PubMed:9203583 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/9203583","sourcedb":"PubMed","sourceid":"9203583","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/9203583","text":"Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis.\nIn eukaryotes, homologs of the bacterial MutS and MutL proteins function in DNA mismatch repair and recombination pathways. The mutL homolog MLH1 is required for nuclear mismatch repair. Previously, cytological analysis of MLH1-deficient mice has implied a role for Mlh1 in crossing-over during meiosis. Here we demonstrate that Saccharomyces cerevisiae diploids containing a deletion of MLH1 have reduced crossing-over in addition to a deficiency in the repair of mismatched DNA during meiosis. Absence of either of the meiosis-specific mutS homologs Msh4 or Msh5 results in a similar reduction in crossing-over. Analysis of an mlh1 msh4 double mutant suggests that both genes act in the same pathway to promote crossing-over. All genetic markers analyzed in mlh1 mutants display elevated frequencies of non-Mendelian segregation. Most of these events are postmeiotic segregations that represent unrepaired heteroduplex. These data suggest that either restorational repair is frequent or heteroduplex tracts are shorter in wild-type cells. Comparison of mlh1 segregation data with that of pms1, msh2, msh3, and msh6 mutants show that the ability to promote crossing-over is unique to MLH1. Taken together these observations indicate that both crossing-over and gene conversion require MutS and MutL functions and that Mlh1 represents an overlap between these two pathways. Models of Mlh1 function are discussed.","tracks":[{"project":"c_corpus","denotations":[{"id":"T1","span":{"begin":0,"end":4},"obj":"PR:Q9ZRV4"},{"id":"T2","span":{"begin":0,"end":4},"obj":"PR:P38920"},{"id":"T3","span":{"begin":0,"end":4},"obj":"PR:Q54KD8"},{"id":"T5","span":{"begin":0,"end":4},"obj":"PR:Q9JK91"},{"id":"T6","span":{"begin":0,"end":4},"obj":"PR:P97679"},{"id":"T7","span":{"begin":0,"end":4},"obj":"PR:Q9P7W6"},{"id":"T8","span":{"begin":0,"end":4},"obj":"PR:000010442"},{"id":"T9","span":{"begin":0,"end":4},"obj":"PR:P40692"},{"id":"T4","span":{"begin":0,"end":4},"obj":"CVCL_G669"},{"id":"T10","span":{"begin":21,"end":36},"obj":"GO:0006298"},{"id":"T11","span":{"begin":37,"end":45},"obj":"CHEBI:36080"},{"id":"T12","span":{"begin":93,"end":100},"obj":"GO:0051321"},{"id":"T16","span":{"begin":105,"end":115},"obj":"D056890"},{"id":"T17","span":{"begin":143,"end":147},"obj":"PR:000023326"},{"id":"T18","span":{"begin":143,"end":147},"obj":"PR:P23909"},{"id":"T19","span":{"begin":143,"end":147},"obj":"PR:Q2FYZ9"},{"id":"T20","span":{"begin":152,"end":156},"obj":"PR:000023324"},{"id":"T21","span":{"begin":152,"end":156},"obj":"PR:Q93T05"},{"id":"T22","span":{"begin":152,"end":156},"obj":"PR:P23367"},{"id":"T23","span":{"begin":152,"end":165},"obj":"D000070956"},{"id":"T25","span":{"begin":178,"end":181},"obj":"GO:0005574"},{"id":"T27","span":{"begin":178,"end":181},"obj":"SO:0000352"},{"id":"T26","span":{"begin":178,"end":181},"obj":"CHEBI:16991"},{"id":"T28","span":{"begin":178,"end":181},"obj":"D004247"},{"id":"T29","span":{"begin":182,"end":197},"obj":"GO:0006298"},{"id":"T30","span":{"begin":230,"end":234},"obj":"PR:000023324"},{"id":"T31","span":{"begin":230,"end":234},"obj":"PR:Q93T05"},{"id":"T32","span":{"begin":230,"end":234},"obj":"PR:P23367"},{"id":"T33","span":{"begin":235,"end":242},"obj":"SO:0000853"},{"id":"T34","span":{"begin":243,"end":247},"obj":"PR:Q9ZRV4"},{"id":"T35","span":{"begin":243,"end":247},"obj":"PR:P38920"},{"id":"T36","span":{"begin":243,"end":247},"obj":"PR:Q54KD8"},{"id":"T38","span":{"begin":243,"end":247},"obj":"PR:Q9JK91"},{"id":"T39","span":{"begin":243,"end":247},"obj":"PR:P97679"},{"id":"T40","span":{"begin":243,"end":247},"obj":"PR:Q9P7W6"},{"id":"T41","span":{"begin":243,"end":247},"obj":"PR:000010