PubMed:9309306
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/9309306","sourcedb":"PubMed","sourceid":"9309306","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/9309306","text":"Alcohol-induced regulation of nuclear regulatory factor-kappa beta in human monocytes.\nAcute ethanol exposure has the capacity to modulate immune functions, particularly, to down regulate monocyte production of inflammatory cytokines. However, the intracellular mechanisms for these effects of ethanol are yet to be understood. Considering that nuclear regulatory factor-kappa beta (NF-kappa B)/Rel is a common regulatory element of the promoter region of the inflammatory cytokine genes, herein, we tested the hypothesis that acute ethanol affects NF-kappa B activation in human monocytes. Adherence-isolated monocytes showed constitutive DNA binding activity of NF-kappa B. A clinically relevant dose (25 mM) of acute ethanol treatment in vitro increased NF-kappa B binding activity in monocytes with a preferential induction of the inhibitory, p50/p50, NF-kappa B/Rel homodimer, and resulted in no induction of the p65/p50 heterodimer. In contrast, lipopolysaccharide stimulation primarily induced the p65/p50 heterodimer that has been shown to result in gene activation. Thus, such unique activation of the inhibitory p50/p50 homodimer by acute ethanol treatment may result in inhibition rather than activation of NF-kappa B-regulated inflammatory cytokine genes. Consequently, these results suggest that physiologically relevant concentrations of ethanol may affect production of inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 by disrupting NF-kappa B signaling in monocytes.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":70,"end":85},"obj":"NP"},{"id":"C2","span":{"begin":211,"end":233},"obj":"NP"},{"id":"C3","span":{"begin":294,"end":301},"obj":"NP"},{"id":"C4","span":{"begin":507,"end":521},"obj":"NP"},{"id":"C5","span":{"begin":522,"end":526},"obj":"NP"},{"id":"C6","span":{"begin":574,"end":589},"obj":"NP"},{"id":"C7","span":{"begin":788,"end":797},"obj":"NP"},{"id":"C8","span":{"begin":831,"end":880},"obj":"NP"},{"id":"C9","span":{"begin":914,"end":937},"obj":"NP"},{"id":"C10","span":{"begin":1001,"end":1024},"obj":"NP"},{"id":"C11","span":{"begin":1025,"end":1029},"obj":"NP"},{"id":"C12","span":{"begin":1107,"end":1139},"obj":"NP"},{"id":"C13","span":{"begin":1352,"end":1359},"obj":"NP"},{"id":"C14","span":{"begin":1385,"end":1407},"obj":"NP"},{"id":"C15","span":{"begin":1522,"end":1531},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-relat","subj":"C5","obj":"C4"},{"id":"R2","pred":"coref-ident","subj":"C6","obj":"C1"},{"id":"R3","pred":"coref-ident","subj":"C7","obj":"C6"},{"id":"R4","pred":"coref-ident","subj":"C10","obj":"C9"},{"id":"R5","pred":"coref-relat","subj":"C11","obj":"C10"},{"id":"R6","pred":"coref-ident","subj":"C12","obj":"C8"},{"id":"R7","pred":"coref-ident","subj":"C13","obj":"C3"},{"id":"R8","pred":"coref-ident","subj":"C14","obj":"C2"},{"id":"R9","pred":"coref-ident","subj":"C15","obj":"C7"}],"attributes":[{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C10","pred":"source","obj":"genia-medco-coref"},{"subj":"C11","pred":"source","obj":"genia-medco-coref"},{"subj":"C12","pred":"source","obj":"genia-medco-coref"},{"subj":"C13","pred":"source","obj":"genia-medco-coref"},{"subj":"C14","pred":"source","obj":"genia-medco-coref"},{"subj":"C15","pred":"source","obj":"genia-medco-coref"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":30,"end":66},"obj":"protein"},{"id":"T2","span":{"begin":70,"end":85},"obj":"cell_type"},{"id":"T3","span":{"begin":211,"end":233},"obj":"protein"},{"id":"T4","span":{"begin":345,"end":381