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PubMed:9311921
Annnotations
jnlpba-st-training
{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":0,"end":5},"obj":"protein"},{"id":"T2","span":{"begin":30,"end":34},"obj":"protein"},{"id":"T3","span":{"begin":61,"end":103},"obj":"protein"},{"id":"T4","span":{"begin":123,"end":158},"obj":"protein"},{"id":"T5","span":{"begin":159,"end":179},"obj":"protein"},{"id":"T6","span":{"begin":181,"end":186},"obj":"protein"},{"id":"T7","span":{"begin":237,"end":292},"obj":"protein"},{"id":"T8","span":{"begin":311,"end":316},"obj":"protein"},{"id":"T9","span":{"begin":350,"end":364},"obj":"cell_line"},{"id":"T10","span":{"begin":382,"end":424},"obj":"protein"},{"id":"T11","span":{"begin":468,"end":472},"obj":"protein"},{"id":"T12","span":{"begin":496,"end":523},"obj":"protein"},{"id":"T13","span":{"begin":536,"end":540},"obj":"protein"},{"id":"T14","span":{"begin":542,"end":585},"obj":"protein"},{"id":"T15","span":{"begin":606,"end":630},"obj":"cell_line"},{"id":"T16","span":{"begin":636,"end":660},"obj":"protein"},{"id":"T17","span":{"begin":686,"end":707},"obj":"protein"},{"id":"T18","span":{"begin":708,"end":713},"obj":"protein"},{"id":"T19","span":{"begin":715,"end":719},"obj":"protein"},{"id":"T20","span":{"begin":725,"end":733},"obj":"protein"},{"id":"T21","span":{"begin":735,"end":739},"obj":"protein"},{"id":"T22","span":{"begin":762,"end":767},"obj":"protein"},{"id":"T23","span":{"begin":798,"end":827},"obj":"protein"},{"id":"T24","span":{"begin":846,"end":850},"obj":"protein"}],"text":"NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.\nActivation of the nuclear factor of activated T cells transcription factor (NF-AT) is a key event underlying lymphocyte action. The CAML (calcium-modulator and cyclophilin ligand) protein is a coinducer of NF-AT activation when overexpressed in Jurkat T cells. A member of the tumor necrosis factor receptor superfamily was isolated by virtue of its affinity for CAML. Cross-linking of this lymphocyte-specific protein, designated TACI (transmembrane activator and CAML-interactor), on the surface of transfected Jurkat cells with TACI-specific antibodies led to activation of the transcription factors NF-AT, AP-1, and NFkappaB. TACI-induced activation of NF-AT was specifically blocked by a dominant-negative CAML mutant, thus implicating CAML as a signaling intermediate."}
pubmed-sentences-benchmark
{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":104},"obj":"Sentence"},{"id":"S2","span":{"begin":105,"end":232},"obj":"Sentence"},{"id":"S3","span":{"begin":233,"end":365},"obj":"Sentence"},{"id":"S4","span":{"begin":366,"end":473},"obj":"Sentence"},{"id":"S5","span":{"begin":474,"end":734},"obj":"Sentence"},{"id":"S6","span":{"begin":735,"end":879},"obj":"Sentence"}],"text":"NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.\nActivation of the nuclear factor of activated T cells transcription factor (NF-AT) is a key event underlying lymphocyte action. The CAML (calcium-modulator and cyclophilin ligand) protein is a coinducer of NF-AT activation when overexpressed in Jurkat T cells. A member of the tumor necrosis factor receptor superfamily was isolated by virtue of its affinity for CAML. Cross-linking of this lymphocyte-specific protein, designated TACI (transmembrane activator and CAML-interactor), on the surface of transfected Jurkat cells with TACI-specific antibodies led to activation of the transcription factors NF-AT, AP-1, and NFkappaB. TACI-induced activation of NF-AT was specifically blocked by a dominant-negative CAML mutant, thus implicating CAML as a signaling intermediate."}
genia-medco-coref
{"project":"genia-medco-coref","denotations":[{"id":"C2","span":{"begin":28,"end":103},"obj":"NP"},{"id":"C1","span":{"begin":0,"end":103},"obj":"NP"},{"id":"C4","span":{"begin":119,"end":187},"obj":"NP"},{"id":"C3","span":{"begin":105,"end":187},"obj":"NP"},{"id":"C5","span":{"begin":233,"end":292},"obj":"NP"},{"id":"C6","span":{"begin":311,"end":327},"obj":"NP"},{"id":"C7","span":{"begin":366,"end":424},"obj":"NP"},{"id":"C8","span":{"begin":451,"end":454},"obj":"NP"},{"id":"C9","span":{"begin":468,"end":472},"obj":"NP"},{"id":"C10","span":{"begin":491,"end":523},"obj":"NP"},{"id":"C11","span":{"begin":536,"end":586},"obj":"NP"},{"id":"C13","span":{"begin":762,"end":767},"obj":"NP"},{"id":"C12","span":{"begin":735,"end":767},"obj":"NP"},{"id":"C14","span":{"begin":846,"end":850},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C6","obj":"C3"},{"id":"R2","pred":"coref-ident","subj":"C7","obj":"C2"},{"id":"R3","pred":"coref-pron","subj":"C8","obj":"C7"},{"id":"R4","pred":"coref-ident","subj":"C9","obj":"C5"},{"id":"R5","pred":"coref-ident","subj":"C10","obj":"C7"},{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C10"},{"id":"R7","pred":"coref-ident","subj":"C13","obj":"C4"},{"id":"R8","pred":"coref-ident","subj":"C12","obj":"C1"},{"id":"R9","pred":"coref-ident","subj":"C14","obj":"C9"}],"text":"NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.\nActivation of the nuclear factor of activated T cells transcription factor (NF-AT) is a key event underlying lymphocyte action. The CAML (calcium-modulator and cyclophilin ligand) protein is a coinducer of NF-AT activation when overexpressed in Jurkat T cells. A member of the tumor necrosis factor receptor superfamily was isolated by virtue of its affinity for CAML. Cross-linking of this lymphocyte-specific protein, designated TACI (transmembrane activator and CAML-interactor), on the surface of transfected Jurkat cells with TACI-specific antibodies led to activation of the transcription factors NF-AT, AP-1, and NFkappaB. TACI-induced activation of NF-AT was specifically blocked by a dominant-negative CAML mutant, thus implicating CAML as a signaling intermediate."}
GENIAcorpus
{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":5},"obj":"protein_molecule"},{"id":"T2","span":{"begin":30,"end":34},"obj":"protein_molecule"},{"id":"T3","span":{"begin":61,"end":103},"obj":"protein_family_or_group"},{"id":"T4","span":{"begin":123,"end":158},"obj":"protein_molecule"},{"id":"T5","span":{"begin":159,"end":179},"obj":"protein_family_or_group"},{"id":"T6","span":{"begin":181,"end":186},"obj":"protein_molecule"},{"id":"T7","span":{"begin":214,"end":231},"obj":"other_name"},{"id":"T8","span":{"begin":237,"end":292},"obj":"protein_molecule"},{"id":"T9","span":{"begin":311,"end":316},"obj":"protein_molecule"},{"id":"T10","span":{"begin":350,"end":364},"obj":"cell_line"},{"id":"T11","span":{"begin":382,"end":424},"obj":"protein_family_or_group"},{"id":"T12","span":{"begin":468,"end":472},"obj":"protein_molecule"},{"id":"T13","span":{"begin":496,"end":523},"obj":"protein_family_or_group"},{"id":"T14","span":{"begin":536,"end":540},"obj":"protein_molecule"},{"id":"T15","span":{"begin":542,"end":569},"obj":"protein_molecule"},{"id":"T16","span":{"begin":570,"end":574},"obj":"protein_molecule"},{"id":"T17","span":{"begin":606,"end":630},"obj":"cell_line"},{"id":"T18","span":{"begin":636,"end":640},"obj":"protein_molecule"},{"id":"T19","span":{"begin":686,"end":707},"obj":"protein_family_or_group"},{"id":"T20","span":{"begin":708,"end":713},"obj":"protein_molecule"},{"id":"T21","span":{"begin":715,"end":719},"obj":"protein_molecule"},{"id":"T22","span":{"begin":725,"end":733},"obj":"protein_complex"},{"id":"T23","span":{"begin":735,"end":739},"obj":"protein_molecule"},{"id":"T24","span":{"begin":762,"end":767},"obj":"protein_molecule"},{"id":"T25","span":{"begin":798,"end":815},"obj":"protein_molecule"},{"id":"T26","span":{"begin":816,"end":820},"obj":"protein_molecule"},{"id":"T27","span":{"begin":846,"end":850},"obj":"protein_molecule"},{"id":"T28","span":{"begin":856,"end":878},"obj":"other_name"}],"text":"NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.\nActivation of the nuclear factor of activated T cells transcription factor (NF-AT) is a key event underlying lymphocyte action. The CAML (calcium-modulator and cyclophilin ligand) protein is a coinducer of NF-AT activation when overexpressed in Jurkat T cells. A member of the tumor necrosis factor receptor superfamily was isolated by virtue of its affinity for CAML. Cross-linking of this lymphocyte-specific protein, designated TACI (transmembrane activator and CAML-interactor), on the surface of transfected Jurkat cells with TACI-specific antibodies led to activation of the transcription factors NF-AT, AP-1, and NFkappaB. TACI-induced activation of NF-AT was specifically blocked by a dominant-negative CAML mutant, thus implicating CAML as a signaling intermediate."}
bionlp-st-gro-2013-development