442"},{"id":"T42","span":{"begin":243,"end":247},"obj":"PR:P40692"},{"id":"T37","span":{"begin":243,"end":247},"obj":"CVCL_G669"},{"id":"T43","span":{"begin":272,"end":287},"obj":"GO:0006298"},{"id":"T44","span":{"begin":325,"end":329},"obj":"PR:Q9ZRV4"},{"id":"T45","span":{"begin":325,"end":329},"obj":"PR:P38920"},{"id":"T46","span":{"begin":325,"end":329},"obj":"PR:Q54KD8"},{"id":"T48","span":{"begin":325,"end":329},"obj":"PR:Q9JK91"},{"id":"T49","span":{"begin":325,"end":329},"obj":"PR:P97679"},{"id":"T50","span":{"begin":325,"end":329},"obj":"PR:Q9P7W6"},{"id":"T51","span":{"begin":325,"end":329},"obj":"PR:000010442"},{"id":"T52","span":{"begin":325,"end":329},"obj":"PR:P40692"},{"id":"T47","span":{"begin":325,"end":329},"obj":"CVCL_G669"},{"id":"T53","span":{"begin":340,"end":344},"obj":"PR:000005054"},{"id":"T55","span":{"begin":340,"end":344},"obj":"O89094"},{"id":"T54","span":{"begin":340,"end":344},"obj":"D051379"},{"id":"T56","span":{"begin":340,"end":344},"obj":"10095"},{"id":"T57","span":{"begin":368,"end":372},"obj":"PR:Q9ZRV4"},{"id":"T58","span":{"begin":368,"end":372},"obj":"PR:P38920"},{"id":"T59","span":{"begin":368,"end":372},"obj":"PR:Q54KD8"},{"id":"T61","span":{"begin":368,"end":372},"obj":"PR:Q9JK91"},{"id":"T62","span":{"begin":368,"end":372},"obj":"PR:P97679"},{"id":"T63","span":{"begin":368,"end":372},"obj":"PR:Q9P7W6"},{"id":"T64","span":{"begin":368,"end":372},"obj":"PR:000010442"},{"id":"T65","span":{"begin":368,"end":372},"obj":"PR:P40692"},{"id":"T60","span":{"begin":368,"end":372},"obj":"CVCL_G669"},{"id":"T66","span":{"begin":397,"end":404},"obj":"GO:0051321"},{"id":"T68","span":{"begin":431,"end":455},"obj":"350141"},{"id":"T71","span":{"begin":431,"end":455},"obj":"9511"},{"id":"T69","span":{"begin":431,"end":455},"obj":"D012441"},{"id":"T70","span":{"begin":431,"end":455},"obj":"4932"},{"id":"T72","span":{"begin":478,"end":486},"obj":"SO:0000159"},{"id":"T76","span":{"begin":490,"end":494},"obj":"CVCL_G669"},{"id":"T73","span":{"begin":490,"end":494},"obj":"PR:Q9ZRV4"},{"id":"T74","span":{"begin":490,"end":494},"obj":"PR:P38920"},{"id":"T75","span":{"begin":490,"end":494},"obj":"PR:Q54KD8"},{"id":"T77","span":{"begin":490,"end":494},"obj":"PR:Q9JK91"},{"id":"T78","span":{"begin":490,"end":494},"obj":"PR:P97679"},{"id":"T79","span":{"begin":490,"end":494},"obj":"PR:Q9P7W6"},{"id":"T80","span":{"begin":490,"end":494},"obj":"PR:000010442"},{"id":"T81","span":{"begin":490,"end":494},"obj":"PR:P40692"},{"id":"T83","span":{"begin":539,"end":549},"obj":"SO:1000029"},{"id":"T85","span":{"begin":578,"end":581},"obj":"CHEBI:16991"},{"id":"T87","span":{"begin":578,"end":581},"obj":"D004247"},{"id":"T86","span":{"begin":578,"end":581},"obj":"SO:0000352"},{"id":"T84","span":{"begin":578,"end":581},"obj":"GO:0005574"},{"id":"T88","span":{"begin":589,"end":596},"obj":"GO:0051321"},{"id":"T89","span":{"begin":623,"end":630},"obj":"GO:0051321"},{"id":"T90","span":{"begin":640,"end":644},"obj":"PR:000023326"},{"id":"T91","span":{"begin":640,"end":644},"obj":"PR:P23909"},{"id":"T92","span":{"begin":640,"end":644},"obj":"PR:Q2FYZ9"},{"id":"T93","span":{"begin":640,"end":653},"obj":"D000074080"},{"id":"T95","span":{"begin":654,"end":657},"obj":"CHEBI:16768"},{"id":"T99","span":{"begin":654,"end":657},"obj":"D009074"},{"id":"T100","span":{"begin":654,"end":657},"obj":"D009074"},{"id":"T101","span":{"begin":654,"end":658},"obj":"PR:P40965"},{"id":"T102","span":{"begin":654,"end":658},"obj":"PR:000010668"},{"id":"T103","span":{"begin":654,"end":658},"obj":"PR:F4JP48"},{"id":"T104","span":{"begin":654,"end":658},"obj":"PR:Q99MT2"},{"id":"T105","span":{"begin":654,"end":658},"obj":"PR:O15457"},{"id":"T106","span":{"begin":654,"end":658},"obj":"PR:Q23405"},{"id":"T108","span":{"begin":662,"end":665},"obj":"CHEBI:16768"},{"id":"T112","span":{"begin":662,"end":665},"obj":"D009074"},{"id":"T113","span":{"begin":662,"end":665},"obj