> top > docs > PubMed:9309306 > annotations

PubMed:9309306 JSONTXT

Annnotations TAB JSON ListView MergeView

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 30-66 protein denotes nuclear regulatory factor-kappa beta
T2 70-85 cell_type denotes human monocytes
T3 211-233 protein denotes inflammatory cytokines
T4 345-381 protein denotes nuclear regulatory factor-kappa beta
T5 382-398 protein denotes (NF-kappa B)/Rel
T6 411-429 protein denotes regulatory element
T7 437-452 DNA denotes promoter region
T8 460-487 DNA denotes inflammatory cytokine genes
T9 549-559 protein denotes NF-kappa B
T10 574-589 cell_type denotes human monocytes
T11 591-619 cell_line denotes Adherence-isolated monocytes
T12 664-674 protein denotes NF-kappa B
T13 757-767 protein denotes NF-kappa B
T14 788-797 cell_type denotes monocytes
T15 847-854 protein denotes p50/p50
T16 856-880 protein denotes NF-kappa B/Rel homodimer
T17 918-937 protein denotes p65/p50 heterodimer
T18 1005-1024 protein denotes p65/p50 heterodimer
T19 1111-1139 protein denotes inhibitory p50/p50 homodimer
T20 1218-1266 DNA denotes NF-kappa B-regulated inflammatory cytokine genes
T21 1385-1407 protein denotes inflammatory cytokines
T22 1417-1444 protein denotes tumor necrosis factor-alpha
T23 1446-1464 protein denotes interleukin-1 beta
T24 1470-1483 protein denotes interleukin-6
T25 1498-1508 protein denotes NF-kappa B
T26 1522-1531 cell_type denotes monocytes

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-86 Sentence denotes Alcohol-induced regulation of nuclear regulatory factor-kappa beta in human monocytes.
S2 87-234 Sentence denotes Acute ethanol exposure has the capacity to modulate immune functions, particularly, to down regulate monocyte production of inflammatory cytokines.
S3 235-327 Sentence denotes However, the intracellular mechanisms for these effects of ethanol are yet to be understood.
S4 328-590 Sentence denotes Considering that nuclear regulatory factor-kappa beta (NF-kappa B)/Rel is a common regulatory element of the promoter region of the inflammatory cytokine genes, herein, we tested the hypothesis that acute ethanol affects NF-kappa B activation in human monocytes.
S5 591-675 Sentence denotes Adherence-isolated monocytes showed constitutive DNA binding activity of NF-kappa B.
S6 676-938 Sentence denotes A clinically relevant dose (25 mM) of acute ethanol treatment in vitro increased NF-kappa B binding activity in monocytes with a preferential induction of the inhibitory, p50/p50, NF-kappa B/Rel homodimer, and resulted in no induction of the p65/p50 heterodimer.
S7 939-1074 Sentence denotes In contrast, lipopolysaccharide stimulation primarily induced the p65/p50 heterodimer that has been shown to result in gene activation.
S8 1075-1267 Sentence denotes Thus, such unique activation of the inhibitory p50/p50 homodimer by acute ethanol treatment may result in inhibition rather than activation of NF-kappa B-regulated inflammatory cytokine genes.
S9 1268-1532 Sentence denotes Consequently, these results suggest that physiologically relevant concentrations of ethanol may affect production of inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 by disrupting NF-kappa B signaling in monocytes.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 70-85 NP denotes human monocytes
C2 211-233 NP denotes inflammatory cytokines
C3 294-301 NP denotes ethanol
C4 507-521 NP denotes the hypothesis
C5 522-526 NP denotes that
C6 574-589 NP denotes human monocytes
C7 788-797 NP denotes monocytes
C8 831-880 NP denotes the inhibitory, p50/p50, NF-kappa B/Rel homodimer
C9 914-937 NP denotes the p65/p50 heterodimer
C10 1001-1024 NP denotes the p65/p50 heterodimer
C11 1025-1029 NP denotes that
C12 1107-1139 NP denotes the inhibitory p50/p50 homodimer
C13 1352-1359 NP denotes ethanol
C14 1385-1407 NP denotes inflammatory cytokines
C15 1522-1531 NP denotes monocytes
R1 C5 C4 coref-relat that,the hypothesis
R2 C6 C1 coref-ident human monocytes,human monocytes
R3 C7 C6 coref-ident monocytes,human monocytes
R4 C10 C9 coref-ident the p65/p50 heterodimer,the p65/p50 heterodimer
R5 C11 C10 coref-relat that,the p65/p50 heterodimer
R6 C12 C8 coref-ident the inhibitory p50/p50 homodimer,"the inhibitory, p50/p50, NF-kappa B/Rel homodimer"
R7 C13 C3 coref-ident ethanol,ethanol
R8 C14 C2 coref-ident inflammatory cytokines,inflammatory cytokines
R9 C15 C7 coref-ident monocytes,monocytes

