> top > docs > PubMed:9203583 > annotations

PubMed:9203583 JSONTXT

Annnotations TAB JSON ListView MergeView

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-4 PR:Q9ZRV4 denotes Mlh1
T2 0-4 PR:P38920 denotes Mlh1
T3 0-4 PR:Q54KD8 denotes Mlh1
T5 0-4 PR:Q9JK91 denotes Mlh1
T6 0-4 PR:P97679 denotes Mlh1
T7 0-4 PR:Q9P7W6 denotes Mlh1
T8 0-4 PR:000010442 denotes Mlh1
T9 0-4 PR:P40692 denotes Mlh1
T4 0-4 CVCL_G669 denotes Mlh1
T10 21-36 GO:0006298 denotes mismatch repair
T11 37-45 CHEBI:36080 denotes proteins
T12 93-100 GO:0051321 denotes meiosis
T16 105-115 D056890 denotes eukaryotes
T17 143-147 PR:000023326 denotes MutS
T18 143-147 PR:P23909 denotes MutS
T19 143-147 PR:Q2FYZ9 denotes MutS
T20 152-156 PR:000023324 denotes MutL
T21 152-156 PR:Q93T05 denotes MutL
T22 152-156 PR:P23367 denotes MutL
T23 152-165 D000070956 denotes MutL proteins
T25 178-181 GO:0005574 denotes DNA
T27 178-181 SO:0000352 denotes DNA
T26 178-181 CHEBI:16991 denotes DNA
T28 178-181 D004247 denotes DNA
T29 182-197 GO:0006298 denotes mismatch repair
T30 230-234 PR:000023324 denotes mutL
T31 230-234 PR:Q93T05 denotes mutL
T32 230-234 PR:P23367 denotes mutL
T33 235-242 SO:0000853 denotes homolog
T34 243-247 PR:Q9ZRV4 denotes MLH1
T35 243-247 PR:P38920 denotes MLH1
T36 243-247 PR:Q54KD8 denotes MLH1
T38 243-247 PR:Q9JK91 denotes MLH1
T39 243-247 PR:P97679 denotes MLH1
T40 243-247 PR:Q9P7W6 denotes MLH1
T41 243-247 PR:000010442 denotes MLH1
T42 243-247 PR:P40692 denotes MLH1
T37 243-247 CVCL_G669 denotes MLH1
T43 272-287 GO:0006298 denotes mismatch repair
T44 325-329 PR:Q9ZRV4 denotes MLH1
T45 325-329 PR:P38920 denotes MLH1
T46 325-329 PR:Q54KD8 denotes MLH1
T48 325-329 PR:Q9JK91 denotes MLH1
T49 325-329 PR:P97679 denotes MLH1
T50 325-329 PR:Q9P7W6 denotes MLH1
T51 325-329 PR:000010442 denotes MLH1
T52 325-329 PR:P40692 denotes MLH1
T47 325-329 CVCL_G669 denotes MLH1
T53 340-344 PR:000005054 denotes mice
T55 340-344 O89094 denotes mice
T54 340-344 D051379 denotes mice
T56 340-344 10095 denotes mice
T57 368-372 PR:Q9ZRV4 denotes Mlh1
T58 368-372 PR:P38920 denotes Mlh1
T59 368-372 PR:Q54KD8 denotes Mlh1
T61 368-372 PR:Q9JK91 denotes Mlh1
T62 368-372 PR:P97679 denotes Mlh1
T63 368-372 PR:Q9P7W6 denotes Mlh1
T64 368-372 PR:000010442 denotes Mlh1
T65 368-372 PR:P40692 denotes Mlh1
T60 368-372 CVCL_G669 denotes Mlh1
T66 397-404 GO:0051321 denotes meiosis
T68 431-455 350141 denotes Saccharomyces cerevisiae
T71 431-455 9511 denotes Saccharomyces cerevisiae
T69 431-455 D012441 denotes Saccharomyces cerevisiae
T70 431-455 4932 denotes Saccharomyces cerevisiae
T72 478-486 SO:0000159 denotes deletion
T76 490-494 CVCL_G669 denotes MLH1
T73 490-494 PR:Q9ZRV4 denotes MLH1
T74 490-494 PR:P38920 denotes MLH1
T75 490-494 PR:Q54KD8 denotes MLH1
T77 490-494 PR:Q9JK91 denotes MLH1
T78 490-494 PR:P97679 denotes MLH1
T79 490-494 PR:Q9P7W6 denotes MLH1
T80 490-494 PR:000010442 denotes MLH1
T81 490-494 PR:P40692 denotes MLH1