":"D009074"},{"id":"T114","span":{"begin":662,"end":666},"obj":"PR:Q6MG62"},{"id":"T115","span":{"begin":662,"end":666},"obj":"PR:Q9QUM7"},{"id":"T116","span":{"begin":662,"end":666},"obj":"PR:O43196"},{"id":"T117","span":{"begin":662,"end":666},"obj":"PR:Q19272"},{"id":"T118","span":{"begin":662,"end":666},"obj":"PR:F4JEP5"},{"id":"T119","span":{"begin":662,"end":666},"obj":"PR:000010669"},{"id":"T120","span":{"begin":662,"end":666},"obj":"PR:Q12175"},{"id":"T121","span":{"begin":688,"end":697},"obj":"MOP:0000569"},{"id":"T122","span":{"begin":731,"end":735},"obj":"PR:Q9ZRV4"},{"id":"T123","span":{"begin":731,"end":735},"obj":"PR:P38920"},{"id":"T124","span":{"begin":731,"end":735},"obj":"PR:Q54KD8"},{"id":"T126","span":{"begin":731,"end":735},"obj":"PR:Q9JK91"},{"id":"T127","span":{"begin":731,"end":735},"obj":"PR:P97679"},{"id":"T128","span":{"begin":731,"end":735},"obj":"PR:Q9P7W6"},{"id":"T129","span":{"begin":731,"end":735},"obj":"PR:000010442"},{"id":"T130","span":{"begin":731,"end":735},"obj":"PR:P40692"},{"id":"T125","span":{"begin":731,"end":735},"obj":"CVCL_G669"},{"id":"T132","span":{"begin":736,"end":739},"obj":"CHEBI:16768"},{"id":"T136","span":{"begin":736,"end":739},"obj":"D009074"},{"id":"T137","span":{"begin":736,"end":739},"obj":"D009074"},{"id":"T138","span":{"begin":736,"end":740},"obj":"PR:P40965"},{"id":"T139","span":{"begin":736,"end":740},"obj":"PR:000010668"},{"id":"T140","span":{"begin":736,"end":740},"obj":"PR:F4JP48"},{"id":"T141","span":{"begin":736,"end":740},"obj":"PR:Q99MT2"},{"id":"T142","span":{"begin":736,"end":740},"obj":"PR:O15457"},{"id":"T143","span":{"begin":736,"end":740},"obj":"PR:Q23405"},{"id":"T144","span":{"begin":741,"end":747},"obj":"SO:0000985"},{"id":"T145","span":{"begin":796,"end":803},"obj":"CHEBI:34922"},{"id":"T146","span":{"begin":834,"end":849},"obj":"D005819"},{"id":"T147","span":{"begin":834,"end":849},"obj":"D005819"},{"id":"T148","span":{"begin":862,"end":866},"obj":"PR:Q9ZRV4"},{"id":"T149","span":{"begin":862,"end":866},"obj":"PR:P38920"},{"id":"T150","span":{"begin":862,"end":866},"obj":"PR:Q54KD8"},{"id":"T152","span":{"begin":862,"end":866},"obj":"PR:Q9JK91"},{"id":"T153","span":{"begin":862,"end":866},"obj":"PR:P97679"},{"id":"T154","span":{"begin":862,"end":866},"obj":"PR:Q9P7W6"},{"id":"T155","span":{"begin":862,"end":866},"obj":"PR:000010442"},{"id":"T156","span":{"begin":862,"end":866},"obj":"PR:P40692"},{"id":"T151","span":{"begin":862,"end":866},"obj":"CVCL_G669"},{"id":"T157","span":{"begin":1126,"end":1135},"obj":"SO:0000817"},{"id":"T158","span":{"begin":1157,"end":1161},"obj":"PR:Q9ZRV4"},{"id":"T159","span":{"begin":1157,"end":1161},"obj":"PR:P38920"},{"id":"T160","span":{"begin":1157,"end":1161},"obj":"PR:Q54KD8"},{"id":"T162","span":{"begin":1157,"end":1161},"obj":"PR:Q9JK91"},{"id":"T163","span":{"begin":1157,"end":1161},"obj":"PR:P97679"},{"id":"T164","span":{"begin":1157,"end":1161},"obj":"PR:Q9P7W6"},{"id":"T165","span":{"begin":1157,"end":1161},"obj":"PR:000010442"},{"id":"T166","span":{"begin":1157,"end":1161},"obj":"PR:P40692"},{"id":"T161","span":{"begin":1157,"end":1161},"obj":"CVCL_G669"},{"id":"T173","span":{"begin":1192,"end":1196},"obj":"PR:P14242"},{"id":"T174","span":{"begin":1192,"end":1196},"obj":"PR:000012913"},{"id":"T177","span":{"begin":1192,"end":1196},"obj":"PR:Q941I6"},{"id":"T178","span":{"begin":1192,"end":1196},"obj":"PR:P54280"},{"id":"T179","span":{"begin":1192,"end":1196},"obj":"PR:Q5NC83"},{"id":"T180","span":{"begin":1192,"end":1196},"obj":"PR:P54277"},{"id":"T181","span":{"begin":1192,"end":1196},"obj":"PR:Q54QA0"},{"id":"T175","span":{"begin":1192,"end":1196},"obj":"C102203"},{"id":"T176","span":{"begin":1192,"end":1196},"obj":"C102203"},{"id":"T183","span":{"begin":1198,"end":1201},"obj":"CHEBI:16768"},{"id":"T187","span":{"begin":1198,"end":1201},"obj":"D009074"},{"id":"T188","span":{"begin":1198,"end":1201},"obj":"D009074