},"obj":"protein"},{"id":"T5","span":{"begin":382,"end":398},"obj":"protein"},{"id":"T6","span":{"begin":411,"end":429},"obj":"protein"},{"id":"T7","span":{"begin":437,"end":452},"obj":"DNA"},{"id":"T8","span":{"begin":460,"end":487},"obj":"DNA"},{"id":"T9","span":{"begin":549,"end":559},"obj":"protein"},{"id":"T10","span":{"begin":574,"end":589},"obj":"cell_type"},{"id":"T11","span":{"begin":591,"end":619},"obj":"cell_line"},{"id":"T12","span":{"begin":664,"end":674},"obj":"protein"},{"id":"T13","span":{"begin":757,"end":767},"obj":"protein"},{"id":"T14","span":{"begin":788,"end":797},"obj":"cell_type"},{"id":"T15","span":{"begin":847,"end":854},"obj":"protein"},{"id":"T16","span":{"begin":856,"end":880},"obj":"protein"},{"id":"T17","span":{"begin":918,"end":937},"obj":"protein"},{"id":"T18","span":{"begin":1005,"end":1024},"obj":"protein"},{"id":"T19","span":{"begin":1111,"end":1139},"obj":"protein"},{"id":"T20","span":{"begin":1218,"end":1266},"obj":"DNA"},{"id":"T21","span":{"begin":1385,"end":1407},"obj":"protein"},{"id":"T22","span":{"begin":1417,"end":1444},"obj":"protein"},{"id":"T23","span":{"begin":1446,"end":1464},"obj":"protein"},{"id":"T24","span":{"begin":1470,"end":1483},"obj":"protein"},{"id":"T25","span":{"begin":1498,"end":1508},"obj":"protein"},{"id":"T26","span":{"begin":1522,"end":1531},"obj":"cell_type"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"},{"subj":"T18","pred":"source","obj":"jnlpba-st-training"},{"subj":"T19","pred":"source","obj":"jnlpba-st-training"},{"subj":"T20","pred":"source","obj":"jnlpba-st-training"},{"subj":"T21","pred":"source","obj":"jnlpba-st-training"},{"subj":"T22","pred":"source","obj":"jnlpba-st-training"},{"subj":"T23","pred":"source","obj":"jnlpba-st-training"},{"subj":"T24","pred":"source","obj":"jnlpba-st-training"},{"subj":"T25","pred":"source","obj":"jnlpba-st-training"},{"subj":"T26","pred":"source","obj":"jnlpba-st-training"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":86},"obj":"Sentence"},{"id":"S2","span":{"begin":87,"end":234},"obj":"Sentence"},{"id":"S3","span":{"begin":235,"end":327},"obj":"Sentence"},{"id":"S4","span":{"begin":328,"end":590},"obj":"Sentence"},{"id":"S5","span":{"begin":591,"end":675},"obj":"Sentence"},{"id":"S6","span":{"begin":676,"end":938},"obj":"Sentence"},{"id":"S7","span":{"begin":939,"end":1074},"obj":"Sentence"},{"id":"S8","span":{"begin":1075,"end":1267},"obj":"Sentence"},{"id":"S9","span":{"begin":1268,"end":1532},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S7","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S8","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S9","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":26},"obj":"other_name"},{"id":"T2","span":{"begin":30,"end":66},"obj":"protein_complex"},{"id":"T3","span":{"begin":70,"end":85},"obj":"cell_type"},{"id":"T4","span":{"begin":139,"end":155},"obj":"other_name"},{"id":"T5","span":{"begin":188,"end":207},"obj":"other_name"},{"id":"T6","span":{"begin":211,"end":223},"obj":"protein_family_or_group"},{"id":"T7","span":{"begin":224,"end":233},"obj":"protein_family_or_group"},{"id":"T8","span":{"begin":248,"end":272},"obj":"other_name"},{"id":"T9","span":{"begin":294,"end":301},"obj":"other_organic_compound"},{"id":"T10","span":{"begin":345,"end":381},"obj":"protein_complex"},{"id":"T11","span":{"begin":382,"end":398},"obj":"protein_complex"},{"id":"T12","span":{"begin":411,"end":429},"obj":"protein_family_or_group"},{"id":"T13","span":{"begin":437,"end":452},"obj":"DNA_domain_or_region"},{"id":"T14","span":{"begin":460,"end":487},"obj":"DNA_family_or_group"},{"id":"T15","span":{"begin":533,"end":540},"obj":"other_organic_compound"},{"id":"T16","span":