PubMed:9160887 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":20,"end":50},"obj":"cell_type"},{"id":"T2","span":{"begin":67,"end":85},"obj":"protein"},{"id":"T3","span":{"begin":130,"end":134},"obj":"protein"},{"id":"T4","span":{"begin":138,"end":169},"obj":"protein"},{"id":"T5","span":{"begin":317,"end":347},"obj":"protein"},{"id":"T6","span":{"begin":349,"end":357},"obj":"protein"},{"id":"T7","span":{"begin":359,"end":368},"obj":"protein"},{"id":"T8","span":{"begin":374,"end":377},"obj":"protein"},{"id":"T9","span":{"begin":384,"end":388},"obj":"protein"},{"id":"T10","span":{"begin":411,"end":425},"obj":"DNA"},{"id":"T11","span":{"begin":529,"end":533},"obj":"protein"},{"id":"T12","span":{"begin":608,"end":620},"obj":"protein"},{"id":"T13","span":{"begin":669,"end":697},"obj":"cell_type"},{"id":"T14","span":{"begin":699,"end":702},"obj":"cell_type"},{"id":"T15","span":{"begin":745,"end":749},"obj":"cell_type"},{"id":"T16","span":{"begin":782,"end":791},"obj":"protein"},{"id":"T17","span":{"begin":848,"end":852},"obj":"protein"},{"id":"T18","span":{"begin":891,"end":903},"obj":"cell_type"}],"text":"Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes.\nTax1, a transcriptional trans-activator of the Human T-cell leukemia virus type I (HTLV-I), induces the expression of many cellular genes through interaction with at least three distinct cellular transcription factors; CREB/ATF, NF-kappaB, and SRF. This Tax1-induced activation of cellular genes is considered to be a critical event in T-cell transformation by HTLV-I. To elucidate the role of each Tax1-inducible transcriptional pathway in T-cell transformation, we introduced Tax1 mutants with different trans-activating phenotypes into peripheral blood lymphocytes (PBL) by retroviral vectors. Analysis of these PBLs revealed that activation of the NF-kappaB pathway is sufficient to promote the growth response to IL-2. However, for the clonal expansion of CD4+ T-cells, which is a characteristic result of HTLV-I infection, activation of the CREB/ATF and SRF pathways is also required."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":67,"end":128},"obj":"NP"},{"id":"C2","span":{"begin":130,"end":134},"obj":"NP"},{"id":"C4","span":{"begin":173,"end":220},"obj":"NP"},{"id":"C3","span":{"begin":136,"end":220},"obj":"NP"},{"id":"C5","span":{"begin":302,"end":347},"obj":"NP"},{"id":"C6","span":{"begin":349,"end":377},"obj":"NP"},{"id":"C7","span":{"begin":466,"end":487},"obj":"NP"},{"id":"C8","span":{"begin":491,"end":497},"obj":"NP"},{"id":"C9","span":{"begin":571,"end":592},"obj":"NP"},{"id":"C10","span":{"begin":608,"end":663},"obj":"NP"},{"id":"C11","span":{"begin":669,"end":703},"obj":"NP"},{"id":"C12","span":{"begin":739,"end":749},"obj":"NP"},{"id":"C13","span":{"begin":867,"end":903},"obj":"NP"},{"id":"C14","span":{"begin":905,"end":910},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-appos","subj":"C3","obj":"C2"},{"id":"R2","pred":"coref-appos","subj":"C6","obj":"C5"},{"id":"R3","pred":"coref-ident","subj":"C8","obj":"C4"},{"id":"R4","pred":"coref-ident","subj":"C9","obj":"C7"},{"id":"R5","pred":"coref-ident","subj":"C10","obj":"C1"},{"id":"R6","pred":"coref-ident","subj":"C12","obj":"C11"},{"id":"R7","pred":"coref-relat","subj":"C14","obj":"C13"}],"text":"Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes.\nTax1, a transcriptional trans-activator of the Human T-cell leukemia virus type I (HTLV-I), induces the expression of many cellular genes through interaction with at least three distinct cellular transcription factors; CREB/ATF, NF-kappaB, and SRF. This Tax1-induced activation of cellular genes is considered to be a critical event in T-cell transformation by HTLV-I. To elucidate the role of each Tax1-inducible transcriptional pathway in T-cell transformation, we introduced Tax1 mutants with different trans-activating phenotypes into peripheral blood lymphocytes (PBL) by retroviral vectors. Analysis of these PBLs revealed that activation of the NF-kappaB pathway is sufficient to promote the growth response to IL-2. However, for the clonal expansion of CD4+ T-cells, which is a characteristic result of HTLV-I infection, activation of the CREB/ATF and SRF pathways is also required."