"},{"id":"T189","span":{"begin":1198,"end":1202},"obj":"PR:000010666"},{"id":"T190","span":{"begin":1198,"end":1202},"obj":"PR:P25847"},{"id":"T191","span":{"begin":1198,"end":1202},"obj":"PR:P43246"},{"id":"T192","span":{"begin":1198,"end":1202},"obj":"P22711"},{"id":"T193","span":{"begin":1198,"end":1202},"obj":"PR:P22711"},{"id":"T194","span":{"begin":1198,"end":1202},"obj":"PR:P54275"},{"id":"T195","span":{"begin":1198,"end":1202},"obj":"PR:O74773"},{"id":"T196","span":{"begin":1198,"end":1202},"obj":"PR:P43247"},{"id":"T197","span":{"begin":1198,"end":1202},"obj":"PR:Q553L4"},{"id":"T198","span":{"begin":1198,"end":1202},"obj":"PR:O24617"},{"id":"T200","span":{"begin":1204,"end":1207},"obj":"CHEBI:16768"},{"id":"T204","span":{"begin":1204,"end":1207},"obj":"D009074"},{"id":"T205","span":{"begin":1204,"end":1207},"obj":"D009074"},{"id":"T206","span":{"begin":1204,"end":1208},"obj":"PR:O65607"},{"id":"T207","span":{"begin":1204,"end":1208},"obj":"PR:000010667"},{"id":"T208","span":{"begin":1204,"end":1208},"obj":"PR:Q59Y41"},{"id":"T209","span":{"begin":1204,"end":1208},"obj":"PR:P25336"},{"id":"T210","span":{"begin":1204,"end":1208},"obj":"PR:P20585"},{"id":"T211","span":{"begin":1204,"end":1208},"obj":"PR:P26359"},{"id":"T212","span":{"begin":1204,"end":1208},"obj":"PR:P13705"},{"id":"T213","span":{"begin":1204,"end":1208},"obj":"PR:Q1ZXH0"},{"id":"T215","span":{"begin":1214,"end":1217},"obj":"CHEBI:16768"},{"id":"T219","span":{"begin":1214,"end":1217},"obj":"D009074"},{"id":"T220","span":{"begin":1214,"end":1217},"obj":"D009074"},{"id":"T221","span":{"begin":1214,"end":1218},"obj":"PR:P52701"},{"id":"T222","span":{"begin":1214,"end":1218},"obj":"PR:P54276"},{"id":"T223","span":{"begin":1214,"end":1218},"obj":"PR:Q9VUM0"},{"id":"T224","span":{"begin":1214,"end":1218},"obj":"PR:Q55GU9"},{"id":"T225","span":{"begin":1214,"end":1218},"obj":"PR:O04716"},{"id":"T226","span":{"begin":1214,"end":1218},"obj":"PR:Q03834"},{"id":"T227","span":{"begin":1214,"end":1218},"obj":"PR:O74502"},{"id":"T228","span":{"begin":1214,"end":1218},"obj":"PR:000010670"},{"id":"T229","span":{"begin":1287,"end":1291},"obj":"PR:Q9ZRV4"},{"id":"T230","span":{"begin":1287,"end":1291},"obj":"PR:P38920"},{"id":"T231","span":{"begin":1287,"end":1291},"obj":"PR:Q54KD8"},{"id":"T233","span":{"begin":1287,"end":1291},"obj":"PR:Q9JK91"},{"id":"T234","span":{"begin":1287,"end":1291},"obj":"PR:P97679"},{"id":"T235","span":{"begin":1287,"end":1291},"obj":"PR:Q9P7W6"},{"id":"T236","span":{"begin":1287,"end":1291},"obj":"PR:000010442"},{"id":"T237","span":{"begin":1287,"end":1291},"obj":"PR:P40692"},{"id":"T232","span":{"begin":1287,"end":1291},"obj":"CVCL_G669"},{"id":"T238","span":{"begin":1364,"end":1368},"obj":"SO:0000704"},{"id":"T239","span":{"begin":1364,"end":1379},"obj":"GO:0035822"},{"id":"T240","span":{"begin":1388,"end":1392},"obj":"PR:000023326"},{"id":"T241","span":{"begin":1388,"end":1392},"obj":"PR:P23909"},{"id":"T242","span":{"begin":1388,"end":1392},"obj":"PR:Q2FYZ9"},{"id":"T243","span":{"begin":1397,"end":1401},"obj":"PR:000023324"},{"id":"T244","span":{"begin":1397,"end":1401},"obj":"PR:Q93T05"},{"id":"T245","span":{"begin":1397,"end":1401},"obj":"PR:P23367"},{"id":"T246","span":{"begin":1421,"end":1425},"obj":"PR:Q9ZRV4"},{"id":"T247","span":{"begin":1421,"end":1425},"obj":"PR:P38920"},{"id":"T248","span":{"begin":1421,"end":1425},"obj":"PR:Q54KD8"},{"id":"T250","span":{"begin":1421,"end":1425},"obj":"PR:Q9JK91"},{"id":"T251","span":{"begin":1421,"end":1425},"obj":"PR:P97679"},{"id":"T252","span":{"begin":1421,"end":1425},"obj":"PR:Q9P7W6"},{"id":"T253","span":{"begin":1421,"end":1425},"obj":"PR:000010442"},{"id":"T254","span":{"begin":1421,"end":1425},"obj":"PR:P40692"},{"id":"T249","span":{"begin":1421,"end":1425},"obj":"CVCL_G669"},{"id":"T255","span":{"begin":1486,"end":1490},"obj":"PR:Q9ZRV4"},{"id":"T256","span":{"begin":1486,"end":1490},"obj":"