{"begin":549,"end":559},"obj":"protein_complex"},{"id":"T17","span":{"begin":574,"end":589},"obj":"cell_type"},{"id":"T18","span":{"begin":591,"end":619},"obj":"cell_line"},{"id":"T19","span":{"begin":640,"end":660},"obj":"other_name"},{"id":"T20","span":{"begin":664,"end":674},"obj":"protein_complex"},{"id":"T21","span":{"begin":714,"end":719},"obj":"other_name"},{"id":"T22","span":{"begin":720,"end":727},"obj":"other_organic_compound"},{"id":"T23","span":{"begin":757,"end":767},"obj":"protein_complex"},{"id":"T24","span":{"begin":788,"end":797},"obj":"cell_type"},{"id":"T25","span":{"begin":847,"end":850},"obj":"protein_subunit"},{"id":"T26","span":{"begin":850,"end":854},"obj":"protein_subunit"},{"id":"T27","span":{"begin":856,"end":866},"obj":"protein_complex"},{"id":"T28","span":{"begin":918,"end":921},"obj":"protein_subunit"},{"id":"T29","span":{"begin":921,"end":925},"obj":"protein_subunit"},{"id":"T30","span":{"begin":952,"end":970},"obj":"lipid"},{"id":"T31","span":{"begin":1005,"end":1008},"obj":"protein_subunit"},{"id":"T32","span":{"begin":1008,"end":1012},"obj":"protein_subunit"},{"id":"T33","span":{"begin":1058,"end":1073},"obj":"other_name"},{"id":"T34","span":{"begin":1111,"end":1121},"obj":"protein_complex"},{"id":"T35","span":{"begin":1122,"end":1125},"obj":"protein_subunit"},{"id":"T36","span":{"begin":1125,"end":1129},"obj":"protein_subunit"},{"id":"T37","span":{"begin":1149,"end":1156},"obj":"other_organic_compound"},{"id":"T38","span":{"begin":1218,"end":1228},"obj":"protein_complex"},{"id":"T39","span":{"begin":1239,"end":1266},"obj":"DNA_family_or_group"},{"id":"T40","span":{"begin":1309,"end":1348},"obj":"other_name"},{"id":"T41","span":{"begin":1352,"end":1359},"obj":"other_organic_compound"},{"id":"T42","span":{"begin":1385,"end":1397},"obj":"protein_family_or_group"},{"id":"T43","span":{"begin":1398,"end":1407},"obj":"protein_family_or_group"},{"id":"T44","span":{"begin":1417,"end":1444},"obj":"protein_molecule"},{"id":"T45","span":{"begin":1446,"end":1464},"obj":"protein_family_or_group"},{"id":"T46","span":{"begin":1470,"end":1483},"obj":"protein_molecule"},{"id":"T47","span":{"begin":1498,"end":1508},"obj":"protein_complex"},{"id":"T48","span":{"begin":1522,"end":1531},"obj":"cell_type"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"},{"subj":"T26","pred":"source","obj":"GENIAcorpus"},{"subj":"T27","pred":"source","obj":"GENIAcorpus"},{"subj":"T28","pred":"source","obj":"GENIAcorpus"},{"subj":"T29","pred":"source","obj":"GENIAcorpus"},{"subj":"T30","pred":"source","obj":"GENIAcorpus"},{"subj":"T31","pred":"source","obj":"GENIAcorpus"},{"subj":"T32","pred":"source","obj":"GENIAcorpus"},{"subj":"T33","pred":"source","obj":"GENIAcorpus"},{"subj":"T34","pred":"source","obj":"GENIAcorpus"},{"subj":"T35","pred":"source","obj":"GENIAcorpus"},{"subj":"T36","pred":"source","obj":"GENIAcorpus"},{"subj":"T37","pred":"source","obj":"GENIAcorpus"},{"subj":"T38","pred":"source","obj":"GENIAcorpus"},{"subj":"T39","pred":"source","obj":"GENIAcorpus"},{"subj":"T40","pred":"source","obj":"GENIAcorpus"},{"subj":"T41","pred":"source","obj":"GENIAcorpus"},{"subj":"T42","pred":"source","obj":"GENIAcorpus"},{"subj":"T43","pred":"source","obj":"GENIAcorpus"},{"subj":"T44","pred":"source","obj":"GENIAcorpus"},{"subj":"T45","pred":"source","obj":"GENIAcorpus"},{"subj":"T46","pred":"source","obj":"GENIAcorpus"},{"subj":"T47","pred":"source","obj":"GENIAcorpus"},{"subj":"T48","pred":"source","obj":"GENIAcorpus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#eaec93","default":true},{"id":"jnlpba-st-training","color":"#d493ec"},{"id":"pubmed-sentences-benchmark","color":"#93ecba"},{"id":"GENIAcorpus","color":"#eca093"}]}]}}