PubMed:9160887 JSON TXT

Annnotations TAB JSON ListView MergeView

Id	Subject	Object	Predicate	Lexical cue
T1	20-50	cell_type	denotes	peripheral blood T-lymphocytes
T2	67-85	protein	denotes	HTLV-I Tax mutants
T3	130-134	protein	denotes	Tax1
T4	138-169	protein	denotes	transcriptional trans-activator
T5	317-347	protein	denotes	cellular transcription factors
T6	349-357	protein	denotes	CREB/ATF
T7	359-368	protein	denotes	NF-kappaB
T8	374-377	protein	denotes	SRF
T9	384-388	protein	denotes	Tax1
T10	411-425	DNA	denotes	cellular genes
T11	529-533	protein	denotes	Tax1
T12	608-620	protein	denotes	Tax1 mutants
T13	669-697	cell_type	denotes	peripheral blood lymphocytes
T14	699-702	cell_type	denotes	PBL
T15	745-749	cell_type	denotes	PBLs
T16	782-791	protein	denotes	NF-kappaB
T17	848-852	protein	denotes	IL-2
T18	891-903	cell_type	denotes	CD4+ T-cells

Id	Subject	Object	Predicate	Lexical cue
C1	67-128	NP	denotes	HTLV-I Tax mutants with different trans-activating phenotypes
C2	130-134	NP	denotes	Tax1
C4	173-220	NP	denotes	the Human T-cell leukemia virus type I (HTLV-I)
C3	136-220	NP	denotes	a transcriptional trans-activator of the Human T-cell leukemia virus type I (HTLV-I)
C5	302-347	NP	denotes	three distinct cellular transcription factors
C6	349-377	NP	denotes	CREB/ATF, NF-kappaB, and SRF
C7	466-487	NP	denotes	T-cell transformation
C8	491-497	NP	denotes	HTLV-I
C9	571-592	NP	denotes	T-cell transformation
C10	608-663	NP	denotes	Tax1 mutants with different trans-activating phenotypes
C11	669-703	NP	denotes	peripheral blood lymphocytes (PBL)
C12	739-749	NP	denotes	these PBLs
C13	867-903	NP	denotes	the clonal expansion of CD4+ T-cells
C14	905-910	NP	denotes	which
R1	C3	C2	coref-appos	a transcriptional trans-activator of the Human T-cell leukemia virus type I (HTLV-I),Tax1
R2	C6	C5	coref-appos	"CREB/ATF, NF-kappaB, and SRF",three distinct cellular transcription factors
R3	C8	C4	coref-ident	HTLV-I,the Human T-cell leukemia virus type I (HTLV-I)
R4	C9	C7	coref-ident	T-cell transformation,T-cell transformation
R5	C10	C1	coref-ident	Tax1 mutants with different trans-activating phenotypes,HTLV-I Tax mutants with different trans-activating phenotypes
R6	C12	C11	coref-ident	these PBLs,peripheral blood lymphocytes (PBL)
R7	C14	C13	coref-relat	which,the clonal expansion of CD4+ T-cells

Id	Subject	Object	Predicate	Lexical cue
S1	0-129	Sentence	denotes	Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes.
S2	130-378	Sentence	denotes	Tax1, a transcriptional trans-activator of the Human T-cell leukemia virus type I (HTLV-I), induces the expression of many cellular genes through interaction with at least three distinct cellular transcription factors; CREB/ATF, NF-kappaB, and SRF.
S3	379-498	Sentence	denotes	This Tax1-induced activation of cellular genes is considered to be a critical event in T-cell transformation by HTLV-I.
S4	499-726	Sentence	denotes	To elucidate the role of each Tax1-inducible transcriptional pathway in T-cell transformation, we introduced Tax1 mutants with different trans-activating phenotypes into peripheral blood lymphocytes (PBL) by retroviral vectors.
S5	727-853	Sentence	denotes	Analysis of these PBLs revealed that activation of the NF-kappaB pathway is sufficient to promote the growth response to IL-2.
S6	854-1020	Sentence	denotes	However, for the clonal expansion of CD4+ T-cells, which is a characteristic result of HTLV-I infection, activation of the CREB/ATF and SRF pathways is also required.

Id	Subject	Object	Predicate	Lexical cue
T1	20-50	cell_type	denotes	peripheral blood T-lymphocytes
T2	67-73	virus	denotes	HTLV-I
T3	101-128	other_name	denotes	trans-activating phenotypes
T4	130-134	protein_molecule	denotes	Tax1
T5	138-169	protein_family_or_group	denotes	transcriptional trans-activator
T6	177-211	virus	denotes	Human T-cell leukemia virus type I
T7	213-219	virus	denotes	HTLV-I
T8	317-325	protein_family_or_group	denotes	cellular
T9	326-347	protein_family_or_group	denotes	transcription factors
T10	349-357	protein_molecule	denotes	CREB/ATF
T11	359-368	protein_complex	denotes	NF-kappaB
T12	374-377	protein_molecule	denotes	SRF
T13	384-388	protein_molecule	denotes	Tax1
T14	411-425	DNA_family_or_group	denotes	cellular genes
T15	466-487	other_name	denotes	T-cell transformation
T16	491-497	virus	denotes	HTLV-I
T17	529-533	protein_molecule	denotes	Tax1
T18	571-592	other_name	denotes	T-cell transformation
T19	608-612	protein_molecule	denotes	Tax1
T20	636-663	other_name	denotes	trans-activating phenotypes
T21	669-685	cell_type	denotes	peripheral blood
T22	686-697	cell_type	denotes	lymphocytes
T23	699-702	cell_type	denotes	PBL
T24	745-749	cell_type	denotes	PBLs
T25	782-791	protein_complex	denotes	NF-kappaB
T26	848-852	protein_molecule	denotes	IL-2
T27	891-903	cell_type	denotes	CD4+ T-cells
T28	941-947	virus	denotes	HTLV-I