T83 539-549 SO:1000029 denotes deficiency
T85 578-581 CHEBI:16991 denotes DNA
T87 578-581 D004247 denotes DNA
T86 578-581 SO:0000352 denotes DNA
T84 578-581 GO:0005574 denotes DNA
T88 589-596 GO:0051321 denotes meiosis
T89 623-630 GO:0051321 denotes meiosis
T90 640-644 PR:000023326 denotes mutS
T91 640-644 PR:P23909 denotes mutS
T92 640-644 PR:Q2FYZ9 denotes mutS
T93 640-653 D000074080 denotes mutS homologs
T95 654-657 CHEBI:16768 denotes Msh
T99 654-657 D009074 denotes Msh
T100 654-657 D009074 denotes Msh
T101 654-658 PR:P40965 denotes Msh4
T102 654-658 PR:000010668 denotes Msh4
T103 654-658 PR:F4JP48 denotes Msh4
T104 654-658 PR:Q99MT2 denotes Msh4
T105 654-658 PR:O15457 denotes Msh4
T106 654-658 PR:Q23405 denotes Msh4
T108 662-665 CHEBI:16768 denotes Msh
T112 662-665 D009074 denotes Msh
T113 662-665 D009074 denotes Msh
T114 662-666 PR:Q6MG62 denotes Msh5
T115 662-666 PR:Q9QUM7 denotes Msh5
T116 662-666 PR:O43196 denotes Msh5
T117 662-666 PR:Q19272 denotes Msh5
T118 662-666 PR:F4JEP5 denotes Msh5
T119 662-666 PR:000010669 denotes Msh5
T120 662-666 PR:Q12175 denotes Msh5
T121 688-697 MOP:0000569 denotes reduction
T122 731-735 PR:Q9ZRV4 denotes mlh1
T123 731-735 PR:P38920 denotes mlh1
T124 731-735 PR:Q54KD8 denotes mlh1
T126 731-735 PR:Q9JK91 denotes mlh1
T127 731-735 PR:P97679 denotes mlh1
T128 731-735 PR:Q9P7W6 denotes mlh1
T129 731-735 PR:000010442 denotes mlh1
T130 731-735 PR:P40692 denotes mlh1
T125 731-735 CVCL_G669 denotes mlh1
T132 736-739 CHEBI:16768 denotes msh
T136 736-739 D009074 denotes msh
T137 736-739 D009074 denotes msh
T138 736-740 PR:P40965 denotes msh4
T139 736-740 PR:000010668 denotes msh4
T140 736-740 PR:F4JP48 denotes msh4
T141 736-740 PR:Q99MT2 denotes msh4
T142 736-740 PR:O15457 denotes msh4
T143 736-740 PR:Q23405 denotes msh4
T144 741-747 SO:0000985 denotes double
T145 796-803 CHEBI:34922 denotes pathway
T146 834-849 D005819 denotes genetic markers
T147 834-849 D005819 denotes genetic markers
T148 862-866 PR:Q9ZRV4 denotes mlh1
T149 862-866 PR:P38920 denotes mlh1
T150 862-866 PR:Q54KD8 denotes mlh1
T152 862-866 PR:Q9JK91 denotes mlh1
T153 862-866 PR:P97679 denotes mlh1
T154 862-866 PR:Q9P7W6 denotes mlh1
T155 862-866 PR:000010442 denotes mlh1
T156 862-866 PR:P40692 denotes mlh1
T151 862-866 CVCL_G669 denotes mlh1
T157 1126-1135 SO:0000817 denotes wild-type
T158 1157-1161 PR:Q9ZRV4 denotes mlh1
T159 1157-1161 PR:P38920 denotes mlh1
T160 1157-1161 PR:Q54KD8 denotes mlh1
T162 1157-1161 PR:Q9JK91 denotes mlh1
T163 1157-1161 PR:P97679 denotes mlh1
T164 1157-1161 PR:Q9P7W6 denotes mlh1
T165 1157-1161 PR:000010442 denotes mlh1
T166 1157-1161 PR:P40692 denotes mlh1
T161 1157-1161 CVCL_G669 denotes mlh1
T173 1192-1196 PR:P14242 denotes pms1
T174 1192-1196 PR:000012913 denotes pms1
T177 1192-1196 PR:Q941I6 denotes pms1
T178 1192-1196 PR:P54280 denotes pms1
T179 1192-1196 PR:Q5NC83 denotes pms1
T180 1192-1196 PR:P54277 denotes pms1