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":129},"obj":"Sentence"},{"id":"S2","span":{"begin":130,"end":378},"obj":"Sentence"},{"id":"S3","span":{"begin":379,"end":498},"obj":"Sentence"},{"id":"S4","span":{"begin":499,"end":726},"obj":"Sentence"},{"id":"S5","span":{"begin":727,"end":853},"obj":"Sentence"},{"id":"S6","span":{"begin":854,"end":1020},"obj":"Sentence"}],"text":"Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes.\nTax1, a transcriptional trans-activator of the Human T-cell leukemia virus type I (HTLV-I), induces the expression of many cellular genes through interaction with at least three distinct cellular transcription factors; CREB/ATF, NF-kappaB, and SRF. This Tax1-induced activation of cellular genes is considered to be a critical event in T-cell transformation by HTLV-I. To elucidate the role of each Tax1-inducible transcriptional pathway in T-cell transformation, we introduced Tax1 mutants with different trans-activating phenotypes into peripheral blood lymphocytes (PBL) by retroviral vectors. Analysis of these PBLs revealed that activation of the NF-kappaB pathway is sufficient to promote the growth response to IL-2. However, for the clonal expansion of CD4+ T-cells, which is a characteristic result of HTLV-I infection, activation of the CREB/ATF and SRF pathways is also required."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":20,"end":50},"obj":"cell_type"},{"id":"T2","span":{"begin":67,"end":73},"obj":"virus"},{"id":"T3","span":{"begin":101,"end":128},"obj":"other_name"},{"id":"T4","span":{"begin":130,"end":134},"obj":"protein_molecule"},{"id":"T5","span":{"begin":138,"end":169},"obj":"protein_family_or_group"},{"id":"T6","span":{"begin":177,"end":211},"obj":"virus"},{"id":"T7","span":{"begin":213,"end":219},"obj":"virus"},{"id":"T8","span":{"begin":317,"end":325},"obj":"protein_family_or_group"},{"id":"T9","span":{"begin":326,"end":347},"obj":"protein_family_or_group"},{"id":"T10","span":{"begin":349,"end":357},"obj":"protein_molecule"},{"id":"T11","span":{"begin":359,"end":368},"obj":"protein_complex"},{"id":"T12","span":{"begin":374,"end":377},"obj":"protein_molecule"},{"id":"T13","span":{"begin":384,"end":388},"obj":"protein_molecule"},{"id":"T14","span":{"begin":411,"end":425},"obj":"DNA_family_or_group"},{"id":"T15","span":{"begin":466,"end":487},"obj":"other_name"},{"id":"T16","span":{"begin":491,"end":497},"obj":"virus"},{"id":"T17","span":{"begin":529,"end":533},"obj":"protein_molecule"},{"id":"T18","span":{"begin":571,"end":592},"obj":"other_name"},{"id":"T19","span":{"begin":608,"end":612},"obj":"protein_molecule"},{"id":"T20","span":{"begin":636,"end":663},"obj":"other_name"},{"id":"T21","span":{"begin":669,"end":685},"obj":"cell_type"},{"id":"T22","span":{"begin":686,"end":697},"obj":"cell_type"},{"id":"T23","span":{"begin":699,"end":702},"obj":"cell_type"},{"id":"T24","span":{"begin":745,"end":749},"obj":"cell_type"},{"id":"T25","span":{"begin":782,"end":791},"obj":"protein_complex"},{"id":"T26","span":{"begin":848,"end":852},"obj":"protein_molecule"},{"id":"T27","span":{"begin":891,"end":903},"obj":"cell_type"},{"id":"T28","span":{"begin":941,"end":947},"obj":"virus"}],"text":"Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes.\nTax1, a transcriptional trans-activator of the Human T-cell leukemia virus type I (HTLV-I), induces the expression of many cellular genes through interaction with at least three distinct cellular transcription factors; CREB/ATF, NF-kappaB, and SRF. This Tax1-induced activation of cellular genes is considered to be a critical event in T-cell transformation by HTLV-I. To elucidate the role of each Tax1-inducible transcriptional pathway in T-cell transformation, we introduced Tax1 mutants with different trans-activating phenotypes into peripheral blood lymphocytes (PBL) by retroviral vectors. Analysis of these PBLs revealed that activation of the NF-kappaB pathway is sufficient to promote the growth response to IL-2. However, for the clonal expansion of CD4+ T-cells, which is a characteristic result of HTLV-I infection, activation of the CREB/ATF and SRF pathways is also required."}