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PubMed:9234696 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-12 protein denotes GABP factors
T2 23-59 DNA denotes distal interleukin 2 (IL-2) enhancer
T3 78-83 protein denotes c-Raf
T4 105-109 protein denotes IL-2
T5 139-166 protein denotes T-cell receptor-CD3 complex
T6 206-219 cell_type denotes T lymphocytes
T7 265-279 protein denotes protein kinase
T8 346-371 DNA denotes interleukin 2 (IL-2) gene
T9 408-422 protein denotes protein kinase
T10 456-495 protein denotes mitogen-activated protein (MAP) kinases
T11 515-520 protein denotes c-Raf
T12 562-565 protein denotes Erk
T13 590-594 protein denotes IL-2
T14 615-638 DNA denotes distal enhancer element
T15 742-751 DNA denotes IL-2 gene
T16 771-791 DNA denotes distal IL-2 enhancer
T17 822-853 DNA denotes proximal IL-2 promoter-enhancer
T18 993-1014 protein denotes transcription factors
T19 1015-1035 protein denotes GABP alpha and -beta
T20 1041-1062 DNA denotes dyad symmetry element
T21 1064-1067 DNA denotes DSE
T22 1076-1091 DNA denotes distal enhancer
T23 1112-1137 DNA denotes palindromic binding sites
T24 1141-1157 protein denotes Ets-like factors
T25 1223-1226 DNA denotes DSE
T26 1264-1279 DNA denotes distal enhancer
T27 1295-1317 DNA denotes IL-2 promoter-enhancer
T28 1348-1360 protein denotes GABP factors
T29 1374-1396 DNA denotes IL-2 promoter-enhancer
T30 1426-1429 protein denotes BXB
T31 1464-1469 protein denotes c-Raf
T32 1501-1504 protein denotes Ras
T33 1505-1508 protein denotes Raf
T34 1509-1512 protein denotes Erk
T35 1551-1555 protein denotes GABP
T36 1643-1648 protein denotes c-Raf
T37 1676-1688 protein denotes GABP factors
T38 1826-1838 protein denotes GABP factors
T39 1846-1849 protein denotes Raf
T40 1874-1878 protein denotes IL-2

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-120 Sentence denotes GABP factors bind to a distal interleukin 2 (IL-2) enhancer and contribute to c-Raf-mediated increase in IL-2 induction.
S2 121-289 Sentence denotes Triggering of the T-cell receptor-CD3 complex activates two major signal cascades in T lymphocytes, (i) Ca2+-dependent signal cascades and (ii) protein kinase cascades.
S3 290-397 Sentence denotes Both signal cascades contribute to the induction of the interleukin 2 (IL-2) gene during T-cell activation.
S4 398-496 Sentence denotes Prominent protein kinase cascades are those that activate mitogen-activated protein (MAP) kinases.
S5 497-752 Sentence denotes We show here that c-Raf, which is at the helm of the classic MAP-Erk cascade, contributes to IL-2 induction through a distal enhancer element spanning the nucleotides from positions -502 to -413 in front of the transcriptional start site of the IL-2 gene.
S6 753-933 Sentence denotes Induction of this distal IL-2 enhancer differs from induction of the proximal IL-2 promoter-enhancer, since it is induced by phorbol esters alone and independent from Ca2+ signals.
S7 934-1158 Sentence denotes In DNA-protein binding studies, we detected the binding of transcription factors GABP alpha and -beta to a dyad symmetry element (DSE) of the distal enhancer, which is formed by palindromic binding sites of Ets-like factors.
S8 1159-1407 Sentence denotes Introduction of point mutations suppressing GABP binding to the DSE interfered with the induction of the distal enhancer and the entire IL-2 promoter-enhancer, while overexpression of both GABP factors enhanced the IL-2 promoter-enhancer induction.
S9 1408-1593 Sentence denotes Overexpression of BXB, a constitutive active version of c-Raf, and of further members of the Ras-Raf-Erk signal cascade exerted an increase of GABP-mediated promoter-enhancer induction.
