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PubMed:9300687 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 21-26 protein denotes Egr-1
T2 78-85 cell_type denotes B cells
T3 108-115 cell_type denotes B cells
T4 120-131 protein denotes Ag receptor
T5 182-202 protein denotes transcription factor
T6 203-208 protein denotes Egr-1
T7 253-258 protein denotes Egr-1
T8 442-447 protein denotes Egr-1
T9 466-478 DNA denotes target genes
T10 495-529 cell_line denotes Egr-1-overexpressing transfectants
T11 539-561 cell_line denotes murine B cell line K46
T12 571-590 cell_line denotes human Ramos B cells
T13 616-627 cell_line denotes K46 B cells
T14 659-663 protein denotes CD44
T15 699-703 protein denotes CD95
T16 705-714 protein denotes Fas/Apo-1
T17 723-727 protein denotes CD23
T18 754-771 cell_line denotes K46 transfectants
T19 837-849 protein denotes anti-CD95 Ab
T20 876-904 cell_line denotes Egr-1-expressing Ramos cells
T21 930-934 protein denotes CD95
T22 953-958 protein denotes Egr-1
T23 994-1017 DNA denotes downstream target genes
T24 1073-1091 protein denotes repressor molecule
T25 1096-1103 cell_type denotes B cells
T26 1105-1110 protein denotes Egr-1
T27 1212-1223 protein denotes Ag receptor
T28 1273-1277 protein denotes CD95
T29 1282-1286 protein denotes CD23

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-86 Sentence denotes Transcription factor Egr-1 activity down-regulates Fas and CD23 expression in B cells.
S2 87-209 Sentence denotes Activation of mature B cells via Ag receptor cross-linking induces transient expression of the transcription factor Egr-1.
S3 210-448 Sentence denotes Although the activating signals leading to Egr-1 induction have been studied extensively, little is known about the genes that are placed further downstream within this activation cascade and that are transcriptionally regulated by Egr-1.
S4 449-591 Sentence denotes To identify such target genes, we established Egr-1-overexpressing transfectants from the murine B cell line K46 and from human Ramos B cells.
S5 592-664 Sentence denotes All clones derived from K46 B cells showed increased expression of CD44.
S6 665-772 Sentence denotes Most interestingly, expression of CD95 (Fas/Apo-1) and of CD23 was down-regulated in all K46 transfectants.
S7 773-860 Sentence denotes As a consequence, they became resistant to apoptosis induced by anti-CD95 Ab treatment.
S8 861-946 Sentence denotes Similarly, the Egr-1-expressing Ramos cells showed reduced levels of CD95 expression.
S9 947-1092 Sentence denotes Thus, Egr-1 seems to control the expression of downstream target genes not only as a transcriptional activator, but also as a repressor molecule.
S10 1093-1301 Sentence denotes In B cells, Egr-1 therefore plays a critical role in integrating the short-lived signal delivered by triggering of the Ag receptor into phenotypic changes, including repression of CD95 and CD23 transcription.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 78-85 NP denotes B cells
C2 178-208 NP denotes the transcription factor Egr-1
C4 322-331 NP denotes the genes
C5 332-336 NP denotes that
C6 402-406 NP denotes that
C7 442-447 NP denotes Egr-1
C3 322-447 NP denotes the genes that are placed further downstream within this activation cascade and that are transcriptionally regulated by Egr-1
C8 461-478 NP denotes such target genes
C9 750-771 NP denotes all K46 transfectants
C10 791-795 NP denotes they
C11 953-958 NP denotes Egr-1
C12 1096-1103 NP denotes B cells
C13 1105-1110 NP denotes Egr-1
R1 C5 C4 coref-relat that,the genes
R2 C6 C4 coref-relat that,the genes
R3 C7 C2 coref-ident Egr-1,the transcription factor Egr-1
R4 C8 C3 coref-ident such target genes,the genes that are placed further downstream within this activation cascade and that are transcriptionally regulated by Egr-1
R5 C10 C9 coref-pron they,all K46 transfectants
R6 C11 C7 coref-ident Egr-1,Egr-1
R7 C12 C1 coref-ident B cells,B cells
R8 C13 C11 coref-ident Egr-1,Egr-1

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-20 other_name denotes Transcription factor
T2 21-26 protein_molecule denotes Egr-1
T3 78-85 cell_type denotes B cells
T4 108-115 cell_type denotes B cells
T5 120-131 protein_family_or_group denotes Ag receptor
T6 154-174 other_name denotes transient expression
T7 182-202 protein_family_or_group denotes transcription factor
T8 203-208 protein_molecule denotes Egr-1
T9 223-241 other_name denotes activating signals
T10 253-258 protein_molecule denotes Egr-1
T11 379-397 other_name denotes activation cascade
T12 442-447 protein_molecule denotes Egr-1
T13 466-478 DNA_family_or_group denotes target genes
T14 495-500 protein_molecule denotes Egr-1
T15 539-561 cell_line denotes murine B cell line K46
T16 571-590 cell_line denotes human Ramos B cells
T17 616-627 cell_line denotes K46 B cells
T18 659-663 protein_molecule denotes CD44
T19 699-703 protein_molecule denotes CD95
T20 705-708 protein_molecule denotes Fas
T21 723-727 protein_molecule denotes CD23
T22 754-771 cell_line denotes K46 transfectants
T23 816-825 other_name denotes apoptosis
T24 837-849 protein_family_or_group denotes anti-CD95 Ab
T25 876-881 protein_molecule denotes Egr-1
T26 930-934 protein_molecule denotes CD95
T27 953-958 protein_molecule denotes Egr-1
T28 994-1017 DNA_family_or_group denotes downstream target genes
T29 1073-1091 protein_family_or_group denotes repressor molecule
T30 1096-1103 cell_type denotes B cells
T31 1105-1110 protein_molecule denotes Egr-1
T32 1212-1223 protein_family_or_group denotes Ag receptor
T33 1273-1277 protein_molecule denotes CD95
T34 1282-1286 protein_molecule denotes CD23