PR:P38920"},{"id":"T257","span":{"begin":1486,"end":1490},"obj":"PR:Q54KD8"},{"id":"T259","span":{"begin":1486,"end":1490},"obj":"PR:Q9JK91"},{"id":"T260","span":{"begin":1486,"end":1490},"obj":"PR:P97679"},{"id":"T261","span":{"begin":1486,"end":1490},"obj":"PR:Q9P7W6"},{"id":"T262","span":{"begin":1486,"end":1490},"obj":"PR:000010442"},{"id":"T263","span":{"begin":1486,"end":1490},"obj":"PR:P40692"},{"id":"T258","span":{"begin":1486,"end":1490},"obj":"CVCL_G669"}],"attributes":[{"subj":"T1","pred":"source","obj":"c_corpus"},{"subj":"T2","pred":"source","obj":"c_corpus"},{"subj":"T3","pred":"source","obj":"c_corpus"},{"subj":"T5","pred":"source","obj":"c_corpus"},{"subj":"T6","pred":"source","obj":"c_corpus"},{"subj":"T7","pred":"source","obj":"c_corpus"},{"subj":"T8","pred":"source","obj":"c_corpus"},{"subj":"T9","pred":"source","obj":"c_corpus"},{"subj":"T4","pred":"source","obj":"c_corpus"},{"subj":"T10","pred":"source","obj":"c_corpus"},{"subj":"T11","pred":"source","obj":"c_corpus"},{"subj":"T12","pred":"source","obj":"c_corpus"},{"subj":"T16","pred":"source","obj":"c_corpus"},{"subj":"T17","pred":"source","obj":"c_corpus"},{"subj":"T18","pred":"source","obj":"c_corpus"},{"subj":"T19","pred":"source","obj":"c_corpus"},{"subj":"T20","pred":"source","obj":"c_corpus"},{"subj":"T21","pred":"source","obj":"c_corpus"},{"subj":"T22","pred":"source","obj":"c_corpus"},{"subj":"T23","pred":"source","obj":"c_corpus"},{"subj":"T25","pred":"source","obj":"c_corpus"},{"subj":"T27","pred":"source","obj":"c_corpus"},{"subj":"T26","pred":"source","obj":"c_corpus"},{"subj":"T28","pred":"source","obj":"c_corpus"},{"subj":"T29","pred":"source","obj":"c_corpus"},{"subj":"T30","pred":"source","obj":"c_corpus"},{"subj":"T31","pred":"source","obj":"c_corpus"},{"subj":"T32","pred":"source","obj":"c_corpus"},{"subj":"T33","pred":"source","obj":"c_corpus"},{"subj":"T34","pred":"source","obj":"c_corpus"},{"subj":"T35","pred":"source","obj":"c_corpus"},{"subj":"T36","pred":"source","obj":"c_corpus"},{"subj":"T38","pred":"source","obj":"c_corpus"},{"subj":"T39","pred":"source","obj":"c_corpus"},{"subj":"T40","pred":"source","obj":"c_corpus"},{"subj":"T41","pred":"source","obj":"c_corpus"},{"subj":"T42","pred":"source","obj":"c_corpus"},{"subj":"T37","pred":"source","obj":"c_corpus"},{"subj":"T43","pred":"source","obj":"c_corpus"},{"subj":"T44","pred":"source","obj":"c_corpus"},{"subj":"T45","pred":"source","obj":"c_corpus"},{"subj":"T46","pred":"source","obj":"c_corpus"},{"subj":"T48","pred":"source","obj":"c_corpus"},{"subj":"T49","pred":"source","obj":"c_corpus"},{"subj":"T50","pred":"source","obj":"c_corpus"},{"subj":"T51","pred":"source","obj":"c_corpus"},{"subj":"T52","pred":"source","obj":"c_corpus"},{"subj":"T47","pred":"source","obj":"c_corpus"},{"subj":"T53","pred":"source","obj":"c_corpus"},{"subj":"T55","pred":"source","obj":"c_corpus"},{"subj":"T54","pred":"source","obj":"c_corpus"},{"subj":"T56","pred":"source","obj":"c_corpus"},{"subj":"T57","pred":"source","obj":"c_corpus"},{"subj":"T58","pred":"source","obj":"c_corpus"},{"subj":"T59","pred":"source","obj":"c_corpus"},{"subj":"T61","pred":"source","obj":"c_corpus"},{"subj":"T62","pred":"source","obj":"c_corpus"},{"subj":"T63","pred":"source","obj":"c_corpus"},{"subj":"T64","pred":"source","obj":"c_corpus"},{"subj":"T65","pred":"source","obj":"c_corpus"},{"subj":"T60","pred":"source","obj":"c_corpus"},{"subj":"T66","pred":"source","obj":"c_corpus"},{"subj":"T68","pred":"source","obj":"c_corpus"},{"subj":"T71","pred":"source","obj":"c_corpus"},{"subj":"T69","pred":"source","obj":"c_corpus"},{"subj":"T70","pred":"source","obj":"c_corpus"},{"subj":"T72","pred":"source","obj":"c_corpus"},{"subj":"T76","pred":"source","obj":"c_corpus"},{"subj":"T73","pred":"source","obj":"c_corpus"},{"subj":"T74","pred":"source","obj":"c_corpus"},{"subj":"T75","pred":"source","obj":"c_corpus"},{"subj":"T77","pred":"source