PubMed:9300687 JSONTXT

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{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":86},"obj":"Sentence"},{"id":"S2","span":{"begin":87,"end":209},"obj":"Sentence"},{"id":"S3","span":{"begin":210,"end":448},"obj":"Sentence"},{"id":"S4","span":{"begin":449,"end":591},"obj":"Sentence"},{"id":"S5","span":{"begin":592,"end":664},"obj":"Sentence"},{"id":"S6","span":{"begin":665,"end":772},"obj":"Sentence"},{"id":"S7","span":{"begin":773,"end":860},"obj":"Sentence"},{"id":"S8","span":{"begin":861,"end":946},"obj":"Sentence"},{"id":"S9","span":{"begin":947,"end":1092},"obj":"Sentence"},{"id":"S10","span":{"begin":1093,"end":1301},"obj":"Sentence"}],"text":"Transcription factor Egr-1 activity down-regulates Fas and CD23 expression in B cells.\nActivation of mature B cells via Ag receptor cross-linking induces transient expression of the transcription factor Egr-1. Although the activating signals leading to Egr-1 induction have been studied extensively, little is known about the genes that are placed further downstream within this activation cascade and that are transcriptionally regulated by Egr-1. To identify such target genes, we established Egr-1-overexpressing transfectants from the murine B cell line K46 and from human Ramos B cells. All clones derived from K46 B cells showed increased expression of CD44. Most interestingly, expression of CD95 (Fas/Apo-1) and of CD23 was down-regulated in all K46 transfectants. As a consequence, they became resistant to apoptosis induced by anti-CD95 Ab treatment. Similarly, the Egr-1-expressing Ramos cells showed reduced levels of CD95 expression. Thus, Egr-1 seems to control the expression of downstream target genes not only as a transcriptional activator, but also as a repressor molecule. In B cells, Egr-1 therefore plays a critical role in integrating the short-lived signal delivered by triggering of the Ag receptor into phenotypic changes, including repression of CD95 and CD23 transcription."}

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