37","obj":"E12"},{"id":"R14","pred":"hasPatient","subj":"T43","obj":"E13"},{"id":"R15","pred":"hasPatient","subj":"T42","obj":"E13"},{"id":"R16","pred":"hasPatient","subj":"T41","obj":"E13"},{"id":"R17","pred":"hasAgent","subj":"T2","obj":"E9"},{"id":"R18","pred":"hasPatient","subj":"E3","obj":"E9"}],"text":"The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation.\nThe homeobox gene GBX2 was identified as a target gene of the v-Myb oncoprotein encoded by the avian myeloblastosis virus (AMV). GBX2 activation by c-Myb requires signal transduction emanating from the cell surface while the leukemogenic AMV v-Myb constitutively induces the GBX2 gene. Mutations in the DNA binding domain of AMV-Myb render it independent of signaling events and concomitantly abrogate the collaboration between Myb and CCAAT Enhancer Binding Proteins (C/EBP), which are involved in granulocyte differentiation. Ectopic expression of GBX2 in growth factor-dependent myeloblasts induces monocytic features and independence from exogenous cytokines, reflecting distinct features of AMV-transformed cells. Our results suggest that Myb or factors it interacts with contribute to hematopoietic lineage choice and differentiation in a signal transduction-dependent fashion."}

{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":205,"end":231},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":233,"end":236},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":348,"end":351},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":435,"end":438},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":806,"end":809},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"11866"},{"id":"A2","pred":"db_id","subj":"T2","obj":"11866"},{"id":"A3","pred":"db_id","subj":"T3","obj":"11866"},{"id":"A4","pred":"db_id","subj":"T4","obj":"11866"},{"id":"A5","pred":"db_id","subj":"T5","obj":"11866"}],"text":"The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation.\nThe homeobox gene GBX2 was identified as a target gene of the v-Myb oncoprotein encoded by the avian myeloblastosis virus (AMV). GBX2 activation by c-Myb requires signal transduction emanating from the cell surface while the leukemogenic AMV v-Myb constitutively induces the GBX2 gene. Mutations in the DNA binding domain of AMV-Myb render it independent of signaling events and concomitantly abrogate the collaboration between Myb and CCAAT Enhancer Binding Proteins (C/EBP), which are involved in granulocyte differentiation. Ectopic expression of GBX2 in growth factor-dependent myeloblasts induces monocytic features and independence from exogenous cytokines, reflecting distinct features of AMV-transformed cells. Our results suggest that Myb or factors it interacts with contribute to hematopoietic lineage choice and differentiation in a signal transduction-dependent fashion."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":84,"end":92},"obj":"Body_part"},{"id":"T3","span":{"begin":609,"end":620},"obj":"Body_part"},{"id":"T4","span":{"begin":692,"end":703},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A2","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000094"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0000835"}],"text":"The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation.\nThe homeobox gene GBX2 was identified as a target gene of the v-Myb oncoprotein encoded by the avian myeloblastosis virus (AMV). GBX2 activation by c-Myb requires signal transduction emanating from the cell surface while the leukemogenic AMV v-Myb constitutively induces the GBX2 gene. Mutations in the DNA binding domain of AMV-Myb render it independent of signaling events and concomitantly abrogate the collaboration between Myb and CCAAT Enhancer Binding Proteins (C/EBP), which are involved in granulocyte differentiation. Ectopic expression of GBX2 in growth factor-dependent myeloblasts induces monocytic features and independence from exogenous cytokines, reflecting distinct features of AMV-transformed cells. Our results suggest that Myb or factors it interacts with contribute to hematopoietic lineage choice and differentiation in a signal transduction-dependent fashion."}

{"project":"Glycosmos15-CL","denotations":[{"id":"T1","span":{"begin":84,"end":92},"obj":"Cell"},{"id":"T3","span":{"begin":609,"end":620},"obj":"Cell"},{"id":"T4","span":{"begin":692,"end":703},"obj":"Cell"},{"id":"T5","span":{"begin":712,"end":721},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A2","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000094"},{"id":"A4","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0000835"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A6","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0001054"}],"text":"The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation.\nThe homeobox gene GBX2 was identified as a target gene of the v-Myb oncoprotein encoded by the avian myeloblastosis virus (AMV). GBX2 activation by c-Myb requires signal transduction emanating from the cell surface while the leukemogenic AMV v-Myb constitutively induces the GBX2 gene. Mutations in the DNA binding domain of AMV-Myb render it independent of signaling events and concomitantly abrogate the collaboration between Myb and CCAAT Enhancer Binding Proteins (C/EBP), which are involved in granulocyte differentiation. Ectopic expression of GBX2 in growth factor-dependent myeloblasts induces monocytic features and independence from exogenous cytokines, reflecting distinct features of AMV-transformed cells. Our results suggest that Myb or factors it interacts with contribute to hematopoietic lineage choice and differentiation in a signal transduction-dependent fashion."}