","obj":"c_corpus"},{"subj":"T78","pred":"source","obj":"c_corpus"},{"subj":"T79","pred":"source","obj":"c_corpus"},{"subj":"T80","pred":"source","obj":"c_corpus"},{"subj":"T81","pred":"source","obj":"c_corpus"},{"subj":"T83","pred":"source","obj":"c_corpus"},{"subj":"T85","pred":"source","obj":"c_corpus"},{"subj":"T87","pred":"source","obj":"c_corpus"},{"subj":"T86","pred":"source","obj":"c_corpus"},{"subj":"T84","pred":"source","obj":"c_corpus"},{"subj":"T88","pred":"source","obj":"c_corpus"},{"subj":"T89","pred":"source","obj":"c_corpus"},{"subj":"T90","pred":"source","obj":"c_corpus"},{"subj":"T91","pred":"source","obj":"c_corpus"},{"subj":"T92","pred":"source","obj":"c_corpus"},{"subj":"T93","pred":"source","obj":"c_corpus"},{"subj":"T95","pred":"source","obj":"c_corpus"},{"subj":"T99","pred":"source","obj":"c_corpus"},{"subj":"T100","pred":"source","obj":"c_corpus"},{"subj":"T101","pred":"source","obj":"c_corpus"},{"subj":"T102","pred":"source","obj":"c_corpus"},{"subj":"T103","pred":"source","obj":"c_corpus"},{"subj":"T104","pred":"source","obj":"c_corpus"},{"subj":"T105","pred":"source","obj":"c_corpus"},{"subj":"T106","pred":"source","obj":"c_corpus"},{"subj":"T108","pred":"source","obj":"c_corpus"},{"subj":"T112","pred":"source","obj":"c_corpus"},{"subj":"T113","pred":"source","obj":"c_corpus"},{"subj":"T114","pred":"source","obj":"c_corpus"},{"subj":"T115","pred":"source","obj":"c_corpus"},{"subj":"T116","pred":"source","obj":"c_corpus"},{"subj":"T117","pred":"source","obj":"c_corpus"},{"subj":"T118","pred":"source","obj":"c_corpus"},{"subj":"T119","pred":"source","obj":"c_corpus"},{"subj":"T120","pred":"source","obj":"c_corpus"},{"subj":"T121","pred":"source","obj":"c_corpus"},{"subj":"T122","pred":"source","obj":"c_corpus"},{"subj":"T123","pred":"source","obj":"c_corpus"},{"subj":"T124","pred":"source","obj":"c_corpus"},{"subj":"T126","pred":"source","obj":"c_corpus"},{"subj":"T127","pred":"source","obj":"c_corpus"},{"subj":"T128","pred":"source","obj":"c_corpus"},{"subj":"T129","pred":"source","obj":"c_corpus"},{"subj":"T130","pred":"source","obj":"c_corpus"},{"subj":"T125","pred":"source","obj":"c_corpus"},{"subj":"T132","pred":"source","obj":"c_corpus"},{"subj":"T136","pred":"source","obj":"c_corpus"},{"subj":"T137","pred":"source","obj":"c_corpus"},{"subj":"T138","pred":"source","obj":"c_corpus"},{"subj":"T139","pred":"source","obj":"c_corpus"},{"subj":"T140","pred":"source","obj":"c_corpus"},{"subj":"T141","pred":"source","obj":"c_corpus"},{"subj":"T142","pred":"source","obj":"c_corpus"},{"subj":"T143","pred":"source","obj":"c_corpus"},{"subj":"T144","pred":"source","obj":"c_corpus"},{"subj":"T145","pred":"source","obj":"c_corpus"},{"subj":"T146","pred":"source","obj":"c_corpus"},{"subj":"T147","pred":"source","obj":"c_corpus"},{"subj":"T148","pred":"source","obj":"c_corpus"},{"subj":"T149","pred":"source","obj":"c_corpus"},{"subj":"T150","pred":"source","obj":"c_corpus"},{"subj":"T152","pred":"source","obj":"c_corpus"},{"subj":"T153","pred":"source","obj":"c_corpus"},{"subj":"T154","pred":"source","obj":"c_corpus"},{"subj":"T155","pred":"source","obj":"c_corpus"},{"subj":"T156","pred":"source","obj":"c_corpus"},{"subj":"T151","pred":"source","obj":"c_corpus"},{"subj":"T157","pred":"source","obj":"c_corpus"},{"subj":"T158","pred":"source","obj":"c_corpus"},{"subj":"T159","pred":"source","obj":"c_corpus"},{"subj":"T160","pred":"source","obj":"c_corpus"},{"subj":"T162","pred":"source","obj":"c_corpus"},{"subj":"T163","pred":"source","obj":"c_corpus"},{"subj":"T164","pred":"source","obj":"c_corpus"},{"subj":"T165","pred":"source","obj":"c_corpus"},{"subj":"T166","pred":"source","obj":"c_corpus"},{"subj":"T161","pred":"source","obj":"c_corpus"},{"subj":"T173","pred":"source","obj":"c_corpus"},{"subj":"T174","pred":"source","obj":"c_corpus"},{"subj":"T177","pred":"source","obj":"c_corpus"},{"subj":"T178","pred":"source","