T181 1192-1196 PR:Q54QA0 denotes pms1
T175 1192-1196 C102203 denotes pms1
T176 1192-1196 C102203 denotes pms1
T183 1198-1201 CHEBI:16768 denotes msh
T187 1198-1201 D009074 denotes msh
T188 1198-1201 D009074 denotes msh
T189 1198-1202 PR:000010666 denotes msh2
T190 1198-1202 PR:P25847 denotes msh2
T191 1198-1202 PR:P43246 denotes msh2
T192 1198-1202 P22711 denotes msh2
T193 1198-1202 PR:P22711 denotes msh2
T194 1198-1202 PR:P54275 denotes msh2
T195 1198-1202 PR:O74773 denotes msh2
T196 1198-1202 PR:P43247 denotes msh2
T197 1198-1202 PR:Q553L4 denotes msh2
T198 1198-1202 PR:O24617 denotes msh2
T200 1204-1207 CHEBI:16768 denotes msh
T204 1204-1207 D009074 denotes msh
T205 1204-1207 D009074 denotes msh
T206 1204-1208 PR:O65607 denotes msh3
T207 1204-1208 PR:000010667 denotes msh3
T208 1204-1208 PR:Q59Y41 denotes msh3
T209 1204-1208 PR:P25336 denotes msh3
T210 1204-1208 PR:P20585 denotes msh3
T211 1204-1208 PR:P26359 denotes msh3
T212 1204-1208 PR:P13705 denotes msh3
T213 1204-1208 PR:Q1ZXH0 denotes msh3
T215 1214-1217 CHEBI:16768 denotes msh
T219 1214-1217 D009074 denotes msh
T220 1214-1217 D009074 denotes msh
T221 1214-1218 PR:P52701 denotes msh6
T222 1214-1218 PR:P54276 denotes msh6
T223 1214-1218 PR:Q9VUM0 denotes msh6
T224 1214-1218 PR:Q55GU9 denotes msh6
T225 1214-1218 PR:O04716 denotes msh6
T226 1214-1218 PR:Q03834 denotes msh6
T227 1214-1218 PR:O74502 denotes msh6
T228 1214-1218 PR:000010670 denotes msh6
T229 1287-1291 PR:Q9ZRV4 denotes MLH1
T230 1287-1291 PR:P38920 denotes MLH1
T231 1287-1291 PR:Q54KD8 denotes MLH1
T233 1287-1291 PR:Q9JK91 denotes MLH1
T234 1287-1291 PR:P97679 denotes MLH1
T235 1287-1291 PR:Q9P7W6 denotes MLH1
T236 1287-1291 PR:000010442 denotes MLH1
T237 1287-1291 PR:P40692 denotes MLH1
T232 1287-1291 CVCL_G669 denotes MLH1
T238 1364-1368 SO:0000704 denotes gene
T239 1364-1379 GO:0035822 denotes gene conversion
T240 1388-1392 PR:000023326 denotes MutS
T241 1388-1392 PR:P23909 denotes MutS
T242 1388-1392 PR:Q2FYZ9 denotes MutS
T243 1397-1401 PR:000023324 denotes MutL
T244 1397-1401 PR:Q93T05 denotes MutL
T245 1397-1401 PR:P23367 denotes MutL
T246 1421-1425 PR:Q9ZRV4 denotes Mlh1
T247 1421-1425 PR:P38920 denotes Mlh1
T248 1421-1425 PR:Q54KD8 denotes Mlh1
T250 1421-1425 PR:Q9JK91 denotes Mlh1
T251 1421-1425 PR:P97679 denotes Mlh1
T252 1421-1425 PR:Q9P7W6 denotes Mlh1
T253 1421-1425 PR:000010442 denotes Mlh1
T254 1421-1425 PR:P40692 denotes Mlh1
T249 1421-1425 CVCL_G669 denotes Mlh1
T255 1486-1490 PR:Q9ZRV4 denotes Mlh1
T256 1486-1490 PR:P38920 denotes Mlh1
T257 1486-1490 PR:Q54KD8 denotes Mlh1
T259 1486-1490 PR:Q9JK91 denotes Mlh1
T260 1486-1490 PR:P97679 denotes Mlh1
T261 1486-1490 PR:Q9P7W6 denotes Mlh1
T262 1486-1490 PR:000010442 denotes Mlh1
T263 1486-1490 PR:P40692 denotes Mlh1
T258 1486-1490 CVCL_G669 denotes Mlh1

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-101 DRI_Challenge denotes Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis.