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-26 other_name denotes Alcohol-induced regulation
T2 30-66 protein_complex denotes nuclear regulatory factor-kappa beta
T3 70-85 cell_type denotes human monocytes
T4 139-155 other_name denotes immune functions
T5 188-207 other_name denotes monocyte production
T6 211-223 protein_family_or_group denotes inflammatory
T7 224-233 protein_family_or_group denotes cytokines
T8 248-272 other_name denotes intracellular mechanisms
T9 294-301 other_organic_compound denotes ethanol
T10 345-381 protein_complex denotes nuclear regulatory factor-kappa beta
T11 382-398 protein_complex denotes (NF-kappa B)/Rel
T12 411-429 protein_family_or_group denotes regulatory element
T13 437-452 DNA_domain_or_region denotes promoter region
T14 460-487 DNA_family_or_group denotes inflammatory cytokine genes
T15 533-540 other_organic_compound denotes ethanol
T16 549-559 protein_complex denotes NF-kappa B
T17 574-589 cell_type denotes human monocytes
T18 591-619 cell_line denotes Adherence-isolated monocytes
T19 640-660 other_name denotes DNA binding activity
T20 664-674 protein_complex denotes NF-kappa B
T21 714-719 other_name denotes acute
T22 720-727 other_organic_compound denotes ethanol
T23 757-767 protein_complex denotes NF-kappa B
T24 788-797 cell_type denotes monocytes
T25 847-850 protein_subunit denotes p50
T26 850-854 protein_subunit denotes /p50
T27 856-866 protein_complex denotes NF-kappa B
T28 918-921 protein_subunit denotes p65
T29 921-925 protein_subunit denotes /p50
T30 952-970 lipid denotes lipopolysaccharide
T31 1005-1008 protein_subunit denotes p65
T32 1008-1012 protein_subunit denotes /p50
T33 1058-1073 other_name denotes gene activation
T34 1111-1121 protein_complex denotes inhibitory
T35 1122-1125 protein_subunit denotes p50
T36 1125-1129 protein_subunit denotes /p50
T37 1149-1156 other_organic_compound denotes ethanol
T38 1218-1228 protein_complex denotes NF-kappa B
T39 1239-1266 DNA_family_or_group denotes inflammatory cytokine genes
T40 1309-1348 other_name denotes physiologically relevant concentrations
T41 1352-1359 other_organic_compound denotes ethanol
T42 1385-1397 protein_family_or_group denotes inflammatory
T43 1398-1407 protein_family_or_group denotes cytokines
T44 1417-1444 protein_molecule denotes tumor necrosis factor-alpha
T45 1446-1464 protein_family_or_group denotes interleukin-1 beta
T46 1470-1483 protein_molecule denotes interleukin-6
T47 1498-1508 protein_complex denotes NF-kappa B
T48 1522-1531 cell_type denotes monocytes