obj":"c_corpus"},{"subj":"T179","pred":"source","obj":"c_corpus"},{"subj":"T180","pred":"source","obj":"c_corpus"},{"subj":"T181","pred":"source","obj":"c_corpus"},{"subj":"T175","pred":"source","obj":"c_corpus"},{"subj":"T176","pred":"source","obj":"c_corpus"},{"subj":"T183","pred":"source","obj":"c_corpus"},{"subj":"T187","pred":"source","obj":"c_corpus"},{"subj":"T188","pred":"source","obj":"c_corpus"},{"subj":"T189","pred":"source","obj":"c_corpus"},{"subj":"T190","pred":"source","obj":"c_corpus"},{"subj":"T191","pred":"source","obj":"c_corpus"},{"subj":"T192","pred":"source","obj":"c_corpus"},{"subj":"T193","pred":"source","obj":"c_corpus"},{"subj":"T194","pred":"source","obj":"c_corpus"},{"subj":"T195","pred":"source","obj":"c_corpus"},{"subj":"T196","pred":"source","obj":"c_corpus"},{"subj":"T197","pred":"source","obj":"c_corpus"},{"subj":"T198","pred":"source","obj":"c_corpus"},{"subj":"T200","pred":"source","obj":"c_corpus"},{"subj":"T204","pred":"source","obj":"c_corpus"},{"subj":"T205","pred":"source","obj":"c_corpus"},{"subj":"T206","pred":"source","obj":"c_corpus"},{"subj":"T207","pred":"source","obj":"c_corpus"},{"subj":"T208","pred":"source","obj":"c_corpus"},{"subj":"T209","pred":"source","obj":"c_corpus"},{"subj":"T210","pred":"source","obj":"c_corpus"},{"subj":"T211","pred":"source","obj":"c_corpus"},{"subj":"T212","pred":"source","obj":"c_corpus"},{"subj":"T213","pred":"source","obj":"c_corpus"},{"subj":"T215","pred":"source","obj":"c_corpus"},{"subj":"T219","pred":"source","obj":"c_corpus"},{"subj":"T220","pred":"source","obj":"c_corpus"},{"subj":"T221","pred":"source","obj":"c_corpus"},{"subj":"T222","pred":"source","obj":"c_corpus"},{"subj":"T223","pred":"source","obj":"c_corpus"},{"subj":"T224","pred":"source","obj":"c_corpus"},{"subj":"T225","pred":"source","obj":"c_corpus"},{"subj":"T226","pred":"source","obj":"c_corpus"},{"subj":"T227","pred":"source","obj":"c_corpus"},{"subj":"T228","pred":"source","obj":"c_corpus"},{"subj":"T229","pred":"source","obj":"c_corpus"},{"subj":"T230","pred":"source","obj":"c_corpus"},{"subj":"T231","pred":"source","obj":"c_corpus"},{"subj":"T233","pred":"source","obj":"c_corpus"},{"subj":"T234","pred":"source","obj":"c_corpus"},{"subj":"T235","pred":"source","obj":"c_corpus"},{"subj":"T236","pred":"source","obj":"c_corpus"},{"subj":"T237","pred":"source","obj":"c_corpus"},{"subj":"T232","pred":"source","obj":"c_corpus"},{"subj":"T238","pred":"source","obj":"c_corpus"},{"subj":"T239","pred":"source","obj":"c_corpus"},{"subj":"T240","pred":"source","obj":"c_corpus"},{"subj":"T241","pred":"source","obj":"c_corpus"},{"subj":"T242","pred":"source","obj":"c_corpus"},{"subj":"T243","pred":"source","obj":"c_corpus"},{"subj":"T244","pred":"source","obj":"c_corpus"},{"subj":"T245","pred":"source","obj":"c_corpus"},{"subj":"T246","pred":"source","obj":"c_corpus"},{"subj":"T247","pred":"source","obj":"c_corpus"},{"subj":"T248","pred":"source","obj":"c_corpus"},{"subj":"T250","pred":"source","obj":"c_corpus"},{"subj":"T251","pred":"source","obj":"c_corpus"},{"subj":"T252","pred":"source","obj":"c_corpus"},{"subj":"T253","pred":"source","obj":"c_corpus"},{"subj":"T254","pred":"source","obj":"c_corpus"},{"subj":"T249","pred":"source","obj":"c_corpus"},{"subj":"T255","pred":"source","obj":"c_corpus"},{"subj":"T256","pred":"source","obj":"c_corpus"},{"subj":"T257","pred":"source","obj":"c_corpus"},{"subj":"T259","pred":"source","obj":"c_corpus"},{"subj":"T260","pred":"source","obj":"c_corpus"},{"subj":"T261","pred":"source","obj":"c_corpus"},{"subj":"T262","pred":"source","obj":"c_corpus"},{"subj":"T263","pred":"source","obj":"c_corpus"},{"subj":"T258","pred":"source","obj":"c_corpus"}]},{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":101},"obj":"DRI_Challenge"},{"id":"T2","span":{"begin":102,"end":225},"obj":"DRI_Background"},{"id":"T3","span":{"begin":226,"end":288},"obj":"DRI_Approach"