PubMed:9144218 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/9144218","sourcedb":"PubMed","sourceid":"9144218","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/9144218","text":"An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus.\nT cell receptor (TCR) alpha and delta gene segments are organized within a single genetic locus but are differentially regulated during T cell development. An enhancer-blocking element (BEAD-1, for blocking element alpha/delta 1) was localized to a 2.0-kb region 3' of TCR delta gene segments and 5' of TCR alpha joining gene segments within this locus. BEAD-1 blocked the ability of the TCR delta enhancer (Edelta) to activate a promoter when located between the two in a chromatin-integrated construct. We propose that BEAD-1 functions as a boundary that separates the TCR alpha/delta locus into distinct regulatory domains controlled by Edelta and the TCR alpha enhancer, and that it prevents Edelta from opening the chromatin of the TCR alpha joining gene segments for VDJ recombination at an early stage of T cell development.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C3","span":{"begin":74,"end":117},"obj":"NP"},{"id":"C2","span":{"begin":37,"end":117},"obj":"NP"},{"id":"C1","span":{"begin":0,"end":117},"obj":"NP"},{"id":"C4","span":{"begin":119,"end":170},"obj":"NP"},{"id":"C5","span":{"begin":192,"end":214},"obj":"NP"},{"id":"C6","span":{"begin":275,"end":348},"obj":"NP"},{"id":"C7","span":{"begin":422,"end":453},"obj":"NP"},{"id":"C8","span":{"begin":461,"end":471},"obj":"NP"},{"id":"C9","span":{"begin":473,"end":479},"obj":"NP"},{"id":"C10","span":{"begin":503,"end":534},"obj":"NP"},{"id":"C11","span":{"begin":640,"end":646},"obj":"NP"},{"id":"C12","span":{"begin":660,"end":670},"obj":"NP"},{"id":"C13","span":{"begin":671,"end":675},"obj":"NP"},{"id":"C14","span":{"begin":686,"end":711},"obj":"NP"},{"id":"C15","span":{"begin":759,"end":765},"obj":"NP"},{"id":"C16","span":{"begin":803,"end":805},"obj":"NP"},{"id":"C17","span":{"begin":815,"end":821},"obj":"NP"},{"id":"C18","span":{"begin":852,"end":887},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C4","obj":"C2"},{"id":"R2","pred":"coref-ident","subj":"C5","obj":"C3"},{"id":"R3","pred":"coref-ident","subj":"C6","obj":"C1"},{"id":"R4","pred":"coref-ident","subj":"C8","obj":"C5"},{"id":"R5","pred":"coref-ident","subj":"C9","obj":"C6"},{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C9"},{"id":"R7","pred":"coref-relat","subj":"C13","obj":"C12"},{"id":"R8","pred":"coref-ident","subj":"C14","obj":"C8"},{"id":"R9","pred":"coref-ident","subj":"C15","obj":"C10"},{"id":"R10","pred":"coref-pron","subj":"C16","obj":"C11"},{"id":"R11","pred":"coref-ident","subj":"C17","obj":"C15"},{"id":"R12","pred":"coref-ident","subj":"C18","obj":"C7"}],"attributes":[{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C10","pred":"source","obj":"genia-medco-coref"},{"subj":"C11","pred":"source","obj":"genia-medco-coref"},{"subj":"C12","pred":"source","obj":"genia-medco-coref"},{"subj":"C13","pred":"source","obj":"genia-medco-coref"},{"subj":"C14","pred":"source","obj":"genia-medco-coref"},{"subj":"C15","pred":"source","obj":"genia-medco-coref"},{"subj":"C16","pred":"source","obj":"genia-medco-coref"},{"subj":"C17","pred":"source","obj":"genia-medco-coref"},{"subj":"C18","pred":"source","obj":"genia-medco-coref"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":3,"end":28},"obj":"DNA"},{"id":"T2","span":{"begin":37,"end":66},"obj":"DNA"},{"id":"T3","span":{"begin":78,"end":117},"obj":"DNA"},{"id":"T4","span":{"begin":119,"end":146},"obj":"protein"},{"id":"T5","span":{"begin":278,"end":303},"obj":"DNA"},{"id":"T6","span":{"begin":305,"end":311},"obj":"DNA"},{"id":"T7","span":{"begin":326,"end":347},"obj":"DNA"},{"id":"T8","span":{"begin":368,"end":381},"obj":"DNA"},{"id":"T9","span":{"begin":388,"end":411},"obj":"DNA"},{"id":"T10","span":{"begin":422,"end":453},"obj":"DNA"},{"id":"T11","span":{"begin":473,"end":479},"obj":"DNA"},{"id":"T12","span":{"begin":507,"end":525},"obj":"DNA"},{"id":"T13","span":{"begin":527,"end":533},"obj":"DNA"},{"id":"T14","span":{"begin":592,"end":622},"obj":"DNA"},{"id":"T15","span":{"begin":640,"end":646},"obj":"DNA"},{"id":"T16","span":{"begin":690,"end":711},"obj":"DNA"},{"id":"T17","span":{"begin":726,"end":744},"obj":"DNA"},{"id":"T18","span":{"begin":759,"end":765},"obj":"DNA"},{"id":"T19","span":{"begin":774,"end":792},"obj":"DNA"},{"id":"T20","span":{"begin":815,"end":821},"obj":"DNA"},{"id":"T21","span":{"begin":839,"end":848},"obj":"DNA"},{"id":"T22","span":{"begin":856,"end":865},"obj":"DNA"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"},{"subj":"T18","pred":"source","obj":"jnlpba-st-training"},{"subj":"T19","pred":"source","obj":"jnlpba-st-training"},{"subj":"T20","pred":"source","obj":"jnlpba-st-training"},{"subj":"T21","pred":"source","obj":"jnlpba-st-training"},{"subj":"T22","pred":"source","obj":"jnlpba-st-training"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":118},"obj":"Sentence"},{"id":"S2","span":{"begin":119,"end":274},"obj":"Sentence"},{"id":"S3","span":{"begin":275,"end":472},"obj":"Sentence"},{"id":"S4","span":{"begin":473,"end":623},"obj":"Sentence"},{"id":"S5","span":{"begin":624,"end":950},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":3,"end":28},"obj":"DNA_domain_or_region"},{"id":"T2","span":{"begin":78,"end":117},"obj":"DNA_domain_or_region"},{"id":"T3","span":{"begin":119,"end":146},"obj":"protein_molecule"},{"id":"T4","span":{"begin":255,"end":273},"obj":"other_name"},{"id":"T5","span":{"begin":278,"end":303},"obj":"DNA_domain_or_region"},{"id":"T6","span":{"begin":305,"end":311},"obj":"DNA_domain_or_region"},{"id":"T7","span":{"begin":326,"end":347},"obj":"DNA_domain_or_region"},{"id":"T8","span":{"begin":368,"end":381},"obj":"DNA_domain_or_region"},{"id":"T9","span":{"begin":388,"end":411},"obj":"DNA_domain_or_region"},{"id":"T10","span":{"begin":422,"end":453},"obj":"DNA_domain_or_region"},{"id":"T11","span":{"begin":473,"end":479},"obj":"DNA_domain_or_region"},{"id":"T12","span":{"begin":507,"end":525},"obj":"DNA_domain_or_region"},{"id":"T13","span":{"begin":527,"end":533},"obj":"DNA_domain_or_region"},{"id":"T14","span":{"begin":592,"end":622},"obj":"DNA_family_or_group"},{"id":"T15","span":{"begin":640,"end":646},"obj":"DNA_domain_or_region"},{"id":"T16","span":{"begin":690,"end":711},"obj":"DNA_domain_or_region"},{"id":"T17","span":{"begin":726,"end":744},"obj":"DNA_domain_or_region"},{"id":"T18","span":{"begin":759,"end":765},"obj":"DNA_domain_or_region"},{"id":"T19","span":{"begin":774,"end":792},"obj":"DNA_domain_or_region"},{"id":"T20","span":{"begin":815,"end":821},"obj":"DNA_domain_or_region"},{"id":"T21","span":{"begin":839,"end":848},"obj":"DNA_family_or_group"},{"id":"T22","span":{"begin":856,"end":865},"obj":"DNA_domain_or_region"},{"id":"T23","span":{"begin":892,"end":909},"obj":"other_name"},{"id":"T24","span":{"begin":931,"end":949},"obj":"other_name"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#ece493","default":true},{"id":"jnlpba-st-training","color":"#ca93ec"},{"id":"pubmed-sentences-benchmark","color":"#93ecb0"},{"id":"GENIAcorpus","color":"#ec9693"}]}]}}