{"project":"bionlp-st-gro-2013-development","denotations":[{"id":"T1","span":{"begin":0,"end":5},"obj":"TranscriptionFactor"},{"id":"T13","span":{"begin":181,"end":186},"obj":"TranscriptionFactor"},{"id":"T14","span":{"begin":214,"end":224},"obj":"Cell"},{"id":"T15","span":{"begin":237,"end":241},"obj":"Protein"},{"id":"T16","span":{"begin":243,"end":283},"obj":"Protein"},{"id":"T18","span":{"begin":311,"end":316},"obj":"Protein"},{"id":"T21","span":{"begin":350,"end":364},"obj":"Cell"},{"id":"T24","span":{"begin":468,"end":472},"obj":"Protein"},{"id":"T27","span":{"begin":536,"end":540},"obj":"Protein"},{"id":"T28","span":{"begin":542,"end":585},"obj":"Protein"},{"id":"T29","span":{"begin":595,"end":602},"obj":"CellComponent"},{"id":"T30","span":{"begin":618,"end":630},"obj":"Cell"},{"id":"T31","span":{"begin":636,"end":640},"obj":"Protein"},{"id":"T32","span":{"begin":650,"end":660},"obj":"Protein"},{"id":"T34","span":{"begin":686,"end":707},"obj":"TranscriptionFactor"},{"id":"T35","span":{"begin":708,"end":713},"obj":"TranscriptionFactor"},{"id":"T36","span":{"begin":715,"end":719},"obj":"TranscriptionFactor"},{"id":"T37","span":{"begin":725,"end":733},"obj":"TranscriptionFactor"},{"id":"T38","span":{"begin":735,"end":739},"obj":"Protein"},{"id":"T40","span":{"begin":762,"end":767},"obj":"Protein"},{"id":"T44","span":{"begin":846,"end":850},"obj":"Protein"},{"id":"T4","span":{"begin":61,"end":91},"obj":"Protein"},{"id":"T5","span":{"begin":30,"end":53},"obj":"Protein"},{"id":"T6","span":{"begin":123,"end":179},"obj":"TranscriptionFactor"},{"id":"T7","span":{"begin":382,"end":412},"obj":"Protein"},{"id":"T9","span":{"begin":496,"end":523},"obj":"Protein"},{"id":"T10","span":{"begin":816,"end":827},"obj":"MutantProtein"},{"id":"E1","span":{"begin":6,"end":16},"obj":"PositiveRegulation"},{"id":"E2","span":{"begin":17,"end":24},"obj":"Increase"},{"id":"E4","span":{"begin":105,"end":115},"obj":"PositiveRegulation"},{"id":"E6","span":{"begin":317,"end":327},"obj":"PositiveRegulation"},{"id":"E7","span":{"begin":333,"end":346},"obj":"PositiveRegulationOfGeneExpression"},{"id":"E8","span":{"begin":668,"end":678},"obj":"PositiveRegulation"},{"id":"E9","span":{"begin":748,"end":758},"obj":"PositiveRegulation"},{"id":"E10","span":{"begin":785,"end":792},"obj":"NegativeRegulation"},{"id":"E11","span":{"begin":856,"end":865},"obj":"SignalingPathway"},{"id":"E3","span":{"begin":668,"end":678},"obj":"PositiveRegulation"},{"id":"E5","span":{"begin":668,"end":678},"obj":"PositiveRegulation"}],"relations":[{"id":"R1","pred":"locatedIn","subj":"E4","obj":"T14"},{"id":"R2","pred":"locatedIn","subj":"E7","obj":"T21"},{"id":"R3","pred":"locatedIn","subj":"T29","obj":"T30"},{"id":"R5","pred":"hasPatient","subj":"T1","obj":"E1"},{"id":"R6","pred":"hasAgent","subj":"T5","obj":"E2"},{"id":"R7","pred":"hasPatient","subj":"E1","obj":"E2"},{"id":"R8","pred":"hasPatient","subj":"T13","obj":"E4"},{"id":"R9","pred":"hasAgent","subj":"T15","obj":"E6"},{"id":"R10","pred":"hasPatient","subj":"T18","obj":"E6"},{"id":"R11","pred":"hasPatient","subj":"T15","obj":"E7"},{"id":"R12","pred":"hasPatient","subj":"T35","obj":"E8"},{"id":"R13","pred":"hasAgent","subj":"T38","obj":"E9"},{"id":"R14","pred":"hasPatient","subj":"T40","obj":"E9"},{"id":"R15","pred":"hasAgent","subj":"T10","obj":"E10"},{"id":"R16","pred":"hasPatient","subj":"E9","obj":"E10"},{"id":"R17","pred":"hasPatient","subj":"T36","obj":"E3"},{"id":"R18","pred":"hasPatient","subj":"T37","obj":"E5"}],"text":"NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.\nActivation of the nuclear factor of activated T cells transcription factor (NF-AT) is a key event underlying lymphocyte action. The CAML (calcium-modulator and cyclophilin ligand) protein is a coinducer of NF-AT activation when overexpressed in Jurkat T cells. A member of the tumor necrosis factor receptor superfamily was isolated by virtue of its affinity for CAML. Cross-linking of this lymphocyte-specific protein, designated TACI (transmembrane activator and CAML-interactor), on the surface of transfected Jurkat cells with TACI-specific antibodies led to activation of the transcription factors NF-AT, AP-1, and NFkappaB. TACI-induced activation of NF-AT was specifically blocked by a dominant-negative CAML mutant, thus implicating CAML as a signaling intermediate."}