},{"id":"T4","span":{"begin":289,"end":405},"obj":"DRI_Background"},{"id":"T5","span":{"begin":406,"end":597},"obj":"DRI_Outcome"},{"id":"T6","span":{"begin":598,"end":622},"obj":"DRI_Background"},{"id":"T7","span":{"begin":623,"end":644},"obj":"Token_Label.OUTSIDE"},{"id":"T8","span":{"begin":645,"end":715},"obj":"DRI_Background"},{"id":"T9","span":{"begin":716,"end":829},"obj":"DRI_Approach"},{"id":"T10","span":{"begin":830,"end":933},"obj":"DRI_Approach"},{"id":"T11","span":{"begin":934,"end":958},"obj":"DRI_Approach"},{"id":"T12","span":{"begin":959,"end":983},"obj":"Token_Label.OUTSIDE"},{"id":"T13","span":{"begin":984,"end":1023},"obj":"DRI_Approach"},{"id":"T14","span":{"begin":1024,"end":1142},"obj":"DRI_Background"},{"id":"T15","span":{"begin":1143,"end":1292},"obj":"DRI_Outcome"},{"id":"T16","span":{"begin":1293,"end":1475},"obj":"DRI_Approach"},{"id":"T17","span":{"begin":1476,"end":1514},"obj":"DRI_Background"}],"attributes":[{"subj":"T1","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T2","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T3","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T4","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T5","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T6","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T7","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T8","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T9","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T10","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T11","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T12","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T13","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T14","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T15","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T16","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T17","pred":"source","obj":"UseCases_ArguminSci_Discourse"}]},{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":102,"end":225},"obj":"DRI_Background"},{"id":"T2","span":{"begin":226,"end":288},"obj":"DRI_Approach"},{"id":"T3","span":{"begin":289,"end":405},"obj":"DRI_Background"},{"id":"T4","span":{"begin":406,"end":597},"obj":"DRI_Outcome"},{"id":"T5","span":{"begin":598,"end":622},"obj":"DRI_Background"},{"id":"T6","span":{"begin":645,"end":715},"obj":"DRI_Background"},{"id":"T7","span":{"begin":716,"end":829},"obj":"DRI_Approach"},{"id":"T8","span":{"begin":830,"end":933},"obj":"DRI_Approach"},{"id":"T9","span":{"begin":934,"end":958},"obj":"DRI_Approach"},{"id":"T10","span":{"begin":984,"end":1023},"obj":"DRI_Approach"},{"id":"T11","span":{"begin":1024,"end":1142},"obj":"DRI_Background"},{"id":"T12","span":{"begin":1143,"end":1292},"obj":"DRI_Outcome"},{"id":"T13","span":{"begin":1293,"end":1475},"obj":"DRI_Approach"},{"id":"T14","span":{"begin":1476,"end":1514},"obj":"DRI_Background"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T2","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T3","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T4","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T5","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T6","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T7","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T8","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T9","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T10","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T11","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T12","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T13","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T14","pred":"source","obj":"PubMed_ArguminSci"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"c_corpus","color":"#ec93e9","default":true},{"id":"UseCases_ArguminSci_Discourse","color":"#93ecd5"},{"id":"PubMed_ArguminSci","color":"#ecbb93"}]}]}}