S10 1594-1914 Sentence denotes In conjunction with previously published data on c-Raf-induced phosphorylation of GABP factors (E. Flory, A. Hoffmeyer, U. Smola, U. R. Rapp, and J. T. Bruder, J. Virol. 70:2260-2268, 1996), these results indicate a contribution of GABP factors to the Raf-mediated enhancement of IL-2 induction during T-cell activation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-12 NP denotes GABP factors
C2 21-59 NP denotes a distal interleukin 2 (IL-2) enhancer
C3 105-119 NP denotes IL-2 induction
C4 177-219 NP denotes two major signal cascades in T lymphocytes
C5 221-288 NP denotes (i) Ca2+-dependent signal cascades and (ii) protein kinase cascades
C6 290-310 NP denotes Both signal cascades
C7 342-371 NP denotes the interleukin 2 (IL-2) gene
C8 379-396 NP denotes T-cell activation
C9 398-431 NP denotes Prominent protein kinase cascades
C10 436-441 NP denotes those
C11 442-446 NP denotes that
C13 515-520 NP denotes c-Raf
C14 522-527 NP denotes which
C12 515-573 NP denotes c-Raf, which is at the helm of the classic MAP-Erk cascade
C15 590-604 NP denotes IL-2 induction
C17 738-751 NP denotes the IL-2 gene
C16 613-751 NP denotes a distal enhancer element spanning the nucleotides from positions -502 to -413 in front of the transcriptional start site of the IL-2 gene
C19 766-791 NP denotes this distal IL-2 enhancer
C18 753-791 NP denotes Induction of this distal IL-2 enhancer
C20 818-853 NP denotes the proximal IL-2 promoter-enhancer
C21 861-863 NP denotes it
C22 993-1035 NP denotes transcription factors GABP alpha and -beta
C24 1072-1091 NP denotes the distal enhancer
C25 1093-1098 NP denotes which
C23 1039-1157 NP denotes a dyad symmetry element (DSE) of the distal enhancer, which is formed by palindromic binding sites of Ets-like factors
C26 1219-1226 NP denotes the DSE
C28 1260-1279 NP denotes the distal enhancer
C27 1243-1279 NP denotes the induction of the distal enhancer
C29 1343-1360 NP denotes both GABP factors
C30 1426-1429 NP denotes BXB
C32 1464-1469 NP denotes c-Raf
C31 1431-1469 NP denotes a constitutive active version of c-Raf
C33 1676-1688 NP denotes GABP factors
C34 1826-1838 NP denotes GABP factors
C35 1874-1888 NP denotes IL-2 induction
C36 1896-1913 NP denotes T-cell activation
R1 C5 C4 coref-appos (i) Ca2+-dependent signal cascades and (ii) protein kinase cascades,two major signal cascades in T lymphocytes
R2 C6 C4 coref-ident Both signal cascades,two major signal cascades in T lymphocytes
R3 C10 C9 coref-pron those,Prominent protein kinase cascades
R4 C11 C9 coref-relat that,Prominent protein kinase cascades
R5 C14 C13 coref-relat which,c-Raf
R6 C15 C3 coref-ident IL-2 induction,IL-2 induction
R7 C17 C7 coref-ident the IL-2 gene,the interleukin 2 (IL-2) gene
R8 C16 C2 coref-ident a distal enhancer element spanning the nucleotides from positions -502 to -413 in front of the transcriptional start site of the IL-2 gene,a distal interleukin 2 (IL-2) enhancer
R9 C19 C16 coref-ident this distal IL-2 enhancer,a distal enhancer element spanning the nucleotides from positions -502 to -413 in front of the transcriptional start site of the IL-2 gene
R10 C21 C20 coref-pron it,the proximal IL-2 promoter-enhancer
R11 C24 C19 coref-ident the distal enhancer,this distal IL-2 enhancer
R12 C25 C24 coref-relat which,the distal enhancer