T2 102-225 DRI_Background denotes In eukaryotes, homologs of the bacterial MutS and MutL proteins function in DNA mismatch repair and recombination pathways.
T3 226-288 DRI_Approach denotes The mutL homolog MLH1 is required for nuclear mismatch repair.
T4 289-405 DRI_Background denotes Previously, cytological analysis of MLH1-deficient mice has implied a role for Mlh1 in crossing-over during meiosis.
T5 406-597 DRI_Outcome denotes Here we demonstrate that Saccharomyces cerevisiae diploids containing a deletion of MLH1 have reduced crossing-over in addition to a deficiency in the repair of mismatched DNA during meiosis.
T6 598-622 DRI_Background denotes Absence of either of the
T7 623-644 Token_Label.OUTSIDE denotes meiosis-specific mutS
T8 645-715 DRI_Background denotes homologs Msh4 or Msh5 results in a similar reduction in crossing-over.
T9 716-829 DRI_Approach denotes Analysis of an mlh1 msh4 double mutant suggests that both genes act in the same pathway to promote crossing-over.
T10 830-933 DRI_Approach denotes All genetic markers analyzed in mlh1 mutants display elevated frequencies of non-Mendelian segregation.
T11 934-958 DRI_Approach denotes Most of these events are
T12 959-983 Token_Label.OUTSIDE denotes postmeiotic segregations
T13 984-1023 DRI_Approach denotes that represent unrepaired heteroduplex.
T14 1024-1142 DRI_Background denotes These data suggest that either restorational repair is frequent or heteroduplex tracts are shorter in wild-type cells.
T15 1143-1292 DRI_Outcome denotes Comparison of mlh1 segregation data with that of pms1, msh2, msh3, and msh6 mutants show that the ability to promote crossing-over is unique to MLH1.
T16 1293-1475 DRI_Approach denotes Taken together these observations indicate that both crossing-over and gene conversion require MutS and MutL functions and that Mlh1 represents an overlap between these two pathways.
T17 1476-1514 DRI_Background denotes Models of Mlh1 function are discussed.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 102-225 DRI_Background denotes In eukaryotes, homologs of the bacterial MutS and MutL proteins function in DNA mismatch repair and recombination pathways.
T2 226-288 DRI_Approach denotes The mutL homolog MLH1 is required for nuclear mismatch repair.
T3 289-405 DRI_Background denotes Previously, cytological analysis of MLH1-deficient mice has implied a role for Mlh1 in crossing-over during meiosis.
T4 406-597 DRI_Outcome denotes Here we demonstrate that Saccharomyces cerevisiae diploids containing a deletion of MLH1 have reduced crossing-over in addition to a deficiency in the repair of mismatched DNA during meiosis.
T5 598-622 DRI_Background denotes Absence of either of the
T6 645-715 DRI_Background denotes homologs Msh4 or Msh5 results in a similar reduction in crossing-over.
T7 716-829 DRI_Approach denotes Analysis of an mlh1 msh4 double mutant suggests that both genes act in the same pathway to promote crossing-over.
T8 830-933 DRI_Approach denotes All genetic markers analyzed in mlh1 mutants display elevated frequencies of non-Mendelian segregation.
T9 934-958 DRI_Approach denotes Most of these events are
T10 984-1023 DRI_Approach denotes that represent unrepaired heteroduplex.
T11 1024-1142 DRI_Background denotes These data suggest that either restorational repair is frequent or heteroduplex tracts are shorter in wild-type cells.
T12 1143-1292 DRI_Outcome denotes Comparison of mlh1 segregation data with that of pms1, msh2, msh3, and msh6 mutants show that the ability to promote crossing-over is unique to MLH1.
T13 1293-1475 DRI_Approach denotes Taken together these observations indicate that both crossing-over and gene conversion require MutS and MutL functions and that Mlh1 represents an overlap between these two pathways.
T14 1476-1514 DRI_Background denotes Models of Mlh1 function are discussed.