R13 C26 C23 coref-ident the DSE,"a dyad symmetry element (DSE) of the distal enhancer, which is formed by palindromic binding sites of Ets-like factors"
R14 C28 C24 coref-ident the distal enhancer,the distal enhancer
R15 C27 C18 coref-ident the induction of the distal enhancer,Induction of this distal IL-2 enhancer
R16 C29 C22 coref-ident both GABP factors,transcription factors GABP alpha and -beta
R17 C32 C12 coref-ident c-Raf,"c-Raf, which is at the helm of the classic MAP-Erk cascade"
R18 C31 C30 coref-appos a constitutive active version of c-Raf,BXB
R19 C33 C1 coref-ident GABP factors,GABP factors
R20 C34 C33 coref-ident GABP factors,GABP factors
R21 C35 C15 coref-ident IL-2 induction,IL-2 induction
R22 C36 C8 coref-ident T-cell activation,T-cell activation

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-12 protein_family_or_group denotes GABP factors
T2 23-59 DNA_domain_or_region denotes distal interleukin 2 (IL-2) enhancer
T3 78-83 protein_molecule denotes c-Raf
T4 105-109 protein_molecule denotes IL-2
T5 139-166 protein_complex denotes T-cell receptor-CD3 complex
T6 206-219 cell_type denotes T lymphocytes
T7 265-279 protein_family_or_group denotes protein kinase
T8 295-310 other_name denotes signal cascades
T9 346-361 DNA_domain_or_region denotes interleukin 2 (
T10 361-365 protein_molecule denotes IL-2
T11 379-396 other_name denotes T-cell activation
T12 408-422 protein_family_or_group denotes protein kinase
T13 456-495 protein_family_or_group denotes mitogen-activated protein (MAP) kinases
T14 515-520 protein_molecule denotes c-Raf
T15 558-562 other_name denotes MAP-
T16 562-565 protein_molecule denotes Erk
T17 590-594 protein_molecule denotes IL-2
T18 615-638 DNA_domain_or_region denotes distal enhancer element
T19 742-746 protein_molecule denotes IL-2
T20 771-777 DNA_domain_or_region denotes distal
T21 778-782 protein_molecule denotes IL-2
T22 822-830 DNA_domain_or_region denotes proximal
T23 831-835 protein_molecule denotes IL-2
T24 878-892 other_organic_compound denotes phorbol esters
T25 920-924 atom denotes Ca2+
T26 937-964 other_name denotes DNA-protein binding studies
T27 993-1014 protein_family_or_group denotes transcription factors
T28 1041-1062 DNA_domain_or_region denotes dyad symmetry element
T29 1064-1067 DNA_domain_or_region denotes DSE
T30 1076-1091 DNA_domain_or_region denotes distal enhancer
T31 1112-1137 DNA_domain_or_region denotes palindromic binding sites
T32 1141-1157 protein_family_or_group denotes Ets-like factors
T33 1175-1190 other_name denotes point mutations
T34 1223-1226 DNA_domain_or_region denotes DSE
T35 1264-1279 DNA_domain_or_region denotes distal enhancer
T36 1295-1299 protein_molecule denotes IL-2
T37 1348-1360 protein_family_or_group denotes GABP factors
T38 1374-1378 protein_molecule denotes IL-2
T39 1426-1429 protein_molecule denotes BXB
T40 1464-1469 protein_molecule denotes c-Raf
T41 1501-1504 protein_molecule denotes Ras
T42 1505-1508 protein_molecule denotes Raf
T43 1509-1512 protein_molecule denotes Erk
T44 1551-1555 protein_molecule denotes GABP
T45 1643-1648 protein_molecule denotes c-Raf
T46 1676-1688 protein_family_or_group denotes GABP factors
T47 1826-1838 protein_family_or_group denotes GABP factors
T48 1846-1849 protein_molecule denotes Raf
T49 1874-1878 protein_molecule denotes IL-2
T50 1896-1913 other_name denotes T-cell activation